In vitro dissolution and flux measurement platform
For professionals in drug development, it is crucial to evaluate the absorption potential of drug formulations accurately. This often requires simultaneous assessment of dissolution, solubility, and permeability in biorelevant volumes to predict pharmacokinetic outcomes effectively.
Simultaneous dissolution and flux measurements
The miniFLUX by Pion is an advanced in vitro analytical platform designed for dissolution and flux measurements of whole dose formulations. This equipment integrates Pion’s in situ fiber optic monitoring systems with their miniDT 250mL dissolution system, providing unparalleled data accuracy. Using biorelevant volumes ranging from 130 to 250mL, miniFLUX mimics gastrointestinal conditions to improve IVIVC modeling. It features a biomimetic separation barrier with a Pion-validated PAMPA permeability membrane. Capable of using both FaSSIF and FeSSIF media, the miniFLUX system allows for better comparison with BioFlux and supports robust standard media change protocols.
Benefits
- Comprehensive data on dissolution, solubility, and permeability
- Biorelevant testing volumes in line with FDA BCS requirements
- Accurate absorption potential assessment
- Enhanced IVIVC modeling with simultaneous concentration measurement
- Suitable for standard media change protocols