Dissolution testing system with Hplc analysis

Streamline your dissolution testing with integrated HPLC analysis, offering precise, semi-automated procedures for reliable, contamination-free drug dissolution results.

Performs HPLC-Integrated Dissolution Testing

The ERWEKA Dissolution HPLC On-/Offline System is a semi-automatic solution designed to enhance pharmaceutical testing precision. By integrating the DT 950 dissolution tester with HPLC online analysis, it automates up to five of eight dissolution steps, ensuring USP/EP/JP compliance. It tackles common contamination issues utilizing double filtration with the maintenance-free PVP 820 pump and AFC 825 filter changer, capable of filtrations up to 0.22 µm. Disso.NET software orchestrates the entire process, offering extensive data management and method development tools. Ideally used for testing pharmaceutical tablets and powders, this system supports seamless sample collection and analysis, significantly improving accuracy and throughput in R&D and quality control operations. Customizable with optional spectrophotometers and compatible with major HPLC brands, it facilitates night-time operation without manual intervention, addressing the need for high-efficiency dissolution testing.

Benefits

  • Enhances analytical precision by automating up to five dissolution steps, reducing human error.
  • Minimizes contamination risk with double filtration, protecting HPLC columns and ensuring data accuracy.
  • Reduces operational costs with a maintenance-free PVP pump and automated filter changer.
  • Facilitates seamless integration with existing systems, supporting major HPLC brands for flexibility.
  • Enables nighttime, unsupervised operations, optimizing laboratory productivity and resource allocation.

General


Applications
Supplements,Pharmaceutical tablets,Nutraceuticals,Pharmaceutical powder,Biopharmaceuticals
End products
Dietary fiber supplements,Sustained-release tablets,Turmeric capsules,Immediate-release tablets,Vitamin c tablets,Fish oil capsules,Powdered antibiotics,Protein supplements,Effervescent tablets,Powdered probiotics
Steps before
Media Preparation,Dissolution Testing
Steps after
HPLC Analysis,Data Evaluation,Report Generation
Input ingredients
dissolution test samples,test medium,samples in transfer block,diluted samples,samples stored against UV radiation
Output ingredients
dissolution test results,filtered samples,HPLC analysis results,comprehensive reports,exported test data
Market info
ERWEKA is renowned for manufacturing high-quality pharmaceutical testing equipment, including dissolution testers, tablet hardness testers, and other analytical instruments, known for their precision and reliability in laboratory testing environments.

Technical Specifications


Compliance
100% USP/EP/JP compliant
Filtration precision
Up to 0.22 µm
Automation level
Semi-automatic
Sampling capacity
Up to 5 of 8 steps automated
Medium compatibility
8 channels high pressure
Software control
Controlled by Disso.NET
Documentation
Audit trail enabled
Filter changer
Automatic,AFC 825
Temperature monitoring
Real-time
Rotation speed recording
Real-time
Pump type
Maintenance-free PVP pump
Sampler control
Automatically controlled
Filtration method
Double filtration
HPLC Analysis
Automated
Software compatibility
LIMS connection

Operating Characteristics


Automation level
Semi-automatic
Batch vs. continuous operation
Batch
Cleaning method
Automatic Filter Change
Integrated steps
Sampling,Filtration,HPLC Analysis
Working mechanism
Dissolution Testing with HPLC Integration
Energy efficiency
Maintenance-free PVP Pump

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm


GMP Compliance
Yes
USP Compliance
USP 1,2,5,6
EP Compliance
Yes
JP Compliance
Yes
FDA Compliance
Yes

Physical Characteristics


Compact footprint
Yes
Discharge method
Automatic / Manual
Control panel type
Touchscreen / Button Interface
Machine material
Stainless Steel
Filtration system type
Double Filtration
Filter size compatibility
0.22 μm membrane
Sample handling
Automatic / Manual

Custom Options


Integration possibilities
Disso.NET software,HPLC system integration
Control Panel Type
Disso.NET software control
Filtration Options
Double filtration with AFC 825
Sample Collection Method
HPLC sampler with cooling and UV protection
Bypass System
AFC 825 integrated bypass for media replacement
Pump Type
PVP 820 high-precision,maintenance-free
Software Features
Method editor,audit trail,data export
Sampler Detection
Automatic injection syringe position detection
Filter Changer Configuration
AFC 825 with 12 or 16 valves
Filter Types
Acrodisc™ PSF,glass fiber syringe filters