Biopharmaceutical Production Technology
Find innovative production technology for making biopharmaceuticals and connect directly with world-leading specialists.
Which biopharmaceuticals equipment do you need?
Complete bioreactor system
An autoclavable bioreactor establishes special conditions for a variety of applications, for examp…
Bioprocess control software
Managing a large number of bioprocesses individually without automation is time-consuming, and th…
Bioreactor software
Comprehensive upstream data acquisition and management are essential in the bioprocessing industry. That’…
Single use bioreactor
Single use, micro-bioreactors could be a good solution for replication processes, especially when they e…
Fully Automated On-Line Sampling for Bioprocesses
Accurate sampling is a critical tool in the design and improvement of a …
Sampling probe for bioreactor samples
In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, …
Online fraction collector for offline bioprocess analysis
Many bioprocesses require offline analysis of samples to monito…
Online sampling system for larger scale bioprocesses
Accurate sampling is vital for improving a wide variety of industrial…
Automatic sampling system for bioprocess monitoring
An accurate, automated sampling of cultures is a key requirement in th…
24 fully controlled bioreactors in a microtiter format
When undertaking a screening study, process development or optimisa…
Purification screening kit for large biomolecules
To purify a specific large biomolecule, for example IgM or a virus or vi…
Automated dispensing system for bioprocesses
Biopharmaceutical manufacturers require precisely known liquid quantities for …
Bag holder and weighing platform for bioprocesses
Single use bags for biopharmaceutical process containment and liquid sto…
Disposable tubing for manifolds in bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to s…
Y sets tubing for bioprocesses
Manufactueres in the bioprocessing industries are increasingly turning to single use solutions…
Biocompatible tubing for peristaltic pumps
Sensitive bioprocess applications requires equipment that will not interfere wit…
Disposable pillow bags for bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to single use…
Disposable mixer bags for bioprocesses
Bioprocessors must use ingredients of known high quality and consistency. Inconsiste…
Normal flow filtration sets for bioprocesses
Bio-processors require reliable, high quality, easy to maintain, filtration eq…
Disposable manifold bags for bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to disposa…
3D disposable bags for bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to single-use sol…
Biological safety cabinet class III
Specially designed for the handling of microbiological agents, when working with indigen…
Biosafety cabinet class II for cytotoxic medicines
For the manipulation of hazardous substances utilized during the prepar…
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Sign upMicrobiological safety cabinet class II
This handy device offers the most advanced features in product-operator protection a…
Single use bioreactor Hyclone
A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead …
Single-use bioreactor CellReady 3L
A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture o…
Single-use bioreactor Appliflex
A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, co…
Mini bioreactors
When a screening study takes place, optimizing media process and working with microbial and cell cultures is q…
Steam-in-place bioreactor systems
Scaling-up from a laboratory scale to pilot plant and small scale production can be simpli…
Scalable bioreactor controller
When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot a…
Small-scale bioreactor controller
When you are working with small bioreactors, starting from 50 ml volumes, you need a good …
Lab scale Bioreactor controller
Success with bioprocesses is all about controlling the environmental conditions controls so y…
Photobioreactor for plant growth
SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth a…
Autoclavable stainless steel bioreactor
For cell culture and microbial culture applications.
