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Sampling is the process of aseptically drawing a sample from the process for analysis, without disturbing the bioprocess itself. The bioprocess needs to be carefully controlled by measuring important process variables and parameters. These parameters include pH, temperature, dissolved oxygen, foam/level, and agitation. The controllers use PID or auto-tuning adaptive control to measure and regulate the process parameters. The choice of a suitable controller depends on the identification of critical process variables.

Biotech sampling and control

sample-mod-2

sample mod

Industrial Sampling Equipment

The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Cream

Although not all women use makeup every day, almost all of them own at least one makeup product, be it lipstick or face powder. Most makeup products share the same basic ingredients of waxes, oils, and fillers with pigments like iron oxide used for colors and shades. Makeup manufacturing equipment includes pulverizers, mixers, and mechanical press machines to produce cosmetic products in different forms such as powder, liquid, or mousse.

Makeup

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.

Liquid dosage forms

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

Industrial sampling equipment are systems that allow manufacturers to test (in other words to take a sample of) the products they are manufacturing. This process is generally implemented as a means of quality control but it can also be used as a mean to ensure that production processes adhere to certain regulatory standards. Quality control in your manufacturing process starts with precision sampling techniques. Automated systems deliver consistent samples at a pre-set rate for accurate testing and probing. Sampling technology uses a calibration system involving a series of sensors to extract the material at high levels of reliability.

Continuous

An accurate and sterile sampling of cultures is vital throughout the biopharmaceutical development process. For constant, accurate monitoring, a reliable automated system is needed that transfers bioprocess samples directly from bioreactors to a range of analytical devices without intervention while maintaining the highest levels of sterility. For small-scale development, the availability of a more cost-effective entry-level system brings large economic advantages.
<h2>Affordable automated bioreactor sampling</h2>
The Seg-Flow 1200 Automated Bioreactor Sampling System from Flownamics is an economical alternative to the larger Seg-Flow 4800. It is available in two models, the Seg-Flow 1200 and the Seg-Flow 1200 Plus.

Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.

By incorporating a disposable, single-use flow path, the Seg-Flow 1200 is easy to use and requires little maintenance and no specialist operator training.

Samples can be collected from up to 2 reactors and delivered to 2 analyzers or collectors. Built-in expansion capability means this can be extended to 4 reactors with the Sample Module.

Integrated control functions such as an automated feed from an at-line glucose measurement can be quickly and easily implemented.

The Seg-Flow 1200 can be used with small laboratory vessels right up to large full-scale production vessels with 12, 19, and 25 mm models.

The unique Flownamics FISP filter probe used in the Seg-Flow 1200 ensures a sterile, cell-free sample can be taken from any vessel.

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Entry-level automated online sampling system

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Sampling

liquid

An accurate, automated sampling of cultures is a key requirement in the development of biopharmaceuticals. For automated sampling across a larger number of bioreactors, a robust and reliable automated system is needed to accurately transfer bioprocess samples directly to a range of analytical devices while maintaining the highest levels of sterility. For medium-scale operations, a cost-effective and efficient system is required to improve process performance.
<h2>Automated multiple bioreactor sampling</h2>
The Flownamics Seg-Flow 4800 is a fully automated online sampling solution for up to 8 bioreactor vessels. Using unique FISP cell-free sampling probes, the Seg-Flow can deliver accurate samples to up to 4 analyzers.

Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.

Rapid and accurate sampling is available for user-defined sample sizes from as little as 250 to 15 ml.

The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.

The Seg-Flow features a single-use fluid path from the vessel to the analyzer to reduce operating and maintenance costs. The sample line is automatically cleaned or sterilized after each sample. The user-friendly operating system means minimal training is required, and setup is straightforward.

The Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.

Automatic sampling system for bioprocess monitoring

Accurate sampling is vital for improving a wide variety of industrial, chemical, and biofuel processes. A sampling solution that provides  24/7 automated, real-time analyte monitoring, fraction collection, feed control, and data processing will allow increased process performance and development to maximize performance.
<h2>Automated sampling for up to eight vessels</h2>
The Flownamics Seg-Flow 8000i is a fully automated online sampling system that offers multiple process monitoring and control solutions designed for biofuel, chemical or industrial processes.

