Let's make active pharmaceutical ingredients (API)
API making equipment must observe rigorous quality standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients make them highly sensitive to their environment, making API production a tightly regulated field.
What active pharmaceutical ingredients (api) equipment do you need?
Particle analysation monitor
Products like granules, tablets and capsules require inspection at numerous steps in the produc...
Hygienic floor scale
The food and pharmaceutical industries require maintaining high levels of sanitations as well as logisti...
Hygienic floor scale with lifting device
The food and pharmaceutical industries require maintaining high levels of sanitati...
Hygienic mobile scale
Having a reliable and accurate weighing and measuring solution is absolutely essential, especially in t...
Fast gravimetric powder microdosing 50 - 200 g
Micro-dosing powders of high-value food or chemical products can be challen...
Gravimetric powder microdosing 2 - 100 g
Powders and granules are commonly dosed for the manufacturing of pharmaceuticals, ...
Gravimetric powder microdosing 0.400 - 2 g
If you need to process high value food, pharmaceuticals or chemicals, there is ...
Single-use powder handling bag
Containers for handling pharmaceutical and biopharmaceutical powders may be disposable, to av...
API powders storage bottle
Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions ...
Single-use containment valve
Safe transfer of liquids and hazardous powders into systems can be a challenge in pharma, bioph...
High containment closing system
Pharma and biopharma laboratories need fast effective solutions for tightly sealing bags for...
High containment sampler
Drawing a sample for evaluation from a running process is not a simple task, especially when dealing...
Metal detector for pharmaceutical powders
wdered and granulated pharmaceuticals require careful screening against metal co...
Semi-automatic powder dosing machine
Powders or granules are common dose types used in many pharmaceutical and nutraceutica...
Industrial fruit dehydration machine
Dried fruits are popular both as food in themselves and as ingredients. Traditional dr...
Vertical paddle dryer
Enable vacuum, atmospheric and pressurized processing of a variety of materials such as powders, filter...
Laboratory conical screw vacuum dryer
The laboratory conical screw vacuum dryer is particularly suitable for the final dryi...
Laboratory scale active freeze dryer
The laboratory-scale active freeze-drying is used for dehydrating high-value products ...
Active freeze dryer
Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying ...
High-shear impact mixer
When you need to mix cohesive powders with liquids or melt binders and require a homogenous end-produ...
In-line continuous blender
When you consider shifting pharmaceutical mixing processes from batch to continuous, accurate in-...
Conical screw vacuum dryer
The conical screw vacuum dryer is particularly suitable for the final drying of powders, granules...
Conical screw mixer
When you want to mix segregative, free-flowing powders and pastes that require perfect mixing quality and...
Laboratory capsule filler for liquid solutions
A recent important change in the industry is the trend toward providing liq...
Entry level HFFS Machine for flat sachets
Traditional horizontal form fill and seal sachet machines for lower volume lines...
Flexible containment docking solution
When sampling or transferring hazardous substances and sensitive bulk goods, a dust-t...
Flexible containment zip
Transfer of sensitive and toxic bulk goods across process units requires specialist handling to prev...
Drum conditioner
Many pharmaceutical production processes involve the use of products that have naturally hardened within thei...
Pharmaceutical container lifter
Moving larger or heavier containers from height is out of the scope for standard handling eq...
Drum tipper
Many pharmaceutical processes require drums of powders or liquids to be fed from one part of the process to the ne...
Vacuum sack lifter
In the production of pharmaceuticals and other high-hygiene environments, manual handling of inputs or int...
Bin blender
Many pharmaceutical processes require the blending of powders or other granular ingredients, the mixing of settled...
Container lifter
Container handling in the pharmaceutical industry brings its own set of unique challenges. Traditional barrel...
Mobile drum lifter
The production of pharmaceuticals and other hygienic products often requires the handling of large and bul...
Powder transfer vessel
Intermediate bulk storage of pharmaceutical product requires specialist containers. For increased effi...
GMP Jib crane
Vacuum manual handling systems are the ideal way of quickly and safely moving small to medium sized loads in all...
Industrial capsule checkweigher
Pharmaceutical manufacturing demands the highest quality standards and completely consistent...
Cleaning and sterilization systems
An increasingly vital part of high quality pharmaceutical production is a dedicated Clea...
