Biopharmaceutical Production Technology
Which biopharmaceuticals equipment do you need?
Autoclavable glass bioreactor
Autoclavable stainless steel bioreactor
Photobioreactor for plant growth
Lab scale Bioreactor controller
Small-scale bioreactor controller
Scalable bioreactor controller
Steam-in-place bioreactor systems
Mini bioreactors
Single-use bioreactor Appliflex
Single-use bioreactor CellReady 3L
Single use bioreactor Hyclone
Microbiological safety cabinet class II
Biosafety cabinet class II for cytotoxic medicines
Biological safety cabinet class III
3D disposable bags for bioprocesses
Disposable manifold bags for bioprocesses
Normal flow filtration sets for bioprocesses
Disposable mixer bags for bioprocesses
Disposable pillow bags for bioprocesses
Biocompatible tubing for peristaltic pumps
Y sets tubing for bioprocesses
Disposable tubing for manifolds in bioprocesses
Bag holder and weighing platform for bioprocesses
Automated dispensing system for bioprocesses
Purification screening kit for large biomolecules
24 fully controlled bioreactors in a microtiter format
Automatic sampling system for bioprocess monitoring
Online sampling system for larger scale bioprocesses
Online fraction collector for offline bioprocess analysis
Sampling probe for bioreactor samples
Fully Automated On-Line Sampling for Bioprocesses
Single use bioreactor
Bioreactor software
Bioprocess control software
Complete bioreactor system
Acoustic cell retention system
Anaerobic Fermentation Monitor
Dissolved Oxygen sensor
Micro-Flask
pH Sensor
Resonance Acoustic Mixer
Vertical scraper centrifuges
Vertical peeler centrifuge
Active freeze dryer
Laboratory scale active freeze dryer
Compact laboratory freeze dryer
Pilot freeze dryer for scale up
Custom engineered freeze dryer
Saturated steam GMP laboratory autoclave
GMP autoclave
Dry heat depyrogenation oven
Electrical pure steam generator
Pure steam generator
Restricted-access barrier systems
Transfer system for high-containment environments
Sterility test isolators
Positive pressure isolator
Negative pressure isolator
Flexible contained handling of powder transfer bags
Disposable tank liners
Magnetic agitator
Automated single use tangential flow filtration system
Semi-automated tangential flow filtration system
Semi-automated normal flow filtration system
Lab scale tangential flow filtration system
Lab scale normal flow filtration system
Single-use pressure sensor
Single-use conductivity sensor
Single-use temperature sensor
Automated cell culture clarification system
Disposable monolithic columns
Short bed monolithic columns for analytics
Compact H2O2 disinfection system
High pressure pilot homogenizer
High pressure industrial homogenizer
Pilot high pressure homogenizer
Liquid nitrogen freezer for safe and dry storage of your samples
Liquid nitrogen vapor storage freezer
Entry-level automated online sampling system
Sampling probe suitable for fermenter samples
Perfusion process controller
Accessory feed pump for various applications
Fluid sensor technology for flow rate measurement
Optical Dissolved Oxygen Sensors
API powders storage bottle
Pharmaceutical rotary labeling machine for vials
Low speed Filler for large-volume parenterals
Lab-scale Radial Flow Chromatography columns for virus clearance
Continuous chocolate line with vertical ball mills
Laboratory spiral jet mill
Multipurpose and R&D freeze dryer
GMP freeze dryer
Steam and air mixture sterilization autoclave
Superheated water shower autoclave
Ethylene oxide sterilization chamber
GMP laboratory freeze dryer
Purified water systems
Aseptic barrier systems
Glove tester
Half-suit tester
Downflow booth
Vertical laminar flow cabinet
Horizontal laminar flow benches
Compact horizontal laminar flow bench
High-speed blister machine
Compact blister machine
Horizontal continuous motion cartoner
Horizontal intermittent motion cartoner
Vertical cartoner
Stretch bander
Case packer for cartons and bundles
High-speed small volume liquid filler
Monobloc small volume liquid filler
Microdosing machine for sterile powders
Aseptic liquid filler for vials
Automatic washing machine for ampoules
Depyrogenation tunnels for ampoules, vials and bottles
Versatile checkweigher
Small bottle checkweigher
Wiped film evaporator
Short path evaporators
Thin film dryers
Horizontal thin film evaporators
Laboratory short path distiller
Laboratory wiped film distiller
Laboratory multi-stage distiller
Pilot short path distiller
Pilot wiped film distiller
Pilot multi-stage distiller
Ampoule filling machine
Pharmaceutical bottles inspection machine
Economic dispersing machine for emulsions and suspensions
Ultra-fine dispersing machine for emulsions and suspensions
Laboratory dispersing machine for low-viscous masses
High-speed aseptic injectable vial filling machine
Plasmid process pack for your pDNA purification process
High containment split butterfly valve
Sterile filling line for injectables
Start-up sterile filling line for injectables
Table top sterile filling line for injectables
Ethylene oxide sterilizer
Flexible automatic inspection machine for syringes
Flexible automatic inspection machine for ampoules, vials, cartridges
Small automatic inspector for ampoules, vials, or cartridges
Semi-automatic inspection machine for ampoules, vials or cartridges
Visual and HVLD inspection for ampoules, vials and cartridges
Microencapsulation system for your drug delivery system
High pressure electric laboratory homogenizer
High pressure air powered laboratory homogenizer
Cryogenic industrial gases transportation supply tank
Vertical cartoner for pharmaceutical applications
High capacity cartoner for pharmaceutical applications
Horizontal cartoner for pharma and cosmetics
Pharmaceutical and cosmetic industry products cartoner
Automatic cartoner for applications in pharma and cosmetics
High-capacity horizontal cartoner for pharma and cosmetics appliances
Distributor of samples to different devices
Fluid sample-taking module for high cell density cultures
Packaging machine for syringes in trays
Continuous pack cartoner
Loading basket for GMP washer
Entry-level chamber washer
Bulk chamber washer