The Seg-Flow’s patented segmented online sampling technology means rapid and accurate sampling for up to 8 vessels and sample delivery to up to 4 analyzers and/or fraction collectors. It uses a chemically inert fluid path with automated cleaning or sterilizing after each sample. A number of feed control options are available for maximum flexibility, and the Seg-Flow 8000i can control up to 2 pumps per vessel.

The 8000i is scaled independent and can be used with laboratory, pilot, or production vessels. It utilizes the unique FISP in-situ sampling probe, which provides an aseptic barrier between the vessel and the Seg-Flow system. The Seg-Flow features a built-in touchscreen HMI, providing control over many samples and feed options. The easy-to-use system requires minimal training and allows parameters to be programmed within minutes.

The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.

Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.

Online sampling system for larger scale bioprocesses

Batch

In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, and improve processes. This needs to be done in aseptic conditions. The risk of contaminating either the test sample or the reactor can be eliminated by using a dedicated sampling probe designed to operate with the range of sample ports in use across all scales of production.
<h2>Risk-free sampling for use with bioreactor top ports</h2>
The Flownamics FISP F-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 12mm or 19mm top ports from lab scale up to production.

FISP is a sterilizable 316 stainless steel carrier that is surrounded by a tubular, microporous membrane.

FISP has been designed to withstand the temperatures, pressures, and chemicals found in fermentation environments and is perfect for aerobic or anaerobic bacteria, yeast, fungi, algae, insect, and mammalian cell cultures. Its design provides risk-free sampling thanks to a sterile barrier provided by its 0.2-micron filter. It offers the flexibility of being able to be used for submerged feeding or adding sterile media.

Compatible with Clean in Place (CIP), Sterilize in Place (SIP), and autoclaving, the FISP is easy to maintain and intuitive to use, with no specialist training required.

The FISP has been developed to work seamlessly with the Flownamics Seg-Flow range of automated samplers for use in fully automated test scenarios.

Sampling probe for bioreactor samples

Accurate, sterile sample collection is vital across a range of biopharmaceutical, chemical, and industrial processes. To eliminate the risk of contaminating either the culture or the sample, specially designed probes developed to withstand fermentation environments can deliver accurate, cell-free samples for monitoring and development.
<h2>Risk-free sampling for use with bioreactor side ports</h2>
The Flownamics FISP D-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 25mm side ports from lab scale up to production.

At the heart of FISP is a fully sterilizable carrier that’s encompassed by a specially designed micro-porous membrane. This has been designed to cope with the most extreme fermentation environments, and it’s ideal for use with anaerobic and aerobic bacterial cultures, yeasts and fungi, and mammal and insect cells.

With a 0.2 micron filter, FISP’s sterile barrier means zero-risk samples can be taken. Its robust design also means it can easily be used to add media or feeding of cultures. FISP is simple to use and requires no additional operator training. It’s also simple to sterilize and can be used as an autoclave and manual sampling process. FISP is fully compatible with the Seg-Flow range - Flownamics’ automated sampling products.

Sampling probe suitable for fermenter samples

Accurate sampling is a critical tool in the design and improvement of a large range of pharmaceutical bioprocesses. For maximum performance you need a robust and highly accurate automated sampling solution that delivers samples to your analysers 24/7 in real-time and can integrate with a large range of instrumentation.
<h2>Automated on-line sampler with increased reliability and ease of use</h2>
The Seg-Flow S3 from Flownamics is the latest generation in their line of automated samplers and has been built to deliver the perfect sampling solution for your most critical processes.

Designed for heavy-duty use, the Seg-Flow S3 has been engineered with increased robustness, featuring a highly durable powder-coated heavy-gauge steel construction. The integrated touchscreen GUI is bright and easy to use, with simple thumbnail navigation, and ideal for any lab environment. Bright LED lights offer “at a glance” status indication for easy monitoring.

