Automated platform for determination of physicochemical properties
In the pharmaceutical industry, understanding the physicochemical properties of drug compounds is crucial for drug development. One often faces challenges such as time constraints and sample quantity limitations while ensuring accurate data for successful drug candidate optimization.
Automates physicochemical property analysis
The SiriusT3, developed by Pion, is a fully automated system designed for compound screening and lead optimization by investigating the physicochemical properties of sample compounds in vitro. The SiriusT3 is recognized globally for its precision in determining pKa, logP/D, and solubility of ionisable compounds. A key feature is its ability to determine pKa values using both spectrometric techniques for UV-active compounds and potentiometric techniques for non-UV active compounds. This system boasts high throughput automated screening capabilities, completing up to 80 assays a day. The SiriusT3 also measures log P/D as a function of pH within less than 2 hours, replacing traditional shake-flask methods. Additionally, it uses Pion’s patented CheqSol technique to determine intrinsic solubility of different forms of polymorph compounds, providing detailed information about supersaturated states. Configurations include fully automated and single vial systems, accommodating laboratories with varying needs. The system also integrates analytical software for automated data analysis, enhancing its efficiency.
Benefits
- High throughput: Up to 80 assays per day
- Requires sub-milligram sample quantities
- Dual techniques for pKa determination
- Quick log P/D measurement
- Detailed solubility insights with patented CheqSol technique