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Maker - Product Challenge

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Formulation Technologies

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DISS Mixing System

The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Cream

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Pet food is a specialty food mostly based on formulated ingredients for various nutritional and dietary requirements. Pet food formulas are becoming more diverse and complex, considering the special health conditions and needs of young and aging pets that live in cities. The production of pet food is similar to processing food in general when it comes to fresh feedstock and flesh products.

Pet food

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Although not all women use makeup every day, almost all of them own at least one makeup product, be it lipstick or face powder. Most makeup products share the same basic ingredients of waxes, oils, and fillers with pigments like iron oxide used for colors and shades. Makeup manufacturing equipment includes pulverizers, mixers, and mechanical press machines to produce cosmetic products in different forms such as powder, liquid, or mousse.

Makeup

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

Liquid

Gummies, a staple in the confectionery industry, can come in various forms, such as gummy bears, vitamin gummies, heart-shaped jellies, and many more mouth-watering alternatives. They are manufactured using specialized equipment for mixing, molding, coating, and packaging. From precise mixers to efficient packaging lines, industrial gummy production relies on a range of equipment to ensure consistent quality and meet consumer demand worldwide.

Gummies

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Continuous

Preparation lines for formulating pharmaceuticals include fixed and mobile tanks for liquid solutions. These vessels must withstand high internal pressures while enabling fast production. Their design must meet aseptic standards for manufacture of pharmaceuticals, and comply with good manufacturing practice.
<h2>Preparation Tanks for Pharmaceutical Formulation</h2>
BRAM-COR manufactures a range of dissolutor tanks. All vessels are made of AISI 316L stainless steel, and comply strictly with PED standards and ASME "U" stamp certification.

Formulation tanks are an indispensable part of all pharmaceutical preparation processes. BRAM-COR DISS fixed or mobile tanks are suitable for low, medium, or high density liquid solutions. This includes parental solutions and also ointments and creams.

Every tank has at least one mixer / agitator, a spray ball for cleaning-in-place, and an optional load cell for maintaining safety, precision and performance. Various levels of automation are available for controlling raw material input. External heating jackets are provided where required.

Tanks capacities range from 50 to 25,000 litres. Staircases and safety platforms provide access to large installations for inspections.

Pharmaceutical formulation and mixing tanks

Formulation

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

liquid

solid

Batch

<span style="font-weight: 400;">The efficient size reduction of granular powders is a key step in many pharmaceutical processes, and choosing the right equipment for your application can be vital. Conical mills offer excellent flexibility, as different forces can be achieved simply by changing the impeller type, and different particle sizes by changing the screen type.</span>
<h2>Highly flexible mill for a wide range of pharmaceutical powder preparations</h2>
<span style="font-weight: 400;">The Sejong Pharma CM Series of conical mills offers a range of milling head sizes to suit a variety of production volumes. Available in 500, 1000 and 2000 kg/hour versions, the CM Conical Mill is a fully portable mill, with electric height control allowing for operation into a range of output containers.</span>

<span style="font-weight: 400;">With easily interchangeable heads providing a wide variety of screen sizes and impeller variants, the CM series adds flexibility to your pharmaceutical powder production with reduced cost.</span>

<span style="font-weight: 400;">Easy to operate, with a simple electronic interface, the unit is also quickly and simply disassembled for cleaning thanks to a simple clamp action attachment system.</span>

Conical mill for drug formulation

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

<span style="font-weight: 400;">For pilot and lab-scale pharmaceutical formulations, a high-shear granulation mixer is the perfect choice for cohesive materials. Traditional low shear mixers used in labs fail to process these materials due to higher amounts of hydrophilic polymer. A high-shear machine specifically designed and built for smaller scale operations will achieve optimum results at less cost.</span>
<h2>Value-for-money cGMP compliant small-scale pharmaceutical mixer/granulator</h2>
<span style="font-weight: 400;">The Sejong Pharmatech SM5C is an entry-level floor-standing mixer for pharmaceutical processes. cGMP compliant, the SM5C features digital controls and uses interchangeable mixing vessels for maximum flexibility.</span>

<span style="font-weight: 400;">Available in 1l, 3l and 5l batch versions, the SM5C is ideal for small scale production, pilot or lab work, and has been engineered to provide high quality particle agglomeration.</span>

<span style="font-weight: 400;">Fully mobile with built-in casters and able to run from a wide range of power supplies, the SM5C offers enhanced flexibility for the pharmaceutical industry.</span>

Entry-level high-shear mixer for drug formulation

Granulation

<span style="font-weight: 400;">Softgel (or soft gelatin) capsules are a very popular method for providing oral doses, pharmaceuticals and supplements thanks to their ease of swallowing, lack of taste and tamper-proof nature. When designing new products, new formulations, or experimenting with softgels as a novel form of dosing for existing products, a lab-scale encapsulating solution allows you to test efficiently with the knowledge that results can be scaled up to full production. For small runs of high-value or low-volume product, a small-scale machine can increase efficiency compared to using equipment designed for larger volumes, as well as saving time on changeover.</span>
<h2>Small-scale, high quality softgel encapsulators for lab or small-batch use</h2>
<span style="font-weight: 400;">The SGL107 and SGL207 softgel encapsulators from Technophar offer industry-leading quality for the lab or small batch production environment. The SGL107 can operate at up to 4,500 capsules per hour, and the SGL207 at up to 9,000 capsules per hour. </span><span style="font-weight: 400;">Both models feature the same high-quality components and robust build-quality. Rather than relying on mechanical gearing, both machines feature servo motors and electronic gearing to increase reliability and reduce downtime. Programmable Logic Controllers (PLC) with touchscreen user interface gives quick access to and control over all the production parameters.</span>

<span style="font-weight: 400;">For maximum durability, the SGL107 and SGL207 are built around a solid aluminium frame design, with stainless steel outer covers. These can be specified to meet GMP/FDA requirements where required for pharmaceutical use. This means that the machines are easy to clean and maintain and will not corrode.</span>

<span style="font-weight: 400;">Fitted on castors for easy movement if required, the SGL107 and 207 are fully self-contained, with control and electrical panels within the machine, ideal for non-permanent or semi-permanent applications, as well as permanent small-batch production. </span><span style="font-weight: 400;">Each machine can produce oval or oblong capsules, with the SGL107 having a single dosing plunger, and the SGL207 having two dosing plungers, allowing you to choose the best option to fit your requirements.</span>

Laboratory scale soft gelatin capsule machine

In the pharmaceutical world, encapsulation refers to various techniques to enclose and protect the drug ingredients by forming the capsule shell. Encapsulation equipment changes depending on whether the manufacturer needs to produce a soft or hard gel capsule. For instance, encapsulation systems and machines for softgels control the entire process from start to finish because their shells are filled at the same time they are produced. On the other hand, the filling of hard gel capsules comes by separating the body from the cap, and after the filling operations, the two parts are sealed together again, forming the shell.

