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Industrial Purification Systems

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BB - PurePac Mini

The nearly 5,000 known minerals on earth share some characteristics to be classified as minerals – they are inorganic, solid, naturally occurring elements and have a particular chemical formula and an ordered internal geometric structure. However, minerals are not all the same. One way to divide them is based on their physical characteristics such as hardness, luster, color, and shape. For example, the diamonds we use to make jewelry are very hard minerals while talc is a soft mineral; gold is a shiny mineral while others are less so.

Minerals

We carry dozens of metals around every day. The ubiquitous smartphone is built with no less than 20 metals, each with specific behaviors and purposes. Metals are a pervasive class of materials that have defined entire eras of human development. It is no exaggeration to say that metal processing equipment is the core of our metallic world. But, paradoxically, this manufacturing technology itself is mainly made of metal.

Metal

Detergents are cleaning agents that help remove dirt and grease from porous and non-porous surfaces. Industrial production of detergents began after World War I. Still, it was after the 1950s and 1960s that the detergent industry grew exponentially due in part to the development of new detergent manufacturing equipment.

Detergents

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Essential oils are known as the liquid gems of nature. The sweet-smelling essences impact not just our senses but also our biochemical and cellular make-up. Besides aromatherapy, the products of an essential oil extraction system found applications in pharmaceuticals and foods.

Essential oil

Energy is constantly changing, but it finds rest in a fuel. Once exposed to heat, though, these natural materials release their captured energy. Every aspect of everyday life – from manufacturing to digital services – is powered by the mastery of this complex conversion from fuel to energy.

Fuel

With the increase in the world population and rising concerns for environmental sustainability, the market for suitable new protein sources is expanding rapidly. Traditional agricultural methods alone can’t deliver sufficient protein to meet the projected food demand over the next decades. Insects provide an alternative source of nutrients. But insect protein does not mean direct insect consumption. Extracting protein and amino acids from farmed insects is more sustainable and efficient. Specialized insect protein processing technology is driving the transformation toward new protein sources.

Insect protein

Cannabinoids are natural compounds obtained from the Cannabis sativa plant. Delta-9-tetrahydrocannabinol or THC is a psychotropic substance. Cannabidiol, or CBD, is non-psychotropic and often used for nutraceutical purposes. Cannabinoid equipment extracts THC and CBD from the plant and prepares the substance for formulations that treat pain, nausea, anxiety, and inflammations. Cannabinoids are processed in various forms, including creams, capsules, and oils.

Cannabinoids

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Ceramics are defined as inorganic and non-metallic materials. Tthey are typically brittle, hard, and elastic as well as resistant to heat and corrosion; in fact, after shaping them into the desired shape, they are heated in an oven called kiln at very high temperatures (1,000 °C to 1,600 °C). Kaolinite and aluminum oxide are the best-known examples of ceramics.

Ceramics

Due to their potential hazardous nature, chemicals are classified for proper identification and safety during production. Chemical classification depends on their properties, structures and functions. In the chemical industry, you can regard them as basic chemicals such as acids, chemical products to produce plastic materials and finished chemicals for use in cosmetology. As a manufacturer or engineer, you want to know their reactivity when using chemical processing equipment.

Chemicals

Ancient civilizations discovered that plant extracts were useful for the treatment of pathologies. The origin of plant extraction cannot be specifically verified, but we can infer that the earliest attempts at plant extraction were more intuitive than scientific. Today, the extraction of compounds is a precise process with plant extraction systems complimenting traditional knowledge.

Plant extracts

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

According to a legend, Cleopatra soaked her sails in her perfume so that Mark Antony could smell her ships before they arrived. This is to say that, from soaps and shampoos to perfumes, conditioners and pomades, cosmetics have always been highly valued and used for their properties of aesthetic enhancement. Cosmetics are a broad class of topical agents applied for various purposes such as cleansing, protecting, beautifying, or otherwise altering your appearance. As a result, a wide array of processing equipment is used in the cosmetics industry.

Cosmetics

Edible oils are fats that you can extract from various plants and animal tissues. The most popular sources are olives and sunflowers. You can use them for different cooking techniques, such as frying, baking, and other methods. Manufacturers are now finding ways to extract oils with a higher natural fat content efficiently using edible oil extraction machines.

Edible Oil

Liquid

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Batch

To purify a specific large biomolecule, for example IgM or a virus or virus-like particle, the first step is to screen the working conditions. Different mobile phases and column chemistries are then tested, according to the biochemical properties of that particular large molecule.
<h2>Efficiently identify, isolate and recover large biomolecules</h2>
The CIMmultus™ Purification Screening Kit from BIA Separations is intended to help scientists quickly discover the optimal stationary phase chemistry for their particular application.

The kit includes two different 1mL CIMmultus™ ion-exchange columns (QA and SO3) and one hydrophobic interaction chemistry column (OH).

By using one of the selected chemistries and applying proper working conditions, the user will be able to discover the combination that will result in appropriate purity and excellent recovery of their required large biomolecule.

