Bioreactors for cell culture processes
Efficiently cultivate sensitive cell lines with customizable bioreactors designed to optimize aeration, mixing, and temperature control for diverse production needs, from vaccines to nutraceuticals.
Cultivates and Processes Cell Cultures Efficiently
Bioengineering AG offers custom bioreactor systems designed for precision in cell cultivation. These bioreactors use innovative aeration strategies and wide impellers to accommodate shear-sensitive cells in applications ranging from monoclonal antibody production to skincare serum formulation. Capacities range from 30 to 25,000 liters, supporting continuous production with integrated perfusion systems. The BioSCADA software allows seamless automation and monitoring, enhancing efficiency with energy-saving temperature control and gas-mixing stations. Available in stainless steel, these systems comply with cGMP standards, ensuring compatibility and corrosion resistance. For flexible operation, optional CIP systems enable efficient cleaning, minimizing downtime, while comprehensive engineering support is available for tailored configurations.
Benefits
- Enhances production efficiency by optimizing cell cultivation processes.
- Minimizes operational costs with energy-efficient temperature and gas control.
- Complies with global cGMP standards, ensuring regulatory adherence in pharmaceutical manufacturing.
- Enables quick turnaround with customizable clean-in-place systems.
- Supports flexible production scales, from lab to pilot, accommodating diverse industry needs.
- Applications
- Homeopathy,Beverages,Food and nutritional products,Metallurgy,Fine chemicals,Nutraceuticals,Alternative medicine,Performance materials,Cosmetics,Biopharmaceuticals,Chemical,Petrochemical,Mining
- End products
- Carbonated beverages,Amino acids,Vitamins,Mineral water,Vaccines,Metal nanoparticles,Industrial enzymes,Insulin,Monoclonal antibodies,Protein shakes,Biopolymers,Cell culture media,Herbal tinctures,Essential oils,Skincare serum,Anti-aging creams,Dietary supplements
- Steps before
- Engineering and Design,Fabrication,Installation,Automation,Commissioning,Qualification,Process Control,Aeration Strategies,Media Preparation,Gas-mixing,Temperature Circuit Setup,Perfusion System Integration
- Steps after
- Sterilization,Data Analysis,Continuous Production,Installation of Super Skids,Spare Parts Management,Technical Support,Product Quality Assurance
- Input ingredients
- mammalian cells,plant cells,insect cells,viruses cultivated on cells,heat-instable media,shear-sensitive cells,adherent cells on micro-carriers,suspended cells,gas-mixing stations,sterilization strategies,auxiliary vessels for metering solutions
- Output ingredients
- cultivated cell cultures,continuous production with perfusion systems,processed cell culture products,high efficiency plants
- Market info
- Bioengineering is known for its expertise in designing and manufacturing customized bioreactors and fermenters, serving the biotechnology and pharmaceutical industries. They are reputed for high-quality, engineered-to-order solutions and innovative process technologies.
- Capacity
- 30 to 25,000 liters
- Vessel geometry
- h
- Aeration strategies
- Gas-mixing stations,surface gassing,bubble-free gassing
- Impeller type
- Wide impellers with low rpm
- Perfusion systems
- Internal or external spin filters
- Temperature control
- Tech core for temperature circuits
- Sterilization strategies
- For heat-sensitive media
- Automation
- BioSCADA software
- Super skids
- For reducing installation time
- Automation level
- SCADA
- Batch vs. continuous operation
- Batch / Inline Continuous
- CIP/SIP
- CIP 121°C / SIP 135°C
- Cleaning method
- CIP
- Changeover time
- Rapid
- Corrosive resistance (e.g. acids)
- Yes
- Cell type compatibility
- Mammalian / Plant / Insect / Virus
- Vessel Capacity
- 30–25,000 liters
- Typical Vessel Geometry
- Height to diameter ratio
- Impeller Design
- Wide impellers with low rpm
- System Configuration
- Benchtop to pilot scale
- Skid Design
- Super skids for reduced installation time
- Control panel type
- Touchscreen
- Integration possibilities
- BioSCADA software
- Automation level
- SCADA integration
- System configuration
- Benchtop to pilot scale
- Vessel capacity
- 30 to 25,000 liters