Encapsulation

<span style="font-weight: 400;">Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compounds to achieve the required moisture content, as well as applying coatings or binders before further processing prior to tablet formulation. For R&amp;D work a fluid bed dryer with economical batch sizes is required, but it must also be able to scale up successfully for satisfactory full-scale production.</span>
<h2>Flexible lab-scale fluid bed dryer/granulator with advanced features</h2>
<span style="font-weight: 400;">The Sejong Pharmatech D5L is a compact small-scale fluid bed dryer/granulator with features specifically designed for lab work and small batch processing in volumes from 1 to 5 litres.</span>

<span style="font-weight: 400;">The D5L features both top and bottom spray arms for maximum flexibility, with fully adjustable height control for both. This allows the machine to be used for drying, granulating and coating.  The product container is ergonomic to use and makes adding and discharging compounds quick and simple, and the capacity is fully controllable based on the required production volume. The container also features a built-in sampler, to allow physical inspection of the progress of the cycle as it runs - perfect for R&amp;D situations.</span>

<span style="font-weight: 400;">The D5L features a full colour touchscreen with easy-to-read schematics for control and diagnostics, allowing the operator to monitor all parts of the cycle. All control software is fully 21CFR part 11 compliant.</span>

<span style="font-weight: 400;">The exhaust features a dust collection system with easy-to-change cartridge filter system, and the unit features a powerful 4.8kW electric coil heat exchanger for precise temperature control.</span>

Fluid bed dryer for lab scale

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

A recent important change in the industry is the trend toward providing liquid doses contained in hard capsules.  The right equipment is need to develop processes to fill hard capsules with the wide variety of liquids used by today's pharmaceutical producers.  Laboratory equipment that is capable of handling waxes and lipids, automatically sealing the capsules, and maintaining a tightly controlled process suitable for scaling to production levels will give pharmaceutical innovators an edge of the competition.


<h2>Fill and seal hard capsules with any pharmaceutical liquid</h2>
Fluidocap 1000 is a semi-automatic machine for filling hard pharmaceutical capsules with liquid an sealing them.  It is provided by ACGE-Associated Capsules a world leader in pharmaceutical machinery manufacturing.  Traditionally liquid doses have been provided in soft gel-cap form and have presented drug makers with the common problems of high cost, wastage, cross contamination, migration of the drug into the capsule, and low bioavailability.

The Fluidocap range of machines address these issues by allowing the filling and sealing of hard capsules with liquid compounds rather that relying on soft gelcaps.  The hard capsules can be filled with a wide range of formulations including lipid-based products, high viscosity pastes, and wax type products.  They are sealed with a gelatin band.  The Fluidocap 1000 capsule filler for liquid is designed for laboratory use and can produce up to 1000 capsules per hour but can easily be scaled up to commercial level production.

Laboratory capsule filler for liquid solutions

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

<span style="font-weight: 400">At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with </span><span style="font-weight: 400">chemicals or hazardous substances since they can be potentially dangerous to human health. </span>

Packing

Use of liquid filled hard capsules is increasingly popular with today's pharmaceutical manufacturers.  Bioavailability and patient compliance are enhanced with drugs delivered in this form.  Production of these liquid filled capsules requires equipment that can handle a wide variety of liquids including lipids and waxes, and automatically produce consistent sealed capsules as well as efficiency and high machine up-time to ensure profitability.


<h2>Automatically fill and seal hard capsules with any pharmaceutical liquid</h2>
Fluidocap F40 is a fully automatic machine for filling hard pharmaceutical capsules with liquid an sealing them.  It is provided by ACGE-Associated Capsules a world leader in pharmaceutical machinery manufacturing. Traditionally liquid doses have been provided in soft gel-cap form and have presented drug makers with the common problems of high cost, wastage, cross contamination, migration of the drug into the capsule, and low bioavailability.

The Fluidocap range of machines address these issues by allowing the filling and sealing of hard capsules with liquid compounds rather that relying on soft gelcaps.  The hard capsules can be filled with a wide range of formulations including lipid-based products, high viscosity pastes, and wax type products. They are sealed with a gelatin band. The capsule filler for liquid is designed for high volume production use and can produce up to 40,000 capsules per hour. Combinations filling including pellets in liquid is also possible using special attachments.

Automatic capsule filler for liquid solutions

Innovators in the highly regulated and highly dynamic pharmaceutical market place need equipment that is worry-free and flexible enough to vary products and process variables as new products are developed.  Laboratory capsule filling machine must be easy to maintain, allow for rapid tooling change-over, and provide tightly controlled process variables and automatic operation in order to ensure results that are reproducible at the production scale.


<h2>A complete encapsulation solution for the laboratory</h2>
The AFT-T Lab system from ACGE is a laboratory capsule filler from the AF series of capsule fillers that is currently running in over 1000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The AFT-T Lab machine has all the benefits associated with the larger equipment in the series but on a scale appropriate for laboratories.  The machine can output up to 6,000 capsules per hour for powder filling and 5,000 capsules per hour for pellet filling.  It uses a 1.1 kW primary motor.  It weighs about 1,200 Kg and occupies only 2.25 square meters of floor space making it the perfect scale for any pharmaceutical laboratory.

Automatic laboratory capsule filler

For pharmaceutical formulations that are highly active specialized capsule filling equipment is often required for operator safety and protection of product quality.  Full containment in a capsule filling process requires, minimal creation of dust, minimized product left-over in the machine, and operation with minimal operator interaction.  This specialized equipment offers these enhanced features including glove box operator access as well as all other capabilities expected from a top-of-the line pharmaceutical capsule filler.


<h2>Contained, safe encapsulation for highly active formulations.</h2>
The Securefill 12T from ACGE is a fully automatic  high containment encapsulation solution for highly active substances. The contained capsule filler is specifically designed to prevent any surface or airborne contamination escaping the machine which can be a risk to operator safety when working with highly active pharmaceutical formulations.  Contact between the operator and the formulation is eliminated greatly reducing the complexity and unreliability of other protective methods commonly used.

Part of the AF series of encapsulation machines which are currently running over 1,000 pharmaceutical production facilities world wide, the Securefill 12T has all the proven design benefits and flexibility of the other machines, with added containment and operator protection features.  Capacity of the contained capsule filler is up to 12,000 capsules per hour.

Contained capsule filler

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Capsule filling should be a worry-step in pharmaceutical and nutraceutical manufacturing.  The right equipment is capable of fully automatic operation, includes accurate dose control, is easily changed over between products, and includes supporting accessories for smooth integration with other processes.  A high quality capsule filler will give plant managers peace of mind and allow them to focus on improving other aspects of their operation.


<h2>A complete, automatic encapsulation solution</h2>
The AF series from ACG-Pam is a production scale capsule filler line that is currently running in over 1000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The automatic capsule fillers can output from 6,000 to 200,000 capsules per hour and can handle powder, microtablet, and pellet, and capsule-in-capsule filling.  They include ACG-Pam's patented ZRO technology which reduces dusting and product loss during operation as well as other features designed for revenue optimization and machine efficiency.  The AF series machines in production have handled over 3,000 different formulations and ACG-Pam's support personnel have developed the expertise and knowledge based needed to tailor an encapsulation solution for even the most difficult formulations.

Automatic capsule filler

Pharmaceutical manufacturers require maximum yield from their encapsulation process for efficient production and competitive results.  Leaving expensive pharmaceutical formulations in the encapsulation machine as left-over or dust is wasteful and inefficient.  Equipment with all the features required for accurate high quality encapsulation as well as enhancements for minimized dust creation and product loss will give users a distinct advantage over the competition.


