Let's make enteric coated tablets
When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.
What enteric coated tablets equipment do you need?
Serialization and aggregation inspection system
Including serialization and aggregation inspection systems to packaging li...
Vision inspection system for tablets and capsules
Pharmaceuticals and healthcare product manufacturers dealing with oral ...
High speed bottle filler with inspection
Medicines in tablet, capsule, or soft gel forms undergo various processes before r...
Granulation line for pharmaceutical solid dosage forms
Granulation is a common technique in production of pharmaceutical ...
Industrial scale tablet coater
During the coating process, tablets pass many stages that can make them wet and sticky or cra...
Fluid bed dryer for pharmaceutical solid dosage form
Fluid bed drying is a pharmaceutical process carried out to reduce t...
Industrial high shear mixer granulator for drug formation
It is rather difficult to successfully produce a pharmaceutica...
Tablet coater for laboratory scale
Tablet coating can be applied for adding colours or glosses, or based around sugar in or...
Tablet counting machine
Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and c...
Pharmaceutical bottle unscrambler
Pharmaceutical packaging industry requires the ability to quickly manage the process yet ...
Dessicant inserting machine
Desiccant canisters play an important role in the pharmaceutical and nutraceutical industries. T...
Dust-tight metal detector for tablets
For FDA-compliant production of tablets, the elimination of airborne dust containing ...
Wash-in-Place metal detector for tablets
Where hygiene and decontamination are vital, traditional pharmaceutical metal dete...
High-speed strip packaging machine
Pack your solid pharmaceutical products in four-side sealed foil packs at very high spee...
Side-load case packer
As the final stage in the packaging process, an automated case-packing solution can ensure that your co...
Entry-level blister packaging machine
Blister packaging is a popular packing method in the pharmaceutical industry thanks t...
Industrial blister packaging machine
High-volume, fully-automated blister packaging is the perfect choice for large scale p...
Plate sealing blister machine
Blister packaging is the preferred choice for most large-scale pharmaceutical lines, and a pla...
Automatic blister packaging machine
Automated blister packaging is a popular choice for pharmaceutical production thanks to...
Horizontal cartoner for pharmaceutical applications
Automatic cartoning for cosmetic or pharmaceutical products is a requ...
Automatic filling line for solid doses
For medium-scale production of solid doses such as tablets, capsules, and softgels t...
Benchtop tablet press
For lab work or small-scale production, a purpose-designed tablet press that meets your exact requireme...
Electronic capsule counter
For lab work or small batch production, hand counting of solid doses into dispensing containers i...
Semi-automatic case packer
Pharmaceutical products require complete traceability throughout the production cycle. For smalle...
Serialization coding and labeling equipment
In the pharmaceutical industry, product serialization is the cornerstone of al...
Feeder with flexible wall hopper
The varying properties of dry powder products mean that specialized feeders are required fo...
Small feeder with flexible wall hopper
In many laboratory applications and production processes, smaller quantities of powd...
Conical mill for drug formulation
The efficient size reduction of granular powders is a key step in many pharmaceutical pro...
Automatic tablet coater for lab scale
The ability to coat tablets in an even and controlled way is an important stage in th...
Tablet auto coater for lab scale
Many pharmaceutical doses in tablet form require a coating before they are ready for use. T...
Single and double layer tablet press
High performance tablet presses that are capable of producing both single and double-l...
Lab scale single layer tablet press
Automated pressing of tablets saves time and improves quality. In R&D or laboratory...
Granulation line of mixer and fluid bed dryer
A complete granulation line allows for the mixing and granulation of pharmac...
Microencapsulation system for your drug delivery system
Whether you want to improve the stability of nutrients, protect a...
Rotary tablet press
For pharmaceutical tablet producers looking to reduce waste, costs and increase production volume, a hig...
Fluid bed dryer for production scale
Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for dryi...
Fluid bed dryer for lab scale
Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compo...
Fluid bed dryer and mixer for lab scale
Designed for pharmaceutical R&D, a lab-scale fluid bed dryer and mixer/granulat...
High-shear mixer
For the efficient mixing of larger batches of pharmaceutical compounds and high-shear mixer provides the opti...
Entry-level high-shear mixer for drug formulation
For pilot and lab-scale pharmaceutical formulations, a high-shear granu...
