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Maker - Product Challenge

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Formulation Technologies

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DISS Mixing System

The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Cream

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Pet food is a specialty food mostly based on formulated ingredients for various nutritional and dietary requirements. Pet food formulas are becoming more diverse and complex, considering the special health conditions and needs of young and aging pets that live in cities. The production of pet food is similar to processing food in general when it comes to fresh feedstock and flesh products.

Pet food

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Although not all women use makeup every day, almost all of them own at least one makeup product, be it lipstick or face powder. Most makeup products share the same basic ingredients of waxes, oils, and fillers with pigments like iron oxide used for colors and shades. Makeup manufacturing equipment includes pulverizers, mixers, and mechanical press machines to produce cosmetic products in different forms such as powder, liquid, or mousse.

Makeup

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

Liquid

Gummies, a staple in the confectionery industry, can come in various forms, such as gummy bears, vitamin gummies, heart-shaped jellies, and many more mouth-watering alternatives. They are manufactured using specialized equipment for mixing, molding, coating, and packaging. From precise mixers to efficient packaging lines, industrial gummy production relies on a range of equipment to ensure consistent quality and meet consumer demand worldwide.

Gummies

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Batch

Pilot

When developing new pellet formulas or refining existing processes, precise testing and adjustments can significantly impact pellet quality and production efficiency. Small batch testing is essential to optimize formulations without committing to large-scale production.
<h2>Pellet different formulations with a controlled process</h2>
The CL Series Laboratory Pellet Press from CPM is designed to support small-scale testing of pellet formulations. The press offers capacities ranging from 30 to 200 pounds per hour, making it suitable for development and pilot projects. The CL3 model comes with a hopper, vibratory feeder featuring variable speed control, and front discharge for efficient operation. The CL5 model includes a conditioner for adding steam or liquid, enhancing pellet quality. Features such as a 3 HP motor, touchscreen controls, and segmented die clamps facilitate quick die changes. Components are sealed with metal-to-metal seals, improving efficiency, while a replaceable quill flange ensures longevity. The single motor design increases operational efficiency.

Laboratory pellet press for testing and formulation

Formulation

Pelleting equipment transforms powdered, mashed, or grounded material into a denser cylindrical shape. Pellet processing compresses the fine material against a perforated die, where it will be shaped and cut. Although granulating and extrusion also produce pellet-like products, manufacturing pellets is a distinct process.

Pelleting

Drawing samples and testing them for conformity with preset quality standards allows manufacturing units to produce a consistent quality of the product. In a batch process, sample testing systems ensures that each batch meets the specified standards. In a continuous process, product and materials testing helps in the early identification of quality issues, saving significant time and resources, and preventing a sub-standard product from reaching the market. The selection of industrial testing equipment depends on the identification of key quality parameters. These parameters may include volume, weight, viscosity, hardness, particle size distribution, sterility, gauge and containment, among other parameters. Testing machinery need regular calibration to ensure that the parameters being tested are accurate. Some of the more common testing solutions include thermal imagers, scratch testers, optical inspectors and texture analyzers.

Testing

solid

Entry level

In the field of pharmaceutical research and development, creating reliable, repeatable formulations requires fine control over granulation and spheronization processes. Achieving precise measurements and consistent results is crucial for scaling up lab findings to production levels.
<h2>Automate mixing, extruding, and spheronizing</h2>
The Multi Lab Scientific (MLS) from Caleva Process Solutions is a bench-top mixer, extruder, and spheronizer specifically designed for formulation development in pharmaceutical labs. The MLS features a digital touchscreen for intuitive operation, automated data capture, and recipe management. It efficiently streamlines the iterative process of formulation development with a small batch size starting from 15 g. The system has a high-integrity safety device and tool-less technology for easy attachment and removal of components. Other notable features include motor load percentage reporting, RPM speed reporting, and ambient and process temperature measurement. The unit is suitable for use with gloves, ensuring user safety and convenience. The MLS is ideal for researchers needing reliable and repeatable results to ensure accurate scale-up programs.

Bench-top mixer and spheronizer for formulation development

Granulation

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Manual

When producing biopharmaceutical formulations, ensuring homogeneity and maintaining precise control over temperature and pH levels is crucial. These processes demand specialized vessels that can consistently deliver uniform mixtures from the first to the last drop, ready for transfer to filling stations.
<h2>Ensure homogeneity for biopharmaceutical formulations</h2>
The formulation vessels from Bioengineering are designed to meet the stringent requirements of biopharmaceutical production, ensuring homogeneity and controlled conditions. These stainless-steel vessels, available in capacities ranging from 50 to 2,500 liters, feature magnetic stirrers for uniform mixing and optional Vibromixers for suspensions, such as those containing aluminum particles. The design ensures effective mixing even at low filling levels. Comprehensive control systems allow for precise adjustments of pH levels through integrated probes, controllers, and dosage systems. Additionally, temperature-controlled transfer lines maintain product quality during transfer to filling stations. Bioengineering’s formulation vessels can be operated manually or fully automated, tailored to fit specific customer needs.

Formulation vessel for biopharmaceutical homogeneity

Blending

Industrial cooling equipment varies according to the consistency and temperature conversion demands the material you are handling, but the process typically involves heat exchange treatment as your products are conveyed through a cooling chamber equipped with extraction fans or circulating water. Temperature control is a crucial aspect of your commercial production and cooling systems are applied to a range of industries.

Cooling

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

liquid

Continuous

Preparation lines for formulating pharmaceuticals include fixed and mobile tanks for liquid solutions. These vessels must withstand high internal pressures while enabling fast production. Their design must meet aseptic standards for manufacture of pharmaceuticals, and comply with good manufacturing practice.
<h2>Preparation Tanks for Pharmaceutical Formulation</h2>
BRAM-COR manufactures a range of dissolutor tanks. All vessels are made of AISI 316L stainless steel, and comply strictly with PED standards and ASME "U" stamp certification.

Formulation tanks are an indispensable part of all pharmaceutical preparation processes. BRAM-COR DISS fixed or mobile tanks are suitable for low, medium, or high density liquid solutions. This includes parental solutions and also ointments and creams.

Every tank has at least one mixer / agitator, a spray ball for cleaning-in-place, and an optional load cell for maintaining safety, precision and performance. Various levels of automation are available for controlling raw material input. External heating jackets are provided where required.

