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<h3>Convert solutions into solid fibers to facilitate solubility</h3>
<p>In the nutraceutical industry, bioactive compounds that make the basis of most nutraceuticals typically have <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806606/" target="_blank" rel="noopener">low aqueous solubility</a>, leading to poor bioavailability. Electrospinning techniques can address this challenge.</p>
<p>The method and manufacturing process applies a high voltage the inclusion solution pumped through a needle. The electric field forces the droplet into a jet stretched to form a solid fiber. The ultrafine material can be woven into microcapsules that dissolve quickly.</p>


<p>Packaging is required to declare what dietary ingredients the nutraceuticals contain. The Supplement Facts panel must include measurable amounts of the 14 <a href="https://www.fda.gov/food/dietary-supplements-guidance-documents-regulatory-information/dietary-supplement-labeling-guide-chapter-iv-nutrition-labeling#4-6" target="_blank" rel="noopener">mandatory dietary ingredients</a>.</p>
<p>The label must also carry warnings about daily intake limits in EU markets. And FDA limits for the US markets. In addition, as a manufacturer, you need to state that your product should not be considered a replacement for daily rations from foods. This is usually aligned by the Current Good Manufacturing Practice regulations, also known as CGMP, a practice enforced by the FDA.</p>


Observe strict packaging regulations for nutraceuticals manufacturing process

<h3>Hemp is a core ingredient in nutraceuticals for livestock</h3>
<p>Veterinary nutraceuticals form a vital component of <a href="https://www.mdpi.com/journal/animals/special_issues/Nutraceuticals_and_Animal_Physiology#:~:text=Nutraceuticals%20are%20feed%20or%20part,nutritional%20supplements%20as%20therapeutic%20agents%E2%80%9D." target="_blank" rel="noopener">integrative</a> animal wellness. But not all ingredients used for human dietary supplements can be consumed by animals.</p>
<p><a href="https://books.google.nl/books?id=drWZDwAAQBAJ&amp;printsec=frontcover&amp;dq=veterinary+nutraceutical&amp;hl=en&amp;sa=X&amp;redir_esc=y#v=onepage&amp;q=veterinary%20nutraceutical&amp;f=false" target="_blank" rel="noopener">Hemp products</a> are driving a trend in the veterinary supplements market, particularly livestock. Nutraceuticals manufacturing derived from low-THC cannabinoids are used in animal feed for their antioxidant and neuroprotective properties.</p>


Making Nutraceuticals

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Continuous

If you are looking to pack your product into stick packs from 17 x 40 mm to 100 x 200 mm in size, you may benefit from the experience from the largest manufacturer of stick pack machines in Europe.


<h2>Benefit from the experience from Europe’s leading producer</h2>
This multilane Stickpack Machine series (ST200, ST400, ST560, ST800, ST1200 ) by VikingMašek can accommodate a large variety of different shapes of stickpack pouches with high efficiency and flexibility.

The versatile multi-lane stick pack machines can accommodate from 1 to 20 lanes, running as fast as 80 cycles per minute.

They are designed to pack powders, dense, fine, loose and particulate materials as well as liquids into StickPack bags and to accommodate different bag shapes including pour spouts, tear notches and easy-open system.

Semi- or fully automated cartoning solutions are also available for individual or bulk cartoning.

Stickpack Machine

Bagging is the process of packing measured portions of a product into bags that protect it from spoilage, enable easy and safe transportation, and secure the product against tampering and pilferage. The choice of a bagging solution depends on the desired mass or volume per bag, the flow characteristics of the product, and bag construction and design. Bags vary in size from small sachets to bulk flexible containers.

Bagging

Packaging preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Choosing the best packaging solution depends on the nature of the product, its end-use, and your production process.

Packing

liquid

solid

Batch

When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g. in the food and pharmaceutical industries.


<h2>Tailor your own conveyor without compromising quality</h2>
The piFLOW®p from piab is the best option when a premium technology is needed.

It is built on standard modules and you can combine and change them in almost endless combinations. All parts still meet the high requirements of the pharma and food industries. So, you have the possibility to tailor your own conveyor without compromising on quality.

The design makes it very easy to use and install; offering with this wide of applications, such as powder and granules transfer or form-fill-seal or big bag loading and unloading drum/bag filling and emptying or Mill/Sieve/Mixer/Blender filling or tablet/fragile products transfer or applications in explosive atmosphere or hygienic applications or compact applications.

Premium vacuum conveyor

Conveyor systems are used for moving materials from one location to another. Considerations for choosing a suitable conveying system include the nature of the product, its physical state, the desired conveying rate, and sensitivity of the product to heat and mechanical shock. Conveying systems are used in the food, pharmaceutical, chemical, biomass, and mineral industries to transport bulk powders, granules, and grains for processing and filling.

Conveying

If you are looking for high end-product fineness for suspensions with good flow properties with a steep particle size distribution, a horizontal agitated media mill can be a good solution. Often used for wet materials like chemicals, foodstuffs, metals, pigments, and paints.


<h2>Continuous wet milling of particles down to the submicron range</h2>
The Agitated Media Mill AHM from Hosokawa Alpine is a horizontal, cylindrical milling chamber that is universal in use for the continuous wet milling of particles down to the submicron range. This horizontal milling chamber was especially designed for suspensions with good flow properties where a steep particle size distribution and high end-product fineness are demanded.

Ball mills rotate around a horizontal axis, partially filled with the material to be ground plus the grinding medium. The mill is suitable for both continuous and batch operations, also available in sizes suitable for the laboratory, the testing center or for large-scale production.

Chemicals, minerals, PCC, ceramics, foodstuffs, metals, pigments, paints (mass production), laboratory, nanoparticles, abrasives, pharmaceutics. This mill is suitable for small amounts of product and for development trials, also in the nanotechnology sector. Extremely small grinding beads (&lt; 0.2 mm) can be employed with this mill, and investigations regarding the stabilization of suspensions in the submicron range can be executed.

Horizontal Agitated Media Mill

Milling &amp; grinding technologies are used to reduce the particle size of your product while preserving its essential properties. The choice of a suitable solution depends on your product feed, desired particle size distribution as well as your production volume.

Milling

For ultrafine classifying operations of mineral fillers such as limestone or calcite, dolomite, talc, baryte and perlite, and in the ceramics industry for the classification of quartz, feldspar and kaolin.  The results are superfine powders in the range d97 &lt; 2-20 µm.


<h2>Ultrafine classifying for superfine powders</h2>
The ATP Turboplex from Hosokawa Alpine is an air classifier for ultrafine classifying operations, obtaining with this superfine powders in the fineness range d97 = 5 to 10 µm; with the NG model, finenesses of d97 = 2 µm (d50 = 0.3 µm) are possible. The horizontal arrangement of the classifying wheel reduces wear even with abrasive products and guarantees a long service life.

The ultrafine air classifier operates across the entire separation range without oversize particles and ensures a high yield thanks to the integrated coarse material classifier, which also increases the cut point. With Turboplex multi-wheel classifiers, several horizontally arranged classifying wheels of the same diameter are driven separately. The common speed control is achieved via an adjustable static frequency converter.
<h2></h2>

Ultrafine air classifier

Separation process to separate components of a liquid mixture, for recovering dissolved solids from liquids. Choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology are widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high purity chemicals.

Separation

For ultrafine classifying operations in inline mode of all types of fine to medium-fine products, such as acrylate, epoxy-polyester, gypsum, plastics, petroleum coke, polyurethane and it is especially suitable for dedusting powder coatings in the particle size range from 5 to 10 µm.


<h2>Efficient classification as a result of internal recirculation of the feed material</h2>
The MikroClassifier CC air classifier from Hosokawa Alpine is a high-performance classifier and it can be easily integrated in-line into a grinding system or can be employed off-line as an independent classifying system. The Mikro classifier CC was designed for all types of fine to medium-fine products. It is especially suitable for powder coating classification aimed at reducing the ultrafine portion under 5 – 10 µm.

The cut point of this air classifier can be adjusted between 5 and 100 µm, because it is easy to clean, it is often employed for producing powder coatings of 5 to 10 µm. This air classifier is also suitable for use in potentially explosive areas.

