Tell us about your production challenge
Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Which biopharmaceuticals equipment do you need?

Autoclavable glass bioreactor

Especially designed for cell culture applications and research applications such as process op...

Autoclavable stainless steel bioreactor

For cell culture and microbial culture applications.

Photobioreactor for plant growth

SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth ...

Lab scale Bioreactor controller

Success with bioprocesses is all about controlling the environmental conditions controls so ...

Small-scale bioreactor controller

When you are working with small bioreactors, starting from 50 ml volumes, you need a good...

Scalable bioreactor controller

When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot ...

Steam-in-place bioreactor systems

Scaling-up from a laboratory scale to pilot plant and small scale production can be simpl...

Mini bioreactors

When a screening study takes place, optimizing media process and working with microbial and cell cultures is ...

Single-use bioreactor Appliflex

A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, c...

Single-use bioreactor CellReady 3L

A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture ...

Single use bioreactor Hyclone

A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

3D disposable bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single-use so...

Disposable manifold bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to dispos...

Normal flow filtration sets for bioprocesses

Bio-processors require reliable, high quality, easy to maintain, filtration e...

Disposable mixer bags for bioprocesses

Bioprocessors must use ingredients of known high quality and consistency.  Inconsist...

Disposable pillow bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single us...

Biocompatible tubing for peristaltic pumps

Sensitive bioprocess applications requires equipment that will not interfere wi...

Y sets tubing for bioprocesses

Manufactueres in the bioprocessing industries are increasingly turning to single use solution...

Disposable tubing for manifolds in bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to ...

Bag holder and weighing platform for bioprocesses

Single use bags for biopharmaceutical process containment and liquid st...

Automated dispensing system for bioprocesses

Biopharmaceutical manufacturers require precisely known liquid quantities for...

Purification screening kit for large biomolecules

To purify a specific large biomolecule, for example IgM or a virus or v...

24 fully controlled bioreactors in a microtiter format

When undertaking a screening study, process development or optimis...

Automatic sampling system for bioprocess monitoring

An accurate, automated sampling of cu...

Online sampling system for larger scale bioprocesses

Accurate sampling is vital for impro...

Online fraction collector for offline bioprocess analysis

Many bioprocesses require offl...

Sampling probe for bioreactor samples

In biopharmaceutical and chemical industries, samplin...

Fully Automated On-Line Sampling for Bioprocesses

Accurate sampling is a critical tool in the design and improvement of a...

Single use bioreactor

Single use, micro-bioreactors could be a good solution for replication processes, especially when they ...

Bioreactor software

Comprehensive upstream data acquisition and management are essential in the bioprocessing industry. That...

Bioprocess control software

Managing a large number of bioprocesses individually without automation is time-consuming, and t...

Complete bioreactor system

An autoclavable bioreactor establishes special conditions for a variety of applications, for exam...

Acoustic cell retention system

Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh o...

Anaerobic Fermentation Monitor

For accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic...

Dissolved Oxygen sensor

The vast majority of all biotechnological processes are aerobic, where a microorganism or cell respon...

Micro-Flask

During the initial stages of scale-up, researchers often have limited data available with which they must decide o...

pH Sensor

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New ...

Resonance Acoustic Mixer

Utilized when applying low-frequency and high-intensity acoustic energy to agitate microbial culture...

Vertical scraper centrifuges

Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the botto...

Vertical peeler centrifuge

A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from ...

Active freeze dryer

Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying ...

Laboratory scale active freeze dryer

The laboratory-scale active freeze-drying is used for dehydrating high-value products ...

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of...

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and "scale up" work.

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are design...

Saturated steam GMP laboratory autoclave

For processing a wide range of products: solid, porous and liquids in a laboratory...

GMP autoclave

When sterilizing and dealing non-thermolabile products, you will want to get a hold of those resistant to the te...

Dry heat depyrogenation oven

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and...

Electrical pure steam generator

Pure steam is defined as the steam which when condensed becomes WFI quality water in accorda...

Pure steam generator

Pure steam is mainly used in the pharmaceutical industry and in biotechnology for sterilization, water f...

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Transfer system for high-containment environments

A high-performance transfer port system that combines ultimate safety, ...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

Flexible contained handling of powder transfer bags

Filling of transportation bags and discharging them into mix tanks or...

Disposable tank liners

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for the...

Magnetic agitator

Reliable mixing and agitation are essential to any quality production process that involves a fluid. This n...

Automated single use tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutica...

Semi-automated tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical proce...