Rotary vial washing machine
Vial sterilization tunnel
Vial filling machine
Industrial vial capping machine
External vial washing machine
Aseptic automatic vial filling machine
Aseptic vial cap sealing machine
Aseptic automatic vial washing machine
Automatic vial tray loader
Syringe tub sterilizer
Nested syringe filling machine
Closed restricted access barrier system
Compounding aseptic isolator
Sterile compounding system
Vacuum mixer for suspensions
Purified water storage tank
Cleaning and sterilization systems
Horizontal cartoner for pharmaceutical applications
Reverse Osmosis water filtration system
Vapor compression distiller
Water distillation system
Pharmaceutical pure steam generator
Labeling machine for BFS containers
Entry-level filler for large-volume parenterals
Lab-scale radial chromatography columns for virus validation
Pre-packed and pre-validated chromatography columns
Automated bubble traps for chromatography
Ultrasonic spraying system for small scale coating and research processes
Automatic forming and sealing blister machine for packing syringes
Clinical trial lab sealer for a laminar airflow bench
Automatic medical forming and sealing blister machine for packing capsules and tablets
Semi-automatic forming and sealing blister machine
Benchtop peristaltic dispenser
Laboratory liquid viewer for colored glass bottles
Laboratory liquid viewer for transparent glass bottles
Manual stoppering equipment for pre-filled syringes
Powder dosing system
Aseptic filling machine for liquids and powders
Individual item serialization equipment
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Select your bio-pharmaceuticals process
Tell us about your production challenge
Modify biopharmaceutical extracts to stimulate antibodies with vaccines
Recombinant DNA technology is used for medicines such as growth hormone or insulin, monoclonal antibodies, or fusion proteins. As part of their manufacturing process, vaccines are grown in tissue culture, and for gene therapy, viruses are artificially manipulated to include desirable parts of genetic material.
Different approaches or treatments for different types of biopharmaceuticals. Cell-based therapy involves modifying a patient’s own cells or donor cells to fight disease. Blood cells are tightly regulated by an interacting network of biological proteins such as hormones, cytokines, and growth factors. Vaccines contain antigenic components for a specific pathogen in order to activate a patient’s immune system so that it has a memory of the invading pathogen and offers protection when encountered. An example of this would be Covid vaccines. In contrast, monoclonal antibodies target antigens and destroy them, which is used for other purposes such as treatment for transplant rejection. Finally, biopharmaceutical extracts are also used for the production of different serums, hemoglobin, and collagen, which are not considered conventional drugs by the FDA.
Purify the extract during downstream preparation of biopharmaceuticals
Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After the developed product is purified for the required density and ready to be harvested, production technology must meet the highest industry standard to ensure that medicines are safe and effective and move through the clinical development stage. Different types of bioreactor systems are used together with different systems for process control and monitoring. Using scalable equipment from R&D to industrial capacity and implementing the right monitoring strategies, for example, CMC regulations will reduce time to market significantly.
After harvest, the production process moves into a downstream process to meet purity and quality requirements. Downstream processing is usually divided into cell disruption, purification, and polishing. (Ultra-)centrifugation is carried out to separate biomass. If the desired product is intracellular, the cell biomass can be disrupted in order to release the product and allow extraction. If the product is extracellular, the medium can be further concentrated. Or, if necessary, de-watering is done by vacuum drying or reverse osmosis. Finally, a purified product is usually mixed with desired excipients before being packed and ready to enter the market.
Cultivate the media in a bioreactor
A bioreactor mixes the cell media together in a sterile, pressure-free environment. A main component of bioreactor systems is the agitator that facilitates the bundling of contents, facilitating the reactions between them.
One of the primary challenges of bioreactors is controlling the center of gravity. An integrated baffle arm minimizes the formation of internal vortex effects that cause this while keeping the temperature at a constant.
High performance liquid chromatography for biopharmaceutical manufacturing
High-performance liquid chromatography (HPLC) offers high-accuracy separation using columns. CIM monoliths are made of porous methacrylate polymers composed of interconnected channels that range in size from 1-6 μm. It is these channels that account for the media separation power and flow characteristics and ability to purify large biomolecules, such as large proteins, viruses, plasmid DNA, and immunoglobulins with their activity intact.
Safe processing and packing in biopharmaceutical manufacturing
The majority of biopharmaceuticals on the market are parenteral formulations and administered by direct injection usually distributed in single-dose vials or prefilled syringes. Product is provided either as a solution, or more commonly as a lyophilized cake, and strict requirements for product purity, activity, and shelf life dictate a very high standard for injectable drug packaging.
All injectables need to be evaluated for leachables that may have migrated over the product shelf life during formal stability testing. These analytics are crucial when it comes to biopharma manufacturing. Many biotech products are lyophilized in the vial before the stopper and seal are introduced. Lyophilization, therefore, presents its own packaging requirements on vial shape and rubber enclosures.