Tanks capacities range from 50 to 25,000 litres. Staircases and safety platforms provide access to large installations for inspections.

Pharmaceutical formulation and mixing tanks

<span style="font-weight: 400;">The efficient size reduction of granular powders is a key step in many pharmaceutical processes, and choosing the right equipment for your application can be vital. Conical mills offer excellent flexibility, as different forces can be achieved simply by changing the impeller type, and different particle sizes by changing the screen type.</span>
<h2>Highly flexible mill for a wide range of pharmaceutical powder preparations</h2>
<span style="font-weight: 400;">The Sejong Pharma CM Series of conical mills offers a range of milling head sizes to suit a variety of production volumes. Available in 500, 1000 and 2000 kg/hour versions, the CM Conical Mill is a fully portable mill, with electric height control allowing for operation into a range of output containers.</span>

<span style="font-weight: 400;">With easily interchangeable heads providing a wide variety of screen sizes and impeller variants, the CM series adds flexibility to your pharmaceutical powder production with reduced cost.</span>

<span style="font-weight: 400;">Easy to operate, with a simple electronic interface, the unit is also quickly and simply disassembled for cleaning thanks to a simple clamp action attachment system.</span>

Conical mill for drug formulation

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

<span style="font-weight: 400;">For pilot and lab-scale pharmaceutical formulations, a high-shear granulation mixer is the perfect choice for cohesive materials. Traditional low shear mixers used in labs fail to process these materials due to higher amounts of hydrophilic polymer. A high-shear machine specifically designed and built for smaller scale operations will achieve optimum results at less cost.</span>
<h2>Value-for-money cGMP compliant small-scale pharmaceutical mixer/granulator</h2>
<span style="font-weight: 400;">The Sejong Pharmatech SM5C is an entry-level floor-standing mixer for pharmaceutical processes. cGMP compliant, the SM5C features digital controls and uses interchangeable mixing vessels for maximum flexibility.</span>

<span style="font-weight: 400;">Available in 1l, 3l and 5l batch versions, the SM5C is ideal for small scale production, pilot or lab work, and has been engineered to provide high quality particle agglomeration.</span>

<span style="font-weight: 400;">Fully mobile with built-in casters and able to run from a wide range of power supplies, the SM5C offers enhanced flexibility for the pharmaceutical industry.</span>

Entry-level high-shear mixer for drug formulation

Industrial

When working with small production batches in pharmaceutical processes, maintaining product quality and batch uniformity is crucial. Traditional drying methods may not suffice for such stringent requirements, making precise freeze drying techniques essential.
<h2>Ensures consistent drying with advanced technology</h2>
The MINIMAX by IMA is a GMP-compliant, small-scale freeze dryer designed to meet the specific demands of handling small production batches. Based on the successful LYOMAX concept, MINIMAX provides scalable lyophilization technologies from formulation to full commercial production. With several configurations available, it offers shelf areas ranging from 1.0 up to 3.9 m², and ice condenser capacities from 29 to 78 kg, with minimum condenser temperatures of –75°C. It is equipped with Process Analytical Technologies (PAT) to optimize drying outcomes and gives a data-rich environment for monitoring. It supports non-aqueous solvents and high-potent products processing and can integrate with isolation technology and automatic vial-loading systems. The patented FUSION™ shelf technology ensures higher-quality heat transfer, enhancing process reliability. Designed with redundancy and configurable options, the MINIMAX provides a reliable and versatile drying solution.

Small-scale freeze dryer for pharmaceutical applications

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Lyophilization

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Powder

Developing formulations with high-viscosity materials often requires a precision kneading process to ensure homogeneity and consistency. Laboratories engaged in such tasks need equipment capable of handling low-volume production efficiently.
<h2>Ensures even kneading of high-viscosity materials</h2>
The GUITTARD LAB Z-arm kneader, from HASLER Group, is specifically designed for laboratory use in low-volume production environments. This unit features Z-shaped arms that cover the entire surface of the tank, ensuring even kneading by breaking up agglomerates. Capable of handling up to 30 liters of material, it offers a range of advanced options like a single-screw extruder, explosion-proof construction, and a PC-based data acquisition system. The blades move in a zigzag pattern and rotate in opposite directions to effectively fold, stretch, and knead the material. Constructed from stainless steel with optional treated glass lids, it is easy to install requiring only a power cable. This kneader is suitable for various industries including fertilizers, hydrometallurgy, and food processing.

Laboratory z-arm kneader for high-viscosity materials

Kneading

Maintaining high product quality standards and precise process control in pharmaceutical manufacturing demands accurate metering of bulk solids. Achieving this level of precision is crucial for feeding upstream wet granulators, controlling tablet press lubrication, and more.
<h2>Enable precise bulk solid metering</h2>
The Gericke high-precision loss-in-weight gravimetric feeders are designed to ensure accurate metering of bulk solids in pharmaceutical applications. Integrated into the Gericke Formulation Skid (GFS), these feeders provide continuous manufacturing support and can function as standalone units. They are ideal for feeding upstream wet granulators, hot melt extrusion, and other critical processes. The feeders support controlled feeding to mills and micronizers, and are also used for batch feeding and automated dispensing of excipients and active pharmaceutical ingredients (APIs). With high precision metering, they enable enhanced product quality and operational efficiency. The feeders are designed to integrate seamlessly into existing systems and provide easy monitoring and control.

Gravimetric feeders for pharmaceutical applications

Industrial feeding systems allows you to control the flow of solid bulk materials throughout the manufacturing line. After loading your material onto the vibrating hopper, a screw at the base drives it out in uniform doses to the next stage of processing. New feeding technologies are designed to deal with challenges of powders clumping together in the hopper (bridging and ratholing) that interrupt the outflow. Common feeder systems include centrifugal feeders, vibratory feeders as well as elevator, linear and pneumatic feeders.