Purification screening kit for large biomolecules

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Purification

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

liquid

When developing a pDNA purification process for eventual transfer into production, efficient examination and selection of protocols is critical.
<h2>Develop plasmid purification procedures quickly</h2>
BIA Separations' CIMmultus™ HiP2 Plasmid Process Pack™ is intended to help scientists easily develop their pDNA purification process and transfer it to production.

Allowing developers to select only the relevant parts of the recommended protocol that best fits their needs, the pack saves time and money on all scales.

The CIMmultus™ HiP2 Plasmid Process Pack™ contains one weak anion-exchange (DEAE) and one hydrophobic (C4 HLD) column and a protocol describing the purification procedure of specific plasmids.

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Plasmid process pack for your pDNA purification process

Continuous

Some industries, such as petrochemical, generate large volumes of oily wastewater due to the amount of oil used. Oil and water separation is a big challenge as their densities are close, emulsion occurs, and prolonged separation time. The right centrifuge has to take all these factors into account and then must be able to handle the continuous, large capacity operation and fast separation.


<h2>Extracting two immiscible liquids</h2>
The RINA SRP S by Riera Nadeu is super centrifuges used to separate two non-miscible liquid phases of different densities, such as the purification of fuel oil, organic and inorganic products liquid/liquid separation, contractors oil purification, and many others. It has a vertical decanting tubular bowl centrifuge, turning very high speed (15.000G mini). During separation, an appropriate diaphragm and collectors capture the heavy liquid and supernatant light phase separately. Adjusting the feed rate will set the residence time of the product inside the decanting rotor.

The RINA SRP S offers easy operation and requires low maintenance. The full opening casing installed functions to lower noise emissions, guarantee the centrifuge's safe operation, and easier extraction from the front side per GMP requirements. The casing can also regulate the liquids' temperature by installing heating or cooling coils. The coils heat or cool the liquids to minimize heat transfer by the rotating rotor's mechanical heat or warm the product up. The RINA SRP S is also adaptable to work in an explosive hazardous area, install with CIP and SIP system, and install auxiliary or complementary devices when necessary.

Water oil separation centrifuge

Industrial centrifuges are widely used for mechanical solid-liquid separation of components in the pharmaceutical and chemical industries. This is achieved by rapidly rotating the contents within a container to separate fluid of different densities or to remove liquids from solids.

Centrifuging

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Glycerol or glycerin is the major by-product generated in the biodiesel production process. But the disposal of glycerin or various other by-products coming from biodiesel production process pose a big challenge to industrial plants, as they can’t be disposed into the environment.


<h2>Distilling and refining glycerin while minimizing the environmental impact</h2>
Glycerin production plant designed by Andreotti Impianti produces technical and pharmaceutical glycerin from a wide range of natural feedstocks. Glycerin can be produced from different by-products coming from three industrial processes: methylesters production, fats saponification and fat splitting. The production steps change depending on the starting by-product.

For by-products such as sweet water (splitting) and spent lyes (saponification), the process path involves chemical treatment, concentration and glycerin distillation and refining. Hydrochloric acid is added in the treatment unit to reduce the solubility of fatty acids, which are then separated. Before moving on distillation process, only one filtration is carried out for sweet water, while for spent lyes, filtration is done twice, before and after the neutralization. Crude glycerin is further processed in the distillation, deodorizing and bleaching plant. The distillation system is composed of several steps: washing, rectification, condensation. In the last purification step, blenching section uses activated carbon to remove color and odor in order to obtain a pure glycerin.

It is worth mentioning that crude glycerin coming from biodiesel (methylesters) production can be sent directly to the distillation process without any further treatments, thus avoiding dilution, purification, and concentration steps.

Since one of the biggest problems caused by industrial plants today is the disposal of by-products, Andreotti Impianti has included in its plants stripping units, which help minimize the environmental impact.

Glycerine manufacturing plant

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

Traditional extraction processes involving hot solvent (ethanol) or Co2 may produce varied results in the mass production of CBD oil. Moreover, the cannabidiol extraction process takes several days to complete, reducing the plant's output capacity. With a growing market for CBD products, companies need to produce high-quality materials consistently at a faster pace.
<h2>Save time with a continuous extraction system for CBD oil</h2>
Devex’s CryoEXS is a time-efficient solution to extract crude CBD oil from cannabis or hemp. It uses cold (-40 C) Ethanol as a solvent to extract useful substances. The equipment is available in 3 sizes depending on the capacity of dry cannabis biomass throughput.

The dried cannabis is fed into the extractor simultaneously with the cold ethanol. This method helps avoid the extra 24 hours of extraction process needed for the winterization step used in traditional methods to eliminate undesired elements from the extract such as fats, waxes, pigments, etc. Additional cannabinoid losses that can occur during the winterization step are also avoided.  Then the mass is recirculated to achieve a highly efficient extraction. The crude CBD oil is then ready for short part distillation. The ethanol used in the extraction process is then sent back to the tank for purification and reuse.