Widely employed in the following industries: powder coatings, chemicals, pharma, food, cosmetics and minerals.
<h2></h2>

High performance classifier

For the gentle crushing of soft to medium-hard substances. Widely used in food industries for size reduction, pulverization, deagglomeration or delumping before they become a finished product.


<h2>Gently crush soft to medium-hard substances</h2>
The Bexmill from Hosokawa Alpine is a Conical gentle crusher, used to crush soft to medium-hard substances.

The mill can be charged both continuously and discontinuously.

Due to its conical form, the Bexmill can be operated in contrast to the classic Flake Crusher at higher revolutions. Through these larger throughputs, a higher fineness can be achieved.

The product spectrum ranges from wet to dry feed material.

This Conical gentle crusher is often used in processes of homogenization of mixtures, after mixer agglomeration, the disintegration of agglomerates, after fluid beds and kilns, and in the finishing of granulates.

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Conical gentle crusher

A hammer mill crushes aggregate material into smaller pieces; the most common applications can be found in food, chemical, plastic and cosmetic industries.


<h2>Grinding, mixing and homogenization in one single process</h2>
The Mikro Pulverizer MP from Hosokawa Alpine is a hammer mill for the gradual crushing of soft to medium-hard products. This unit comes with three operations such as grinding, mixing and homogenization.

Easy to clean and maintain, the MikroPulverizer MP grinds, mixes and homogenizes in one single processing step. The system is well-proven in combined grinding and drying systems, as well as in cryogenic and inert gas systems.

Different rotors, liners, screens and grinding elements are available for a wide range of applications and products, e.g. carbon black, iron oxide, casein, melamine, sugar, urea, etc.

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Hammer mill

Jet mills are frequently used in the pharmaceutical industry and also for the production of fine-grade chemicals. Jet milling uses highly compressed air or other gasses to reduce particles into powders with dimensions as small as one micron across.


<h2>Milling with high purity and minimal contamination</h2>
The Spiral Jet Mill - AS Aeroplex from Hosokawa Alpine is used to manufacture fine-grade chemicals for ultrafine size reduction of dry materials with a crystalline structure up to a Mohs hardness of 3.

Because it has no rotating components, there are consequently no bearings and shaft seals, and thus no lubricants are used. Contamination from these sources is therefore impossible.

This device is frequently used in the pharmaceutical industry to manufacture fine-grade chemicals, to create polymer powders for the plastics industry, adhesives, cosmetics, paint and ink compounds, pharmaceuticals, and more.

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Spiral jet mill

When you consider shifting pharmaceutical mixing processes from batch to continuous, accurate in-line continuous blending can be a real challenge.


<h2>In-line continuous blender with fast reactivity and minimum residue</h2>
The Modulomix from Hosokawa Micron is a continuous modular mixer and it has been designed to be compact with fast reactivity, minimum residue and rapid start-up and shutdown protocols, very useful in pharmaceutical applications.

It is a very compact blender because you will be able to combine the Modulomix modular mixer with PTS, LIW feeders, continuous blenders, PAT technologies and even downstream processing, like (wet) granulation and/or compact. It is adaptable due to it lets you have two different mixing environments in one single phase, multiple Modulomix mixers can be cascaded in series.

In-line continuous blender

Industrial mixing is used to combine a heterogeneous mix of two or more solid, liquid or gaseous ingredients into a homogenous product. The choice of a suitable mixing solution depends on the physical state of the ingredients and the desired mixing process; the sensitivity of the ingredients and process temperature and pressure requirements are also important factors.

Mixing

When you want to mix segregative, free-flowing powders and pastes that require perfect mixing quality and accuracy but require careful treatment, a conical screw mixer is a proven solution.


<h2>Gently mixing with perfect accuracy</h2>
The Vrieco-Nauta® conical screw mixer from Hosokawa Micron is a convective mixer with high mixing efficiency and accuracy for large volumes of up to 100.000 liters, specially designed for segregative, free-flowing powders and pastes. The conical vessel design allows a wide range of filling capacities and the mass flow characteristic design minimizes segregation upon discharge. Because there are no horizontal internal surfaces, products are completely discharged, minimizing product loss and providing for easy cleaning. Suitable for a wide range of processing activities in the pharmaceutical, food, plastic, metals &amp; minerals, nuclear, chemical, pigments and coatings industries.

Conical screw mixer

The conical screw vacuum dryer is particularly suitable for the final drying of powders, granules, pastes and viscous slurries especially when they are brittle and/or temperature-sensitive. It is often used for active pharmaceutical ingredients, pesticides, sterile APIs, chemically produced toner and cocoa.


<h2>Gentle drying of temperature-sensitive products</h2>
The Vrieco-Nauta® conical screw vacuum dryer from Hosokawa Micron is a universal batch dryer, capable of drying volumes ranging from 5 to 22 000 liters, suitable for powders, granules, pastes, viscous slurries, heavy and sticky products. Specially designed for heat-sensitive products or products that contain solvents that are toxic or explosive. It can also be used for vacuum operations such as reaction/crystallization, heating/cooling,
sterilization, liquid/solid separation and de-aeration. Controlling the moisture content by monitoring the weight of condensate or using the Hosokawa sampler for taking samples from the product inside the dryer under vacuum.

Conical screw vacuum dryer

Drying technologies are used to remove moisture from your product. Energy or heat can be supplied directly by blowing hot air or gas, through a product, or indirectly by using a heating medium. Choosing drying equipment depends on your product feed and the required flow of your commercial or industrial production line.

Drying

Flash drying refers to the removal of moisture by a stream of hot gas that goes through a stream of small particles that moves in the opposite direction. When drying large quantities of bulk powders, it can be important to better control the output characteristics of the powder. For this, combining drying, milling and classifying steps in one piece of equipment can be beneficial.


<h2>More control in your flash drying system</h2>
The Micron Dryer flash dryer, Drymeister® (DMR-H) from Hosokawa, can dry temperature-sensitive products, safely, even under increased temperatures, in a matter of seconds. Process parameters like classifier speed and outlet temperature can be adapted to control moisture content and particle size of the end product. The drying system is very flexible, handling moisture content fluctuations from a few % up to more than 80% in suspensions, slurries, pastes, dough, filter cakes and wet powders. The Drymeister® requires 75% less space and uses about 30-40% less energy per kilogram of evaporated water than conventional methods. The Flash combines drying system can be used in different industries such as the food industry, the chemical industry with applications in products such as pesticides, inorganic pigments and fish feed.

Flash drying system

Fluidized bed opposed jet mills rely purely on particle-to-particle attrition in the center of a fluidized bed of material; this is achieved by focusing in compressed gas nozzles into the milling chamber which accelerates the particles to produce collisions where energy is released causing particle breakdown.


<h2>Maximum fineness with the highest product purity</h2>
The Fluidized Bed Opposed Jet Mill AFG from Hosokawa Alpine is used for manufacturing powders with a steep particle size distribution and sharp top size limitation in the range &lt; 5 µm to 200 µm; maximum fineness values at maximum product purity. Such particle sizes can only be obtained in connection with an air classifying step. Fluidized bed opposed jet mills are equipped with a dynamic deflector-wheel classifier.

Even difficult products can be processed efficiently with the AFG jet mills. Heat-sensitive materials such as toner, resin, wax, fat, ion exchangers, plant protectors, dyestuffs, and pigments; highly pure materials where the requirement is contamination-free processing such as fluorescent powders, silica gel, silica, special metals, ceramic raw materials, pharmaceuticals.

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Fluidized bed opposed jet mills

For the laboratory or small amount compaction, granulation and briquetting of mineral and chemical products, abrasive products, and for frequent product changes.


<h2>Small scale granulation with effortless product changes</h2>
The Kompaktor® CS 25 from Hosokawa Alpine is particularly suited for the laboratory and for small product amounts. Where you will be able of processing powder to get granulate or briquettes. This process is described as compaction or briquetting.

This Laboratory roller compactor is made for frequent product changes and abrasive products because the rollers can be easily replaced. Due to the cantilever bearing the Kompaktor CS 25 is particularly easy to maintain and this with 25 tons of press force.

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Laboratory roller compactor

You may press finely sized powders together into dosages and quantities using compaction machines. The process separates the fed material into predefined measurements and packs the powders into blocks according to the specified density and shape to accommodate different end products.