Feeding

In research and development (R&D) settings and for pilot plant operations, achieving consistent and high-quality mixing of small batches is essential. Traditional industrial mixers often do not scale down effectively, leading to inefficiency and inconsistent results in small volume operations.
<h2>Fast and efficient small batch mixing</h2>
The GMS Compact Batch Mixer by Gericke is specifically designed for laboratory and small-scale production. This twin-rotor mixer offers excellent mixing quality with a volume range of 1 to 20 liters. Its low-speed operation, characteristic of the GMS family, creates a fluidized zone using two horizontally arranged, superimposed mixing tools. This design ensures even mixing while preserving high-quality ingredients. The mixer is built for easy cleaning and sterilization, with interchangeable mixing chambers and dismantleable parts. Operating at an optimal Froude number of 1.1, it reduces R&D costs due to its low minimal filling volume. This compact mixer is also mobile, standalone, and requires only a standard electric supply (220 V AC/50 Hz), making it ideal for agile product development and recipe formulation.

Laboratory mixer for r&d and small batch production

Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

Sterilization

During drug discovery and formulation development, producing spray-dried powders efficiently and safely is crucial. Challenges include handling both aqueous and organic solvents, maintaining a controlled environment, and ensuring portability for versatile applications in various lab settings.
<h2>Efficiently dry powders at the benchtop scale</h2>
The GSD-LAB Micro GENESIS™ by Freund is a benchtop spray dryer designed for the rapid development of spray-dried powders during drug discovery and substance feasibility studies. This system supports open loop operation for both aqueous and organic solvents, making it suitable for use under a hood or inside an isolator. Fully self-contained, it includes a stainless steel drying chamber, atomizing nozzle, cyclone, product collection container, and an optional exhaust HEPA filter, all integrated into a portable unit. The dryer features a 2-fluid atomizing nozzle and an integrated peristaltic pump system to ensure consistent spray rates. It offers validatable process control, with parameters such as inlet airflow and temperature, spray rate, and delivery amount accessible via a color touchscreen control system. Additionally, the system can record data through a USB port. The system supports an evaporation capacity of 0.5 kg/hr (based on water at 210°C inlet / 80°C outlet) and conforms to CE, ATEX, UL, NFPA, and CSA standards, making it a versatile and reliable solution for laboratory-scale spray drying.

Benchtop spray dryer for drug discovery

Evaporation technology is used to reduce or remove the moisture content of a mixture. Considerations for choosing suitable evaporation equipment include the moisture content in the mixture, the boiling point of the solvent, heat sensitivity of the product, and the amount of material to be processed. Evaporators are used for applications such as obtaining fruit and vegetable concentrates in the food industry, concentrating aromas and herbal extracts in the cosmetics industry, and isolating active ingredients in the pharmaceutical industry.

Evaporation

Spraying

When conducting formulation development or basic scientific research, precise control over small batch sizes is crucial. Scaling up these processes for larger production can pose significant challenges, particularly in ensuring consistency and reliability in the results.
<h2>Process small batches with reliable scale-up capabilities</h2>
The ZSK 18 MEGAlab laboratory twin screw extruder by Coperion is designed specifically for processing the smallest batch sizes with high-performance capabilities. Featuring the successful ZSK technology, this extruder facilitates reliable scale-up to larger ZSK twin screw extruders, making it ideal for both formulation development and basic scientific research. It offers throughput rates up to 40 kg/h, with the ability to handle batch sizes as small as 200 grams. The system is characterized by its fast plug-and-play installation, low-noise drive concept, and modular structure with exchangeable 4D barrels and standard screw elements. Operation is simplified through a PLC controller and touchscreen interface, enabling quick product changes via quick-release connections. The compact design includes a mobile base frame with integrated motor and extruder control system, water cooling, and a vacuum unit, enhancing its practicality and ease of use.

Laboratory twin screw extruder for small batch processing

The extruder was first developed to make lead pipes in the late 18th century. But the extrusion process technique quickly spread to other manufacturing sectors, including food, feed, and biomass products. An extruder machine presses a fluid or solid material through a die. Depending on your use case, extruders adopt single- or twin-screw systems to push the premixed feed material through a barrel. Thermal pressure applied in this step can chemically modify the mixture, so the screw system must be precisely calibrated to achieve the desired result. Finally, a knife head cuts the extruded material into your designed dimensions. Extrusion machinery produces items of a uniform size, shape, and consistency.

Extrusion

In nuclear medicine, there is a critical need for reliable production of Tc-99m generators, crucial for diagnostic imaging. Traditional manual methods are inefficient, subject to human error, and pose significant safety risks due to radiation exposure.
<h2>Automates tc-99m generator production under Gmp conditions</h2>
The Tc-99m Generator Production Plant by Comecer is a semi-automatic line designed for the efficient production of 99mTc generators, adhering to GMP standards. This production line features 12 working chambers with lead shielding of either 100mm or 150mm. The plant automates several processes, including 99Mo formulation, automatic filling, and washing of generator columns, and in-line QC for 99Mo breakthrough. With its progressive-shielding chambers, it ensures operator safety through all stages, from loading high-activity bulk to final QC operations. The double pass-through autoclave allows for efficient transfer and sterilization of columns, ensuring productivity even during autoclave maintenance. The production line is capable of producing 250 generators every 12 hours, with operations scalable to three batches per week.

Technetium-99m generator production line

Control

Industrial washing systems are used to clean and disinfect a variety of items in research and manufacturing facilities. Industrial washers use solvents and cleaning agents with mechanical action to remove deposits and residues from stainless steel machinery components, empty containers, and other soiled surfaces. The selection of an industrial or commercial washer depends on the type of items and surfaces to be cleaned, the type of deposits/residue that is typically present, whether drying is required after rinsing and the level of sterilization necessary. Manufacturers will have cleaning specifications and as a result, require washers to be engineered to meet these specs.

Washing

When producing radiopharmaceutical generators like Rb-82, maintaining strict aseptic conditions and ensuring high productivity are crucial. Additionally, handling hazardous materials safely and efficiently poses significant challenges in the manufacturing process.
<h2>Ensure sterile, high-volume rb-82 generator production</h2>
The Rb-82 Generators Production Plant by Comecer is a sophisticated facility designed for the aseptic production of Sr-82/Rb-82 generators. Comprising eight shielded isolators interconnected for seamless operation, the plant utilizes lead shielding of varying thicknesses (125mm, 75mm, 50mm) to ensure worker safety. Integrated automation systems manage the formulation, filling, and washing of generator columns, adhering to GMP and FDA requirements. The aseptic area (Class A – ISO 5) features automatic sterilization via vaporized H2O2 generators. Conveyor systems and automatic assembly stations assist throughout the process, culminating in rigorous QC and sterility testing of the final product. The plant's design supports high productivity, enabling the production of 100 generators in an 8-hour shift, up to three times a week.