<h2>A complete encapsulation solution for maximum yield</h2>
The ZRO 90T system from ACGE is a production scale capsule filler from the AF series of capsule fillers that is currently running in over 1,000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The ZRO 90T machine has all the benefits associated with the series as well as additional features to minimize formulation loss during processing and maximizing yield.  The capsule filler includes ACGE's patented ZRO technology which minimizes dusting and separation by containing the formulation within the dosing disk.  This technology reduces formulation waste and maximizes powder use efficiency for maximum yield.

High-yield capsule filler

Staying competitive in today's highly dynamic and highly regulated pharmaceutical production market requires encapsulation equipment with the utmost process control and batch documentation.  Quick changeover, and accurate dose control are required as well as enhanced features like environmental sensors, online weight adjustment and automated documentation and reporting.  Successful modern producers use these next-generation features to maintain an edge of competitors with more traditional equipment.


<h2>A complete automatic encapsulation solution with state-of-the-art accuracy controls and reporting functionality.</h2>
The Legend 2500 from ACG-PAM is a fully automatic capsule filler with next generation design which greatly enhances production speed and efficiency.  ACG-Pam has over three decades of experience in the pharmaceutical manufacturing industry and the success of the company's AF series of encapsulating machines which are installed in over 1,000 facilities across the globe provides a knowledge base and industry expertise that is second to none.  The Legend 2500 encapsulation represents the application of this knowledge and experience specifically to improve upon existing encapsulation systems and better meet the needs of today's pharmaceutical producers.

The system includes Industrial PC based controls, online weight adjustment, and a screw type auger for use with the widest variety of formulations.  The need for an extra doing disc when filling doses are 50% of slug length is eliminated by use of a slug length adjustment kit.  Anti-jamming features for trouble free capsule loading and automatic lubrication are also included.  The system makes use of integrated environmental sensors, a stand-alone security enabled IPC control pedestal, and full 21 CFR Part 11 compliant reporting to ensure an encapsulation process that is accurate, controlled, and well documented.

Easy to validate capsule filler

A multipurpose unit in the research and development field. Some of the most common applications are galenic formulation, freeze drying experimentation, taxidermy, underwater archaeology, aliquot preservation,  diagnosis and other research.


<h2>Start your research with this multipurpose high-performance device</h2>
The LyoQuest laboratory, multipurpose and R&amp;D freeze dryer from Telstar Life-Sciences has been designed as a multipurpose unit for the research and development field. It is a small freeze dryer, more compact than most but in spite of its small size, its capacity is quite unbeatable. A state-of-the-art control system and a range of specially designed accessories make the LyoQuest a benchmark in its category.

The unit's design offers the best performance in the least possible space. Suitable for laboratories: compact and easy to install, solidly designed laboratory equipment. On a functional level, cooling management ensures optimum performance.

Multipurpose and R&D freeze dryer

Designed for biological, pharmaceutical and food products formulation and "scale up" work.


<h2>Best performance for technology transfer activities and work in advanced R&amp;D Centers</h2>
The LyoBeta from Telstar Life-Sciences is a freeze drying unit for biological, pharmaceutical and food products formulation and "scale up" work, facilitating transfer technology to the R&amp;D centers and production. It is a high performance unit with a GLP design that allows for performing the entire freeze drying process fully automatically as well as accurately monitoring it. Very easy to clean, stainless steel chamber, condenser and plates; includes industrial components, such as sensors, vacuum pump, exchangers, etc.

Some of the most common applications are production in pilot plants, functional food research, preservation of diagnosis kits, small batches for clinical trials and so on.

Pilot freeze dryer for scale up

Particularly suitable for research centers requiring greater freeze drying capacity. Some of the most common applications are galenic formulation, freeze drying experimentation, aliquot preservation, taxidermy, experimental food and so on.


<h2>The laboratory freeze dryer that is easy-to-use</h2>
The LyoAlfa from Telstar Life-Sciences is a compact laboratory freeze dryer. It comes as a console and is mounted on casters which make it easy to install. The unit is very flexible, allowing for the simultaneous freeze drying of bottles, vials or bulk products through the connection of different manifold systems or a chamber.

It is available in two models LyoAlfa 6 -50, with a final condenser temperature of -50 ºC; and LyoAlfa 6 -80, with a final condenser temperature of -80 ºC. This enables a higher freeze drying speed and is much more suitable for working with biological samples or products with very low eutectic or collapse points.

Compact laboratory freeze dryer

Products like granules, tablets and capsules require inspection at numerous steps in the production and packaging process. Since all pharmaceutical and chemical manufacturers have to follow standard quality specifications, automatic visual inspection, measurements, real time reports, statistical data and control are crucial at various stages of production and packaging.
<h2>Visual inspection and measurement of pellets, granules and mini tablets</h2>
Patvis APA by Sensum visualizes, measures and diagnoses quality of various particles, such as pellets, granules, and mini tablets in real-time when mounted on the process equipment. It consists of a high-resolution camera which performs non-destructive acquisition of live images. These images can be saved for later analysis and research purposes or are analysed in real-time, where the image analysis software programs ensure accurate measurements of particles. Furthermore, it is programmed to monitor and control the quality of particles in accordance with FDA and GAMP. It can detect variations in size, shape and extent of agglomeration during pellet coating, granulation and pelletisation processes. With its graphical user interface various statistical reports can be obtained during and after the process.

Particle analysation monitor

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Pelleting equipment transforms powdered, mashed, or grounded material into a denser cylindrical shape. Pellet processing compresses the fine material against a perforated die, where it will be shaped and cut. Although granulating and extrusion also produce pellet-like products, manufacturing pellets is a distinct process.

Pelleting

In the herbal medicine industry, an ultrasonic extractor is a valid alternative to conventional extraction methods that have a long extraction time. Ultrasounds are able to reduce production time by breaking cell walls to get the active ingredient. With the use of ultrasound only physical properties are needed and there’s no need to add chemicals to achieve extraction. This leads to a purer extraction. Although it’s a pilot machine in line with experimental research needs, it can also be used by small-scale manufacturers who wish to scale up their industrial production process.


<h2>Ultrasonic machine for extracting active ingredients in herbal medicine</h2>
The Prosonic1000 is a complete ultrasonic liquid treatment equipment that can be applied to the chemical and pharmaceutical (nanomaterial preparation), electronics (graphene preparation), food (sauces, mayonnaise, dietary supplements) and cosmetics (creams, ointments, lotions) industry. The machine designed by Cheersonic is a bridge between laboratory and small-scale production with the purpose to reduce the gap between experimental research and industrial production. The extraction process of natural products in the herbal medicine field is one of the most used applications for the Prosonic1000, but this ultrasonic equipment is also used for other procedures such as emulsification, homogenization, dispersion and lysis and cell disruption.

The operating principle of the Prosonic1000 is based on cavitation. During operation, a liquid is inserted into the tank through an open pump. The tank consists of two layers: internal and external layer. The internal layer stores the liquid, in which the ultrasonic horn transmits ultrasound waves. When high-power ultrasound waves touch the liquid, cycles of high-and low-pressure are generated. In the low-pressure stage, small vapour bubbles are formed before they collapse. This phenomenon of bubble formation, growth and implosion is called acoustic cavitation. By breaking intermolecular bonds, the penetration of an active ingredient into a solvent is easier, and it allows speeding up the extraction time. The ultrasonic horn can be customized according to customer needs in regard to the process. Moreover, the ultrasonic system has the ability to combine different operation modes, such as cyclic and static experimental methods.

