Automated platform for determination of physicochemical properties
Optimize your compound screening process with a fully automated system that determines critical physicochemical properties such as pKa, logP/D, and solubility, transforming analytical lab workflows into high-throughput, precision-driven operations.
Analyzes Physicochemical Properties of Drug Compounds
The SiriusT3 from Pion is an automated analytical platform designed to tackle the complexities of characterizing physicochemical properties in drug compounds. This fully automated system uniquely combines spectrometric and potentiometric techniques to determine pKa, logP/D, and solubility of ionizable compounds with high throughput capabilities, processing up to 80 assays daily. This versatility makes it an indispensable tool in pharmaceutical and biotech research, particularly for developing active pharmaceutical ingredients, medicinal tablets, and oral dosage formulations. The SiriusT3 employs Pion’s patented CheqSol technique to analyze intrinsic solubility and manage supersaturation states, driving efficiency in your laboratory with quick, accurate results. Its modular design offers flexibility, with configurable systems ranging from fully automated high-throughput to single-vial setups, ensuring seamless integration into your laboratory operations. Engineered for precision and reliability, the SiriusT3 supports compliance with industry standards and promotes cost-effective drug discovery and development.
Benefits
- Increases lab productivity by completing up to 80 assays per day.
- Minimizes sample use, requiring only sub-milligram quantities for accurate analysis.
- Enhances decision-making in drug development with precise pKa, logP/D, and solubility data.
- Integrates easily into existing workflows with flexible configuration options.
- Supports cost-effective drug discovery by optimizing experimental design with predictive software.
- Applications
- Drug compounds,Ionisable compounds,Oral formulation delivery,Polymorphs compounds,Pharmaceuticals
- End products
- Proton pump inhibitors,Active pharmaceutical ingredients,Ionized drug solutions,Medicinal tablets,Crystalline polymorphs,Drug capsules,Oral dosage formulations,Amorphous solid dispersions
- Steps before
- Chemical Synthesis,Sample Preparation,Compound Isolation
- Steps after
- Data Analysis,Lead Optimization,Formulation Development
- Input ingredients
- sub-milligram sample quantities,UV-active compounds,non-UV active compounds,ionizable compounds,crystalline forms,amorphous forms,polymorph compounds
- Output ingredients
- physicochemical properties,pKa values,log P/D values,intrinsic solubility,kinetic solubility,supersaturated states
- Market info
- Automation
- Fully automated
- High Throughput Capability
- Up to 80 assays/day
- Titration Time
- Less than 6 minutes per titration
- PKa Determination Techniques
- Spectrometric and Potentiometric
- Log P/D Measurement Time
- Less than 2 hours
- Sample Quantity
- Sub-milligram samples
- Solubility Determination
- CheqSol technique
- Configuration Options
- Four configurations (DTAu,DTu,DTA,DT)
- Software
- SiriusT3 Control and Refinement
- Assay Prediction Software
- Optional Assay Expert module
- Measurement Techniques
- UV spectra collection
- Automation level
- Fully automated
- High throughput screening
- 80 assays per day
- Batch vs. continuous operation
- Batch
- Cleaning method
- Automated
- Sample quantity requirement
- Sub-milligram
- Assay completion time
- 6 minutes per titration
- Biological compatibility
- Suitable for drug discovery applications
- Corrosive resistance (e.g. acids)
- Compatible with various chemical solutions during assays
- Cleanability
- Easy to clean due to automated design
- Density/particle size
- Can handle sub-milligram sample quantities
- Physicochemical property determination
- pKa,logP/D,solubility
- Configuration options
- DTAu,DTu,DTA,DT
- Control panel type
- Touchscreen interface
- Discharge method
- Automated
- System Configuration
- DTAu / DTa / DT / DTu
- Assay Capabilities
- Spectroscopic / Potentiometric