Rb-82 generators production plant

In nuclear medicine and radiopharmacy, precise and contaminant-free dispensing of radiopharmaceuticals like Lutetium-177 (Lu-177) is crucial. This ensures accurate dosing and patient safety while maintaining compliance with stringent regulatory standards.
<h2>Automate radiopharmaceutical dispensing processes</h2>
The Lu-177 dispensing line by Comecer is designed for the dissolution, formulation, and dispensing of Lu-177 radiopharmaceuticals. This line includes four main components: a target dissolution and formulation unit, a dispensing unit, a transfer air-lock, and a laminar airflow (LAF) hood. These units are operated by two 6-axis robots that are suitable for cleanroom environments, ensuring a high level of precision and cleanliness. The automation minimizes human error and exposure to radiation, making it an ideal choice for GMP radiopharmacies and nuclear medicine labs. The integrated systems streamline operations and enhance the overall safety and efficacy of the radiopharmaceutical preparation process.

Lu-177 radiopharmaceutical dispensing solution

Dispensing

Dissolution

Handling and packaging radioactive isotopes like 131I requires stringent GMP compliance to ensure safety and precision throughout the production cycle. Achieving this involves integrating specialized filling lines designed to mitigate contamination and exposure risks.
<h2>Cover the entire aseptic filling process</h2>
The Aseptic Filling Line for 131I by Comecer encompasses the complete filling process, from the receipt of raw materials to the final packaging of radiopharmaceuticals in shielded lead containers. The system adheres strictly to current GMP regulations, ensuring safe and sterile operations. Key components include a Receipt Hot Cell for initial stock handling, a Laminar Flow hood for sterile disposable introduction, and a Formulation Hot Cell for bulk product preparation. Additionally, a Loading Flowbox enables unpacking and prefilter integrity testing, while the Filling Hot Cell facilitates precise vial filling. Quality control is maintained with a QC Micro-Hot-Cell for sterility testing and inspection. Final product inspection and labeling occurs in the Inspection and Labelling Hot Cell, where activity is measured and labeled vials are safely delivered using a mechanical handling system.

Aseptic filling line for 131i sodium Iodide

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

Labels provide customers with important information about both your product and your brand. Different labeling technology attaches the printed film to the packaging using a range of methods such as shrink wrapping, side sealing, and adhesives. For added traceability and protection, you may also use serialization coding equipment and anti-tampering labeling systems.

Labeling

When developing new ice cream formulations or scaling up production, it is crucial to have a reliable pilot plant that mimics industrial-scale processes. This ensures consistent results and helps identify any adjustments necessary before full-scale manufacturing.
<h2>Test and develop ice cream recipes at scale</h2>
The Catta 27 Ice Cream Production Pilot Plant is a specialized facility for small-scale ice cream production and formulation testing. Designed to replicate industrial processes, it enables accurate scaling from pilot tests to large-scale manufacturing. Available in two models, K60 and K120, it offers cycle production capacities of 200 liters and 300 liters, respectively. These plants are equipped with water condensation systems and use refrigerant fluids R 404A or R 507, providing efficient temperature control. The pilot plant features electrical specifications of 400V/3Ph/50Hz and consumes 60 Nl/min of compressed air at 6 bar. With total power inputs of 23 kW for the K60 and 40 kW for the K120, these units are robust and versatile. The compact designs, with dimensions of 2,485x1,300x1,300 mm for the K60 and 3,300x1,500x1,600 mm for the K120, ensure they fit within most laboratory or pilot-scale production environments. Catta 27 manufactures these plants, ensuring high-quality construction and reliable performance.

Pilot plant for ice cream production

In large-scale gummy candy production, ensuring proper drying and setting of soft gelatin capsules is crucial to consistently achieve high-quality products. The challenges include maintaining uniform drying, preventing sticking, and maximizing output efficiency.
<h2>Ensure uniform drying and easy handling</h2>
The drying trays and dollys from CandyPros offer a specialized approach to efficiently dry and set gummy candy. Made from stainless steel, these trays come equipped with four casters for easy movement and handling. They support high-volume production environments, accommodating between 400 to 1000 kg per hour. These trays are compatible with both pectin and gelatin gummy formulations, catering to varied production needs. The robust construction ensures durability and longevity, making them a reliable component in the gummy manufacturing process.

Drying trays for gummy candy production

Developing formulations with variable batch sizes is often challenging, particularly when scaling from small laboratory samples to larger production batches. Managing different batch sizes efficiently while maintaining product consistency is crucial.
<h2>Achieve precise wet granulation with batch flexibility</h2>
The Multi Bowl Spheronization Kit by Caleva is a versatile solution for wet granulation pellets, designed for laboratory bench-tops. The kit includes the Caleva bench-top screen Extruder 20, which comes with both full height and reduced height screens to handle varying batch sizes from 50g to 1kg. Additionally, the system features interchangeable spheronizer bowls of sizes 60 mm, 85 mm, 120 mm, and 250 mm diameter, allowing users to start with one bowl and add more as needed. This flexibility facilitates effective product development and easy scale-up to larger production without the need for extensive reconfiguration. The equipment is fully compliant with GLP/GMP requirements, making it suitable for pharmaceutical, nutraceutical, and food industries.

Flexible spheronization kit for wet granulation pellets

Developing new polymer formulations or testing small amounts of high-value materials often requires precise control over the compounding process. Challenges include ensuring optimal mixing, minimizing material loss, and speeding up the cleaning process for frequent formulation changes.
<h2>Enables efficient small-scale compounding</h2>
The Mini-Compounder KETSE 12/36 from Brabender is a highly adaptable and easy-to-use tool designed for laboratory-scale polymer processing. It features a horizontally divided barrel that can be tilted open for easy visual assessment of processing steps, along with quick cleaning capabilities. The barrel length is 36 D, with metering or venting ports available at 6 D, 12 D, and 26 D lengths. Additional side feeders can be installed at a 14 D processing length, enhancing its versatility. This mini-compounder is ideal for a range of applications, providing reliable results with small sample sizes, which makes it a valuable asset in research and development settings.