Compaction

Pharmaceutical granulators are often used with active substance mixtures to be processed into granulates, a process also known as compaction.


<h2>Dry granulation of pharmaceutical powders</h2>
With the Pharmapaktor® Serie (Pharmapaktors series L, K, and C 250) from Hosokawa Alpine, active substance mixtures are processed into granulate.

For this, the powder is first pressed into flakes/pellets. These are often crushed with a Flake Crusher into granulate.

Compaction (dry granulation) is understood to be the compression of powder between two synchronized, counter-rotating rollers. The powder is fed to the counter-rotating rollers in a regulated manner. Here, adhesive forces between the product particles are created under high pressure between the rollers.

For capsule or sachet filling the granulate must be de-dusted in a screening machine. The sieved fines can then be directly fed to the Pharmapaktor again

Pharmaceutical granulator

A granulator is a high-speed knife mill designed to cut down large components of feedstock and reduce them to smaller particle sizes. Selecting the right scissor geometry and configuration allows granulators to process plastic bottles, organic fibers, films, wires, cables, and other difficult materials. Agglomeration granulators combine fine particles into larger granules by creating bonds between them. Bonds are formed by compressing fine particles or through the use of a binding agent. Granulation is used extensively in the pharmaceutical industry to prevent segregation of the constituents of a powder mix.

Granulating

A laboratory fine impact mill is used for fine and ultrafine grinding, for defibration, and for cutting soft materials.


<h2>Small scale size reduction of soft materials</h2>
The 100 UPZ und 160 UPZ Fine Impact Mills from Hosokawa Alpine are designed for fine and ultrafine grinding, for defibration, and for cutting materials of Mohs' hardness up to 3. Depending on the equipment, powder fineness values range from approx. 100 µm to 1500 µm.

The fine of the final product is adjusted by the selection of the corresponding size reduction elements and as a function of the machine speed.

This mill has many applications in the chemical industry, foodstuffs, and animal feed industry as well as in the pharmaceutical industry.

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Laboratory fine impact mill

A Laboratory hammer mill in pharma design for the comminution of pharmaceutical and chemical products. Depending on the project, the mill can be delivered integrated into an isolator.


<h2>Easy to clean pharmaceutical grade hammer mill</h2>
The Laboratory Hammer Mill 20/10 from Hosokawa Alpine is a laboratory device to perform size reduction and disintegration of agglomerates and lumps of pharmaceutical and chemical products with an achievable end-product fineness of &lt; 500 µm with minimum fines.

It is easy to dismantle, this results in easy and effective cleaning of all product-contact components. The inside of the machine can be cleaned with the beater unit removed and a special cover installed to protect the bearings.

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Laboratory hammer mill

Ideal for the ultra-fine size reduction on a laboratory scale of dry materials up to Mohs' hardness 3 and powder fineness of 5 µm to 40 µm. Suitable for high-grade pharmaceuticals and fine-grade chemicals.


<h2>Ultrafine size reduction of mini-batches</h2>
The laboratory spiral jet mill, 50 AS from Hosokawa alpine is used for ultra-fine size reduction of dry materials with a crystalline structure up to Mohs hardness of three and production of a powder with a high ultra-fine portion between 0.5 and 30µm.

Often used for processing pharmaceutical active substances like parenteralia, DPIs (dry powder inhalants) and other active substances.

This compact and portable design meets the highest pharmaceutical standards and is ideal for the operation in an isolation containment device.
<h2></h2>

Laboratory spiral jet mill

Tabletop model for the wet grinding of small to ultra-small product batches down to the nano fineness range. Suitable for a wide range of applications such as engineering ceramics, mineral substances, pigments, paints, fine-grade chemicals, pharmaceutical products, dental ceramics, food supplements, abrasives, submicron, and nano grinding.


<h2>For the wet grinding down to the nano fineness range</h2>
The Wet mill 90 AHM from Hosokawa Alpine is a laboratory device for the wet grinding of small to ultra-small product batches down to the nano fineness range. It is suitable for small amounts of product and for development trials - also in the nanotechnology sector. Extremely small grinding beads (&lt; 0.2 mm) can be employed with this mill, and investigations regarding the stabilization of suspensions in the submicron range can be executed.

In contrast to the other AHM mill types, the laboratory version has a variable-speed direct drive; it is easy to fill in, empty, and clean up due to its pivoted support.

Laboratory horizontal agitated ball mill

The Alpine Picoline is a series of miniature laboratory machines for processing samples down to 1 gram. The Picoline is ideally suited for research and development or for manufacturing expensive materials such as nano-particles, pharmaceuticals, plastics, ceramics, and specialty chemicals.


<h2>Designed for ease of operation, maintenance, and cleanability</h2>
Picoline from Hosokawa Alpine is a new series of eight individual machines specifically designed for the production of very small batches of between &lt;1g and several grams.

The Alpine Picoline equipment maintains, in miniature, the top engineering standards and leading-edge technology. With machines in the Alpine Picoline series for size reduction, classifying, and mixing.

Because the principle of operation of the Alpine Picoline machines is the same as that of large production-scale machines, R&amp;D departments can be confident that the transfer of a manufacturing process developed using a Picoline machine to a production-scale machine will be smooth and problem-free.

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Laboratory mill for small batches

Pusher centrifuges are continuously operating filter centrifuges and can have several basket stages depending on the application. Widely used for processing salts, fertilizers, but also plastics, soda and cellulose.


<h2>Continuous solids throughput under the toughest conditions</h2>
Pusher centrifuges from Ferrum are continuously operating filter centrifuges that are based on the very successful Sulzer Escher Wyss design. The slurry is fed continuously to the product acceleration disc via the filling pipe. The solids are transported out of the centrifuge basket into the discharge channel, from where they leave the pusher centrifuge. The cake is cleaned in the centrifuge by adding washing liquid on to the solid cake.

Various models have been developed with basket sizes ranging from 230mm to 1200mm. The most common applications are developed in agricultural and petrochemical industries, such as filtration for obtaining zinc sulphate, lysine, nitrocellulose, sea salt, sodium carbonate, urea, Glauber’s salt, potassium chlorate, potassium nitrate, linters and so on.

Pusher centrifuge

Industrial centrifuges are widely used for mechanical solid-liquid separation of components in the pharmaceutical and chemical industries. This is achieved by rapidly rotating the contents within a container to separate fluid of different densities or to remove liquids from solids.

Centrifuging

Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the bottom. They are suitable for the demanding continuous operation in the chemical and fine chemical industry or for complex pharmaceutical applications.


<h2>Efficient and reliable process cycles with low vibration</h2>
The Vertical Scraper centrifuges VBC (Vertical Bottom discharge Centrifuge) from Ferrum include many application areas in the solid-liquid separation due to the modularity and the comprehensive range of optional equipment. The solid-liquid separation is effected discontinuously in a sequence of specific process steps. The individual process steps last from a few minutes to several hours depending on the characteristics of the product.

The most common applications are in the paint industry with pigments; herbicides, insecticides and carbofuran in the agrochemical industry; antibiotics, vitamins, APIs and other intermediates in the pharma industry; and plenty of applications in the food industry.

Vertical scraper centrifuges

A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from suspension liquid feed mixtures in the pharmaceutical industry, where the scrapped solids are discharged through the bottom of the centrifuge vessel.


<h2>Excellent inspection outside and below the centrifuge basket</h2>
The Vertical Peeler centrifuge is a new development of the centrifuge type VBC-S (Vertical Bottom discharge Centrifuge - Swivel Open Housing) from Ferrum and it was specially designed for use in the demanding pharmaceutical industry.

Pharmaceutical centrifuges are used for products that can be filtered with solids concentrations from 2 w% and particle sizes of minimum 4 μm. The continuous operation of centrifuge allows all process steps are carried out simultaneously, increases the overall throughput.

The most common applications in the pharma industry are in Active pharmaceutical ingredients (APIs), antibiotics, salicylic acid, pharmaceutical intermediate products, etc.

Vertical peeler centrifuge

Discharge solids vertically upward through manual action, optionally using a filter bag or a special suction device.


<h2>Optimally designed controls for easy, efficient operations</h2>
The top discharge centrifuges from Ferrum include many application areas in the solid-liquid separation due to the modularity and the comprehensive range of optional equipment. The applications of the vertical top discharge centrifuge, range from pilot plants, small-quantity production to production applications in the chemical and pharmaceutical industries.