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Fully certified CBD crude oil extraction machine

Industrial extraction equipment unlocks the valuable compounds hidden away in natural materials. Automated extraction equipment is applied in the pharmaceutical and cosmetic industries to extract active compounds from medicinal plants or herbs. For example, extracting cannabinoids from cannabis plants. But the process is also fundamental to the food industry, recovering various components like aromas, oleoresins, and proteins.  Considerations for selecting suitable extraction technology include the type of plant material to be processed, the extract's heat sensitivity, and the production volume.

Extraction

Also referred to as biogas purification, biogas upgrading is an excellent alternative to a CHP (combined heat and power) system that generates heat and electricity. CHP’s are usually expensive and causes air pollution. However, a biogas upgrading system can turn your plant into a sustainable and profitable organization. You thus need a membrane separation technology which is able to upgrade biogas to natural gas quality by filtering out CO2 and other unwanted components.


<h2>Separates methane from biogas with more than 99.5% efficiency</h2>
PurePac Grand by Bright Biomethane is a sustainable biogas upgrading solution, ideal for large-scale biomethane production. The membrane separation modules are designed into a 45 ft. container, whereas the pre-treatment and compressor are situated outside the housing. You can also use this model as an indoor unit solution, but the pre-treatment will then have to be placed outside the building.

It is capable of upgrading over 1,000 Nm3/hr of biogas to biomethane, making it ideal for vehicular fuel production and gas grid injection. The unit can also be extended with a carbon dioxide recovery system for food-grade CO2 production, thus creating an additional source of revenue for plant owners.

The patented three-stage membrane separation process ensures that the biomethane is able to meet the requirements of specific applications. Operators can install a special heat recovery system for the production of high-temperature water.

Furthermore, the process does not require water or chemicals, eliminating any disposal problems and unforeseen costs. Lastly, it can produce biomethane from most types of biomass feedstock, including agricultural waste, manure, and municipal wastes and sludges.

Efficient sized biomethane production system

Membrane separation technology for biogas purification is considered as an effective alternative to combined heat and power system due to the decrease in electricity prices as well as in the demand for electricity and heat. Most importantly, the purified biogas production, also known as biomethane or renewable natural gas, utilizes the biogas produced from organic waste streams, which turns waste into energy. It is thus a sustainable solution to fossil fuels.


<h2>Ensures low maintenance costs and low energy consumption</h2>
A patented design by Bright Biomethane, PurePac Medium is an incredibly effective and relatively compact biogas upgrading system. The membrane separation modules are designed to fit inside a single 40 ft. container, while the compressor and pre-treatment mechanism are situated outside the housing.

Boasting a three-stage membrane arrangement, the system’s patented and innovative design achieves an incredibly efficient methane recovery of more than 99.5%, with a methane slip of less than 0.5%.  Since it uses highly selective membranes, with high separation efficiency, it is able to achieve the highest possible methane yield.

The membrane unit separates the gas by applying an imposed pressure difference over the membrane, which results in two different gas streams. One is a CO2-rich gas, and the other is a product gas that has a high methane value. The model is ideal for upgrading 400 to 1000 Nm3/hr of biogas to biomethane and can be used for the production of vehicle fuel or for gas grid injection. A CO2 recovery system can be added to the unit, enabling the production of food-grade carbon dioxide.

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Large-scale biomethane production system

Biogas upgrading refers to the process of purifying biogas through separating methane from carbon dioxide and other gases. The purified biogas, also known as renewable natural gas or biomethane, can be injected into a gas distribution network or used as vehicle fuel. If you need to upgrade biogas produced from organic wastes such as cow manure and wastewater, you need a solution which can easily be integrated with your existing biogas plant.


<h2>Proven membrane technology ensures high methane recovery</h2>
Innovatively designed by Bright Biomethane, PurePac Mini can fit inside one sustainable housing. The unit’s pre-treatment, membrane separation, and compressor are all fitted inside one 40 ft. container. It can create a biogas flow of 30 to 65 Nm3/hr, making it ideal for small scale biomethane production and gas grid injection.

The small-scale biogas upgrading system uses highly efficient membranes to separate methane from biogas, which ensures a methane recovery of more than 99.5% and less than 0.5% of methane loss, making it more efficient than any other biogas purification systems.

Moreover, the unit can be used to purify gas to the desired methane concentration, according to the specific grid and user requirements. Suitable for use in agricultural industries and wastewater treatment plants, PurePac Mini provides a robust design, optimal gas cleaning, and a state-of-the-art patented control system.

Small-scale biogas upgrading system

Systems for the filtration of liquids with suspended solid contents can be challenging with corrosion issues and cold spots. They require high maintenance and operational costs. If you are a small-scale company in industries that require sulphur processing, amine treating or need to continuously filter out fine solids, you need a flexible solution and cost-efficient solution which is easy to maintain.


<h2>Low maintenance and flexible filtration system</h2>
Sulphurnet’s Horizontal plate filter is configured for both continuous and batch wise filtration without leaving any solid residue. It is equipped with a scavenger plate which refilters the residue left in the tank at the end of a batch. It also allows complete product recovery by washing or drying the cake.