Mini-compounder for laboratory polymer processing

Compaction machines and technologies crush or compress materials and make them denser. Compaction can be used to simply save space or to shape materials into a desired form or format. Tablets, pellets, or briquets are formed by compactors but powder presses also help form cosmetic eyeshadow or face powder.

Compaction

In research and material development, precise control over experimental conditions is crucial to achieving reliable results. Challenges such as material homogeneity, energy efficiency, and resource optimization demand advanced extruder technology for testing formulations on a laboratory or pilot scale.
<h2>Optimize material processes with twin screw extruders</h2>
The Brabender TwinLab-C 20/40 is a twin screw extruder designed for lab and pilot-scale applications, providing comprehensive control over the extrusion process. It features a modular framework that allows you to tailor components such as screws, die heads, and feeders to your material requirements. This flexibility supports the development and testing of novel formulations with minimal resource consumption. Capable of handling small sample quantities while preserving manufacturing resources, these extruders enable rigorous testing without relying on full-scale production setups. Brabender's live process monitoring ensures continuous oversight of process parameters, allowing for the correlation of process variables with the properties of the extrudate. Suitable for industries including the chemical and food sectors, the TwinLab-C 20/40 is an invaluable tool for innovation in material science.

Lab-scale twin screw extruders for material development

In the production of pharmaceuticals, food, chemicals, and plastics, precise dosing of raw materials in micro quantities is critical. Manual weighing can be labor-intensive and error-prone, especially when dealing with hazardous materials.
<h2>Automate dosing for precise and reproducible results</h2>
The AZO RoLog® is a robotic system designed for the automatic dosing of bulk solids in micro quantities ranging from 100 g to 5 kg. Featuring a flexible, modular structure, this solution allows for the variable dosing of numerous raw materials. The system ensures consistent formulation accuracy and is enclosed within a safety cage, providing complete protection for both the product and the operator. The robot doses raw materials accurately and efficiently, prepared by the automation range in dispensing and storage units. With continuous traceability and a shielded work envelope, it enables safe handling of critical raw materials without operator contact. The system supports 24/7 production and can be integrated into an overall logistics system for enhanced efficiency.

Robotic dosing system for accurate micro quantities

Handling

Weighing

In the pharmaceutical industry, ensuring sterility and precise control in Active Pharmaceutical Ingredient (API) production is critical. Challenges often include contamination risks, inefficient processing workflows, and manual operation bottlenecks that jeopardize product quality and safety.
<h2>Automate and optimize sterile Api powder processing</h2>
The sterile API production line from Austar provides an all-encompassing solution for powder treatment in sterile API workshops. This system includes raw material weighing, formulation, closed feeding in reactors, sterile conveying, and transferring. Key features encompass sterile weighing and packaging, automatic bag-opening, automated measuring, capping, sealing of tins, and CIP/SIP systems. With cutting-edge powder processing technology and extensive engineering experience, this production line ensures enhanced productivity and safety. Austar’s system leverages extensive automation, significantly reducing manual intervention and workflow inefficiencies. The engineering team adheres to rigid project management protocols, providing comprehensive and traceable verification documents for regulatory compliance. This system is designed to help pharmaceutical companies speed up time to market, enhance operational benefits, and maintain consistent product quality.

Sterile Api production line for powder treatment

Conveyor systems are used for moving materials from one location to another. Considerations for choosing a suitable industrial conveying system include the nature of the product, its physical state, the desired conveying rate, and sensitivity of the product to heat and mechanical shock. Conveying equipment is used in the food, pharmaceutical, chemical, biomass, and mineral industries to move materials around a warehouse as well as to transport bulk powders, granules, and grains for processing and filling. These types of systems are usually automated and there is a wide variety of solutions to choose when it comes to the type of conveyor. Types include screw, gravity, chain, roller and belt conveyors.

Conveying

<span style="font-weight: 400">At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with </span><span style="font-weight: 400">chemicals or hazardous substances since they can be potentially dangerous to human health. </span>

Packing

Accurate formulation of buffers is essential in various biopharmaceutical processes. Traditional methods often require large volumes of pre-mixed solutions and significant storage space, leading to inefficiencies and increased costs.
<h2>Ensure precise buffer formulation in real-time</h2>
The In-line Conditioning System from Austar is designed to streamline buffer preparation by diluting single-component, highly concentrated stock solutions of salt, acid, and base with water. Utilizing dynamic feedback control, it ensures precise formulation by continuously monitoring flow rate, pH, and conductivity through sensors. Austar's proprietary technology calculates buffer composition accurately, providing stable concentrations and pH levels. The system saves time, investment cost, resources, and space by using small amounts of stock solutions to prepare various buffers on demand, making it ideal for incorporating into biopharmaceutical production environments.

In-line conditioning system for buffer preparation

Developing new products or optimizing formulations often requires precise and controlled mixing processes to ensure consistency and quality. Challenges such as achieving the right mixing intensity and maintaining homogeneous mixtures are common, especially when scaling from laboratory to pilot production levels.
<h2>Ensures precise control and scalable results</h2>
The Pilot Scale Mixers by Admix are designed specifically for product development, formula optimization, and small production runs. These mixers offer high levels of control over rotational speed, mixing intensity, and shear rates via an optional variable frequency drive (VFD). The system comes with a mobile lift stand equipped with a large, easy-to-turn hand crank for height adjustment. Available in two versions—the RS-02 with a Rotosolver high shear impeller, and the XP-02 with a Rotostat high shear impeller—these mixers cater to various applications. The sturdy design includes a wide base for added stability and mobility, allowing easy movement through standard doorways. Each model ensures optimal shear and flow patterns, suitable for diverse industries including food and beverage, pharmaceuticals, and chemicals. Admix guarantees seamless scale-up from pilot to production levels through their Process Guarantee, offering consistent and reliable mixing performance.