Autoclavable glass bioreactor
Especially designed for cell culture applications and research applications such as process opt…
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Complete bioreactor system
An autoclavable bioreactor establishes special conditions for a variety of applications, for examp…
Bioprocess control software
Managing a large number of bioprocesses individually without automation is time-consuming, and th…
Bioreactor software
Comprehensive upstream data acquisition and management are essential in the bioprocessing industry. That’…
Single use bioreactor
Single use, micro-bioreactors could be a good solution for replication processes, especially when they e…
Fully Automated On-Line Sampling for Bioprocesses
Accurate sampling is a critical tool in the design and improvement of a …
Sampling probe for bioreactor samples
In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, …
Online fraction collector for offline bioprocess analysis
Many bioprocesses require offline analysis of samples to monito…
Online sampling system for larger scale bioprocesses
Accurate sampling is vital for improving a wide variety of industrial…
Automatic sampling system for bioprocess monitoring
An accurate, automated sampling of cultures is a key requirement in th…
24 fully controlled bioreactors in a microtiter format
When undertaking a screening study, process development or optimisa…
Purification screening kit for large biomolecules
To purify a specific large biomolecule, for example IgM or a virus or vi…
Automated dispensing system for bioprocesses
Biopharmaceutical manufacturers require precisely known liquid quantities for …
Bag holder and weighing platform for bioprocesses
Single use bags for biopharmaceutical process containment and liquid sto…
Disposable tubing for manifolds in bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to s…
Y sets tubing for bioprocesses
Manufactueres in the bioprocessing industries are increasingly turning to single use solutions…
Biocompatible tubing for peristaltic pumps
Sensitive bioprocess applications requires equipment that will not interfere wit…
Disposable pillow bags for bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to single use…
Disposable mixer bags for bioprocesses
Bioprocessors must use ingredients of known high quality and consistency. Inconsiste…
Normal flow filtration sets for bioprocesses
Bio-processors require reliable, high quality, easy to maintain, filtration eq…
Disposable manifold bags for bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to disposa…
3D disposable bags for bioprocesses
Manufacturers in the bioprocessing industries are increasingly turning to single-use sol…
Biological safety cabinet class III
Specially designed for the handling of microbiological agents, when working with indigen…
Biosafety cabinet class II for cytotoxic medicines
For the manipulation of hazardous substances utilized during the prepar…
Microbiological safety cabinet class II
This handy device offers the most advanced features in product-operator protection a…
Single use bioreactor Hyclone
A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead …
Single-use bioreactor CellReady 3L
A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture o…
Single-use bioreactor Appliflex
A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, co…
Mini bioreactors
When a screening study takes place, optimizing media process and working with microbial and cell cultures is q…
Steam-in-place bioreactor systems
Scaling-up from a laboratory scale to pilot plant and small scale production can be simpli…
Scalable bioreactor controller
When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot a…
Small-scale bioreactor controller
When you are working with small bioreactors, starting from 50 ml volumes, you need a good …
Lab scale Bioreactor controller
Success with bioprocesses is all about controlling the environmental conditions controls so y…
Photobioreactor for plant growth
SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth a…
Autoclavable stainless steel bioreactor
For cell culture and microbial culture applications.
Autoclavable glass bioreactor
Especially designed for cell culture applications and research applications such as process opt…
Lab-scale Radial Flow Chromatography columns for virus clearance
The use of appropriate and compatible chromatography col…
Low speed Filler for large-volume parenterals
Large-volume parenteral bottles are usually manufactured with a resin that ca…
Pharmaceutical rotary labeling machine for vials
Small, cylindrical-shaped glass bottles or vials are mainly used for vacci…
API powders storage bottle
Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions f…
Optical Dissolved Oxygen Sensors
Sufficient oxygen is critical to the success of processes like cell culture and fermentation…
Fluid sensor technology for flow rate measurement
For many bioprocesses, precise measurement of media flow rates is vital …
Accessory feed pump for various applications
In many biopharmaceutical or chemical development processes, lab work can be g…
Perfusion process controller
Advanced biopharmaceutical and lab systems involving microcarrier and stem cell applications req…
Sampling probe suitable for fermenter samples
Accurate, sterile sample collection is vital across a range of biopharmaceuti…
Entry-level automated online sampling system
An accurate and sterile sampling of cultures is vital throughout the biopharma…
Liquid nitrogen vapor storage freezer
For biotech and pharmaceutical cryopreservation, liquid nitrogen vapor storage provide…
Liquid nitrogen freezer for safe and dry storage of your samples
Remove the risks of cross-contamination and liquid nitro…
Pilot high pressure homogenizer
For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot…
High pressure industrial homogenizer
For any industrial pharmaceutical process that relies on high pressure homogenization i…
High pressure pilot homogenizer
Biotech and pharmaceutical development programs often require a mixing method that achieves b…
Compact H2O2 disinfection system
Dry fogging provides safe, effective microbiological cleaning of critical areas in biotech, …
Short bed monolithic columns for analytics
Samples taken at various process steps need to be analysed quickly and accurate …
Disposable monolithic columns
Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA requ…
Automated cell culture clarification system
Efficient harvest from the bioreactor is essential to any successful cell cultu…
Single-use temperature sensor
Biopharmaceutical manufacturers are increasingly making use of single-use temperature sensors t…
Single-use conductivity sensor
Biopharmaceutical manufacturers are increasingly making use of single-use conductivity sensors…
Single-use pressure sensor
Biopharmaceutical manufacturers are increasingly making use of Single-use pressure sensors to enha…
Lab scale normal flow filtration system
Normal Flow Filtration is frequently used the biopharmaceutical processing industry …
Lab scale tangential flow filtration system
Tangential Flow Filtration is an essential to the biopharmaceutical processing …
Semi-automated normal flow filtration system
Normal Flow Filtration is frequently used the biopharmaceutical processing ind…
Semi-automated tangential flow filtration system
Tangential Flow Filtration is an essential to the biopharmaceutical proces…
Automated single use tangential flow filtration system
Tangential Flow Filtration is an essential to the biopharmaceutical…
Magnetic agitator
Reliable mixing and agitation are essential to any quality production process that involves a fluid. This ne…
Disposable tank liners
Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for thei…
Flexible contained handling of powder transfer bags
Filling of transportation bags and discharging them into mix tanks or …
Negative pressure isolator
Used for products biologically hazardous, that also require minimized cross contamination.