Pilot ultrasonic extractor

Industrial extraction equipment unlocks the valuable compounds hidden away in natural materials. Automated extraction equipment is applied in the pharmaceutical and cosmetic industries to extract active compounds from medicinal plants or herbs. For example, extracting cannabinoids from cannabis plants. But the process is also fundamental to the food industry, recovering various components like aromas, oleoresins, and proteins.  Considerations for selecting suitable extraction technology include the type of plant material to be processed, the extract's heat sensitivity, and the production volume.

Extraction

During the coating process, tablets pass many stages that can make them wet and sticky or crack and split around the edges. These damages can be caused by under or over-heating during spraying or poor spreading of spray droplets associated with inaccurate spray atomization. The high technology tablet coater allows an automatic adjustment control of the flow, avoiding the damp in drum, saving coating, and optimizing the processing time.
<h2>Coating tablets using a perforated, rotating coating drum</h2>
The  Tablet Coater from Romaco Tecpharm is a film coating machine based in perforated coating pan technology. Uncoated tablets (or pellets) can be fed to the rotating drum of the machine, in which flow-directing panels gently mix the tablets. A central nozzle arm sprays the coating film on the tablets and a flow of heated air evaporates the solvent.

Using sonar technology, the product load in the drum is detected (without any manual operation) and all the parameters for the coating process are automatically adjusted, such as distance and position of the spray guns, inlet and exhaust airflow and temperature, path and flow of the air, etc. The capacity of the machine ranges from 0,5 Kg to 600 Kg. Adding an automatic cleaning system is optional.

Industrial scale tablet coater

To coat your consumer products with color or taste-enhancing substances, specialized technologies are available that ensure all the contents are individually and evenly covered. The process starts with loading your goods onto rotating drums, exposing the products to spray nozzles that treat them with your prescribed coating formula.

Coating

Granulation is a common technique in production of pharmaceutical solid dosage forms. Due to high quality requirements of the formed granules in terms of content uniformity and its physicochemical properties, it is important to choose the right process. The wet granulations process will ensure that a fine-powder heterogeneous mixture will turn into a uniform granulation, with increased particle size and higher density.
<h2>Complete turnkey solution for granulation of tablets</h2>
The Granulation Line from Romaco Tecpharm is a single frame solution which carries out all options for wet granulation process. It integrates the High Shear Granulator for mixing and granulation, the Fluidized Bed Dryer for drying, granulation and coating, and the Conical and Cylindrical Calibrators for calibration. It thus helps in reducing the space required in the clean-room and minimizing the risks of cross-contamination while giving maximum flexibility to process development and scalability studies.

The Granulation Line for pharmaceutical solid dosage forms is available in capacities ranging from 25 L to 1.400 L and can carry out two different processes. The first being, wet granulation where an agglutinative solution is added to form granules. The equipment combines one or more dust particles and forms a granule within the required limits.

The second being, the drying process by fluidization which is widely used in the pharmaceutical industry to reduce the moisture content of powder and granules. Hot air is passed at a given pressure and flow rate through a perforated bed of moist solid particles. The wet solids are lifted from the bottom and suspended in a stream of air. Heat is transferred by direct contact between the wet solid and hot gases. The vaporized liquid is then carried away by the drying gasses.

Granulation line for pharmaceutical solid dosage forms

It is rather difficult to successfully produce a pharmaceutical solid dosage forms with the desired properties such as size, morphology, hardness and friability. You need a solution that can transform fine heterogeneous powders into homogeneous blend of granules with bigger size and higher density in a short time and with repeatability. Wet granulation is carried out to convert fine and cohesive active ingredient and excipients, into more uniform, free-flowing granules that are optimised for downstream processing.
<h2>Achieve uniform particle size distribution for wet granulation</h2>
The High Shear Mixer Granulator from Romaco Tecpharm is configured to optimize the wet granulation process. It is used to turn a fine-powder heterogeneous mixture into a uniform granulation, with increased particle size and higher density.

The equipment offers you proper flow and compactness while having a shorter operational time. It can handle capacities ranging from 25 L to 1,400 L.The bottom impeller and the side chopper enables the intensive mixing in a short period of time. In addition, the equipment uses a synchronized system to avoid extrusion effect.

The high-shear granulator for drug formation processes the solid material down to the desired particle size, and the mixture is then pumped to the fluid bed dryer where the moisture is removed, leaving behind the granular product. During the process of wet granulation, the constituents of the oral solid dosage form blend are combined, along with agglutinative solution, to form granules with a homogenous composition.

Industrial high shear mixer granulator for drug formation

Tablet coating can be applied for adding colours or glosses, or based around sugar in order to increase palatability. Some coatings also increase stability where some have an active or functional pharmaceutical property and can directly affect the means that the primary dose is released. When used for development or small batch production, a full-size coater is too large to be feasible. You need a flexible solution to coat tablets in an even and controlled way.
<h2>Flexible tablet coater for research and development</h2>
The Laboratory Tablet Coater from Romaco Tecpharm is designed to produce the film coating of tablets or pellets, suitable in aqueous and organic coatings. It is important to optimise processes before industrialization. Therefore, to minimise time and cost risks, the tablet coater for laboratory scale is used for testing purposes prior to industrialization.

The equipment controls each critical variable, such as applied liquid flow, air flow, air temperature, tablet temperature during the process, and the turning speed of the pan drum,  which  ensures a state of balance between continuing processes. Being a R&amp;D equipment, controlling different variables allows you to decide changing which variable could best optimize your production process.

The standard equipment is suitable to work with interchangeable drums from 0.5 to 2 kg. With a perforated coating pan, the equipment allows different capacity to be processed without need to change the drum.

Tablet coater for laboratory scale

Radial flow chromatography processes require special attention and the right use of high-quality appliances in order to deliver upon specific laboratory requirements. This is where the bubble trap becomes an integral part of the process as it efficiently removes any unwanted gas or air bubbles in process fluids without providing areas where harmful bacteria could accumulate.
<h2>Bubble and gases bubble trap extractor</h2>
Bubble traps are an essential part of the pharmaceutical, food, and chemical industries that are responsible for the extraction of bubbles and gases from chromatographic processes and operations. Bubble traps are most often used in combination with Proxcys Radial Flow Chromatography columns or are simply installed inline onto piping, skids, or for stand-alone use via an expended foot.

The bubble traps are designed in accordance with customer requirement specifications and can range between volumes of 0.5L to 60L. Moreover, the bubble traps have various outlets and inlets that allow for the implementation of add-ons like an expanded feed for stand-alone use in laboratory environments. In general, the standard material of manufacturing is 316L stainless steel with a borosilicate glass cylinder. Additionally, onto the glass cylinder, a straight or at 90-degree elbow Tri-Clamp inlet and outlet to connect to piping are available for a wide range of process flows.

Still, it is completely optional to upgrade materials to a higher grade of steel. All of the materials that have been used come with the proper certifications for usage in pharmaceutical production.