The Industrial Liquid filtration system is configured with horizontally positioned filter plates with holes. These plates are positioned uniformly in a vertical tank. The plates have varying depths depending on the filtration surface and cake volumes. The fluid to be filtered passes over these horizontal filter plates which can be fitted with different kinds of filter media. The solid particles then collect in the form of a filter cake, which then remains on the filter medium and the polished liquid flows through the filter plates to the filtrate outlet.

The industrial liquid filtration system can be used for numerous batch and continuous filtration processes. It is easy to maintain as it contains no moving parts, the filter cartridges can be quickly removed and replaced with a spare cartridge. Its applications include, removal of activated carbon, filtration of varnishes, paints and resins, removal and recovery of catalysts, purification of chemicals, recovery of precious metals, processing of edible oils, juices, glucose and also in the pharmaceutical industry.

Industrial liquid filtration system

Usually, all spent protective gas is vented from metal treatment processes, such as annealing and sintering. However, this waste stream has a high hydrogen content, making it incredibly valuable. The problem is that most mixed atmospheres can be extracted from industrial processes at lower pressures, but gas purification needs a larger pressure differential.


<h2>Recover pure hydrogen gas from high hydrogen containing mixtures</h2>
The Hy.REC pure is designed to recover pure hydrogen from mixtures containing high hydrogen, such as those in the metal treatment industry.

Able to recover spent protective gas from the upstream side, this system can be used as an integrated skid. It purifies the mixture by removing particles, converting it into high-quality hydrogen that’s integrated back into the gas system. Since it generates pure hydrogen process gas, the Hy.REC pure is applicable in metal, flat glass, electronics, and chemical industries.

Moreover, the system pressurizes the low-pressure feed flow to the minimum required level, then subsequently cools it, resulting in the condensation of the higher hydrocarbons present in the spent atmosphere. HyGear’s innovative vacuum pressure swing adsorption technology also reduces the need for compression, further ensuring minimum electricity consumption. Lastly, the VPSA technology is able to achieve 6.0 (99.9999%) level hydrogen purity. For higher purities, the system also includes an integrated catalytic polishing system.

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Containerized hydrogen upgrading system

This label marks production technology and processing know-how that can help to move away from fossil dependency and work towards renewable energy sources. 

making-logo

making logo

Reducing fossil dependency

HyGear makes affordable, on-site (bio)hydrogen accessible and takes the lead in both hydrogen generation with a low or carbon-negative footprint and in the supply of sustainable gas

Hydrogen is an all-purpose element and can be simply defined as energy’s Swiss Army knife. It can be generated without any greenhouse gases, can be combined with a fuel cell to generate electricity without combustion, and is highly flammable, making it an ideal combustion fuel. However, isolating hydrogen from other elements, storing it, and converting it into useful energy takes a lot of energy and money. Currently, hydrogen is supplied by electrolysis and road transportation of liquefied or compressed gas. This can lead to an unreliable hydrogen supply, making the entire process time-consuming and costly.


<h2>Save time and money with the hy.GEN natural gas to hydrogen generator</h2>
To decrease the costs and ensure a reliable supply of hydrogen, HYGEAR has developed the innovative hy.GEN plug &amp; play natural gas to hydrogen generator.

Hygear’s Hy.GEN® systems use Steam Methane Reforming to convert natural gas to hydrogen. A decentralized hydrogen production system results in a more reliable, cost-effective, and safer alternative to traditional hydrogen supply by electrolyzers and tube trailers. Boasting an incredibly lower environmental impact, the Hy.Gen systems do not need any external fuel gases for steam generation.

Reusing waste heat and waste gases, Hy.GEN has optimized energy efficiency to the highest level. The system features water purification and gas desulphurization, and can thus be connected to the feed water and natural gas lines directly. It’s also designed with Vacuum Pressure Swing Adsorption technology, which uses the differences in adsorption properties to separate hydrogen from other gaseous species. This makes the system more cost-efficient than conventional gas separation systems.

The Hy.GEN® systems have several different applications, including the flat glass industry, the metal industry, and the chemical industry.

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Plug and play natural gas to hydrogen generator

Dry, saturated steam can be used to sterilise pharmaceutical manufacturing equipment, and active pharmaceutical ingredients. The water should be sufficiently pure after condensation for use in intravenous applications, as well as non-parenteral treatments applied externally to the body.
<h2>Pure Steam Meeting USP Standards for Injection Water</h2>
The BRAM-COR CSPG pure steam generator turns purified water, or water for injections, into pure steam. This steam complies with USP requirements for injection water when re-condensed. It is also suitable for equipment sterilization, as well as when preparing a wide range of parenteral and non-parenteral dosages.

Purified water - or water for injections - is fed into the generator and heated using industrial steam. However, this can also be achieved using superheated water, or energy from an electrical power supply. Following this, steam purification is by centrifugal and gravity separation.

This pure steam generator uses a single boiling column and a double tube sheet heat exchanger.  The automated touchscreen control panel accepts digital and analogue values. Thereafter, an automated unit manages automatic sequences according to user selections.

BRAM-COR CSPG industrial steam is in the range of 7.9 to 2.0 bars. Capacity varies from 44 to 17,600 pounds per hour, or 20 to 8,000 kilograms.