Vertical top discharge centrifuge

The system is perfectly suited for pilot plants as well as small-quantity productions in the fine chemical and pharmaceutical industries.


<h2>Compact and mobile centrifugation</h2>
The mobile pilot plant centrifuge from Ferrum, combines centrifuge, control and drive components as well as inertisation system in one mobile turnkey unit. The system is perfectly suited for pilot plants as well as low volume production in the fine chemical and pharmaceutical industries. The solids are discharged vertically upward manually or using a filter bag.

Mobile pilot plant centrifuge

For transferring highly active pharmaceutical ingredients (HAPI) without contamination from the isolator centrifuge to the next process step (e.g. vacuum tray dryer).


<h2>Simple and efficient handling within the isolator</h2>
The VTC isolator centrifuge from Ferrum is designed especially for the use in an isolator.

This allows the operator contamination-free transport of toxic active pharmaceutical ingredients (HAPI) from the centrifuge to the next process step (e.g. vacuum dryer).

The solids are discharged from the basket either manually or by means of a lifting device.

The system is Suitable for pilot plants as well as small production quantities in the pharmaceutical industry.

Isolator centrifuge

For slurries difficult to discharge, a scraper can improve process reliability, efficiency, and operating cost. At reduced speed, the scraper knife swings into the filter cake and scrapes out the product vertically downward via the discharge chute.


<h2>Easy to access centrifuge for the best inspection</h2>
The HPZ 630-1600 range from Ferrum for pharmaceutical centrifuges HPZ range from pilot plants and low volume production to production applications in the demanding pharmaceutical industry. Ferrum pharmaceutical centrifuges are used for products that can be filtered with solids concentrations from 2 w% and particle sizes of min. 4 μm.

When expecting the processing area and the internals, the entire housing is swiveled open. An optional front door further eases and improves inspection. The centrifuges can be operated in an automatic, semi-automatic, manual or service mode. With the Horizontal pharmaceutical scraper centrifuge, a wide range of production recipes can be saved.

Horizontal pharmaceutical scraper centrifuge

For slurries difficult to discharge, a scraper can improve process reliability, efficiency and operating cost. At a reduced speed, the scraper knife swings into the filter cake and scrapes out the product vertically downward via the discharge chute.


<h2>High solids throughput with low energy consumption</h2>
The Ferrum HCZ 1000 and 2000 centrifuges were purposely designed for high throughputs and continuous operation under the toughest conditions in the chemical and fine chemical industry. The design features are robust and very reliable in accordance to the latest standards and directives. The centrifuges are built for permanent operation under the toughest conditions.

The Horizontal chemical scraper centrifuge is widely tested for herbicides and pesticides, special applications such as ABS, iron sulphate, melamine and so on can also be developed.

Horizontal chemical scraper centrifuge

When you need to mix cohesive powders with liquids or melt binders and require a homogenous end-product, a high-shear mixer can be used.


<h2>High-speed, intensive paddle mixer and agglomerator</h2>
The Cyclomix® from Hosokawa Micron is a multi-purpose high-shear impact mixer. It combines different processes in one single machine and is the ideal choice for intensive thermal processing of high energy input; high degree of dispersion and homogeneity and ultra-short cycle times.
The mixing vessel is conical shaped and has a central rotor that rotates at a speed up to 30 m/s. The speed of the rotor creates centrifugal forces that push the product to the vessel wall where the shape of the vessel causes an upward movement.

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High-shear impact mixer

Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying processes. The product is dried by freezing, subsequently to the sublimation and ice formation, typically with a vacuum and at low temperatures.


<h2>Mixing and freeze-drying in one step</h2>
The active freeze dryer from Hosokawa Micron uses very low temperatures and a vacuum to dry your product and to obtain it in very good quality. Due to the low temperatures usage the damage of heat sensitive products, such as enzymes, flavors, proteins, vitamins and so on is avoided. Hand traditional tray-type freeze dryers are slow and labor-intensive. Hosokawa's Active Freeze Dryer ® eliminates these drawbacks.
Typical applications include pharmaceuticals like antibiotics, collagens, <a href="https://making.com/active-pharmaceutical-ingredients-api/">APIs</a> and electrolytes; Food industry and in special materials like nanomaterials, polymers, ceramics, pigments, fillers, limestone, catalysts, glass powder and salts.

Active freeze dryer

The laboratory-scale active freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying processes. The product is dried by freezing and subsequent sublimation of ice formation, typically in vacuum and at low temperatures, in a small laboratory and pilot plant scale, enabling a smooth transition to the production plant.


<h2>Start innovating with freeze-drying technology</h2>
The 1-liter laboratory-scale freezer dryer from Hosokawa Micron is quicker and less labor-intensive than traditional tray-type freeze dryers. It offers the possibility of producing loose and free-flowing powder at low temperatures and low pressures, all in one vessel. Ideal for testing and simulating processes, the lab unit is "plug and play", including controls and all necessary equipment for reliable operation in your laboratory environment. Ideally suited for pharmaceuticals like antibiotics, collagens, APIs and electrolytes; food industry and special materials like nanomaterials, polymers, ceramics, pigments, fillers, limestone, catalysts, glass powder and salts.

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Laboratory scale active freeze dryer

The laboratory conical screw vacuum dryer is particularly suitable for the final drying of powders, granules, pastes and viscous slurries especially when they are brittle and/or temperature-sensitive. Useful during research and development when only a few grams of a new substance are available. Ideally suited for testing pharmaceutical products, pesticides, sterile APIs, chemically produced toner and cocoa.


<h2>Test drying processes for sensitive products</h2>
The 5-liter conical vacuum dryer from Hosokawa Micron is used for drying off heat-sensitive materials at typical 10 - 20 mbar absolute pressure in a batch process, this orbital vacuum dryer is the right tool for laboratory-scale experiments. It can handle pasty products, cakes or high viscosity slurries and delivers reliable attempts or simulations of drying and mixing. Suitable for powders, granules, pastes, viscous slurries, heavy and sticky products. Specially designed for heat-sensitive products or products that contain solvents that are toxic or explosive. It can also be used for vacuum operations such as reaction/crystallization, heating/cooling, sterilization, liquid/solid separation and de-aeration.

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Laboratory conical screw vacuum dryer

A Laboratory high shear impact mixer can be used to simulate different processes; from slow speed pre-blending to high-speed coating, agglomeration, and dispersion.
<h2>Experiment with cohesive powders on a lab scale</h2>
The Hosokawa Micron high shear impact mixer 1 liter is a downsized Cyclomix lab model, with a working volume of typical 0.3 - 1 liters powder content, mainly used for cohesive powders. Using frequency control, any mixing process can be imitated on this small-scale mixer: from slow speed pre-blending to high-speed coating, agglomeration, and dispersion.
It is used in the adhesives, chemical, cosmetic, food, pharmaceutical, and plastics industries for emulsification, homogenization, particle size reduction, and dispersion in the batch process.
Combining different processes in one single machine and is the ideal choice for intensive thermal processing of high energy input; high degree of dispersion and homogeneity and ultra-short cycle times.

Laboratory high shear impact mixer

An emulsifier is used to mix two immiscible liquids. Heating or cooling requirements during emulsification, overpressure or vacuum requirements, the need for wall scrapers, design of the mixing head, the viscosity of the liquids, and the desired droplet size are all important considerations when selecting an emulsifying system. Emulsifiers are typically used in the food industry for the production of batters, creams, and sauces, in the pharmaceutical and cosmetics industry for the production of creams and lotions, and in the chemical industry for the production of paint and other emulsions.

Emulsifying

When you have a very limited amount of powder available, you can still test your processes with the Hosokawa Picoline. The Picomix is the mixing module in the Picoline. It is a high-shear mixer that allows you to work with 30ml to 100ml batches.