Positive pressure isolator
Ideal for products which have no biological risk but require high sterile conditions.
Sterility test isolators
Designed to avoid this risk and protect the product from both the process and externally generated fa…
Transfer system for high-containment environments
A high-performance transfer port system that combines ultimate safety, s…
Restricted-access barrier systems
Create a physical barrier between the operator and the product. More flexible than an isol…
Pure steam generator
Pure steam is mainly used in the pharmaceutical industry and in biotechnology for sterilization, water fo…
Electrical pure steam generator
Pure steam is defined as the steam which when condensed becomes WFI quality water in accordan…
Dry heat depyrogenation oven
Specially designed for the drying and sterilization of glass containers, vials or ampoules, and …
GMP autoclave
When sterilizing and dealing non-thermolabile products, you will want to get a hold of those resistant to the tem…
Saturated steam GMP laboratory autoclave
For processing a wide range of products: solid, porous and liquids in a laboratory …
Custom engineered freeze dryer
For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are designe…
Pilot freeze dryer for scale up
Designed for biological, pharmaceutical and food products formulation and "scale up" work.
Compact laboratory freeze dryer
Particularly suitable for research centers requiring greater freeze drying capacity. Some of …
Laboratory scale active freeze dryer
The laboratory-scale active freeze-drying is used for dehydrating high-value products t…
Active freeze dryer
Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying p…
Vertical peeler centrifuge
A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from s…
Vertical scraper centrifuges
Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the bottom…
Resonance Acoustic Mixer
Utilized when applying low-frequency and high-intensity acoustic energy to agitate microbial cultures…
pH Sensor
pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New t…
Micro-Flask
During the initial stages of scale-up, researchers often have limited data available with which they must decide on…
Dissolved Oxygen sensor
The vast majority of all biotechnological processes are aerobic, where a microorganism or cell respond…
Anaerobic Fermentation Monitor
For accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic …
Acoustic cell retention system
Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh or…
GMP dispersing machine for liquid formulations
Multi-staged rotor/stator mixers generate the high shear forces required to …
Individual item serialization equipment
Traceability is critical to quality assurance in the pharmaceutical sector. But seri…
Aseptic filling machine for liquids and powders
Aseptic filling of containers such as vials, syringes, bottles, and cartrid…
Powder dosing system
Dosing of powder products must be done in a continuously controlled manner to provide a precise amount of…
Manual stoppering equipment for pre-filled syringes
Air present in the empty space of pre-filled syringes may prevent the …
Laboratory liquid viewer for transparent glass bottles
In the pharmaceutical industry, an inspection of liquids in vials o…
Laboratory liquid viewer for colored glass bottles
In the pharmaceutical industry, an inspection to detect any particulate…
Benchtop peristaltic dispenser
When filling vials and ampoules, high standards of hygiene are required to avoid the risk of c…
Semi-automatic forming and sealing blister machine
As a manufacturer of medical device, the packaging is a critical factor…
Automatic medical forming and sealing blister machine for packing capsules and tablets
Product safety is very importan…
Clinical trial lab sealer for a laminar airflow bench
When running small production for clinical trials, stability studies…
Automatic forming and sealing blister machine for packing syringes
Controlling contamination is on every manufacturer's …
Ultrasonic spraying system for small scale coating and research processes
Ultrasonic spraying technology has the abilit…
Automated bubble traps for chromatography
Radial flow chromatography processes require special attention and the right use …
Pre-packed and pre-validated chromatography columns
In chromatography, you must always take into account the apparatus tha…
Lab-scale radial chromatography columns for virus validation
In the food industry, as an example, during lab-testing and …
Entry-level filler for large-volume parenterals
Large volume parenterals are unit-dose containers that are larger than 100m…
Labeling machine for BFS containers
The pharmaceutical sector is unquestionably one of the major industries that rely on the…
Pharmaceutical pure steam generator
Dry, saturated steam can be used to sterilise pharmaceutical manufacturing equipment, an…
Water distillation system
Water used in pharmaceutical processes must meet high standards of regulatory bodies. These include…
Vapor compression distiller