Pharmaceutical pure steam generator

<span style="font-weight: 400">The heating process is a step of raising the temperature of food, pharma, cosmetics, and many other types of products. You may employ different heating solutions for this process, depending on the type of product you intend to manufacture. Selecting the appropriate heater machine for your product is quite important since various products require different ranges of temperatures and different ways of heat transfer using exchangers. Industrial heating equipment varies in two ways - the type of material it can process and the reaction you want to achieve.</span>

Heating

Samples taken at various process steps need to be analysed quickly and accurate results delivered, without affecting the state or condition of the original sample.
<h2>Understand a bioprocess through real-time monitoring</h2>
CIMac™ Analytical Columns from BIA Separations are short bed, high performance monolithic columns offering all the advantages of CIM® monolithic technology. They are primarily intended for fast, efficient, and reproducible separations of biomolecules like large proteins, plasmid DNA, and viral particles.

Small volume and short column length allow operation at high volumetric flow rates (from 1 to 30 column volumes/min), enabling product quantity and purity information to be available in just a few minutes.

The CIMac™ Analytical Columns are pre-packed in dedicated stainless steel housings and allow user-friendly connections to HPLC equipment, hence they can be effectively used for both the in-process and final control of various samples from different purification processes.

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Short bed monolithic columns for analytics

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA require the high structural strength and contamination protection usually provided by expensive medical grade stainless steel.
<h2>Separate complex biomolecules using strong, versatile multi-use columns</h2>
CIMmultus™ disposable monolithic columns from BIA Separations have the structural integrity and leachable profile of medical grade stainless steel, but the process economics of a single or multi-use device.

With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ columns offer safety and high performance.

CIMmultus™ columns can be used at any step in the separation process and, with their 2 µm flow-through channels allowing convective mass transfer, make a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other large biomolecules.

Disposable monolithic columns

Single use bags for biopharmaceutical process containment and liquid storage are being used with increasing frequency in the industry due to their convenience, efficiency, and inherent cleanliness.  Integration of single use bags into biopharmaceutical processes is a great way to reduce required maintenance, and improve the versatility of equipment without increasing risk of cross contamination.
<h2>A mobile, vertical bag holder with integrated scale compatible with bags from any manufacturer</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s WeighStation system is a wheeled bag stand that works with single use bags from any manufacturer.  The system includes integrated load cells and local display which allow it to be used as a stand-alone scale or to be integrated into other Scilog processing platforms for metered dispensing and purification.  The system has a minimized footprint and superior mobility when compared to a traditional floor scale.  The mobility and use of single use bags allow this piece of equipment to support several processes in your facility rather than being dedicated to just one.

Bag holder and weighing platform for bioprocesses

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Weighing

Sensitive bioprocess applications requires equipment that will not interfere with the chemical and biological processes being carried out.  At the same time, production bioprocesses, in particular those that involve peristaltic pumping, require robust tubing not prone to wear or mechanical failures.  Traditional transfer tubing for these more rigorous ans sensitive bioprocesses often proves inadequate.


<h2>A robust biocompatible tube designed for longevity in production peristaltic pumping applications</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers tubing solutions specifically designed for use in peristaltic pumps in bioprocess production environments. The tubes are of the PharMed BPT brand and are completely bio-compatible and less permeable to gasses and vapors than traditional silicone tubes.  This makes the PharMed BPT tubes ideal for protecting sensitive biological processes like cell culture, fermentation, separation, synthesis, and purification.  At the same time, they have been formulated for enhanced flex and wear characteristics allowing trouble free used in peristaltic pumping applications.  The combination of these qualities increases the efficiency of the bio-production process by reducing down time from tubing failure without making any sacrifices in bio compatibility.

Biocompatible tubing for peristaltic pumps

The fermentation process stimulates enzymatic activity in organic substrates to transform their chemical composition. Fermentation is aided by storying the biomaterials in anaerobic environments, allowing the microorganisms to decompose their nutrient structures. The process is integral to some of the most popular products throughout time such as wine, beer, cheese, and kimchi. But besides the food sector, fermentation is also an important stage in the industrial manufacturing of chemicals, pharmaceuticals, and biofuels.

Fermentation

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

Quality of gypsum and stucco products are highly influenced by the quality of the calcining process employed in production. Consistent grinding, purification, and drying of raw mineral inputs prior to their being entrained in the hot gas flow of the calcining equipment ensures efficient calcining and a resultant high-quality final product.


<h2>Grinding, purifying, drying, and calcining from a single piece of equipment</h2>
Claudius Peters’ EM Mill is a calcining system for gypsum and stucco with an integrated grinding mill. The mill uses free moving steel balls rather than stationary rollers which ensures uniform fine grinding while avoiding the need for any bearings inside the mill. The grinding system employed requires very little maintenance and has been known to achieve a service life of over 40,000 hours. At the base of the grinding system, a scraper acts on the ball track conveying foreign material out of the mill into the reject box.

The efficiency of the grinding system allows low material time inside the mill enhancing the controllability of the process and ensuring uniform product quality. After sufficient grinding material is entrained in a calcining gas flow of unusually high temperature which yields lower gas volumes and optimal energy consumption. The constant randomized motion of the ball grinding system ensures even and constant distribution of raw gypsum for exposure to the calcining flow.

