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Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

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Originally only manufactured in discoid shape, tablet today also come in triangular, rectangular, round, oval, oblong, or cylindrical varieties. Colors can vary to distinguish different medicines, and tablets are often stamped with symbols, letters, and numbers, enabling them to be identified.

According to their route of administration and the method of manufacture, it is possible to classify tablets into chewable tablets, effervescent tablets and multi-layer tablets, to name a few. Still, the compressed tablet remains the most popular dosage form nowadays.

Production processes involved in making pharmaceutical tablets

In the pharmaceutical industry, the methods used for tablet making can be classified as granulation (wet granulation and dry granulation) and direct compression.

Wet granulation vs. dry granulation

Granulation is a complex multi-stage process in which small powder particles are combined together to form agglomerates called granules.

The main difference between wet granulation and dry granulation is that wet granulation involves a granulating fluid like water, isopropanol, ethanol, or mixtures thereof. In contrast, dry granulation is the formation of granules without using any liquid solution.

 

Dry granulation can be accomplished with two methods, slugging and roller compaction, and it is used above all for those tablet ingredients that are sensitive to moisture or are unable to withstand elevated temperatures.

In wet granulation, powder particles are bound together using liquid solutions to achieve particle enlargement. The granulating fluid should be volatile to be easily removed by drying and should be non-toxic.

Tablet making equipment for direct compression

Direct compression refers to a process in which powdered APIs are mixed with excipients and lubricants without involving granulation steps. It has grown in popularity because it provides the shortest, cheapest, and most effective way to produce tablets while minimizing processing time, steps, and equipment required. This tablet production method is suitable for moisture and heat-sensitive API ingredients. Direct compression requires a tablet press in which the upper and lower punches are pressed together within the die hole and compress the tablet until it is formed.

 

The tablet equipment used for compression is the single punch tablet press and the rotary tablet press. The difference is that the single punch tablet press has two punches (upper and lower), but it uses only the upper one for compression. The rotary press has multiple punches and uses both the upper and the lower ones to compress the granules.

Uncoated tablets vs. coated tablets. When is a tablet coating machine needed?

Have you ever wondered why some tablets are coated and others are not?

Let’s start by understanding the difference, although the name already says it all. Uncoated tablets are simply made by compressing the granules with no coating added afterward. They don’t taste good and are harder to swallow, especially for children. This can be an excellent reason to use a coating; for instance, tablets are coated to mask an unpleasant taste.

An example of coated tablets is enteric coated tablets. The enteric coating is necessary when the tablet’s active ingredient is acid sensitive. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity. This involves spraying the film-forming material onto the tablet surface as the tablets rotate in the pan.

Keep your tablet safe by choosing suitable packaging

Solid dosage forms such as tablets are commonly packed in blister packs. This type of packaging assures the integrity of each dose since each cavity is separate, so if one of their seals is breached, this doesn’t compromise the quality of the whole product

The main aim of pharmaceutical packaging, like all others, is usually to protect products from any physical and biological damage and from external conditions that can alter the property of the product inside.

The importance of serialization in the pharmaceutical industry

When it comes to informing the buyer, medical packaging must provide correct information about product name, ingredients, use, and dose, to mention a few. This way, consumers are more aware of product origin or manufacture. To be able to access all this information, product traceability needs to be provided.

The most commonly used standard to facilitate traceability on drug units is serialization. A barcode needs to be printed on a different level of drug packaging (primary, secondary, and tertiary). With the help of this printed symbol, it is easier to track and trace the origin of a drug and reduce the chance of counterfeit products.

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Blister packaging is a popular packing method in the pharmaceutical industry thanks t...

Industrial blister packaging machine

High-volume, fully-automated blister packaging is the perfect choice for large scale p...

Plate sealing blister machine

Blister packaging is the preferred choice for most large-scale pharmaceutical lines, and a pla...

Automatic blister packaging machine

Automated blister packaging is a popular choice for pharmaceutical production thanks to...

Horizontal cartoner for pharmaceutical applications

Automatic cartoning for cosmetic or pharmaceutical products is a requ...

Stand-alone aggregation station

The aggregation of pharmaceutical products for tracking purposes is already compulsory in ma...

Serialization coding and labeling equipment

In the pharmaceutical industry, product serialization is the cornerstone of al...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a wa...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning an...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the productio...

Contained capsule filler

For pharmaceutical formulations that are highly active specialized capsule filling equipment is ofte...

High-yield capsule filler

Pharmaceutical manufacturers require maximum yield from their encapsulation process for efficient ...

Feeder with flexible wall hopper

The varying properties of dry powder products mean that specialized feeders are required fo...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Conical mill for drug formulation

The efficient size reduction of granular powders is a key step in many pharmaceutical pro...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

Fluid bed dryer and mixer for lab scale

Designed for pharmaceutical R&D, a lab-scale fluid bed dryer and mixer/granulat...

High-shear mixer

For the efficient mixing of larger batches of pharmaceutical compounds and high-shear mixer provides the opti...

Entry-level high-shear mixer for drug formulation

For pilot and lab-scale pharmaceutical formulations, a high-shear granu...

Starch-free depositor for hard candy

Forming hard candies requires careful handling of syrups in order to avoid quality iss...

In-line colour or flavour addition for confectionery

The addition of colourings and flavourings increases value and quali...

Thin-film cooker for confectionery products

Producing excellent confectionery products requires high quality cooking. Trad...

Dissolver of confectionery syrups

Many high quality confectionery products require a dissolved syrup as their starting poin...

Automatic weigher and mixer of confectionery ingredients

The production of accurately proportioned and homogenous slurrie...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

High containment split butterfly valve

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. ...

Sorption dehumidifier with air-chilled condenser

It is not always possible to duct out the wet air from a dehumidifier ser...

Small portable dehumidifier

Water damaged areas require dehumidification to limit the damage and prepare the area for restor...

Sorption dehumidifier for large temperature differences

Small, humid areas can be difficult to dehumidify in humid ambien...

Sorption dehumidifier for deep drying

Humid ambient conditions such as those in tropical climates make dehumidification mor...

Dehumidifier for difficult wet airflows

Sealed rooms can be challenging to dehumidify with ordinary dehumidifiers. The wet ...

Sorption dehumidifier for overpressured rooms

Small humid spaces, used for processing or storage, often need a simple dehu...

Heat recycling sorption dehumidifier

Facilities that handle large amounts of water can become very humid. High humidity may...

Industrial desiccant dehumidifier

Dehumidification of medium sized manufacturing and processing facilities can be a dauntin...

Large scale desiccant dehumidifier

Moisture sensitive processing and storage facilities need low humidity environments to s...

Customizable dehumidifier

Dehumidification needs can vary significantly from one project to another. Dehumidifiers with a fi...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Entry-level blister machine

A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

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