Automated bubble traps for chromatography

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

The use of appropriate and compatible chromatography columns proves essential in the development of feasibility studies as well as virus validation. Micro columns prove to be an integral part in the development or scaling down of virus clearance studies. And so, making use of robust chromatography columns is critical in successfully carrying out operations in a laboratory environment that mimics larger radial processes as it not only guarantees for a quality output but is also cost-efficient as compared to full-scale columns.
<h2>Micro RFC columns for initial development of virus clearance studies</h2>
Proxcy’s Micro columns are tubular columns with the smallest possible volume that can successfully mimic larger radial processes. These small-scale columns are available for various bed heights ranging from 6 to 30 centimeters and different bed volumes varying from 5 to 25 milliliters which make them the perfect choice for initial development and feasibility studies, as well as virus validation.

The high-performance radial flow columns (HP-RFC) tend to thrive at short bed height adsorptive separations. They are mostly made use of in capture-elute application processes. Radial Flow Chromatography (RFC) is an efficient and low-pressure technology suitable for bio-molecule fractionations.

In this case, the Micro Column design imitates full Radial Flow Chromatography column performance with small scale column volumes. Just like the large scale RFC columns, the integrated packing port ensures an even and firm gel bed build-up. The Micro Columns have a maximum operating pressure of 3 Bar(g) and are designed to provide optimal performance.  Other frit porosities, such as 5μm - GP9 - GP15 - 40μm - 100μm - 200μm, are available upon request.

Lab-scale Radial Flow Chromatography columns for virus clearance

Pharmaceutical research and development projects may require small samples of high quality tablets for testing. Laboratory tablet presses must have full functional integrity while taking less space than equipment for commercial production.
<h2>Compact Laboratory Tablet Press</h2>
The KIKUSUI Vela G laboratory tablet press is a scaled-down version of the company’s large production machines, yet it achieves the same levels of functional excellence. It is suitable for compact laboratory conditions, and produces high quality tablet samples from very small amounts of powder granules.

This compact, flexible and easy-to-use equipment features standard compression turret interchangeability, allowing variable tooling on a smaller footprint. Powder and tablet contact points are in grade 316L stainless steel, with electro-polishing finish.

Laboratory Tablet Press

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

The process of forming allows you to shape your products homogeneously. Forming machines are fed the manufactured material in bulk and cut it down to specification, so the process takes place between formulation of the mass and the packaging of the final item.

A special class of this equipment – Form, Fill, and Seal Machines (FFS) – creates bags and pouches from flat material such as plastic sheets, fills them with your designated product, and seals them.

Forming

Pressing

<span style="font-weight: 400;">In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, and improve processes. This needs to be done in aseptic conditions. The risk of contaminating either the test sample or the reactor can be eliminated by using a dedicated sampling probe designed to operate with the range of sample ports in use across all scales of production.</span>
<h2>Risk-free sampling for use with bioreactor top ports</h2>
<span style="font-weight: 400;">The Flownamics FISP F-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 12mm or 19mm top ports from lab scale up to production.</span>

<span style="font-weight: 400;">FISP is a sterilizable 316 stainless steel carrier that is surrounded by a tubular, microporous membrane.</span>

<span style="font-weight: 400;">FISP has been designed to withstand the temperatures, pressures, and chemicals found in fermentation environments and is perfect for aerobic or anaerobic bacteria, yeast, fungi, algae, insect, and mammalian cell cultures. Its design provides risk-free sampling thanks to a sterile barrier provided by its 0.2-micron filter. It offers the flexibility of being able to be used for submerged feeding or adding sterile media.</span>

<span style="font-weight: 400;">Compatible with Clean in Place (CIP), Sterilize in Place (SIP), and autoclaving, the FISP is easy to maintain and intuitive to use, with no specialist training required.</span>

<span style="font-weight: 400;">The FISP has been developed to work seamlessly with the Flownamics Seg-Flow range of automated samplers for use in fully automated test scenarios.</span>

Sampling probe for bioreactor samples

Industrial sampling equipment are systems that allow manufacturers to test (in other words to take a sample of) the products they are manufacturing. This process is generally implemented as a means of quality control but it can also be used as a mean to ensure that production processes adhere to certain regulatory standards. Quality control in your manufacturing process starts with precision sampling techniques. Automated systems deliver consistent samples at a pre-set rate for accurate testing and probing. Sampling technology uses a calibration system involving a series of sensors to extract the material at high levels of reliability.

Sampling

<span style="font-weight: 400;">An accurate and sterile sampling of cultures is vital throughout the biopharmaceutical development process. For constant, accurate monitoring, a reliable automated system is needed that transfers bioprocess samples directly from bioreactors to a range of analytical devices without intervention while maintaining the highest levels of sterility. For small-scale development, the availability of a more cost-effective entry-level system brings large economic advantages.</span>
<h2>Affordable automated bioreactor sampling</h2>
<span style="font-weight: 400;">The Seg-Flow 1200 Automated Bioreactor Sampling System from Flownamics is an economical alternative to the larger Seg-Flow 4800. It is available in two models, the Seg-Flow 1200 and the Seg-Flow 1200 Plus.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">By incorporating a disposable, single-use flow path, the Seg-Flow 1200 is easy to use and requires little maintenance and no specialist operator training.</span>

<span style="font-weight: 400;">Samples can be collected from up to 2 reactors and delivered to 2 analyzers or collectors. Built-in expansion capability means this can be extended to 4 reactors with the Sample Module.</span>

<span style="font-weight: 400;">Integrated control functions such as an automated feed from an at-line glucose measurement can be quickly and easily implemented.</span>

<span style="font-weight: 400;">The Seg-Flow 1200 can be used with small laboratory vessels right up to large full-scale production vessels with 12, 19, and 25 mm models.</span>

<span style="font-weight: 400;">The unique Flownamics FISP filter probe used in the Seg-Flow 1200 ensures a sterile, cell-free sample can be taken from any vessel.</span>

&nbsp;

Entry-level automated online sampling system

<span style="font-weight: 400;">For medium scale production, you can improve line efficiency and reduce setup costs by opting for a fully flexible weight sorter that can handle a wide variety of dosage shapes and sizes without modification or parts changes. By minimizing wastage of valuable product you can see an even quicker return on investment.</span>
<h2>High precision weight sorter that saves money through reduced product waste</h2>
<span style="font-weight: 400;">The SADE SP240 from CI Precision is a highly accurate, easy to operate and fully flexible solid dosage weight checker for use in larger-scale production environments. Featuring 2 60 litre hoppers and 2 weighing channels for bulk operations at up to 9,000 units per hour and an easy-to-use operator interface, the SADE SP240 is accurate to within +/- 1mg.</span>

<span style="font-weight: 400;">The unit has the ability to reclaim “good” items from a weight-rejected batch, saving valuable product and producing less waste. For record-keeping, the unit saves all sort operations and can print reports direct to a printer or send data to a PC for further analysis. A secure access system limits control operation only to authorised personnel.</span>

<span style="font-weight: 400;">Designed with flexibility in mind, the SADE SP240 can handle a wide range of tablets and capsules, switching between them with no requirement for changing physical parts to accommodate different dose types. The SADE is able to weigh tablets up to 20mm x 24mm, and capsules from 5 through to 00 size (larger sizes may be accommodated). The machine is also able to be quickly and easily dismantled for cleaning and sanitizing.</span>

Waste minimization weight sorter for tablets & capsules

Sorting is the process of arranging items systematically, using a specified criterion, to categorize and group similar items and identify non-conforming items for removal. The choice of a sorting machine depends on the type of item to sort, the sorting criteria, the number of categories that the items need to be sorted into, sorting speed, and accuracy. Sorting machines can be used in the food processing industry for sorting and categorizing fruits, vegetables, empty bottles, crates, and other items; other examples include sorting of tablets and capsules by weight for quality control in the pharmaceutical industry. As well as sorting waste in the recycling industry. Manual sorting is a laborious task however, with the use of specialized equipment, manufacturers are able to automate their sorting at high speeds.

