Single-use lab-scale bioreactor for upstream bioprocessing
Streamline your bioprocess development with a customizable, single-use bioreactor that reduces contamination risks and simplifies scale-up from lab to pilot production, enhancing flexibility and efficiency in cell culture, fermentation, and process development.
Cultivates and Scales-Up Cell Cultures
The Applikon AppliFlex ST from Getinge offers a versatile single-use stirred tank bioreactor designed for biopharmaceutical applications. This bioreactor stands out with its fully customizable design, incorporating 3D printing technology for tailored head plate configurations. It excels in cell line development and process scale-up for producing monoclonal antibodies, CAR-T cell therapies, and other biologics. Capable of cultivation, mixing, and fermentation processes, it offers working volumes of 500 mL to 15 L. With the use of single-use technology, it ensures sterility and minimizes contamination risk, effectively supporting batch, fed-batch, and perfusion operations. The bioreactor is constructed for easy integration into lab environments and complies with industry standards, promoting efficient, reproducible results in research and development settings.
Benefits
- Enhances lab efficiency by minimizing setup time with pre-assembled, single-use design.
- Reduces contamination risk, thanks to fully closed, sterile operation.
- Supports rapid scale-up and process development with customizable configurations.
- Increases experiment throughput with fast mixing times and adaptable impeller options.
- Facilitates cost-effective research by eliminating cleaning and sterilization requirements.
- Applications
- Cell culture,Fermentation,Nutraceuticals,Biopharmaceuticals,Enzymes,Cell and gene therapy
- End products
- Recombinant proteins,Car-t cell therapies,Stem cells,Industrial enzymes,Insulin,Monoclonal antibodies,Probiotics
- Steps before
- Media preparation,Cell thawing,Inoculum preparation
- Steps after
- Harvesting,Purification,Storage
- Input ingredients
- cell cultures,microbial cultures,media,supplements,buffers,gases
- Output ingredients
- bioproducts,cultured cells,biomass,metabolites
- Market info
- Getinge is known for providing innovative healthcare and life sciences products, specializing in medical technology, infection control, surgical workflows, and critical care solutions. They maintain a strong reputation for quality and technological advancement in these sectors.
- Capacity
- 500 mL,3 L,15 L
- Impeller type
- Marine / Rushton / Anchor / None / Hydrofoil / Helical
- Sparger type
- Pipe with Ø2mm hole / Open pipe / Sparger stone / Jet sparger / Porous sparger
- Working temperature
- 5 – 45 °C
- Storage temperature
- -80 – 45 °C
- Design pressure
- 0 – 0.5 barg / 0 – 0.1 barg
- Mixing time
- ~3 seconds
- Sterilization
- >25 kGy Gamma irradiation
- Sensors options
- Single-use sensors or traditional multi-use sensors
- Automation level
- Manual / PLC / SCADA
- Batch vs. continuous operation
- Batch
- CIP/SIP
- Pre-sterilized
- Cleaning method
- Pre-sterilized
- Biological compatibility
- Yes
- Cleanability
- Easy to clean
- Corrosive resistance (e.g. acids)
- High
- Density/particle size
- 500 mL,3 L,15 L capacity
- Dimensions (h x Ø)
- 236 mm x 75 mm / 340 mm x 130 mm / 500 mm x 223 mm
- Weight
- 0.2 kg (1 bioreactor) / 0.7 kg (1 bioreactor) / 1.7 kg (1 bioreactor)
- Bottom
- Dished bottom
- Total volume
- 575 ml / 3 L / 15 L
- Working volume
- 100 – 400 ml / 0.65 – 2.4 L / 3 - 12 L
- H/D ratio total volume
- 2.0
- H/D ratio working volume
- 1.33
- Impeller type
- Marine / Rushton / Anchor / None / Hydrofoil / Helical
- Impeller diameter
- 28 mm / 52 mm / 89 mm
- Sparger type
- Pipe with Ø2mm hole / Open pipe / Sparger stone / Jet sparger / Porous sparger
- Bioreactor Size
- 500 mL,3 L,15 L
- Impeller Type
- Marine / Rushton / Anchor / None / Hydrofoil / Helical
- Sparger Type
- Pipe with Ø2mm hole / Open pipe / Sparger stone / Jet sparger / Porous sparger
- Head Plate Configuration
- Fully customizable using 3D printing technology
- Sensor Options
- Single-use sensors or traditional multi-use sensors