GMP washer
In order to guarantee zero cross-contamination between production batches, the proper cleaning of all product-conta...
Portable IBC washer
The thorough cleaning of bulk containers and other storage and processing equipment is a vital step in th...
IBC bin washer and dryer
Many pharmaceutical processes use IBCs of multiple sizes throughout production. Careful washing and ...
CIP system for bulk tanks
Clean in Place (CIP) technology offers many advantages, but traditional systems are often inflexib...
Contained capsule filler
For pharmaceutical formulations that are highly active specialized capsule filling equipment is ofte...
Tumbler sieve for classifying and dedusting granular materials
For the classification of delicate granular material, scr...
Feeder with flexible wall hopper
The varying properties of dry powder products mean that specialized feeders are required fo...
Small feeder with flexible wall hopper
In many laboratory applications and production processes, smaller quantities of powd...
Checkweigher for sachets and sticks
The checkweighers for multiple lanes have a 1.5 times faster response speed and 2 times...
Microencapsulation system for your drug delivery system
Whether you want to improve the stability of nutrients, protect a...
Centrifugal disc filter
The pharmaceutical and bioprocess industries need filtration processes of particularly high quality t...
Spherical dryer
Drying vessels that are simple, reliable, and easy to maintain increases product quality and process efficienc...
Filter dryer
The pharmaceutical and bioprocess industries need filtration processes of particularly high quality to ensure the...
Laboratory mill for small batches
The Alpine Picoline is a series of miniature laboratory machines for processing samples d...
Transfer system for high-containment environments
A high-performance transfer port system that combines ultimate safety, ...
Half-suit tester
Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...
Glove tester
Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...
Rotary vacuum dryer
Powdered products tend to agglomerate during vacuum drying. This adds an additional step to the productio...
Premium vacuum conveyor
When you have a need to tailor make your conveyor and still have the high requirement on hygiene, e.g...
Hygienic automatic iris valve
In automated systems where controlled discharge of powders and bulk solids is required with a ...
Hygienic hand-operated iris valve
Hand-operated valves are required for the walls of clean rooms for glanding around cables...
Slide gate valve
In the powder and bulk handling industries, in-line shut off valves are required to provide uninterrupted smo...
Roller gate valve
In large scale operations, modular and configurable valves are required to isolate and control dry powders,...
Horizontal vacuum dryer with eccentric agitator
Conventional dryers are inefficient and can lead to significant mechanical...
Vacuum tray dryer with clean-in-place system
Cabinet tray dryers can be difficult to clean, making their use difficult for...
Horizontal paddle vacuum dryer
Agitated vacuum dryers can be difficult to clean which makes them unsuitable for multi-produc...
Laboratory-scale vacuum tray drying oven
Vacuum drying is used to remove moisture from sensitive materials. Drying small ba...
Bellows for pharmaceutical powders
Thermal and mechanical changes can lead to stresses in industrial piping systems. These ...
High containment split butterfly valve
Transferring active pharmaceutical ingredients from one vessel to another can lead t...
High containment segment ball valve
Valves fitted in blenders and dryers can have dead spaces that prevent complete process...
Removable GMP compliant connections for tubing
Tubing frameworks can have rough welding joints, corners and sharp angles t...
Negative pressure isolator
Used for products biologically hazardous, that also require minimized cross contamination.
Downflow booth
Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...
Vertical laminar flow cabinet
HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...
Horizontal laminar flow benches
HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...
Compact horizontal laminar flow bench
HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...
Microbiological safety cabinet class II
This handy device offers the most advanced features in product-operator protection ...
Biosafety cabinet class II for cytotoxic medicines
For the manipulation of hazardous substances utilized during the prepa...
Positive pressure isolator
Ideal for products which have no biological risk but require high sterile conditions.
Biological safety cabinet class III
Specially designed for the handling of microbiological agents, when working with indige...
Economic dispersing machine for emulsions and suspensions
For products of medium viscosity and relatively consistent par...
Ultra-fine dispersing machine for emulsions and suspensions
Producing the finest micro-emulsions and suspensions require...
Laboratory dispersing machine for low-viscous masses
Laboratory mixers have not always been easy to work with. Getting a...
Mobile pallet turner
Turning your pallet may allow for more effective pallet changing than the conventional lifting and grabb...
In-line pallet changer
When you need to transfer load from one pallet to another without tilting or turning, then selecting t...