Pilot scale mixers for product development and small production runs

In pharmaceutical and nutraceutical industries, producing tablets in small and medium batches can present challenges, such as the need for precise control across various stages of tablet production. Ensuring tablet uniformity, consistent dissolution profiles, and minimal production downtime are critical considerations.
<h2>Facilitate efficient tablet compression</h2>
The PROTAB™ 300 by ACG World is a single rotary tablet press designed to bridge the gap between R&D and production-scale operations. This model is ideal for both small and medium-batch production, featuring an intuitive user interface and an interactive dashboard to streamline the tablet-compression process. The system includes an R&D turret capable of testing different formulations and tooling, which is easily scalable to larger production runs. Interchangeable turrets offer flexibility, allowing you to compress a variety of tablet sizes at different speeds. The lightweight, toolless design of the assemblies ensures mechanical changeovers can be completed in under 30 minutes, maximizing production uptime. Additionally, the PROTAB™ 300 is equipped with InstAmend technology for faulty punch detection and rectification, reducing long process interruptions and increasing efficiency. The sophisticated feeder design minimizes leftover powder, reducing valuable formulation loss to less than 50 grams.

Single rotary tablet press for small and medium-batch production

Compression

When developing and scaling pharmaceutical formulations, finding an efficient and safe method for granulation and drying is crucial. Top-spray granulation and wet-mass drying processes require equipment that ensures consistent results while maintaining operational safety standards.
<h2>Enhance granulation and drying safety</h2>
The FBE 1800 X•ONE from ACG World is designed to provide advanced fluid bed granulation and drying for batches up to 1,800 liters. Manufactured in their Design Centre in Mülheim, Germany, it offers exceptional performance and operational safety. It features a 12-bar pressure-shock-resistant system, equipped with the MOST™ concept, approved by FSA from Germany, ensuring no mechanical deformation occurs during pressure shocks. The system supports applications such as top-spray granulation, wet-mass drying, and hot-melt granulation. With ATEX (Directive 2014/34/EU) compliance, the FBE 1800 X•ONE integrates unique C-flanges to prevent the external release of explosion pressure, X•ONE inflatable seals for low-pressure safety, and QASV (Quick Action Stop Valves) that contain explosions within 20 milliseconds. Additionally, the exclusive X•ONE command process control system facilitates secure and intuitive monitoring, adhering to GAMP 5 and 21 CFR Part 11 standards. The fluid bed granulator is customizable with charging, discharging, and WIP (wash-in-place) systems, available in standalone or granulation-train configurations suitable for the pharmaceutical industry.

Fluid bed granulator for pharmaceutical applications

<span style="font-weight: 400;">Softgel (or soft gelatin) capsules are a very popular method for providing oral doses, pharmaceuticals and supplements thanks to their ease of swallowing, lack of taste and tamper-proof nature. When designing new products, new formulations, or experimenting with softgels as a novel form of dosing for existing products, a lab-scale encapsulating solution allows you to test efficiently with the knowledge that results can be scaled up to full production. For small runs of high-value or low-volume product, a small-scale machine can increase efficiency compared to using equipment designed for larger volumes, as well as saving time on changeover.</span>
<h2>Small-scale, high quality softgel encapsulators for lab or small-batch use</h2>
<span style="font-weight: 400;">The SGL107 and SGL207 softgel encapsulators from Technophar offer industry-leading quality for the lab or small batch production environment. The SGL107 can operate at up to 4,500 capsules per hour, and the SGL207 at up to 9,000 capsules per hour. </span><span style="font-weight: 400;">Both models feature the same high-quality components and robust build-quality. Rather than relying on mechanical gearing, both machines feature servo motors and electronic gearing to increase reliability and reduce downtime. Programmable Logic Controllers (PLC) with touchscreen user interface gives quick access to and control over all the production parameters.</span>

<span style="font-weight: 400;">For maximum durability, the SGL107 and SGL207 are built around a solid aluminium frame design, with stainless steel outer covers. These can be specified to meet GMP/FDA requirements where required for pharmaceutical use. This means that the machines are easy to clean and maintain and will not corrode.</span>

<span style="font-weight: 400;">Fitted on castors for easy movement if required, the SGL107 and 207 are fully self-contained, with control and electrical panels within the machine, ideal for non-permanent or semi-permanent applications, as well as permanent small-batch production. </span><span style="font-weight: 400;">Each machine can produce oval or oblong capsules, with the SGL107 having a single dosing plunger, and the SGL207 having two dosing plungers, allowing you to choose the best option to fit your requirements.</span>

Laboratory scale soft gelatin capsule machine

In the pharmaceutical world, encapsulation refers to various techniques to enclose and protect the drug ingredients by forming the capsule shell. Encapsulation equipment changes depending on whether the manufacturer needs to produce a soft or hard gel capsule. For instance, encapsulation systems and machines for softgels control the entire process from start to finish because their shells are filled at the same time they are produced. On the other hand, the filling of hard gel capsules comes by separating the body from the cap, and after the filling operations, the two parts are sealed together again, forming the shell.

Encapsulation

<span style="font-weight: 400;">Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compounds to achieve the required moisture content, as well as applying coatings or binders before further processing prior to tablet formulation. For R&amp;D work a fluid bed dryer with economical batch sizes is required, but it must also be able to scale up successfully for satisfactory full-scale production.</span>
<h2>Flexible lab-scale fluid bed dryer/granulator with advanced features</h2>
<span style="font-weight: 400;">The Sejong Pharmatech D5L is a compact small-scale fluid bed dryer/granulator with features specifically designed for lab work and small batch processing in volumes from 1 to 5 litres.</span>

<span style="font-weight: 400;">The D5L features both top and bottom spray arms for maximum flexibility, with fully adjustable height control for both. This allows the machine to be used for drying, granulating and coating.  The product container is ergonomic to use and makes adding and discharging compounds quick and simple, and the capacity is fully controllable based on the required production volume. The container also features a built-in sampler, to allow physical inspection of the progress of the cycle as it runs - perfect for R&amp;D situations.</span>

<span style="font-weight: 400;">The D5L features a full colour touchscreen with easy-to-read schematics for control and diagnostics, allowing the operator to monitor all parts of the cycle. All control software is fully 21CFR part 11 compliant.</span>

<span style="font-weight: 400;">The exhaust features a dust collection system with easy-to-change cartridge filter system, and the unit features a powerful 4.8kW electric coil heat exchanger for precise temperature control.</span>

Fluid bed dryer for lab scale

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

A recent important change in the industry is the trend toward providing liquid doses contained in hard capsules.  The right equipment is need to develop processes to fill hard capsules with the wide variety of liquids used by today's pharmaceutical producers.  Laboratory equipment that is capable of handling waxes and lipids, automatically sealing the capsules, and maintaining a tightly controlled process suitable for scaling to production levels will give pharmaceutical innovators an edge of the competition.