Sorting

Weighing

<span style="font-weight: 400;">By employing a weight sorter that is fully flexible and able to handle a wide variety of dose shapes and sizes you can benefit from reduced equipment cost and improved production. Such flexibility without the requirement to change machine parts is now available for large scale production facilities.</span>
<h2>Easy to use, fully flexible weight sorter for large scale production</h2>
<span style="font-weight: 400;">The SADE SP440 from CI Precision is a highly accurate, easy to operate and fully flexible dosage weight sorter for use in larger-scale production environments. Featuring a single 150l hopper and 4 weighing channels for bulk operations at up to 22,000 units per hour and an easy-to-use operator interface, the SADE SP440 is accurate to within +/- 2mg.</span>

<span style="font-weight: 400;">Designed with flexibility in mind, the SADE SP440 can handle a wide range of tablets and capsules, switching between them with no requirement for changing physical parts to accommodate different dose types. The SADE is able to weigh tablets up to 20mm x 24mm, and capsules from 5 through to 00 size (larger sizes may be accommodated). The machine is also able to be quickly and easily dismantled for cleaning and sanitizing.</span>

<span style="font-weight: 400;">The unit has the ability to reclaim “good” product from a weight-rejected batch, saving valuable product and producing less waste. The unit records all sort operations and can print reports direct to a printer or send to a PC.</span>

High capacity weight sorter for tablets &amp; capsules

<span style="font-weight: 400;">Many pharmaceutical doses in tablet form require a coating before they are ready for use. These layers can be purely visual, providing a color difference, or may be based around sugars in order to increase palatability. Some coatings also have an active pharmaceutical property or can directly affect the means that the primary dose is released. For use in an R&amp;D situation, a full size coater is inefficient and too large to be viable. Smaller standalone jacketed coating machines offer a much more economical and efficient solution.</span>
<h2>Flexible tablet coater with advanced features for the development environment</h2>
<span style="font-weight: 400;">The Sejong Pharmatech C30JC automatic tablet coater has been designed to meet the needs of lab operations, research and development and small batch production of coated pharmaceutical tablets. Different pans allow for the accurate and uniform coating of as little as 0.4l and up to 6.3l per batch.</span>

<span style="font-weight: 400;">The pans for the C30JC are fully perforated and constructed of mirror-finish 316L stainless steel, which minimises any clumping or sticking. Different pan designs allow for different volumes of tablets to achieve the perfect results. The low height of the machine means that removal and replacement of the jacketed pans is simple and only requires one operator using the easy to operate lifting and removal unit supplied. </span>

<span style="font-weight: 400;">The built in coating spray unit is easy to set and features an integral measurement scale, making it simple to set the optimum position and angle of the spray head for each pan type.</span>

<span style="font-weight: 400;">Rather than relying on steam as found in larger scale coaters, the C30JC uses and efficient electric an electric heat exchanger that is able to run from a single phase supply for convenience. </span>

<span style="font-weight: 400;">The touchscreen interface has been designed for simplicity and clarity, and the whole system is fully 21CFR part 11 compliant.</span>

<span style="font-weight: 400;">Optional extras include companion stainless steel solution storage tank with heater element and a HEPA filtration system to allow maximum dust extraction or to handle hazardous product.</span>

Tablet auto coater for lab scale

<span style="font-weight: 400;">The ability to coat tablets in an even and controlled way is an important stage in the production of pharmaceutical doses. Layers can be aesthetic, protective, or active as part of the dose release mechanism. Large scale tablet coating machines are either inefficient or unsuitable when used in development or small batch production environments, where flexibility is a key requirement.</span>
<h2>Flexible tablet coater with advanced features for the development environment</h2>
<span style="font-weight: 400;">The Sejong Pharmatech C30FC automatic tablet coater has been developed specifically for the needs of R&amp;D, lab work and small scale production. With a flexible coating volume from 0.4 to 6.3l per batch and a small and portable form factor, the C30FC has features made to improve ease of use.</span>

<span style="font-weight: 400;">The C30FC features removable, fully perforated coating pans in mirror-finish 316L stainless to eliminate tablet sticking/clumping. Different pan designs allow for different volumes of tablets to achieve the perfect results. The low height of the machine means that removal and replacement is simple and only requires one operator and no additional equipment. All round observation windows make it easy to visually inspect the coating process throughout the cycle.</span>

<span style="font-weight: 400;">The built in spray gun has an easy set system with integrated measuring rule. This makes it very easy to set the correct spray position and head angle for each of the different coating pans.</span>

<span style="font-weight: 400;">As part of its standalone design, the C30FC features and electric heat exchanger, rather than relying on steam used in higher volume coaters. The unit also features a fully modular peristaltic pump for the coating solution, allowing for very simple maintenance, cleaning or repair.</span>

<span style="font-weight: 400;">The HMI graphical interface has been designed for ease of use and simplicity, and the whole system is fully 21CFR part 11 compliant.</span>

<span style="font-weight: 400;">Optional extras include companion stainless steel solution storage tank with heater element and a HEPA filtration system to allow maximum dust extraction or to handle hazardous product.</span>

Automatic tablet coater for lab scale

<span style="font-weight: 400;">For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot/small scale pharmaceutical production is the ideal choice. Full control over all process elements and 100% scalability coupled with cost-effective electric operation offers substantial cost-savings over alternative options.</span>
<h2>Cost-effective unit suited for both laboratory and pilot use</h2>
<span style="font-weight: 400;">The Mini DeBEE from BEE International is hydraulically driven homogenizer that is suitable for both laboratory use and in pilot plants or in small-scale production. Offering the highest process intensity available in its class, it will disrupt the toughest cells with the highest yield, or obtain the smallest particle size.  </span>

<span style="font-weight: 400;">With proprietary modular homogenising cell, the Mini DeBEE offers completely independent control of pressure, flow, cavitation, impact, shear and process duration. The minimal sample size of only 10ml makes it an excellent choice for R&amp;D and lab work. Because it guarantees 100% scalability, it can easily be transferred to pilot operations, or the machine itself can also be used for small-scale and batch production, offering continuous flow of up to 15 litres per hour.</span>

<span style="font-weight: 400;">PLC control with digital interface means simple operation and monitoring, with user-adjustable operating pressure from 2,000 to 45,000 PSI. Coupled with a wide range of options, this makes the Mini DeBEE suitable for application in the pharmaceutical, biotech, chemicals, cosmetics and food industries.</span>

