In vitro dissolution and flux measurement platform
Optimize drug formulation by accurately assessing dissolution, solubility, and permeability in real-time to predict pharmacokinetic outcomes and enhance absorption potential.
Measures Drug Dissolution and Permeability
The miniFLUX from Pion is an in vitro analytical platform designed for pharmaceutical and biotech companies aiming to advance drug development through precise dissolution and permeability analysis. Equipped with Pion’s validated PAMPA permeability membrane, it enables accurate prediction of drug absorption potential using real-time concentration monitoring with the Rainbow R6. The system seamlessly integrates with Pion’s miniDT 250mL dissolution platform, offering the flexibility to conduct flux measurements in biorelevant volumes ranging from 130 to 250mL. This makes it ideal for evaluating immediate-release, extended-release, and enteric-coated tablets, as well as liquid and chewable formulations. Ensuring compliance with FDA requirements, the miniFLUX supports Pion’s standardized media protocols, including FaSSIF and FeSSIF, for consistent and realistic IVIVC modeling. Compact and bench-top friendly, it’s optimized for in vitro testing environments in R&D and laboratory settings, offering pharmaceutical manufacturers and research laboratories a comprehensive solution for accurate absorption assessment.
Benefits
- Enhances drug formulation predictability with real-time absorption data.
- Optimizes development timelines through simultaneous dissolution and permeability testing.
- Ensures compliance with FDA solubility standards using biorelevant testing volumes.
- Reduces experimental variability with integrated PAMPA membranes.
- Supports versatile formulation evaluation, from tablets to liquid solutions.
- Applications
- Liquid formulations,Oral formulation delivery,Pharmaceutical tablets
- End products
- Syrup formulations,Chewable tablets,Soft gel capsules,Enteric-coated tablets,Extended-release tablets,Immediate-release tablets,Oral solutions
- Steps before
- Formulation,Preparation,Blending,Mixing
- Steps after
- Pharmacokinetic Analysis,Packaging,Labeling,Distribution
- Input ingredients
- whole dose formulations,dissolution media,biorelevant volumes,PAMPA permeability membrane,FaSSIF,FeSSIF
- Output ingredients
- dissolution data,flux measurements,absorption potential assessment,pharmacokinetic outcomes
- Market info
- Volume
- 130 to 250 mL
- Membrane Type
- PAMPA permeability
- Volume Compatibility
- Biorelevant volumes
- Monitoring System
- In situ fiber optic
- Dissolution System
- miniDT 250mL
- Compliance
- FDA requirements for BCS solubility tests
- Data Output
- Real-time concentration monitoring
- Usage
- In vitro dissolution and flux measurements
- Working mechanism
- In vitro Flux technology
- Integrated steps
- Dissolution and permeability testing
- Batch vs. continuous operation
- Batch
- Automation level
- Integrated with in situ fiber optic monitoring
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Dissolution Volume
- 130–250 mL
- Compact footprint
- Yes
- Discharge method
- N/A
- Platform size
- 250 mL
- Simultaneous measurement capability
- Yes
- Integration with Pion Systems
- miniDT 250mL platform integration
- Data Monitoring System
- Rainbow R6 real-time concentration monitoring
- Membrane Type
- Pion validated PAMPA permeability membrane
- Donor Volume Range
- 130 to 250mL
- Dissolution Media Compatibility
- FaSSIF / FeSSIF protocols