Semi-automated normal flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing in...

Lab scale tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical processing...

Lab scale normal flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing industry...

Single-use pressure sensor

Biopharmaceutical manufacturers are increasingly making use of Single-use pressure sensors to enh...

Single-use conductivity sensor

Biopharmaceutical manufacturers are increasingly making use of single-use conductivity sensor...

Single-use temperature sensor

Biopharmaceutical manufacturers are increasingly making use of single-use temperature sensors ...

Automated cell culture clarification system

Efficient harvest from the bioreactor is essential to any successful cell cult...

Disposable monolithic columns

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA req...

Short bed monolithic columns for analytics

Samples taken at various process steps need to be analysed quickly and accurate...

Compact H2O2 disinfection system

Dry fogging provides safe, effective microbiological cleaning of critical areas in biotech,...

High pressure pilot homogenizer

Biotech and pharmaceutical development programs often requir...

High pressure industrial homogenizer

For any industrial pharmaceutical process that relies ...

Pilot high pressure homogenizer

For maximum value, a high-pressure homogenizer that’s suita...

Liquid nitrogen freezer for safe and dry storage of your samples

Remove the risks of cro...

Liquid nitrogen vapor storage freezer

For biotech and pharmaceutical cryopreservation, liqu...

Entry-level automated online sampling system

An accurate and sterile sampling of cultures ...

Sampling probe suitable for fermenter samples

Accurate, sterile sample collection is vital...

Perfusion process controller

Advanced biopharmaceutical and lab systems involving microcarri...

Accessory feed pump for various applications

In many biopharmaceutical or chemical develop...

Fluid sensor technology for flow rate measurement

For many bioprocesses, precise measurem...

Optical Dissolved Oxygen Sensors

Sufficient oxygen is critical to the success of processes like cell culture and fermentatio...

API powders storage bottle

Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions ...

Pharmaceutical rotary labeling machine for vials

Small, cylindrical-shaped glass bottles or vials are mainly used for vacc...

Low speed Filler for large-volume parenterals

Large-volume parenteral bottles are usually manufactured with a resin that c...

Lab-scale Radial Flow Chromatography columns for virus clearance

The use of appropriate and compatible chromatography co...

Continuous chocolate line with vertical ball mills

To mix and refine cocoa liquor, cocoa powder, sugar, and lecithin, sev...

Laboratory spiral jet mill

Ideal for the ultra-fine size reduction on a laboratory scale of dry materials up to Mohs' hardne...

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common applic...

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in ac...

Steam and air mixture sterilization autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Superheated water shower autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Ethylene oxide sterilization chamber

Designed for the terminal sterilization of temperature sensitive medical-health produc...

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Compact blister machine

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

High-speed small volume liquid filler

Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottl...

Monobloc small volume liquid filler

These intermittent motion monobloc machines are designed for filling various liquids in...

Microdosing machine for sterile powders

Fill sterile pharmaceutical powders into vials under aseptic conditions with a spee...

Aseptic liquid filler for vials

Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.

Automatic washing machine for ampoules

Automatic washing machine designed for cleaning ampoules and achieving a maximum out...

Depyrogenation tunnels for ampoules, vials and bottles

Sterilize and depyrogenize ampoules, vials, bottles and similar gl...

Versatile checkweigher

This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also sui...

Small bottle checkweigher

Any small-diameter bottle, containing prescription medication or cosmetic applications, can be pro...

Wiped film evaporator

With wiped film distillation, a substantial decrease of boiling temperature is obtained by reducing the...

Short path evaporators

With short path distillation, a substantial decrease of boiling temperature is obtained by reducing th...

Thin film dryers

Dry dissolved or slurried crystallizing or amorphous products to a pourable powder.

Horizontal thin film evaporators

Horizontal thin film evaporators can increase the residence time of the product and achieve...

Laboratory short path distiller

Get to reliable conclusions for the separation of high-boiling and heat-sensitive products u...

Laboratory wiped film distiller

Reach reliable conclusions testing the distillation of high-boiling or highly viscous materi...

Laboratory multi-stage distiller

A laboratory multi-stage distillers that combines the wiped film and short path distillatio...

Pilot short path distiller

Generate scalable data and results during the pilot tests with short path distillation, distill o...

Pilot wiped film distiller

Generate scalable data and results during the pilot tests with wiped film distillation,  distill ...

Pilot multi-stage distiller

If generating an scalable data and bring in results with small sample quantities of high-boiling...