Pilot high pressure homogenizer

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

<span style="font-weight: 400;">Offering lab-scale to small pharmaceutical production scale output for in one unit means maximum cost-benefit when acquiring a homogenizer. Capable of achieving a range of processes including cell disruption, particle size reduction, creating stable nano/micro emulsions and working with polymers and liposomes, this benchtop scale unit can operate at up to 15 litres per hour capacity, yet still offer lab quality results.</span>
<h2>Air-operated, compact, bench-top homogenizer suitable for a broad range of applications</h2>
<span style="font-weight: 400;">The Micro DeBEE from BEE International is a compact, laboratory-scale homogenizer that can also be used for small-scale production. This is an air-powered unit that can process as little as a single 5ml sample, up to as much as 15L per hour, offering exceptional flexibility.</span>

<span style="font-weight: 400;">Features that make it an excellent R&amp;D machine include maximum pressure of 45,000 PSI/3100 bar (at 150 PSI, 55 CFM). In addition, the back pressure can reach 5,000 PSI/350 bar, but this is adjustable to your specific process.</span>

Micro DeBEE is simple in operating, and exceptionally easy to maintain and clean (with no disassembly required), adding further to the value proposition.

High pressure air powered laboratory homogenizer

<span style="font-weight: 400;">It’s vital that small units for experimentation can scale up with 100% accuracy. Ease of use, reliability and simple maintenance means increased work efficiency, and rapid cleaning and suitability for sanitary uses increase flexibility and improve return on investment.</span>
<h2>Cost-effective benchtop homogenizer with reliable and consistent process for R&amp;D</h2>
<span style="font-weight: 400;">The Nano DeBEE from BEE International is a market-leader in laboratory-scale homogenizers. Designed for maximum flexibility, the Nano DeBEE can be used for a range of procedures including cell disruption, particle size reduction, nano/micro emulsions and nano/micro dispersions. Despite the minimum sample size of only 5ml, the results obtained from the DeBEE are guaranteed 100% scalable to production processes.</span>

<span style="font-weight: 400;">Offering excellent value for money, the Nano DeBEE can operate at up to 45,000 PSI of pressure and yet it is simple to clean and maintain and it’s suitable for sanitary applications where required. A further major benefit is that DeBEE will provide new staff training for the lifetime of the product.</span>

High pressure electric laboratory homogenizer

<span style="font-weight: 400;">For any industrial pharmaceutical process that relies on high pressure homogenization it’s vital that the equipment used is robust enough to cope with the demands of continuous operation. More than this, modern production demands high levels of process control and automation, as well as seamless integration with plant controls and providing results that satisfy the highest regulatory demands.</span>
<h2>Homogenizer offering the highest level of automation, compliance and capacity</h2>
<span style="font-weight: 400;">The DeBEE 4000 series from BEE International is the company’s top-of-line homogenizing solution for high performance situations. Designed from the ground up to achieve the best results as efficiently as possible, the DeBEE 4000 uses DeBEE’s proprietary homogenization technology for unequalled results, coupled with a hydraulically driven vertical intensifier pumps with a slow stroke rate to provide higher pressure and higher process intensity, all with lower maintenance costs.</span>

<span style="font-weight: 400;">Featuring a PLC with bespoke HMI software and full-colour touch screen, the DeBEE 4000 offers easy access to several features including security modes and authorisations, integrations with plant controls using network data gathering, and dynamic visual schematics for at-a-glance system status and component parameters.</span>

<span style="font-weight: 400;">The DeBEE 4000 features a fully sanitary design making it ideal for pharmaceutical and biotech production, as well as use in the chemical industries.</span>

High pressure industrial homogenizer

<span style="font-weight: 400;">Biotech and pharmaceutical development programs often require a mixing method that achieves both particle size reduction and complete cell lysis. When piloting production systems, it’s vital that you have complete control over the pressure to accommodate all cell types, and that the results of testing are completely scalable to full production.</span>
<h2>High-pressure homogenizer offering all configurations</h2>
<span style="font-weight: 400;">The DeBEE 2000 from BEE International is a complete pilot solution for high pressure homogenization in a highly compact format. Offering user-adjustable pressure control from 5,000 to 45,000 psi, the unit is suitable for a wide range of pharmaceutical and biotechnology applications and its modular design means lower costs of maintenance and repair.</span>

<span style="font-weight: 400;">This pilot unit also offers a wide range of options to suit all process and budget requirements, including Dual Feed, Dual Jet, control of cavitation, shear and impact and secondary additive feed for particle synthesis.</span>

<span style="font-weight: 400;">PLC control and HMI touch screen provide simple monitoring, and the unit is designed to be easily cleaned (Clean in Place) and portable.</span>

High pressure pilot homogenizer

Whether you want to improve the stability of nutrients, protect an active chemical agent or control the release rate of a given ingredient, you may benefit from a continuous solution that generates reproducible microspheres and is scalable from pilot to production capacities.
<h2>Rapid, uniform and reproducible microsphere formation</h2>
Both the INFINITY Mini and the INFINITY Lab from EmulTech’s Microfluidic Encapsulation System are versatile platforms for rapid uniform and reproducible microsphere formation for encapsulating small molecules, peptides and proteins, with a particle size of 1 μm and up. This system’s unique continuous flow technology provides high reproducibility, which reduces process development costs and eliminates out-of-spec material.

Microencapsulation system for your drug delivery system

Vacuum drying is used to remove moisture from sensitive materials. Drying small batches in the laboratory for R&amp;D work or removing moisture from high-potency active pharmaceutical ingredients requires careful handling and control.
<h2>Vacuum dry small batches and HPAPI's</h2>
LaboDry from Italvacuum is a laboratory-scale, vacuum tray, drying oven designed to meet small batches and high potency API production requirements. It features a separate cells construction and has been designed for glove box installation. It can be fitted with skid-mounted auxiliary accessories. LaboDry is available in in AISI 316L (1.4404), AISI 904L (1.4539) and ALLOY C-22 (2.4602) construction to meet the requirements of appropriate material for product contact. LaboDry is ideal for laboratory use and the pharmaceutical industry.

Laboratory-scale vacuum tray drying oven

Innovators in process development need laboratory equipment that helps their ideas be reliably scaled up to production.  For dispersion equipment, this requires important process parameters like circumferential speed, tool, and mixing chamber geometry to be structurally identical to production level equipment.
<h2>A highly adaptable dispersion machine for the lab, designed for reliable scale-up</h2>
IKA's Labor-Pilot is a versatile, compact, and highly reliable inline laboratory dispersing machine.  It is designed for solid-liquid mixing, homogenizing, emulsifying, suspending, and wet milling.  It is designed specifically to match process characteristics of larger dispersion machines so developed processes can be reliably scaled up.  The units can work at elevated temperatures, pressure/vacuum conditions, and with abrasive substrates.  Changeout between the several different working modules is quick and easy with each module giving the machine the particular characteristics needed to perform particular tasks and work with a particular type of product.  Compared to stirrers, mixing time for a wide variety of dispersions from coarse to fine can be reduced by up to 50%.