<h2>Intensive and homogenous mixing on microscale</h2>
The mini Cyclomix from Hosokawa Micron is a high-shear batch mixer for dry powders in a miniature scale. It is the downsized version from the Hosokawa Cyclomix, which combines different processes in one single machine for intensive thermal processing of high energy input; high degree of dispersion and homogeneity and ultra-short cycle times.
Moreover, the speed of this mixer can reach up to 6,000 L /min, the maximum volume it can handle is 20-100mL, and the product batch should weigh approximately 20 g. The result of the unique composition of the mixing element is an intensive homogenous and quick mixing of the powder components.
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Miniature scale high-shear mixer

Purposely focused on the indirect heating and drying of slurry, filter cakes, powders, pastes and granulates at a high speed - Dispersing liquids quickly and transforming products such as filter cakes and slurries from centrifuges, wet solids from decanters and press cake after press filtration into dry powders are among its striking features.


<h2>Continuous paddle dryer for rapid and effective indirect drying</h2>
This continuous paddle dryer from Hosokawa Micron is a high-speed dryer. It consists of a fixed cylindrical chamber with an eccentric agitator inside and two independent movements, perfectly capable of rotating on its own axis and tangentially to the cylindrical chamber too.

It has a patented jet rotor design, which allows the injection of a gas or liquid through the paddles and into a thin layer of material as it spirals along the cylindrical wall of the unit. This continuous paddle dryer is designed to be utilized with a variety of heat sources and for other numerous applications, not to mention its speed and effectiveness.

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Continuous paddle dryer

Enable vacuum, atmospheric and pressurized processing of a variety of materials such as powders, filter cakes, pastes and viscous slurries, especially when they are brittle and/or heat sensitive.


<h2>Fast-drying in a compact, multi-functional design</h2>
The Conical Paddle Dryer from Hosokawa Micron is a vertical, centrally-driven dryer that combines extremely fast drying rates with a compact design. This combination of several processes in one vessel offers savings on investment costs, labor and space.
Originally designed for vacuum drying of solid-based materials, but can be used in a wide range of other applications requiring thermal processing or vacuum treatment of solids.
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Vertical paddle dryer

Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottles with volumes ranging from 2 to 500ml and with maximum speed of 12,000 units per hour.


<h2>Fill liquid products in ampoules and bottles with fast product change-over</h2>
The new and innovative Romaco Macofar LF 200 series are an efficient solution for the filling of liquids and are perfectly adjusted to the increasing market requirements. The systems working in the medium and high speed range are suitable for products with different flow properties. All models are very easy to operate and individually configurable. The high degree of automation optimizes the process safety and the overall equipment effectiveness.

It has a weight of 1900 to 3800kg and speed of 4500 to 12,000 units per hour depending on the machine configuration.

High-speed small volume liquid filler

Dosing systems include hoppers, feeders, filling machines, and checkweighers. The selection of suitable dosing equipment depends on the need to dose by quantity, the size of each dose, and the desired dosing rate. The physical form of the material, health and safety requirements and the container to be filled are also important considerations. Dosing systems are used for filling containers in the pharmaceutical industry and for accurate dosing of ingredients in the food and chemical industries. Discuss your dosing challenge with us to receive advice on the most suitable solution for your application.

Dosing

Industrial filling equipment solutions are used to package a measured mass or volume of a product, at the end of a production line, into a packaging container suitable for the product. The choice of filling system or filling line depends on the physical state of the product, the packaging container of choice, the desired mass or volume per container, the required production volume, and considerations of sterilization and safety.

Filling

The checkweighers for multiple lanes have a 1.5 times faster response speed and 2 times higher accuracy than conventional models with the high-rigidity electromagnetic balancing weigh cell.


<h2>Specialized multi-lane check weighing system</h2>
The checkweigher for sachets and sticks, from Anritsu is a specially multi-lane check weighing system, utilized to weigh individual packages that are in small stick shapes, like individual water bottle flavour packs. Most of the products consist of granulated sugar. The stick pack weighing system consists of the KW6023F type, available in six different models. All the models have weighing control of up to six lanes with just one indicator.

Checkweigher for sachets and sticks

A crucial step before your products leave the production line is a quality check for dosage and standards. Equipment for measurement and control employs a range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized systems allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

When working with several lines of stand-up pouches, you can benefit from controlling the weight on the different lanes with a single checkweigher.


<h2>Weighing control of up to two lanes with just one indicator</h2>
The Checkweigher for stand-up pouches from Anritsu, is a space-saving checkweigher for multiple lanes. These checkweighers are suitable for lines where multiple lanes of products are inspected with just one unit, such as divided filling packaging or tube filling lines. The Anritsu KW6205E type - allows weighing control of up to two lanes with just one indicator. It has colour LCD touch panel, automatic power switching and support of GMP and HACCP.

Checkweigher for stand-up pouches

Staying competitive in today's highly dynamic and highly regulated pharmaceutical production market requires encapsulation equipment with the utmost process control and batch documentation.  Quick changeover, and accurate dose control are required as well as enhanced features like environmental sensors, online weight adjustment and automated documentation and reporting.  Successful modern producers use these next-generation features to maintain an edge of competitors with more traditional equipment.


<h2>A complete automatic encapsulation solution with state-of-the-art accuracy controls and reporting functionality.</h2>
The Legend 2500 from ACG-PAM is a fully automatic capsule filler with next generation design which greatly enhances production speed and efficiency.  ACG-Pam has over three decades of experience in the pharmaceutical manufacturing industry and the success of the company's AF series of encapsulating machines which are installed in over 1,000 facilities across the globe provides a knowledge base and industry expertise that is second to none.  The Legend 2500 encapsulation represents the application of this knowledge and experience specifically to improve upon existing encapsulation systems and better meet the needs of today's pharmaceutical producers.

The system includes Industrial PC based controls, online weight adjustment, and a screw type auger for use with the widest variety of formulations.  The need for an extra doing disc when filling doses are 50% of slug length is eliminated by use of a slug length adjustment kit.  Anti-jamming features for trouble free capsule loading and automatic lubrication are also included.  The system makes use of integrated environmental sensors, a stand-alone security enabled IPC control pedestal, and full 21 CFR Part 11 compliant reporting to ensure an encapsulation process that is accurate, controlled, and well documented.

Easy to validate capsule filler

Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

Pharmaceutical manufacturers require maximum yield from their encapsulation process for efficient production and competitive results.  Leaving expensive pharmaceutical formulations in the encapsulation machine as left-over or dust is wasteful and inefficient.  Equipment with all the features required for accurate high quality encapsulation as well as enhancements for minimized dust creation and product loss will give users a distinct advantage over the competition.


<h2>A complete encapsulation solution for maximum yield</h2>
The ZRO 90T system from ACGE is a production scale capsule filler from the AF series of capsule fillers that is currently running in over 1,000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The ZRO 90T machine has all the benefits associated with the series as well as additional features to minimize formulation loss during processing and maximizing yield.  The capsule filler includes ACGE's patented ZRO technology which minimizes dusting and separation by containing the formulation within the dosing disk.  This technology reduces formulation waste and maximizes powder use efficiency for maximum yield.

High-yield capsule filler

Innovators in the highly regulated and highly dynamic pharmaceutical market place need equipment that is worry-free and flexible enough to vary products and process variables as new products are developed.  Laboratory capsule filling machine must be easy to maintain, allow for rapid tooling change-over, and provide tightly controlled process variables and automatic operation in order to ensure results that are reproducible at the production scale.


<h2>A complete encapsulation solution for the laboratory</h2>
The AFT-T Lab system from ACGE is a laboratory capsule filler from the AF series of capsule fillers that is currently running in over 1000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The AFT-T Lab machine has all the benefits associated with the larger equipment in the series but on a scale appropriate for laboratories.  The machine can output up to 6,000 capsules per hour for powder filling and 5,000 capsules per hour for pellet filling.  It uses a 1.1 kW primary motor.  It weighs about 1,200 Kg and occupies only 2.25 square meters of floor space making it the perfect scale for any pharmaceutical laboratory.

Automatic laboratory capsule filler

A recent important change in the industry is the trend toward providing liquid doses contained in hard capsules.  The right equipment is need to develop processes to fill hard capsules with the wide variety of liquids used by today's pharmaceutical producers.  Laboratory equipment that is capable of handling waxes and lipids, automatically sealing the capsules, and maintaining a tightly controlled process suitable for scaling to production levels will give pharmaceutical innovators an edge of the competition.