Water for injections must be of highest achievable quality to eliminate the possibility of contam…
Reverse Osmosis water filtration system
Reverse osmosis uses a partially permeable membrane to remove undesirable molecules,…
Horizontal cartoner for pharmaceutical applications
Automatic cartoning for cosmetic or pharmaceutical products is a requi…
Cleaning and sterilization systems
An increasingly vital part of high quality pharmaceutical production is a dedicated Clean…
Purified water storage tank
Many pharmaceutical and cosmetic production lines require holding vessels for the storage of liqu…
Vacuum mixer for suspensions
The production of high quality pharmaceuticals often requires mixing of suspensions and similar …
Sterile compounding system
Hospitals and compounding centres have traditionally used manual aseptic compounding processes. As…
Compounding aseptic isolator
Bespoke aseptic isolators designed for production environments don’t meet the needs of small-sc…
Closed restricted access barrier system
Pharmaceutical production techniques often require isolation of compounds and chemic…
Nested syringe filling machine
Increasingly, pre-sterilized Ready To Use (RTU) nested vials, cartridges and syringes are the …
Syringe tub sterilizer
A common challenge is how to transfer nested syringe tubs to the aseptic filling area without compromis…
Automatic vial tray loader
In modern pharmaceutical production, end-line processes are often still manual or slow. This can c…
Aseptic automatic vial washing machine
The production of the latest high value pharmaceuticals often requires aseptic handli…
Aseptic vial cap sealing machine
Aseptic production methods are at the heart of the latest development in pharmaceuticals in …
Aseptic automatic vial filling machine
Current and future developments in pharmaceuticals increasingly rely on aseptic produ…
External vial washing machine
Exterior washing solutions for vials often suffer from high water consumption and low throughpu…
Industrial vial capping machine
The high capacity production of pharmaceuticals delivered in vials and cartridges requires a …
Vial filling machine
The volume filling of vials, cartridges and syringes is a vital part of the production of a wide range of…
Vial sterilization tunnel
Sterilization of vials, ampoules and syringes before filling is a vital step in the production of r…
Rotary vial washing machine
When washing vial, ampoules, or cartridges for pharmaceutical production there is often a trade-o…
Bulk chamber washer
The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning and…
Entry-level chamber washer
When cleaning smaller products contacting filling or compressing components used in the production…
Loading basket for GMP washer
To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a way…
Continuous pack cartoner
High volume automatic cartoning is vital for large scale production of cosmetic or pharmaceutical pro…
Packaging machine for syringes in trays
Pre-dosed syringes are rapidly becoming the method of choice for the delivery of inj…
Fluid sample-taking module for high cell density cultures
Automatic sampling of reactor vessels requires careful fluid ma…
Distributor of samples to different devices
The ability to expand your automatic sampling solution provides increased flexi…
High-capacity horizontal cartoner for pharma and cosmetics appliances
Cartoners take carton blanks which are formed and …
Automatic cartoner for applications in pharma and cosmetics
For high capacity production of cosmetics and pharmaceuticals…
Pharmaceutical and cosmetic industry products cartoner
A large number of cosmetic and pharmaceutical products are packed i…
Horizontal cartoner for pharma and cosmetics
Most pharmaceutical and cosmetics products are packed in cardboard cartons for…
High capacity cartoner for pharmaceutical applications
Many pharmaceutical products are packed in protective and decorativ…
Vertical cartoner for pharmaceutical applications
Many pharmaceutical and cosmetic products are sold in protective and dec…
Cryogenic industrial gases transportation supply tank
For safe and convenient delivery of liquid nitrogen a robust and por…
High pressure air powered laboratory homogenizer
Offering lab-scale to small pharmaceutical production scale output for in …
High pressure electric laboratory homogenizer
It’s vital that small units for experimentation can scale up with 100% accur…
Microencapsulation system for your drug delivery system
Whether you want to improve the stability of nutrients, protect an…
Visual and HVLD inspection for ampoules, vials and cartridges
Do you need to improve the efficiency and capability of you…
Semi-automatic inspection machine for ampoules, vials or cartridges
If you need to increase the efficiency of your manua…
Small automatic inspector for ampoules, vials, or cartridges
Inspect small batch production of ampoules, vials, or cartri…
Flexible automatic inspection machine for ampoules, vials, cartridges
If you are looking to improve the efficiency of yo…
Flexible automatic inspection machine for syringes