High capacity weight sorter for tablets & capsules
By employing a weight sorter that is fully flexible and able to ha...
Premium vacuum conveyor
When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...
Sorption dehumidifier with air-chilled condenser
It is not always possible to duct out the wet air from a dehumidifier ser...
Small portable dehumidifier
Water damaged areas require dehumidification to limit the damage and prepare the area for restor...
Sorption dehumidifier for large temperature differences
Small, humid areas can be difficult to dehumidify in humid ambien...
Sorption dehumidifier for deep drying
Humid ambient conditions such as those in tropical climates make dehumidification mor...
Dehumidifier for difficult wet airflows
Sealed rooms can be challenging to dehumidify with ordinary dehumidifiers. The wet ...
Sorption dehumidifier for overpressured rooms
Small humid spaces, used for processing or storage, often need a simple dehu...
Heat recycling sorption dehumidifier
Facilities that handle large amounts of water can become very humid. High humidity may...
Industrial desiccant dehumidifier
Dehumidification of medium sized manufacturing and processing facilities can be a dauntin...
Large scale desiccant dehumidifier
Moisture sensitive processing and storage facilities need low humidity environments to s...
Customizable dehumidifier
Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fi...
Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent par...
Ultra-fine dispersing machine for emulsions and suspensions
Producing the finest micro-emulsions and suspensions require...
High-speed blister machine
If you are looking for a compact machine that produces blisters with an output of up to 700 blist...
Horizontal intermittent motion cartoner
User-friendly cartooning solution with an intermittent motion for a wide range of p...
Horizontal continuous motion cartoner
An automatic cartoning machine designed for both high-speed operations and medium pac...
Pick and place transfer for strips into cartoner
Transfer your strip packs products directly to the cartoner.
Versatile strip packaging machine
Pack diverse products such as diagnostics, pharmaceutical liquids or flat, stable product...
Entry-level blister machine
A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...
Compact blister machine
A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...
Case packer for cartons and bundles
Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...
Stretch bander
A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.
Vertical cartoner
A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...
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Why is an enteric-coated tablet needed?
So if it can’t be the stomach’s job to dissolve the tablets, whose job will that be? Enteric comes from the Greek word énteron, meaning intestine. As we mentioned earlier, some drugs like Rabeprazole or Pantoprazole are destroyed by the acidic pH of the stomach acids.
The funny thing is that these drugs are meant to reduce the acids in the stomach, but they are destroyed by the acids themselves without having a chance to provide their effectiveness. So they need to bypass the stomach and be released in the small intestine.
The enteric coating ensures that the tablet remains unaltered and stable in the stomach’s acidic pH (pH ~3) but breaks down and dissolves at higher pH (alkaline, pH 7–9) of the intestine. On the other hand, some drugs like aspirin and NSAIDs (Nonsteroidal anti-inflammatory drugs) can also cause side effects such as gastric irritation or nausea. The enteric coating protects the gastric mucosa from the drug itself. Another reason for enterically coated tablets is to provide a delayed release of the medication.
Polymers used for enteric coating
The enteric coating is nothing more than applying a polymer film on a tablet. Obviously, the polymers used for this coating must be resistant to gastric fluids. Polymers for enteric coating remain unionized at low pH, but when they reach the small intestine, they become soluble and swell, and begin to dissolve at a pH of 5.0-5.5. In addition to this, they should be compatible with the drug substrate and the coating solution and should be non-toxic in nature.
Examples of enteric film-coating polymers are cellulose acetate phthalate (CAP), which is the oldest and the most used for enteric coating, Cellulose acetate trimellitate (CAT), Hydroxypropyl methylcellulose phthalate (HPMCP) and Shellac.
Applying a polymer film using tablet coating equipment
When preparing an enteric coating formulation, you need to pay attention to the mixing part. The mixture should be uniform and fine enough to pass through the coating system. The most common tablet coating equipment used for enteric coating is a pan coating system. This involves spraying the film-forming material onto the tablet surface as the tablets rotate in the pan.
Hot air is applied which helps the organic solvent evaporate and form the coat over the tablets. You need to repeat the process according to the desired thickness of the tablet’s film.
Processing steps involved in enteric coated tablets making
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