Pilot dispersing machine for testing and scale-up

Dispersing systems are used to produce emulsions of two immiscible liquids or dispersions of solid particles in a liquid medium. The mixers generally operate on the rotor/stator principle and apply a high shear force on the suspended particles to break them down. The choice of a dispersion mixer depends on the physical state of the material being dispersed, the continuous or batch nature of the process, desired particle size, and the viscosity of the mixture. Dispersion mixers are widely used in the food industry for the dispersion of solid ingredients in oil or water and in the coatings industry for the dispersion of pigments.

Dispersing

An emulsifier is used to mix two immiscible liquids. Heating or cooling requirements during emulsification, overpressure or vacuum requirements, the need for wall scrapers, design of the mixing head, the viscosity of the liquids, and the desired droplet size are all important considerations when selecting an emulsifying system. Emulsifiers are typically used in the food industry for the production of batters, creams, and sauces, in the pharmaceutical and cosmetics industry for the production of creams and lotions, and in the chemical industry for the production of paint and other emulsions.

Emulsifying

Developing and validating new processes requires reliable and highly versatile equipment.  Innovators need mixing equipment that can be adapted to a wide variety of processes and has the function and controllability they need to fine-tune their results.
<h2>Multi-functional, small scale dispersion for the laboratory</h2>
The Magic LAB from IKA is a uniquely versatile small-scale dispersion machine.  It is designed for mixing, dispersing, wet milling, and incorporation of powders into liquids.  The laboratory dispersing machine is commonly used for developing new products and improving existing processes in the chemical, cosmetic, pharmaceutical, and food industries.  It is an ideal machine for continuous, circulating, and batch processing using different interchangeable modules.  It is designed to match functional parameters of larger scale production dispersion equipment making scale-up predictable and successful.  The units can be configured for single or multi-stage operation among others and important process parameters such as speed, torque, and temperature can be recalled.

Small-scale laboratory dispersing machine

Successful pharmaceutical manufacturers know that high quality, reliable equipment is essential in order to be competitive in highly regulated and highly dynamic market.  Reliable, flexible forming equipment that works with a variety of tooling types and is adjustable to meet the needs of different products gives producers peace of mind.  A tablet press with full audit trail compliance from a world renowned pharmaceutical equipment supplier is certain give any high volume pharmaceutical producer an edge over the competition.


<h2>A tablet press with premium features and low cost</h2>
The Legacy 6100 tablet press from ACGE is a tablet press of proven design and well known quality.  The consistent, high quality production and user friendliness demanded by today's producers as well as a low upfront cost and revenue optimization features make this unit the ideal choice for high volume tablet production in a competitive environment.

The unit includes 10 tonne compression rollers in both the 1st and 2nd stages and well-tuned dwell time to ensure gradual compression.  Non-complying tablets are identified and sorted automatically and product recipes and production parameters are stored internally.  The system is designed for economic operation and includes features for easy cleaning, and rapid change-over, as well as a online support and video training materials to ensure competent and confident operators and efficient production.

Economic tablet press

Creating batches of consistent high quality pharmaceutical grade tablets from your powdered ingredients requires equipment that complies with strict regulations and record keeping requirements while at the same time is flexible and easily adapted to a variety of products.  Easily maintained, equipment with quick tooling changeovers and faulty punch detection gives producers the worry-free tablet production capabilities that they need to be competitive.


<h2>A simple and robust tableting platform for efficiency and regulatory compliance.</h2>
The Protab 300 from ACGE is a simplified rotary tablet press with features designed specifically to meet the demands of today's small and medium batch pharmaceutical producers.  It is designed for easy maintenance, rapid changeover, high reliability and Overall Equipment Efficiency in general.  A dust extraction system , feeder assembly, turret, and exit chute assemblies have all be rethought and include features such as auto-lubrication, swing-in swing-out design, modular design of supporting assemblies to ease machine use and increase production efficiency.

ACGE's Protab 300 also includes features that assure a tablet product of the highest quality including digitally aided feeder height adjustment, precise tablet weight control, and safety features such as process interlocks and noise reduction.  Productivity is enhanced with higher machine up-times, low feeder leftover losses, improved paddle design for elimination of dead zones, and and intelligent 'batch over' detection system.

Single rotary tablet press

Sensitive bioprocess applications requires equipment that will not interfere with the chemical and biological processes being carried out.  At the same time, production bioprocesses, in particular those that involve peristaltic pumping, require robust tubing not prone to wear or mechanical failures.  Traditional transfer tubing for these more rigorous ans sensitive bioprocesses often proves inadequate.


<h2>A robust biocompatible tube designed for longevity in production peristaltic pumping applications</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers tubing solutions specifically designed for use in peristaltic pumps in bioprocess production environments. The tubes are of the PharMed BPT brand and are completely bio-compatible and less permeable to gasses and vapors than traditional silicone tubes.  This makes the PharMed BPT tubes ideal for protecting sensitive biological processes like cell culture, fermentation, separation, synthesis, and purification.  At the same time, they have been formulated for enhanced flex and wear characteristics allowing trouble free used in peristaltic pumping applications.  The combination of these qualities increases the efficiency of the bio-production process by reducing down time from tubing failure without making any sacrifices in bio compatibility.

Biocompatible tubing for peristaltic pumps

The fermentation process stimulates enzymatic activity in organic substrates to transform their chemical composition. Fermentation is aided by storying the biomaterials in anaerobic environments, allowing the microorganisms to decompose their nutrient structures. The process is integral to some of the most popular products throughout time such as wine, beer, cheese, and kimchi. But besides the food sector, fermentation is also an important stage in the industrial manufacturing of chemicals, pharmaceuticals, and biofuels.

Fermentation

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Freeze dryer designed for aseptic and small-scale production of high-value products.


<h2>Industrial freeze dryer in a compact envelope</h2>
Lyotris from Telstar Life-Sciences is a lab scale production freeze dryer designed for the production of small batches of high-value pharmaceutical products. With a 1m2 loading surface and capacity for approximately 1,600 10R-type vials or 30 liters of bulk product. It has been specially designed for aseptic production in vials or in bulk and its novel fascia and door design provides easy isolator integration.

The GMP laboratory freeze dryer comes with all  the necessary components for an automatic cleaning (CIP) and steam sterilization (SIP) processes, filter integrity testing (WIT) and also incorporates an advanced SCADA system which includes Telstar's patented ‘Lyometrics' system; providing advanced real-time information on the freeze-drying process.

GMP laboratory freeze dryer

A Laboratory high shear impact mixer can be used to simulate different processes; from slow speed pre-blending to high-speed coating, agglomeration, and dispersion.
<h2>Experiment with cohesive powders on a lab scale</h2>
The Hosokawa Micron high shear impact mixer 1 liter is a downsized Cyclomix lab model, with a working volume of typical 0.3 - 1 liters powder content, mainly used for cohesive powders. Using frequency control, any mixing process can be imitated on this small-scale mixer: from slow speed pre-blending to high-speed coating, agglomeration, and dispersion.
It is used in the adhesives, chemical, cosmetic, food, pharmaceutical, and plastics industries for emulsification, homogenization, particle size reduction, and dispersion in the batch process.
Combining different processes in one single machine and is the ideal choice for intensive thermal processing of high energy input; high degree of dispersion and homogeneity and ultra-short cycle times.

Laboratory high shear impact mixer

Blending

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.