Manufacture of pre-filled syringes requires the highest quality inspect…
Ethylene oxide sterilizer
When medical devices like syringes, catheters, dialysis cartridges, plastic dressings and sutures h…
Table top sterile filling line for injectables
Where a compact solution is required for filling vials for the injectables m…
Start-up sterile filling line for injectables
For smaller-scale production of vials and syringes for the injectables market…
Sterile filling line for injectables
Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries r…
High containment split butterfly valve
Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. F…
Plasmid process pack for your pDNA purification process
When developing a pDNA purification process for eventual transfer …
High-speed aseptic injectable vial filling machine
Fill up to 24,000 vials per hour with pharmaceutical powders or liquids…
Laboratory dispersing machine for low-viscous masses
Laboratory mixers have not always been easy to work with. Getting al…
Ultra-fine dispersing machine for emulsions and suspensions
Producing the finest micro-emulsions and suspensions requires…
Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent part…
Pharmaceutical bottles inspection machine
For the visual inspection of small to medium batch-sizes of vials, ampoules or bo…
Ampoule filling machine
Filling ampoules or vials with parenteral fluids are an essential matter for which you need to conside…
Pilot multi-stage distiller
If generating an scalable data and bring in results with small sample quantities of high-boiling,…
Pilot wiped film distiller
Generate scalable data and results during the pilot tests with wiped film distillation, distill o…
Pilot short path distiller
Generate scalable data and results during the pilot tests with short path distillation, distill or…
Laboratory multi-stage distiller
A laboratory multi-stage distillers that combines the wiped film and short path distillation…
Laboratory wiped film distiller
Reach reliable conclusions testing the distillation of high-boiling or highly viscous materia…
Laboratory short path distiller
Get to reliable conclusions for the separation of high-boiling and heat-sensitive products us…
Horizontal thin film evaporators
Horizontal thin film evaporators can increase the residence time of the product and achieve …
Thin film dryers
Dry dissolved or slurried crystallizing or amorphous products to a pourable powder.
Short path evaporators
With short path distillation, a substantial decrease of boiling temperature is obtained by reducing the…
Wiped film evaporator
With wiped film distillation, a substantial decrease of boiling temperature is obtained by reducing the …
Small bottle checkweigher
Any small-diameter bottle, containing prescription medication or cosmetic applications, can be prop…
Versatile checkweigher
This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also suit…
Depyrogenation tunnels for ampoules, vials and bottles
Sterilize and depyrogenize ampoules, vials, bottles and similar gla…
Automatic washing machine for ampoules
Automatic washing machine designed for cleaning ampoules and achieving a maximum outp…
Aseptic liquid filler for vials
Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.
Microdosing machine for sterile powders
Fill sterile pharmaceutical powders into vials under aseptic conditions with a speed…
Monobloc small volume liquid filler
These intermittent motion monobloc machines are designed for filling various liquids int…
High-speed small volume liquid filler
Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottle…
Case packer for cartons and bundles
Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions lik…
Stretch bander
A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.
Vertical cartoner
A cartoning solution that can be operated in either continuous or intermittent mode depending on the cartoni…
Horizontal intermittent motion cartoner
User-friendly cartooning solution with an intermittent motion for a wide range of pr…
Horizontal continuous motion cartoner
An automatic cartoning machine designed for both high-speed operations and medium pack…
Compact blister machine
A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applica…
High-speed blister machine
If you are looking for a compact machine that produces blisters with an output of up to 700 bliste…
Compact horizontal laminar flow bench
HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space …
Horizontal laminar flow benches
HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work ar…
Vertical laminar flow cabinet
HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area a…
Downflow booth
Provides the highest levels of operator protection from potentially harmful airborne contaminants generated duri…
Half-suit tester
Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mate…
Glove tester
Testing device of the containment capability of gloves, which is as important as the other parts of the integrated…
Aseptic barrier systems
Designed for sterile product and Potent API’s either with low or high OEL requirements.