Ampoule filling machine

Filling ampoules or vials with parenteral fluids are an essential matter for which you need to consid...

Pharmaceutical bottles inspection machine

For the visual inspection of small to medium batch-sizes of vials, ampoules or b...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

High-speed aseptic injectable vial filling machine

Fill up to 24,000 vials per hour with pharmaceutical powders or liquid...

Plasmid process pack for your pDNA purification process

When developing a pDNA purification process for eventual transfer...

High containment split butterfly valve

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. ...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables ...

Ethylene oxide sterilizer

When medical devices like syringes, catheters, dialysis cartridges, plastic dressings and sutures ...

Flexible automatic inspection machine for syringes

Manufacture of pre-filled syringes requires the highest quality inspec...

Flexible automatic inspection machine for ampoules, vials, cartridges

If you are looking to improve the efficiency of y...

Small automatic inspector for ampoules, vials, or cartridges

Inspect small batch production of ampoules, vials, or cartr...

Semi-automatic inspection machine for ampoules, vials or cartridges

If you need to increase the efficiency of your manu...

Visual and HVLD inspection for ampoules, vials and cartridges

Do you need to improve the efficiency and capability of yo...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

High pressure electric laboratory homogenizer

It’s vital that small units for experimenta...

High pressure air powered laboratory homogenizer

Offering lab-scale to small pharmaceutica...

Cryogenic industrial gases transportation supply tank

For safe and convenient delivery of...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic produc...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are p...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pha...

Automatic cartoner for applications in pharma and cosmetics

For high capacity production...

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take ca...

Distributor of samples to different devices

The ability to expand your automatic sampling ...

Fluid sample-taking module for high cell density cultures

Automatic sampling of reactor ...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method ...

Continuous pack cartoner

High volume automatic cartoning is vital for large scale production ...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be place...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing ...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceutical...

Rotary vial washing machine

When washing vial, ampoules, or cartridges for pharmaceutical pr...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a ...

Vial filling machine

The volume filling of vials, cartridges and syringes is a vital part of ...

Industrial vial capping machine

The high capacity production of pharmaceuticals delivered in...

External vial washing machine

Exterior washing solutions for vials often suffer from high wa...

Aseptic automatic vial filling machine

Current and future developments in pharmaceuticals i...

Aseptic vial cap sealing machine

Aseptic production methods are at the heart of the latest d...

Aseptic automatic vial washing machine

The production of the latest high value pharmaceuticals often requires aseptic handl...

Automatic vial tray loader

In modern pharmaceutical production, end-line processes are often...

Syringe tub sterilizer

A common challenge is how to transfer nested syringe tubs to the asept...

Nested syringe filling machine

Increasingly, pre-sterilized Ready To Use (RTU) nested vials,...

Closed restricted access barrier system

Pharmaceutical production techniques often require ...

Compounding aseptic isolator

Bespoke aseptic isolators designed for production environments ...

Sterile compounding system

Hospitals and compounding centres have traditionally used manual ...

Vacuum mixer for suspensions

The production of high quality pharmaceuticals often requires m...

Purified water storage tank

Many pharmaceutical and cosmetic production lines require holdin...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutica...

Horizontal cartoner for pharmaceutical applications

Automatic cartoning for cosmetic or p...

Reverse Osmosis water filtration system

Reverse osmosis uses a partially permeable membrane to remove undesirable molecules...

Vapor compression distiller

Water for injections must be of highest achievable quality to eliminate the possibility of conta...

Water distillation system

Water used in pharmaceutical processes must meet high standards of regulatory bodies. These includ...

Pharmaceutical pure steam generator

Dry, saturated steam can be used to sterilise pharmaceutical manufacturing equipment, a...

Labeling machine for BFS containers

The pharmaceutical sector is unquestionably one of the major industries that rely on th...

Entry-level filler for large-volume parenterals

Large volume parenterals are unit-dose containers that are larger than 100...

Lab-scale radial chromatography columns for virus validation

In the food industry, as an example, during lab-testing and...

Pre-packed and pre-validated chromatography columns

In chromatography, you must always take into account the apparatus th...

Automated bubble traps for chromatography

Radial flow chromatography processes require special attention and the right use...

Ultrasonic spraying system for small scale coating and research processes

Ultrasonic spraying technology has the abili...

Automatic forming and sealing blister machine for packing syringes

Controlling contamination is on every manufacturer's...

Clinical trial lab sealer for a laminar airflow bench

When running small production for clinical trials, stability studie...

Automatic medical forming and sealing blister machine for packing capsules and tablets

Product safety is very importa...