Mill for calcining gypsum

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

solid

If generating an scalable data and bring in results with small sample quantities of high-boiling, heat sensitive and highly viscous products using a short path and wiped film distillation system, then the Pilot multi-stage distiller is your ideal solution.


<h2>Short path and wiped film distillation combined in one technology</h2>
Combining short path and wiped film distillation methods can provide you with a more flexible approach on achieving your desired product quality. In multi-stage systems, complex product mixtures can be separated in the individual fractions with the desired quality. The multistage pilot plant distillation system by VTA can be configured based your particular requirement.

The VTA pilot multistage distillation units are suitable for generating scalable data for industrial system, producing certain sample quantities and optimization of existing process like concentration, fractionation, distillation, purification and drying of heat sensitive and high-boiling products.

Pilot multi-stage distiller

Industrial distillation equipment is used in the process of separating different constituents of a liquid mixture. Considerations for choosing suitable distillation systems include the boiling points of the components, heat sensitivity of the product of interest, pressure requirements during the process, and the scale of production. Distillation is used for concentrating extracts such as herbal extracts, flavors, and aromas in the food industry. In the pharmaceutical industry, distillation is used in the production of active ingredients and in the chemical industry for the purification of chemical products.

Distillation

Generate scalable data and results during the pilot tests with wiped film distillation,  distill or dry of small product quantities with as little as 30 kg of crude material.


<h2>Modular wiped film distillation units that enable a later scale up to industrial systems</h2>
With pilot wiped film distillers, a substantial decrease of boiling temperature is obtained by reducing the operating pressure. It is a continuous process with very short residence time. The VTA pilot wiped film distillers are utilized to process small product quantities that enable a later scale up to an industrial system. A proper and reliable test can easily be performed with an amount of crude material as low as 30 kg. It can handle material with a maximum viscosity of 100,000 mPas (cP) at operating temperature.

The VTA pilot wiped film distillers are suitable for generating scalable data for an industrial system, producing numerous sample quantities and optimization of existing process like separation, drying, concentration, fractionation, distillation, deodorization and purification.

Pilot wiped film distiller

Generate scalable data and results during the pilot tests with short path distillation, distill or dry of small product quantities with as little as 30 kg of crude material.


<h2>Modular short path distillation units that will enable a later scale up to industrial systems</h2>
With short path distillation, a substantial decrease of boiling temperature is obtained by reducing the operating pressure. The VTA Pilot short path distillers are set up as modules and used to separate small product quantities that will enable a later scale up to industrial systems. The evaporator has an achievable operating pressure down to 0.001mbar. It can process a material with a maximum viscosity of 15,000 mPas (cP) at operating temperature.

The VTA Pilot short path distillers are suitable for generating scalable data for industrial systems, producing certain sample quantities and optimization of existing process like concentration, fractionation, distillation, purification and drying.

Pilot short path distiller

A laboratory multi-stage distillers that combines the wiped film and short path distillation technique allows you to test the separation of high-boiling, heat sensitive and highly viscous products by just using a small amount of material.


<h2>Short path distillation and wiped film distillation in one technology</h2>
The VTA Laboratory multi-stage distillers are a combination of short path and wiped film distillation technique. It is recommended to equip such systems with continuous feed and discharge pumps to have a smooth and simple operation.

The VTA Laboratory multi-stage distillers can be configured based on customer’s requirement.

It is suitable for feasibility studies, doing first process development steps, producing small sample amounts of final product and optimizing existing processes such as concentration, fractionation, distillation, purification and drying of heat sensitive products and high-boiling products.

Laboratory multi-stage distiller

Reach reliable conclusions testing the distillation of high-boiling or highly viscous material using as little as 2 kg of crude material.


<h2>Small scale thermal separation with wiped film distillation</h2>
With wiped film distillation, a substantial decrease of boiling temperature is obtained by reducing the operating pressure. It is a continuous process with very short residence time. The VTA wiped film distillation laboratory unit is designed to distill small product quantities for acquiring reliable data of the separation process.

The unit can handle high-boiling and highly viscous feed with maximum viscosity of 15,000 mPas (cP). The fabrication of the unit’s main components using Borosilicate glass enables observation of the product properties for foaming or potential fouling during distillation.

It is suitable for feasibility studies, doing first process development steps, producing small sample amounts of final product and optimizing existing processes like separation, drying, concentration, fractionation and purification.

Laboratory wiped film distiller

Get to reliable conclusions for the separation of high-boiling and heat-sensitive products using as little as 2 kg of crude material.


<h2>Small scale thermal separation with short path distillation</h2>
With short path distillation, a substantial decrease of boiling temperature is obtained by reducing the operating pressure. The VTA Laboratory short path distillers integrate the short path distillation technique and are set-up as modules.

The fabrication of the unit’s main components enables observation of the product properties for foaming or potential fouling during distillation contributing to additional data for analysis.