Purified water systems
Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need …
GMP laboratory freeze dryer
Freeze dryer designed for aseptic and small-scale production of high-value products.
Ethylene oxide sterilization chamber
Designed for the terminal sterilization of temperature sensitive medical-health product…
Superheated water shower autoclave
Specially designed for sterilizing large batches of parenteral solutions.
Steam and air mixture sterilization autoclave
Specially designed for sterilizing large batches of parenteral solutions.
GMP freeze dryer
Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in acc…
Multipurpose and R&D freeze dryer
A multipurpose unit in the research and development field. Some of the most common applica…
Laboratory spiral jet mill
Ideal for the ultra-fine size reduction on a laboratory scale of dry materials up to Mohs' hardnes…
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Modify biopharmaceutical extracts to stimulate antibodies with vaccines
Recombinant DNA technology is used for medicines such as growth hormone or insulin, monoclonal antibodies, or fusion proteins. As part of their manufacturing process, vaccines are grown in tissue culture, and for gene therapy, viruses are artificially manipulated to include desirable parts of genetic material.
Different approaches or treatments for different types of biopharmaceuticals. Cell-based therapy involves modifying a patient’s own cells or donor cells to fight disease. Blood cells are tightly regulated by an interacting network of biological proteins such as hormones, cytokines, and growth factors. Vaccines contain antigenic components for a specific pathogen in order to activate a patient’s immune system so that it has a memory of the invading pathogen and offers protection when encountered. An example of this would be Covid vaccines. In contrast, monoclonal antibodies target antigens and destroy them, which is used for other purposes such as treatment for transplant rejection. Finally, biopharmaceutical extracts are also used for the production of different serums, hemoglobin, and collagen, which are not considered conventional drugs by the FDA.
Purify the extract during downstream preparation of biopharmaceuticals
Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After the developed product is purified for the required density and ready to be harvested, production technology must meet the highest industry standard to ensure that medicines are safe and effective and move through the clinical development stage. Different types of bioreactor systems are used together with different systems for process control and monitoring. Using scalable equipment from R&D to industrial capacity and implementing the right monitoring strategies, for example, CMC regulations will reduce time to market significantly.
After harvest, the production process moves into a downstream process to meet purity and quality requirements. Downstream processing is usually divided into cell disruption, purification, and polishing. (Ultra-)centrifugation is carried out to separate biomass. If the desired product is intracellular, the cell biomass can be disrupted in order to release the product and allow extraction. If the product is extracellular, the medium can be further concentrated. Or, if necessary, de-watering is done by vacuum drying or reverse osmosis. Finally, a purified product is usually mixed with desired excipients before being packed and ready to enter the market.
Cultivate the media in a bioreactor
A bioreactor mixes the cell media together in a sterile, pressure-free environment. A main component of bioreactor systems is the agitator that facilitates the bundling of contents, facilitating the reactions between them.
One of the primary challenges of bioreactors is controlling the center of gravity. An integrated baffle arm minimizes the formation of internal vortex effects that cause this while keeping the temperature at a constant.
High performance liquid chromatography for biopharmaceutical manufacturing
High-performance liquid chromatography (HPLC) offers high-accuracy separation using columns. CIM monoliths are made of porous methacrylate polymers composed of interconnected channels that range in size from 1-6 μm. It is these channels that account for the media separation power and flow characteristics and ability to purify large biomolecules, such as large proteins, viruses, plasmid DNA, and immunoglobulins with their activity intact.
Safe processing and packing in biopharmaceutical manufacturing
The majority of biopharmaceuticals on the market are parenteral formulations and administered by direct injection usually distributed in single-dose vials or prefilled syringes. Product is provided either as a solution, or more commonly as a lyophilized cake, and strict requirements for product purity, activity, and shelf life dictate a very high standard for injectable drug packaging.
All injectables need to be evaluated for leachables that may have migrated over the product shelf life during formal stability testing. These analytics are crucial when it comes to biopharma manufacturing. Many biotech products are lyophilized in the vial before the stopper and seal are introduced. Lyophilization, therefore, presents its own packaging requirements on vial shape and rubber enclosures. Contact us to find out more about the biopharmaceutical technology that is right for your production needs.