<h2>Fill and seal hard capsules with any pharmaceutical liquid</h2>
Fluidocap 1000 is a semi-automatic machine for filling hard pharmaceutical capsules with liquid an sealing them.  It is provided by ACGE-Associated Capsules a world leader in pharmaceutical machinery manufacturing.  Traditionally liquid doses have been provided in soft gel-cap form and have presented drug makers with the common problems of high cost, wastage, cross contamination, migration of the drug into the capsule, and low bioavailability.

The Fluidocap range of machines address these issues by allowing the filling and sealing of hard capsules with liquid compounds rather that relying on soft gelcaps.  The hard capsules can be filled with a wide range of formulations including lipid-based products, high viscosity pastes, and wax type products.  They are sealed with a gelatin band.  The Fluidocap 1000 capsule filler for liquid is designed for laboratory use and can produce up to 1000 capsules per hour but can easily be scaled up to commercial level production.

Laboratory capsule filler for liquid solutions

Creating batches of consistent high quality pharmaceutical grade tablets from your powdered ingredients requires equipment that complies with strict regulations and record keeping requirements while at the same time is flexible and easily adapted to a variety of products.  Easily maintained, equipment with quick tooling changeovers and faulty punch detection gives producers the worry-free tablet production capabilities that they need to be competitive.


<h2>A simple and robust tableting platform for efficiency and regulatory compliance.</h2>
The Protab 300 from ACGE is a simplified rotary tablet press with features designed specifically to meet the demands of today's small and medium batch pharmaceutical producers.  It is designed for easy maintenance, rapid changeover, high reliability and Overall Equipment Efficiency in general.  A dust extraction system , feeder assembly, turret, and exit chute assemblies have all be rethought and include features such as auto-lubrication, swing-in swing-out design, modular design of supporting assemblies to ease machine use and increase production efficiency.

ACGE's Protab 300 also includes features that assure a tablet product of the highest quality including digitally aided feeder height adjustment, precise tablet weight control, and safety features such as process interlocks and noise reduction.  Productivity is enhanced with higher machine up-times, low feeder leftover losses, improved paddle design for elimination of dead zones, and and intelligent 'batch over' detection system.

Single rotary tablet press

Successful pharmaceutical manufacturers know that high quality, reliable equipment is essential in order to be competitive in highly regulated and highly dynamic market.  Reliable, flexible forming equipment that works with a variety of tooling types and is adjustable to meet the needs of different products gives producers peace of mind.  A tablet press with full audit trail compliance from a world renowned pharmaceutical equipment supplier is certain give any high volume pharmaceutical producer an edge over the competition.


<h2>A tablet press with premium features and low cost</h2>
The Legacy 6100 tablet press from ACGE is a tablet press of proven design and well known quality.  The consistent, high quality production and user friendliness demanded by today's producers as well as a low upfront cost and revenue optimization features make this unit the ideal choice for high volume tablet production in a competitive environment.

The unit includes 10 tonne compression rollers in both the 1st and 2nd stages and well-tuned dwell time to ensure gradual compression.  Non-complying tablets are identified and sorted automatically and product recipes and production parameters are stored internally.  The system is designed for economic operation and includes features for easy cleaning, and rapid change-over, as well as a online support and video training materials to ensure competent and confident operators and efficient production.

Economic tablet press

Equipment operating under the rotor/stator principal is often employed when more traditional methods of stirring cannot achieve desired results. High performance continuous dispersing equipment is needed to achieve desirable results for almost any mixing process in circumstances where other machines fail.
<h2>Rotor/stator mixing in a robust and simple package that is easy to clean</h2>
The IKA ULTRA-TURRAX UTL 2000 is inline high-performance single-stage dispersing machine used for the production of emulsions and suspensions. The UTL 2000 uses the rotor/stator principle and is best suited for continuous applications that cannot be accomplished using conventional stirring methods.

During the full continuous process the components to be mixed are fed into the machine at an appropriate rate through various inlet connections. These components are then thoroughly mixed, dispersed or homogenized within the machine and discharged from the machine through the outlet. Thus, all particles or droplets are treated producing a narrow particle or droplet size distribution with minimal concentration/quality variations. Additionally, the UTL 2000 creates a pumping action which can be used for transfer purposes at low to moderate viscosities with a maximum of about 20 m (ca. 2 bar).

The machines are designed for easy and reliable scale-up and sizes are available with throughput from 50 to 125.000 liters per hour.

Dispersing machine for emulsions and suspensions

Dispersing systems are used to produce emulsions of two immiscible liquids or dispersions of solid particles in a liquid medium. The mixers generally operate on the rotor/stator principle and apply a high shear force on the suspended particles to break them down. The choice of a dispersion mixer depends on the physical state of the material being dispersed, the continuous or batch nature of the process, desired particle size, and the viscosity of the mixture. Dispersion mixers are widely used in the food industry for the dispersion of solid ingredients in oil or water and in the coatings industry for the dispersion of pigments.

Dispersing

Homogenization

For products of medium viscosity and relatively consistent particle size such as honey, cremes, and some plastics, a simple, low cost mixing machine is useful to ensure even dispersion.  The most efficient production plants take advantage of such equipment in continuous production processes to minimize required floor space and serve double-duty as mixing and pumping/transfer equipment.
<h2>A basic effective mixing machine with transport pump capabilities and low cost</h2>
The lower-priced ULTRA-TURRAX UTL 1000 machines from IKA are particularly multifunctional and are used for the mixing, dispersing (emulsifying/suspending) and homogenizing of solid and liquid substances up to viscosities of several thousand mPa·s, such as honey, plastic masses and crèmes. The mixing components are fed into the machine at the inlet connection. The materials are mixed, homogenized and then discharged from the machine via the outlet connection. The economic dispersing machine does not have automatic suction, but does have a conveyor height of up to 20 meters.  Units are available with flow rates from 4.800 to 125.000 liters per hour.

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Economic dispersing machine for emulsions and suspensions

For continuous high performance mixing of solid and liquid raw materials rotor/stator equipment is often used because of the high shear forces it applies to the mixture which reduces particle size and aids dispersion.  Use of equipment that uses three stages of rotor/stator action to achieve extremely small and evenly distributed particles for production of very fine emulsions and suspensions will guarantee the success of your process.
<h2>Three stages of rotor/stator mixing power for extremely fine emulsions and suspensions</h2>
The IKA DISPAX-REACTOR® DR 2000 is a three-stage high shear inline dispersing machine used for the production of very fine emulsions and suspensions. Shear forces that occur in the working chamber produce a drastic increase of mass transfer and accelerate the dissolving rates of mono and macromolecular substances. Three rotor-stator combinations (generators) in a series ensure small- droplet or particle size and a very narrow distribution spectrum. This process promotes a long stability of mixtures in a single pass, especially when working with emulsions.

In order to configure the DISPAX-REACTOR® DR to meet a variety of application needs, IKA offers a wide selection of generators. The standard rotor-stator (generator) combination consists of a coarse, medium and fine rotor-stator. When installed in a series, this configuration ensures satisfactory particle size reduction while providing optimum dispersing results in a single pass. The units are designed for easy and reliable scalability and are available in sizes with flow rates from 80 to 125.000 liters per hour.

Dispersing machine for very fine emulsions and suspensions

Producing the finest micro-emulsions and suspensions requires a mixing machine that generates extremely high shear.  Multi-staged rotor/stator dispersing machines work well for this purpose because of the high shear forces applied to the mixture at each rotor/stator stage.  A rotor /stator dispersing machine that also incorporates extremely fast rotation and resultant tip speeds for even greater shearing action will lead to the creation of super-fine emulsions and ensure the success of your process.
<h2>Top-of-the-line rotor/stator dispersion with utlra high shear for nano-scale particle emulsions and suspensions</h2>
The DISPAX-REACTOR® DRS from IKA is an inline ultra high shear dispersing machine used to achieve the finest micro-emulsions and suspensions. Extremely high shear rates (up to 190.000 1/s) combined with a fine generator geometry enable crushing of droplets and solids particles down to the nanoscale. The resulting product has long-term stability which reduces the need for emulsifying agents and thickeners. Because of the extremely high energy density, other dispersing aids can be reduced or possibly eliminated.