The VTA Laboratory short path distiller is suitable for feasibility studies, doing first process development steps, producing small sample amounts of final product and optimizing existing processes like concentration, fractionation, distillation, purification and drying of heat sensitive products and high boiling point components.

Laboratory short path distiller

With short path distillation, a substantial decrease of boiling temperature is obtained by reducing the operating pressure. It is a continuous process with very short residence time.


<h2>Evaporation at low operating pressure with very gentle distillation</h2>
The special design of short path evaporators by VTA allows operating pressures down to 0.001 mbar. The very low operating pressures ensure very low distillation temperatures and therefore a very gentle distillation is possible. The short path distillation allows the thermal separation of high molecular and high-boiling products.

Thanks to short residence time, low evaporation temperature and the immediate cooling of the concentrate, thermal stress and decomposition of the product can be minimized.

Suitable for concentration, fractionation, distillation, purification and drying of heat sensitive products and high boiling point components.

Short path evaporators

Evaporation technology is used to reduce or remove the moisture content of a mixture. Considerations for choosing suitable evaporation equipment include the moisture content in the mixture, the boiling point of the solvent, heat sensitivity of the product, and the amount of material to be processed. Evaporators are used for applications such as obtaining fruit and vegetable concentrates in the food industry, concentrating aromas and herbal extracts in the cosmetics industry, and isolating active ingredients in the pharmaceutical industry.

Evaporation

With wiped film distillation, a substantial decrease of boiling temperature is obtained by reducing the operating pressure. It is a continuous process with very short residence time.


<h2>Separate high-boiling and highly viscous materials in a wiped film evaporator</h2>
The VTA wiped film evaporator has a rotating wiper system which speeds up the evaporation process by keeping the product film turbulent so that the heat transfer and mass transfer are optimized.

The residence time of the product at the evaporator wall is very short and the vapours are condensed on an external condenser.

It is ideal for separation, drying, concentration, fractionation, distillation, deodorization and purification of materials which have high boiling points and high viscosity.

Wiped film evaporator

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need to be controlled, except where water for injection is required.


<h2>Fully compliant water purification in flexible executions</h2>
The purified water systems from Telstar Life-Sciences are specially designed to generate purified water in accordance with the International Pharmacopoeia specifications for Purified or Highly Purified water; and in full compliance with cGMP guidelines as per FDA and EMEA, EP, JP and USP requirements.

Offering two flexible outputs:  from 300 to 10,000 L/h with Oasys and from 100 to 10,000 L/h with Genesys. The Genesys system is designed to allow automatic hot water sanitization of the complete unit including the pipework feeding the purified water into the storage vessel, whereas the Oasys system works with chemical sanitization.

Purified water systems

The primary purpose of biogas upgrading technology is to increase the volumetric energy content to enhance the quality of gas through CO2 removal. This process is essential for alternative vehicle fuel and natural gas pipeline injection. Although chemical solvent scrubbing and pressurized water scrubbing are widely used biogas upgrading technologies, newer technologies have broken through that lower costs, decrease environmental footprint, and improve efficiencies. One such technology is membrane separation.


<h2>Achieve the highest possible biomethane yield</h2>
PurePac Compact by Bright Biomethane is a sustainable and compact biogas upgrading system. Its compressor and membrane separation mechanism are designed into one 40 ft. container, whereas the pre-treatment is situated outside the housing. It can be easily integrated with existing biogas plants from sewage sludge or food industry waste processing.

After the biogas goes through the pre-treatment unit, it is compressed to a required pressure, making it ready for membrane separation. Ideal for upgrading 65 to 400 Nm3/hr of biogas to biomethane, this modular biogas to biomethane system can be used for the production of vehicular fuel and gas grid injection. The system also offers the option of adding a CO2 recovery system for the production of food-grade carbon dioxide.

PurePac Compact enables operators to start and stop the machine at their convenience with virtually no wasted energy consumption and minimal methane loss.

Modular biogas to biomethane system

One of the highest volume industrial gases, hydrogen serves a wide range of applications that use its unique chemical and physical properties. However, since hydrogen is a highly hazardous material, its storage and supply are highly regulated. The storage of large amounts of hydrogen requires a lot of site space as well. For flat glass and metal manufacturers who need a safe, reliable, and continuous supply of pure hydrogen in large quantities, this can be extremely costly.


<h2>Increase the reliability of hydrogen supply</h2>
Decentralized hydrogen production results in a more reliable, cost-effective, and safer alternative to traditional hydrogen supply by tube trailers. For this reason, HyGear has designed Hy.GEN-E on-site hydrogen generation systems varying from 1000 Nm3/h down to 10 Nm3/h, making them highly suitable for hydrogen filling stations and industrial sites.

The Hy.GEN-E on-site hydrogen generation system uses Steam Methane Reforming and alkaline electrolysis to convert natural gas into hydrogen. The system works by first feeding pre-treated water into the lye tank, and sending it to the electrolyzer. The electrolyzer then uses electric power to split water into oxygen and hydrogen gas. Lastly, oxygen and hydrogen gas enter the oxygen separator and hydrogen separator, respectively, where the lye pump separates the lye from the gases and recycles it back into the electrolyzer.