Semi-automatic forming and sealing blister machine

As a manufacturer of medical device, the packaging is a critical facto...

Benchtop peristaltic dispenser

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of ...

Laboratory liquid viewer for colored glass bottles

In the pharmaceutical industry, an inspection to detect any particulat...

Laboratory liquid viewer for transparent glass bottles

In the pharmaceutical industry, an inspection of liquids in vials ...

Manual stoppering equipment for pre-filled syringes

Air present in the empty space of pre-filled syringes may prevent the...

Powder dosing system

Dosing of powder products must be done in a continuously controlled manner to provide a precise amount o...

Aseptic filling machine for liquids and powders

Aseptic filling of containers such as vials, syringes, bottles, and cartri...

Individual item serialization equipment

Traceability is critical to quality assurance in the pharmaceutical sector. But ser...
Show more equipment

Stories about biopharmaceuticals

Select your bio-pharmaceuticals process

Contact us

Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
Contact us

Modify biopharmaceutical extracts to stimulate antibodies with vaccines

Recombinant DNA technology is used for medicines such as growth hormone or insulin, monoclonal antibodies, or fusion proteins. As part of their manufacturing process, vaccines are grown in tissue culture, and for gene therapy, viruses are artificially manipulated to include desirable parts of genetic material.

Different approaches or treatments for different types of biopharmaceuticals. Cell-based therapy involves modifying a patient’s own cells or donor cells to fight disease. Blood cells are tightly regulated by an interacting network of biological proteins such as hormones, cytokines, and growth factors. Vaccines contain antigenic components for a specific pathogen in order to activate a patient’s immune system so that it has a memory of the invading pathogen and offers protection when encountered. An example of this would be Covid vaccines. In contrast, monoclonal antibodies target antigens and destroy them, which is used for other purposes such as treatment for transplant rejection. Finally, biopharmaceutical extracts are also used for the production of different serums, hemoglobin, and collagen, which are not considered conventional drugs by the FDA.

Purify the extract during downstream preparation of biopharmaceuticals

Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After the developed product is purified for the required density and ready to be harvested, production technology must meet the highest industry standard to ensure that medicines are safe and effective and move through the clinical development stage. Different types of bioreactor systems are used together with different systems for process control and monitoring. Using scalable equipment from R&D to industrial capacity and implementing the right monitoring strategies, for example, CMC regulations will reduce time to market significantly.

After harvest, the production process moves into a downstream process to meet purity and quality requirements. Downstream processing is usually divided into cell disruption, purification, and polishing. (Ultra-)centrifugation is carried out to separate biomass. If the desired product is intracellular, the cell biomass can be disrupted in order to release the product and allow extraction. If the product is extracellular, the medium can be further concentrated. Or, if necessary, de-watering is done by vacuum drying or reverse osmosis. Finally, a purified product is usually mixed with desired excipients before being packed and ready to enter the market.

Cultivate the media in a bioreactor

A bioreactor mixes the cell media together in a sterile, pressure-free environment. A main component of bioreactor systems is the agitator that facilitates the bundling of contents, facilitating the reactions between them.

One of the primary challenges of bioreactors is controlling the center of gravity. An integrated baffle arm minimizes the formation of internal vortex effects that cause this while keeping the temperature at a constant.

 

High performance liquid chromatography for biopharmaceutical manufacturing

High-performance liquid chromatography (HPLC) offers high-accuracy separation using columns. CIM monoliths are made of porous methacrylate polymers composed of interconnected channels that range in size from 1-6 μm. It is these channels that account for the media separation power and flow characteristics and ability to purify large biomolecules, such as large proteins, viruses, plasmid DNA, and immunoglobulins with their activity intact.

Safe processing and packing in biopharmaceutical manufacturing

The majority of biopharmaceuticals on the market are parenteral formulations and administered by direct injection usually distributed in single-dose vials or prefilled syringes. Product is provided either as a solution, or more commonly as a lyophilized cake, and strict requirements for product purity, activity, and shelf life dictate a very high standard for injectable drug packaging.

All injectables need to be evaluated for leachables that may have migrated over the product shelf life during formal stability testing. These analytics are crucial when it comes to biopharma manufacturing.  Many biotech products are lyophilized in the vial before the stopper and seal are introduced. Lyophilization, therefore, presents its own packaging requirements on vial shape and rubber enclosures.

Let's talk about your project!

Tell us about your production challenge and connect directly with leading manufacturers worldwide
All your data is kept confidential