The DRS is usually equipped with a two-stage rotor-stator system (generators). The high tip speed of 40 m/s (10.000 fpm) often negates the need for a third stage. The ultra-fine dispersing machine, designed with the same high quality features as the ULTRA-TURRAX® UTL and the DISPAX-REACTOR® DR, is especially well suited for challenging pharmaceutical applications.  The units are designed for easy and reliable scalability and sizes are available with flow rates from 70 to 40.000 liters per hour.

Ultra-fine dispersing machine for emulsions and suspensions

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  These machines use pressure shock to create very even distributions of extremely small particles.  They are; however, limited in their available flow rates and their ability to handle tough agglomerations of solids.  For these applications where a high pressure homogenizer cannot handle the raw materials or provide enough throughput, a colloid mill is often the better choice.
<h2>Extremely high quality dispersions of consistently sized particles with a very high throughput</h2>
The IKA MK 2000 is a high-performance inline colloid mill capable of performing wet and fine milling of tough and grainy raw materials. The MK 2000 is especially suitable for the production of colloidal solutions or extremely fine emulsions and suspensions. Excellent dispersing performance allows the IKA Colloid Mill MK 2000 to be used for continuous processes, providing a narrow distribution range of ground particles in a single pass. For challenging milling tasks the colloid mill can be installed into a recirculation loop with a working vessel by means of tube connections.

The conical geometry of the milling tools enables an axial displacement of the stator for an infinite adjustment of the milling gap. This allows influencing the dispersing effect, particularly regarding tasks with variable raw materials.

As neither the rotor nor the stator is slotted throughout, the probability of particles passing through the generator untreated is negligibly small. These collective features enable the IKA Colloid Mill MK to achieve the finest particle size reduction, thereby contending with a high pressure homogenizer by attaining similar dispersing results at higher flow rates.

The machines are designed for easy and reliable scalability and sizes are available with flow rates from 200 to 80,000 liters per hour.

Colloid mill

When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process needs a steady, consistent flow of smaller particle sizes you need a high performance mill that is both powerful and flexible.  Furthermore, to ensure an efficient facility and maximum machine up time, the equipment should have a minimal footprint and be easy to clean.
<h2>Powerful and consistent milling of tough particles and viscous mixtures</h2>
IKA's MKO 2000 is a high-performance inline cone mill capable of performing wet and fine milling of tough and grainy or crystalline raw materials. The MKO 2000 is especially suitable for the de-agglomeration of suspensions. Excellent dispersing performance allows the IKA Cone Mill MKO 2000 to be used for continuous processes, providing a narrow distribution range of ground particles in a single pass.

For challenging milling tasks the cone mill can be installed into a recirculation loop with a working vessel by means of tube connections.  The gap between the conical shaped rotor and stator is infinitely adjustable allowing for excellent control of particle and droplet size.  Rotation speed and the resultant dispersion effect are also adjustable.  the unique conical milling head geometry also allows excellent grinding performance while the rotor and stator tools are never in contact with one another.  This, together with the extremely tough and high quality surface finishes on the tools, prolongs life and reduces contamination of the product due to machine wear.  The units are designed for easy and reliable scalability and sizes are available with flow rates from 150 to 6000 liter per hour.

Cone mill machine

Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mustard, and lubricants is successfully carried out by mills using rotating corundum disks.  Equipment with excellent grinding performance, adjustable process parameters, and many customizable options will give you an edge in these challenging applications.


<h2>Powerful and controllable wet grinding from a reliable, modular machine</h2>
The MCD 2000 Corundum Disk Mill from IKA is an inline mill for wet milling and grinding of viscous liquid or paste-like products. The mixing chamber consists of two corundum disks, one rotary and one stationary. The corundum disks are available in different grain sizes (grit) depending on the grinding process requirements. The units offer an adjustable milling gap to accommodate various particle or droplet sizes. This, together with the many customization options make the machine adaptable to a wide variety of wet grinding applications.

The systems are designed for use in food-grade production and can include FDA certification and IQ/OQ documentation when required.  All variants of hte MCD 2000 are easy to clean with CIP or SIP capability.  The large range of sizes available ensures that your process is readily and reliably scalable.  Units are available with flow rates from 20 to 4500 liters per hour.

Corundum disk mill

Several issues often arise when your process requires batch-wise mixing of powders into liquids.  The mixing process can be slow, dust and liquid solvent may be released to the surrounding work area, agglomerate powder masses may form and the ratio of ingredients may be inconsistent.  The right equipment is needed to address all of these issues and improve the efficiency and quality of your process.
<h2>Reliable batch mixing improves process quality and efficiency</h2>
The CMX 2000 inline batch mixer from IKA incorporates powders into liquids and mixes these materials reliably and consistently in a batch process. Its multi-level design and unique pumping stage enables processing of high viscosity products without any additional aggregates. The system is usually supplied with a solid material dosing feeder and mixing containers. Depending on the application and the requirements of the customer, the solid material can be fed via a bulk bag unloader, a funnel, sack-emptying boxes or directly from the bag via a suction lance.  Units are available with typical batch sizes from 2 to over 5.000 liters.

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Inline batch mixer for solids and liquids

Certain mixing tasks present unique challenges and manufacturers need equipment that is specifically designed to handle them.  When a single pass process is needed, high solid concentrations are involved, the ingredients quickly react with one-another, the product is sensitive to air inclusions, or the solid is granular and needs to be mechanically crushed as well as mixed, the right equipment is needed to get the job done.
<h2>A single pass mixer, disperser, and homogenizer for difficult mixing tasks</h2>
IKA's MHD-2000 system is a continuous homogenizing system designed for the high quality dispersions of solids in liquids.  The system includes two horizontal liquid connections and one vertical connection for solids.  the liquids and solid components of the mixture are brought together in a controlled fashion in a pre-mixing chamber in which the liquid is evenly distributed by entering through several different apertures.  Immediately after mixing, the liquid and solid components are dispersed through a rotor/stator system with high shearing action creating a high quality, output product that is free of agglomerations.

Use of this system greatly reduces production times due to its continuous operation.  Its design allows it to process highly viscous liquid ingredients, mixtures with solid contents up to 80%, and even solids that are granular and must be mechanically crushed during the mixing process.  Units are available with throughput volumes from 60 and 40.000 liters per hour.
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Continuous homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing machines often give unsatisfactory results.  For precisely controlled, quantitative mixes of liquid and solid ingredients you need a machine with better control designed to create a ready-to-use product that meets your exact requirements every time.
<h2>Create precise, quantitative mixes and fine suspensions in a single pass</h2>
The Dispax-Reactor from IKA is a purpose-built high accuracy homogenizing system for the food, chemical, pharmaceutical, and other industries.  It achieves extremely accurate mixes and suspensions by dosing both the liquid and the solid phase into the mixing chamber unlike traditional mixers which typically only dose the solid.  In this way the exact quantities of the raw materials in the final product are known regardless of variations in the physical characteristics of inputs.  The units include three distinct dispersing stages which allow for the creation of extremely fine suspensions from a wide range of solid raw materials.  Different rotor/stator dispersing heads are available allowing the machine to be optimized to your particular process.  Capacities are available from 500 to 35.000 liters per hour.

High accuracy homogenizing system

For high viscosity products, better results and reduced process times can be achieved with kneading type rather than conventional extrusion type equipment.  Process engineers in a wide variety of industries need to reliably and efficiently mix highly viscous substrates.  Process engineers in these situations need efficient, thorough mixing with controllable parameters.
<h2>Better dispersion results with less processing time from a highly controllable process</h2>
IKA's high performance horizontal kneading machines known as HKD and HKS are twin-bowl kneaders with horizontally arranged kneading blades able to process mixtures with very high viscosities. These horizontal kneaders are unique in the selection of kneading elements that they can employ allowing them to process a wide variety of mixes with varying solid content.  This flexibility makes users' lives easy by facilitating product change over and allowing selection of  blades that are optimized o the particular products being mixed.

The kneading blades are inter meshing and driven at a 2:1 ratio crating an alternating motion of blade surfaces toward and away from one another.  This motion creates highly dynamic pressure gradients and shearing forces which achieve excellent dispersion results.  The blade speed is finitely controllable via a variable frequency drive.  The units are easy to clean and maintain with the entire side wall of the kneading bowl being removable.  This exposes the kneading blades and discharge screw for easy cleaning during product changeover.