Seg-Flow S3 offers complete flexibility to match your sampling needs. It can simultaneously sample from between one and eight vessels or process streams with cell-free or cell-containing samples, and then deliver to up to four analyzers or fraction collectors.

The S3 will automatically clean and/or sterilize the sample lines after every collection, removing cross-contamination risk entirely.

For process monitoring, the S3 can export data to any OPC-enabled DCS, PLC or PC, allowing easy performance data monitoring and analysis.

A wide range of feed control strategies can be programmed into the sampler, including setpoint and gravimetric. The S3 can control 2 feed pumps per vessel.

Fully Automated On-Line Sampling for Bioprocesses

Many bioprocesses require offline analysis of samples to monitor development and optimize performance. By using an automated fraction collector, the collection process can be accelerated and delivered with increased accuracy. Compatibility with automated reactor samplers is vital.
<h2>Collect fractions from reactor vessels automatically</h2>
The Flownamics FlowFraction is used in conjunction with the Flownamics Seg-Flow sampling systems. It allows the online collection of fractions from up to eight reactor vessels for further offline analysis of a range of bioprocesses.

The FlowFraction system is customizable to accommodate various tube types and sizes and can sample volumes from 250 µl to 50 ml. An added benefit is that vials can be equipped with a septum as a piercing option is available. For storage, racks in a range of standard sizes can be shipped with the FlowFraction, but custom rack sizes can also be produced to meet exact requirements.

A range of advanced options can be specified to meet your requirements perfectly, including temperature control modules featuring Peltier or water-based cooling systems. Using the options Seg-Flow Sample module, sample dilutions, and reagent additions can be performed before vial deposits.

Thanks to the included Flownamics WebFlow software, the interface allows easy control and data capture with minimal operator training. Maintenance time is reduced thanks to all internal fluid paths being self-cleaned after each sample.

Online fraction collector for offline bioprocess analysis

The ability to expand your automatic sampling solution provides increased flexibility and improved return on investment for your system. The addition of a precise sample distributor with enhanced features allows samples to be sent to an extended range of analyzers or other equipment.
<h2>Enhanced sample distribution accessory for Seg-Flow automated samplers</h2>
The Flownamics Sample-Mod 300 is an enhanced accessory that complements the popular Seg-Flow line of automated samplers.

Sample-Mod 300 allows for distribution of samples to a further 4 devices using a single-use fluid path via a zero dead volume syringe. It’s been engineered to deliver maximum precision.

The Sample-Mod enables sample dilution, including serial dilution, and allows for reagent addition for sample preparation. Ultrasonic sensor for enhanced precision.

Distributor of samples to different devices

Automatic sampling of reactor vessels requires careful fluid management to achieve cell-free sampling. In high-density cultures or highly viscous media, this becomes even more important. A self-calibrating fluid control module can be added to sampling probes and automatic samplers that overcome these challenges and provides consistent sample quality.
<h2>Increased fluid management for automatic samplers</h2>
The Flownamics Seg-Mod 202 is a self-calibrating fluidic module for high cell density cultures.

Seg-Mod 202 mounts easily to the Flownamics FISP probes used with the trendy Seg-Flow line of automated samplers and uses ultrasonic sensors for increased accuracy and reliability.

The Seg-Mod calculates the fluidic pull on the probe to ensure accurate cell-free sampling. When it detects an increase in viscosity, it will decrease flow rates to maintain sample quality.

The unit is completely scale-independent, and it’s been designed to work with vessels from any manufacturer at scales from the lab through to full production.

Fluid sample-taking module for high cell density cultures

Ancient civilizations were using yeast as it naturally occurred in bread-making and brewing. But yeast processing equipment wasn't developed and fully commercialized until the end of the 18th century. Today, this industrialized micro-organism is critical in producing biofuels and other products beyond food and drinks.

Yeast

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