<h2>Fill and seal hard capsules with any pharmaceutical liquid</h2>
Fluidocap 1000 is a semi-automatic machine for filling hard pharmaceutical capsules with liquid an sealing them.  It is provided by ACGE-Associated Capsules a world leader in pharmaceutical machinery manufacturing.  Traditionally liquid doses have been provided in soft gel-cap form and have presented drug makers with the common problems of high cost, wastage, cross contamination, migration of the drug into the capsule, and low bioavailability.

The Fluidocap range of machines address these issues by allowing the filling and sealing of hard capsules with liquid compounds rather that relying on soft gelcaps.  The hard capsules can be filled with a wide range of formulations including lipid-based products, high viscosity pastes, and wax type products.  They are sealed with a gelatin band.  The Fluidocap 1000 capsule filler for liquid is designed for laboratory use and can produce up to 1000 capsules per hour but can easily be scaled up to commercial level production.

Laboratory capsule filler for liquid solutions

Use of liquid filled hard capsules is increasingly popular with today's pharmaceutical manufacturers.  Bioavailability and patient compliance are enhanced with drugs delivered in this form.  Production of these liquid filled capsules requires equipment that can handle a wide variety of liquids including lipids and waxes, and automatically produce consistent sealed capsules as well as efficiency and high machine up-time to ensure profitability.


<h2>Automatically fill and seal hard capsules with any pharmaceutical liquid</h2>
Fluidocap F40 is a fully automatic machine for filling hard pharmaceutical capsules with liquid an sealing them.  It is provided by ACGE-Associated Capsules a world leader in pharmaceutical machinery manufacturing. Traditionally liquid doses have been provided in soft gel-cap form and have presented drug makers with the common problems of high cost, wastage, cross contamination, migration of the drug into the capsule, and low bioavailability.

The Fluidocap range of machines address these issues by allowing the filling and sealing of hard capsules with liquid compounds rather that relying on soft gelcaps.  The hard capsules can be filled with a wide range of formulations including lipid-based products, high viscosity pastes, and wax type products. They are sealed with a gelatin band. The capsule filler for liquid is designed for high volume production use and can produce up to 40,000 capsules per hour. Combinations filling including pellets in liquid is also possible using special attachments.

Automatic capsule filler for liquid solutions

Innovators in the highly regulated and highly dynamic pharmaceutical market place need equipment that is worry-free and flexible enough to vary products and process variables as new products are developed.  Laboratory capsule filling machine must be easy to maintain, allow for rapid tooling change-over, and provide tightly controlled process variables and automatic operation in order to ensure results that are reproducible at the production scale.


<h2>A complete encapsulation solution for the laboratory</h2>
The AFT-T Lab system from ACGE is a laboratory capsule filler from the AF series of capsule fillers that is currently running in over 1000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The AFT-T Lab machine has all the benefits associated with the larger equipment in the series but on a scale appropriate for laboratories.  The machine can output up to 6,000 capsules per hour for powder filling and 5,000 capsules per hour for pellet filling.  It uses a 1.1 kW primary motor.  It weighs about 1,200 Kg and occupies only 2.25 square meters of floor space making it the perfect scale for any pharmaceutical laboratory.

Automatic laboratory capsule filler

For pharmaceutical formulations that are highly active specialized capsule filling equipment is often required for operator safety and protection of product quality.  Full containment in a capsule filling process requires, minimal creation of dust, minimized product left-over in the machine, and operation with minimal operator interaction.  This specialized equipment offers these enhanced features including glove box operator access as well as all other capabilities expected from a top-of-the line pharmaceutical capsule filler.


<h2>Contained, safe encapsulation for highly active formulations.</h2>
The Securefill 12T from ACGE is a fully automatic  high containment encapsulation solution for highly active substances. The contained capsule filler is specifically designed to prevent any surface or airborne contamination escaping the machine which can be a risk to operator safety when working with highly active pharmaceutical formulations.  Contact between the operator and the formulation is eliminated greatly reducing the complexity and unreliability of other protective methods commonly used.

Part of the AF series of encapsulation machines which are currently running over 1,000 pharmaceutical production facilities world wide, the Securefill 12T has all the proven design benefits and flexibility of the other machines, with added containment and operator protection features.  Capacity of the contained capsule filler is up to 12,000 capsules per hour.

Contained capsule filler

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Capsule filling should be a worry-step in pharmaceutical and nutraceutical manufacturing.  The right equipment is capable of fully automatic operation, includes accurate dose control, is easily changed over between products, and includes supporting accessories for smooth integration with other processes.  A high quality capsule filler will give plant managers peace of mind and allow them to focus on improving other aspects of their operation.


<h2>A complete, automatic encapsulation solution</h2>
The AF series from ACG-Pam is a production scale capsule filler line that is currently running in over 1000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The automatic capsule fillers can output from 6,000 to 200,000 capsules per hour and can handle powder, microtablet, and pellet, and capsule-in-capsule filling.  They include ACG-Pam's patented ZRO technology which reduces dusting and product loss during operation as well as other features designed for revenue optimization and machine efficiency.  The AF series machines in production have handled over 3,000 different formulations and ACG-Pam's support personnel have developed the expertise and knowledge based needed to tailor an encapsulation solution for even the most difficult formulations.

Automatic capsule filler

Pharmaceutical manufacturers require maximum yield from their encapsulation process for efficient production and competitive results.  Leaving expensive pharmaceutical formulations in the encapsulation machine as left-over or dust is wasteful and inefficient.  Equipment with all the features required for accurate high quality encapsulation as well as enhancements for minimized dust creation and product loss will give users a distinct advantage over the competition.


<h2>A complete encapsulation solution for maximum yield</h2>
The ZRO 90T system from ACGE is a production scale capsule filler from the AF series of capsule fillers that is currently running in over 1,000 production facilities throughout the world.  The AF series of machines is built for regulatory compliance, revenue optimization, and flexibility giving pharmaceutical manufacturers the features they demand such as formulation and dosing control, minimal product loss, a wide range of peripheral equipment, and globally available support.

