Stainless steel bioreactors

Enhance your bioproduction capabilities with robust solutions designed for efficient fermentation and cultivation processes, ensuring optimal yields of critical biopharmaceuticals and cell therapies.

Facilitates Fermentation and Cultivation for Biomanufacturing

The Biostat® Cplus and Biostat® D-DCU from Sartorius are stainless steel bioreactors designed specifically for biopharmaceutical manufacturing. These systems stand out due to their integration of advanced process analytical technologies (BioPAT®) for precision control and regulation during fermentation and cultivation processes. Ideal for producing monoclonal antibodies, mRNA vaccines, and other biologics, these bioreactors offer scalable solutions from pilot to small production scales. Each unit supports seamless PLC-based automation, ensuring consistent product quality and efficiency while reducing manual intervention.

With capabilities extending from 5L to 2,000L, they facilitate diverse operations such as mixing, separation, and purification, essential for maintaining high purity levels in bioproducts like insulin and CAR-T cell therapies. Available in corrosion-resistant stainless steel, these bioreactors are designed for durability and compliance with GMP and FDA standards, ensuring suitability for regulated environments. Their design includes features for easy cleaning and maintenance, including a CIP system, making them an optimal choice for hassle-free operation and long-term reliability in demanding bioprocess settings. Customization options further enhance the adaptability of Biostat® systems to specific application needs, backed by Sartorius’s expert engineering support.

Benefits

  • Enhances production efficiency with precise process control, minimizing variability in output quality.
  • Scales flexibly from 5L to 2,000L, meeting evolving production needs without equipment overhaul.
  • Ensures regulatory compliance, supporting GMP and FDA standards for peace of mind in biotech manufacturing.
  • Reduces maintenance time with CIP system, maintaining high uptime and operational continuity.
  • Supports diverse bioprocess applications, increasing facility versatility and return on investment.

General


Applications
Vaccines,Nutraceuticals,Monoclonal antibodies,Mrna production,Biosimilars,Regenerative medicine,Bioconjugation,Biopharmaceuticals,Blood and plasma,Cell and gene therapy
End products
Car-t cell therapies,Insulin,Covid-19 vaccines,Rituximab,Antibody-drug conjugates,Epoetin alfa,Omega-3 supplements,Pfizer-biontech covid-19 mrna vaccine,Albumin,Growth factors
Steps before
Sample Preparation,Media Preparation,Cell Line Development,Cell Banking
Steps after
Sterility Testing,Batch Release Testing,Product Characterization,Downstream Processing
Input ingredients
cell culture media,microbial culture media,buffer solutions,cells,microorganisms
Output ingredients
bioproducts,fermented products,culture supernatant,biomass,cell culture harvest
Market info
Sartorius AG is renowned for manufacturing high-precision laboratory and bioprocess equipment. They specialize in filtration, fermentation, and cell cultivation systems, known for their innovation and reliability in the pharmaceutical and biotech industries.

Technical Specifications


Capacity
5 L to 2,000 L
Fermentation temperature range
18–37°C
Automation
Advanced process analytical technologies (BioPAT®)
Material
Stainless Steel
Integration
Component of hybrid systems

Operating Characteristics


Batch vs. continuous operation
Batch / Inline Continuous
Automation level
Manual / PLC / SCADA
CIP/SIP
CIP 121°C / SIP 135°C
Energy efficiency
0.5–2 kWh/kg moisture
Cleaning method
CIP / Manual

Material Compatibility


Biological compatibility
Yes
Cleanability
High
Corrosive resistance
Stainless steel
Density/particle size
Varied

Product type Characteristics


Process scale
Pilot / Production

Physical Characteristics


Capacity
5 L to 2,000 L
Tank shape
Cylindrical
Material
Stainless Steel
Integration capability
Hybrid systems

Custom Options


Control panel type
PLC / HMI
Integration possibilities
Hybrid systems
Customization capacity
5 L to 2,000 L
Process Analytical Technologies (PAT)
BioPAT® Integration
Application range
Pilot to Production
Engineering Solutions
Customized solutions available