Single-use bioreactor for cell cultures

Enhance your cell culture efficiency and minimize contamination risks with a state-of-the-art single-use bioreactor designed to seamlessly scale from pilot studies to commercial production while maintaining optimal mixing dynamics for high-density cell lines.

Optimizes Cell Culture Mixing and Bioprocessing

The DynaDrive™ Single-Use Bioreactor from Thermo Scientific is engineered to revolutionize bioprocessing with its advanced stir-tank design. This bioreactor excels in mixing and mass transfer for high-density cell cultures, catering to applications such as monoclonal antibodies, CAR-T cell therapies, and recombinant proteins. Designed for use in biopharmaceutical and biotechnology industries, it supports batch, fed-batch, and perfusion processes with significant scalability, ranging from 50 to 5,000 liters. The DynaDrive bioreactor integrates seamlessly into existing production lines via an open-architecture approach, allowing interoperability with contemporary control systems. Its ergonomic hardware, combined with a robust Thermo Scientific Aegis 5-14 film, ensures durability and ease-of-use. Additionally, the bioreactor’s components adhere to stringent leachable and extractable standards as per BioPhorum Operations Group guidelines. With enhanced seed train processes, offering up to a 20:1 turndown ratio, it reduces the risk of contamination and increases efficiency, making it an indispensable tool for pilot to commercial-scale operations.

Benefits

  • Enhances production efficiency with optimized mixing dynamics for high-density cell cultures.
  • Minimizes contamination risk through reduced seed-train turndown ratios.
  • Facilitates seamless scale-up from pilot to commercial production with consistent performance.
  • Ensures compliance with industry standards through rigorous leachable and extractable evaluations.
  • Integrates effortlessly into existing systems, reducing operational complexity.

General


Applications
Cell and gene therapy,Biopharmaceuticals
End products
Car-t cell therapies,Viral vectors,Monoclonal antibodies,Stem cell therapies,Vaccine components,Recombinant proteins
Steps before
Seed Train Preparation,Cell Culture Media Preparation
Steps after
Harvesting,Protein Purification,Sterilization
Input ingredients
cell culture media,seed train,bioprocess container (BPC) contents
Output ingredients
protein expression,batch cultures,fed batch cultures,perfusion cultures
Market info
Thermo Fisher Scientific is renowned for providing innovative scientific instruments, laboratory equipment, and engineered-to-order solutions across various industries, esteemed for their high-quality products and expertise in life sciences, pharmaceuticals, and biotechnology sectors.

Technical Specifications


Capacity
50–5000 L
Material
Stainless Steel
Height (Metric)
2 m 32 cm
Height (English)
7 ft. 8 in.
Length (Metric)
77 cm
Length (English)
2 ft. 7 in.
Width (Metric)
69 cm
Width (English)
2 ft. 4 in.
Mixing and Mass Transfer Performance
Optimized for modern cell culture processes with >100 million cells/mL
Turndown Ratio
10
Film and Components
Aegis 5-14 bioprocessing film
L,E Evaluation
According to BPOG guidelines

Operating Characteristics


Mixing method
Stir-tank design
Turndown ratio
10
20
1 in 500 L
Scalability
50 L to 5000 L
Sparging approach
Redesigned for performance
Interoperability
Open-architecture control systems
Uniform bioprocess container loading
Ergonomically friendly hardware
Perfusion cell culture compatibility
Optimized hardware

Material Compatibility


Biological compatibility
Yes
Abrasion resistance
High
Cleanability
Easy CIP/SIP
Corrosive resistance (e.g. acids)
High
Density/particle size
0.5–2.5 g/cm³

Physical Characteristics


Machine footprint
2 ft. 7 in. length x 2 ft. 4 in. width
Height
7 ft. 8 in.
Tank shape
Stir-tank design
Capacity
50 L
Material
Stainless Steel
Jacketed hardware
Yes,with load cells
Ergonomics
User-friendly design
Interoperability
Open-architecture approach

Custom Options


Control panel type
Open-architecture,interoperability with available control systems
Integration possibilities
Interoperability with available control systems
Mixer type
Revolutionary stir-tank design for optimized mixing dynamics
Impeller type
Redesigned mixing impeller (drive train)
Sparging approach
Redesigned to optimize performance