The ZRO 90T machine has all the benefits associated with the series as well as additional features to minimize formulation loss during processing and maximizing yield.  The capsule filler includes ACGE's patented ZRO technology which minimizes dusting and separation by containing the formulation within the dosing disk.  This technology reduces formulation waste and maximizes powder use efficiency for maximum yield.

High-yield capsule filler

Staying competitive in today's highly dynamic and highly regulated pharmaceutical production market requires encapsulation equipment with the utmost process control and batch documentation.  Quick changeover, and accurate dose control are required as well as enhanced features like environmental sensors, online weight adjustment and automated documentation and reporting.  Successful modern producers use these next-generation features to maintain an edge of competitors with more traditional equipment.


<h2>A complete automatic encapsulation solution with state-of-the-art accuracy controls and reporting functionality.</h2>
The Legend 2500 from ACG-PAM is a fully automatic capsule filler with next generation design which greatly enhances production speed and efficiency.  ACG-Pam has over three decades of experience in the pharmaceutical manufacturing industry and the success of the company's AF series of encapsulating machines which are installed in over 1,000 facilities across the globe provides a knowledge base and industry expertise that is second to none.  The Legend 2500 encapsulation represents the application of this knowledge and experience specifically to improve upon existing encapsulation systems and better meet the needs of today's pharmaceutical producers.

The system includes Industrial PC based controls, online weight adjustment, and a screw type auger for use with the widest variety of formulations.  The need for an extra doing disc when filling doses are 50% of slug length is eliminated by use of a slug length adjustment kit.  Anti-jamming features for trouble free capsule loading and automatic lubrication are also included.  The system makes use of integrated environmental sensors, a stand-alone security enabled IPC control pedestal, and full 21 CFR Part 11 compliant reporting to ensure an encapsulation process that is accurate, controlled, and well documented.

Easy to validate capsule filler

A multipurpose unit in the research and development field. Some of the most common applications are galenic formulation, freeze drying experimentation, taxidermy, underwater archaeology, aliquot preservation,  diagnosis and other research.


<h2>Start your research with this multipurpose high-performance device</h2>
The LyoQuest laboratory, multipurpose and R&amp;D freeze dryer from Telstar Life-Sciences has been designed as a multipurpose unit for the research and development field. It is a small freeze dryer, more compact than most but in spite of its small size, its capacity is quite unbeatable. A state-of-the-art control system and a range of specially designed accessories make the LyoQuest a benchmark in its category.

The unit's design offers the best performance in the least possible space. Suitable for laboratories: compact and easy to install, solidly designed laboratory equipment. On a functional level, cooling management ensures optimum performance.

Multipurpose and R&D freeze dryer

Designed for biological, pharmaceutical and food products formulation and "scale up" work.


<h2>Best performance for technology transfer activities and work in advanced R&amp;D Centers</h2>
The LyoBeta from Telstar Life-Sciences is a freeze drying unit for biological, pharmaceutical and food products formulation and "scale up" work, facilitating transfer technology to the R&amp;D centers and production. It is a high performance unit with a GLP design that allows for performing the entire freeze drying process fully automatically as well as accurately monitoring it. Very easy to clean, stainless steel chamber, condenser and plates; includes industrial components, such as sensors, vacuum pump, exchangers, etc.

Some of the most common applications are production in pilot plants, functional food research, preservation of diagnosis kits, small batches for clinical trials and so on.

Pilot freeze dryer for scale up

Particularly suitable for research centers requiring greater freeze drying capacity. Some of the most common applications are galenic formulation, freeze drying experimentation, aliquot preservation, taxidermy, experimental food and so on.


<h2>The laboratory freeze dryer that is easy-to-use</h2>
The LyoAlfa from Telstar Life-Sciences is a compact laboratory freeze dryer. It comes as a console and is mounted on casters which make it easy to install. The unit is very flexible, allowing for the simultaneous freeze drying of bottles, vials or bulk products through the connection of different manifold systems or a chamber.

It is available in two models LyoAlfa 6 -50, with a final condenser temperature of -50 ºC; and LyoAlfa 6 -80, with a final condenser temperature of -80 ºC. This enables a higher freeze drying speed and is much more suitable for working with biological samples or products with very low eutectic or collapse points.

Compact laboratory freeze dryer

In industries dealing with heat-sensitive products, ensuring proper drying without degradation is a significant challenge. Typical issues include handling toxic or explosive materials and ensuring no product segregation or degradation during the drying process.
<h2>Efficiently dries heat-sensitive powders and granules</h2>
The Nauta conical screw dryer by Hosokawa Micron is a vacuum dryer designed for drying materials such as powders, granules, pastes, and viscous slurries. It operates with a rotating cantilevered mixing screw that conveys the product from the bottom of the vessel to the surface, enhancing convective mixing and shear. The heated jacket, which can use steam, hot oil, or water, ensures rapid heat distribution, making the drying process efficient. Ideal for heat-sensitive materials, this dryer removes vapors at low temperatures, preventing product degradation. It includes a condenser with a solvent recovery tank and a dust filter to keep the vacuum system free from contaminants. Batch volumes range from 5 to 22,000 liters, and the system is compliant with international standards such as FDA and cGMP.

Vacuum dryer for powders and granules

In pharmaceutical research and development, creating precise and consistent coating for tablets is crucial. Challenges include achieving uniform coating, managing batch sizes from small to large, and ensuring quick changeovers and cleaning between batches.
<h2>Supports flexible batch sizes and coating types</h2>
The LDCS-Plus Laboratory Development Coating System is designed by Freund-Vector® for small to medium-scale tablet coating operations. This portable, self-contained unit includes eight fully perforated and interchangeable coating pans, ranging from 1.5L to 20L in volume. The standard features include an anti-marking coating pan for smooth finishes, a recipe-driven control system for precise process control, and an anti-bearding spray gun to prevent nozzle clogging. The system supports film, sugar, and solvent coating processes and offers options such as Smart-Safe™ containment and EcoClean™ technology. With an integral drain for rapid cleaning and a quick-change mounting system, the LDCS-Plus ensures efficient and flexible tablet coating operations. Freund makes this system ideal for development and clinical batch production.