Non-tilting pallet changer
Stable vertical lifting of the load from the pallet to enable EPAL or industrial pallet exchange.
V-shaped pallet changer
If you are looking for a sturdy pallet changing solution, a stationary V-shaped pallet changer can be...
Pallet changer floor level
For transferring goods from wooden pallets to plastic pallets, or vice-versa, this Pallet changer...
Pallet changer
For turning loads and exchanging them on pallets, here is a stationary pallet changer that will load and unload...
Mobile pallet changer without turning
If you are looking to change the pallet without turning the load, through a lateral p...
Versatile mobile pallet turner
Here is the versatile mobile pallet turner that completes the typical features of all mobile ...
Mobile pallet turner for higher stacks
When you need to opt a pallet changer that is capable of lifting and turning loads a...
Dosing machine for nonfree-flowing powders
Fill poorly flowing powders, dry syrups and similar substances into various gla...
Aseptic barrier systems
Designed for sterile product and Potent API’s either with low or high OEL requirements.
Sterility test isolators
Designed to avoid this risk and protect the product from both the process and externally generated f...
Horizontal chemical scraper centrifuge
For slurries difficult to discharge, a scraper can improve process reliability, effi...
Horizontal pharmaceutical scraper centrifuge
For slurries difficult to discharge, a scraper can improve process reliabilit...
Isolator centrifuge
For transfering highly active pharmaceutical ingredients (HAPI) without contamination from the isolator c...
Mobile pilot plant centrifuge
The system is perfectly suited for pilot plants as well as small-quantity productions in the f...
Vertical top discharge centrifuge
Discharge solids vertically upward through manual action, optionally using a filter bag o...
Vertical peeler centrifuge
A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from ...
Vertical scraper centrifuges
Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the botto...
Pusher centrifuge
Pusher centrifuges are continuously operating filter centrifuges and can have several basket stages dependi...
Checkweigher for stand-up pouches
When working with several lines of stand-up pouches, you can benefit from controlling the...
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Tell us about your production challenge
Manufacturing API from a natural, synthetic, or semi-synthetic base
Synthetic APIs are developed from chemical conversions in a lab. Natural APIs, on the other hand, are derived from plants or animals and then purified. Semi-synthetic options stand somewhere in between. They are extracted from natural sources but then biochemically converted into the final API.
The three main groupings of active pharmaceutical ingredients, however, employ similar extraction methods. The intermediaries are extracted from raw materials in a reactor before passing through a series of filtering and centrifuges for isolation and purification. Depending on the end product, API are milled or freeze-dried before packaging.
Follow GMP standards for your API equipment
Your API manufacturing equipment must have official certification for reaching production standards.
There are multiple protocols, but Good Manufacturing Practices (GMP) are the global benchmark in pharmaceutical product certification. The World Health Organization (WHO) issues guidelines in this department but other jurisdictions such as China, the EU, and Canada have developed their own GMP.
Classification of API must be clearly displayed on your product label
There are hundreds of active pharmaceutical ingredients used for a wide range of finished pharmaceutical products. Orphenadrine, for example, is the main API found in muscle relaxants, while antivirals are composed of oseltamivir carboxylate. The pharmacological effects of antidepressants are driven by active ingredients such as memantine, amitriptyline, and citalopram.
The WHO keeps and updates a catalog of all API, ensuring common application and labeling across markets. The names of these ingredients are non-proprietary and must be displayed under the brand names of packaged pharmaceutical products.
HPAPI manufacturing requires expert containment solutions
The API sector is moving in the direction of highly potent active pharmaceutical ingredients (HPAPI). These special components deliver a stronger drug efficacy than regular API and at a reduced dose. Medicines made from HPAPI minimize side effects and are an important development in the treatment of chronic conditions.
Manufacturing HPAPI, however, raises a series of considerations. Producers must ensure strict handling and cleansing procedures to adhere to occupational exposure limits (OEL) and keep their workers safe.
Processing steps involved in active pharmaceutical ingredients (API) making
Aseptic filling equipment
Biosafety cabinets
Contained transfer systems
Containment isolators
Containment technology
Dosing systems
Downflow booths
Filter presses
Filtration equipment
Formulation technology
High-shear mixers
Industrial checkweighers
Industrial hoppers
Mixing equipment
Separation and purification technology
Let's talk about your project!