Horizontal kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather than conventional extrusion because more consistent dispersions can be achieved in a shorter time.  Competitive manufacturer's need controllable kneading processes with worry free seals and a degree of automated operation.
<h2>Better mixing in less time for highly viscous products</h2>
The Planetron HKV from IKA is a heavy-duty vertical kneading machine with two kneading blades.  The overhead mounting of the blades and drives allows all seals to never be in contact with the product.  These vertical kneaders achieve excellent kneading and dispersion results due to the action of inter-meshing kneading blades.  With one blade rotating in a planetary motion around the other and the two together having a mutual stripping action causing high pressure variations and shear forces in the substrate.  The geared motor that powers the machine is equipped with a variable frequency drive allowing the rotation speed of the blades to be infinitely adjustable giving the user precise control of the process and results.  All bowls in the HKV series are prepared for heating or cooling.  Units are available with working volumes from 0.5 to 1.600 liters.

Vertical kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the results from traditional extrusion type equipment are often unsatisfactory.  Much more thorough and intense mixing can be achieved and higher solid contents attained with kneading technology.
<h2>Continuous highly controlled kneading from a flexible machine</h2>
IKA's Conterna machine is a multi-chambered continuous kneader which technology is patent protected all over the world. The standard continuous kneader consists of 6 chambers arranged together in a horizontal block.  Each chamber contains two kneading elements which are driven by a variable frequency AC motor.  There is one independently controlled motor for each chamber.  Liquid and solid ingredients are introduced into each chamber according to the process needs and the mix is advanced from chamber to chamber via the kneading action of the impellers.  By adjusting the motor speed and the discharge rate , users can control the resident time of the product in the machine to achieve the desired results.  The continuous kneading action ensures that evenly mixed products are produced and products with extremely high solids content can be processed. Units are available with approximate throughput rates of 80 to 4.000 kg/hour.

Continuous kneader

Equipment operating under the rotor/stator principal is often employed when more traditional methods of stirring cannot achieve desired results.  This technology can achieve desirable results for almost any mixing process in circumstances where other machines fail.
<h2>Rotor/stator mixing with flexible mounting and a robust simple package</h2>
The Ultra-Turrax UTC is IKA's batch dispersing machine for high quality mixing and dispersing of products when more conventional stirring equipment cannot be used. Working on the rotor/stator principal, the units consist of a motor, a mounting flange, a stator, a rotor, and a rotor drive shaft. A variety of dispersion tools known as generators can be fixed to the rotor making the units adaptable to most mixing tasks.  These units are designed for diagonal from above, diagonal from the side, or vertical off-center mounting orientations. They can be used with open, or pressurized vessels. For open vessel operations, the units are supported via wall mounts or floor stands. Units are available for batch sizes from 150 to 6.000 liters.

Batch dispersing machine

For mixing and dispersing tasks that cannot be completed by conventional stirring means, equipment using the rotor/stator principal are often well suited.  Batchwise production of emulsions and suspensions of abrasive products is highly demanding and the use of well suited equipment is crucial.
<h2>Top entry rotor/stator dispersing equipment for highly abrasive products</h2>
The Ultra-Turrax UTS is IKA's dispersing machine for abrasive products when more conventional stirring equipment cannot be used.  Working on the rotor/stator principal, the units consist of a motor, a mounting flange, a stator with extension rods, a rotor, and a rotor drive shaft.  A variety of dispersion tools known as generators can be fixed to the rotor making the units adaptable to most mixing tasks.  The shaft seal is located at the motor flange and therefore is never in contact with the product.

These units are designed for diagonal from above or vertical off-center mounting orientations.  They can be used with open, or pressurized vessels.  For open vessel operations, the units are supported via wall mounts or floor stands. All variants of the UTS dispersing machines stand out for their unique ability to process highly abrasive ingredients.  Units are available for batch sizes from 500 to 1.700 liters.

Batch dispersing machine for abrasive products

When your process requires high performance mixing or dispersion but conventional stirring methods cannot be employed due to access or other restrictions, you need a machine designed for bottom entry into a vessel.
<h2>Bottom entry mixing in a simple and compact package</h2>
IKA's Ultra-Turrax UTE is a high performance dispersing machine designd for bottom entry into vessels.  It mixes, emulsifies, and disperses free-flowing or liquid media with a viscosity of up to 5.000 mPas in batch operation.  The units use the rotor-stator principal and a wide variety of generators is available to tailor the process to your needs.  No strong vortices or product aeration occurs as a result of the mixing action even when the vessel is filled to a very low level or is emptied during the stirring operation.

The units are compact and simple, primarily consisting of a motor, a a rotor drive shaft, a dispersion tool (generator) and a mounting flange conbined by a lantern housing.  The shaft seal is of an easily maintained mechanical type with several variants depending on the particular application.  Options for speed control, special materials, and special surface finishes also exist.  The units are available with batch capacities from 70 to 4.000 liters.

Batch dispersing machine for bottom entry into vessels

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accurate mixing form a reliable, user friendly machine will give plant managers the peace of mind and worry free operation they need to focus on improving other areas of their process. A high quality piece of equipment allows for low maintenance, easy cleaning, enables the direct feed of solids and liquids, mixing and dispersing of the vessel contents, heating or cooling of the product, and processing under vacuum or under pressure.
<h2> A universal mixing system with precise, reproducible results and safe operation</h2>
The Master Plant homogenizing and emulsifying system from IKA was designed specifically to meet the production mixing needs of the pharmaceuticals industry but has also proven useful in the production of food, beverages, cosmetics, and chemicals.  Several mixing heads are interchangeable depending on the process and desired results.  Each mixing head can be heated or cooled to control product temperature simultaneous to the mixing process. Flexible PTFE scrapers move with the mixing head and keep product from adhering to the vessel walls.  Products of up to 100.000 mPas viscosity can be processed.  The GMP homogenizing systems  can be fully discharged without the need for additional pumping and are available in capacities from 10 to 4.000 liters.

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, easy to maintain, and low cost to stay competitive.  Accurate mixing form a reliable, user friendly machine will give plant managers the peace of mind and worry free operation they need  to focus on improving other areas of their process.
<h2>Consistent mix quality from an easy to use, low cost system</h2>
IKA's SPP Standard Production Plant is a simple yet very capable system for all standard mixing processes such as homogenizing, emulsifying, stirring, and dispersing ingredients.  The emulsifying system includes a robust anchor agitator with a fixed flow breaker which moves the entire batch volume even  for mixes of high viscosities.  A highly advanced scraper design keeps the vessel walls free from scaling and unique vessel geometry allows processing of small batches down to 30% or the rated working volume.

IKA's SPP systems include interchangeable dispersing tools and adjustable speed control and dispersing quality and options exist for a heated or cooled double walled vessel, and vacuum degassing of the working chamber among others.  The systems are easy to clean using a CIP system and maintenance and inspection is simplified by concentrating major components in easily accessible areas.  This design also helps keep the required floorspace of the units as low as possible. Units are available with working capacities from 25 to 4.000 liters.

Cost-effective homogenizing and emulsifying system

Producers in a wide variety of industries benefit from equipment that can continuously create highly accurate homogeneous mixtures of liquid and solid ingredients.  The use of a continuous process requires less floor space for storage and greatly reduces production times.  Closed systems eliminate the creation of dust thereby enhancing safety and efficiency.  Equipment that offers all these characteristics will give its users an edge over the competition.
<h2>Continuous dispersion of solids into liquids without the generation of dust</h2>
IKA's mixing Plant MHD includes a mixing machine, metering units, an electrical control system, and peripheral equipment which is customized to meet the customer's facility and process needs.  The Plant MHD is a homogenizing system that allows the dust-free mixing of liquids and solid granules or powders in a continuous process.  The ingredients are continuously fed into the plant's working chamber in the precisely controlled ratios required by the final product, where they are mixed and then dispersed.  In this way, a ready-to-use final product is produced in just one pass.

The units can handle mixtures of up to 80% solid content and viscosities of up to 50.000 mPas.  Since the only agitation of the solid occurs within the machines working chamber after the liquid components have been introduced, no dust is generated.  A wide variety of solid feeding systems is available and IKA can help select the process that is best suited to your needs.  The Plant MHD unit is available with capacities from 200 to 40.000 liters per hour.

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