Using a specially designed material and bipolar pressurization technology, the electrolyzer prevents leakage during operation. This results in higher system efficiency reduced maintenance costs and longer life.

It’s further designed with Temperature Swing Adsorption technology, enabling it to operate under a 15 bar(g) pressure without the use of a compressor. The TSA is also designed with three hydrogen adsorbers to ensure continuous and steady removal of moisture from recirculated hydrogen. Lastly, a special activation process in the electrolyzer ensures higher efficiency with relatively lower power consumption.

These systems are containerized to reduce the floor space needed, making them ideal for flat glass industries, metal industries, chemical industries, food industries, and semiconductor industries.

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Plug & play water to hydrogen generator

Around a third of your natural protein composition is collagen. But the human body still finds good use for more of it, whether to reinforce joints or aid digestion. Collagen powder processing breaks the chains of amino acids into smaller units, allowing them to be consumed at higher concentrations without changing your diet.

Collagen powder

The body produces earwax to protect the ear canal from microbial growth. But no one wants too much protection of this kind. Thankfully, simple solutions are available over the counter to medicate excess cerumen. Besides wax removal, eardrops and OTIC manufacturing provides an effective delivery technique to treat infections or administer anesthetic.

Eardrops

Originally created to supply US soldiers with vitamin C in World War II, fruit concentrate has found many other uses. Whether you want to drink soda or eat gummy bears, you need fruit concentrate for the color and flavor. The fruit concentrate processing line involves fruit peelers, conveyor belts, filters, and evaporators that help producers make fruit concentrate with all of the fruit’s original aroma.

Fruit concentrate

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Kombucha is a fermented drink made out of sweetened black or green tea. This slightly fizzy, sweet, and sour beverage has recently gained popularity for its health benefits. The main step in the kombucha making process is fermentation. Add the symbiotic culture of bacteria and yeast known as SCOBY at the base of the sweetened black or green tea to set off this reaction. The rest is up to your creativity. Enhance your kombucha with artificial or natural additives depending on the flavor you want to achieve.

Kombucha

Mineral water is mother nature’s cocktail of dissolved solids. The concentration of essential chemicals in the water makes it an excellent source of nutrients and electrolytes. Although your bottled product retains most of the properties present at its natural condition, the water still needs some help before it can be safely consumed.

Mineral water

Pectin plays a pivotal role in the creation of various culinary delights, especially gummies and jellies. Unlike its animal-derived counterpart gelatin, pectin provides a vegan-friendly alternative that still achieves the desired consistency and texture. Derived from fruits such as apples and citrus peels, pectin is a natural thickening agent. This versatile substance isn't limited to just gummies or jellies; you can use it in a wide array of recipes, from jams to fruit preserves.

Pectin

Plant waste

It took the scientific community almost 70 years to agree on the name ‘protein’ and discard the popular alternative, proteid. But protein powder processing still needed another five decades to be commercialized in the 1950s. Once extraction and purification could be industrialized, protein powder soon became a basic staple supplement.

Protein powder

The inventor of the lithium-ion battery predicted that solid-state batteries would become commercially available by the mid-2020s, making them an attractive option for energy storage in a wide range of applications, including electric vehicles. This battery type promises a marked improvement in safety, power, and environmental impact compared to current battery packs that use a liquid electrolyte. However, recent breakthroughs in the lab don’t automatically translate into mass production. The complex processing requires specially-designed manufacturing technology to make solid-state batteries a real solution, especially for the automotive industry.

Solid-state batteries

In Ancient Egypt, starch production was used mainly for coating and gluing the papyrus sheets. Today, the paper industry still uses the same technique even if starch processing equipment has changed immensely. But besides shiny reams, starch has a fundamental place in the food and beverages industry.

Starch

Straw

Sugar is the fuel that drives photosynthesis in plants. The leafy organisms constantly convert water and carbon dioxide into glucose. But it takes manufacturers specialized sugar processing technology to extract the sweet crystals from them. Today, most sugar products are derived either from sugarcane or sugar beet.

Sugar

Sulphur

Tea tree oil, also known as melaleuca oil, is an essential oil with immune system stimulants produced mainly in Australia. The tea tree oil manufacturing process starts from the leaves of Melaleuca alternifolia. In terms of market value, the one for tea tree oil was valued at 38.8 million USD last 2017 and is projected to increase to 59.5 million USD by 2025.

Tea tree oil

The cannabis industry is one of the fastest growing in the world with a revenue of $20.47 billion in 2020 which is expected to soar up to $197.74 billion in 2028. The famous cannabis substance that causes marijuana's psychological effects is THC and it was first isolated in 1964. There are two methods of extracting THC from cannabis: solvent-based and non-solvent extraction. Each technique requires different THC oil extraction equipment.

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Wastewater

If you've ever heard the acronym WFI spoken, know that we're not talking about wireless technology to connect your computer. WFI stands for water for injection, a sterile water used as a solvent to dilute other solutions for injections to the body. Traditionally, WFI was only produced through the distillation process using water for injection equipment until other methods such as reverse osmosis, electrodeionization, and ultrafiltration were developed.

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Water for injection

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