Cell culture bioreactor for mabs and vaccines
In the field of biopharmaceutical manufacturing, scaling up production from research to clinical trial stages poses significant challenges. Achieving consistent cell growth and product yield while maintaining the integrity of monoclonal antibodies (mAbs) and vaccines requires precise control of various parameters.
Optimize cell growth and product yield
The Sartorius cell culture bioreactors range supports diverse bioprocessing needs from early-stage research to large-scale cGMP production. These bioreactors are designed to handle batch, fed-batch, and continuous processing of various cell lines. Key features include advanced control systems for online glucose and lactate measurement, off-gas monitoring, and viable biomass cell density measurement. The use of Flexsafe® polyethylene film in bioprocessing bags ensures robustness and compliance, making these bioreactors suitable for critical applications like regenerative medicine. They offer seamless scale-up from benchtop units to large pilot systems, maintaining process consistency and efficiency. Sartorius also provides specific solutions such as the Ambr® 15 and Ambr® 250 for high throughput clone screening and process optimization, as well as the Biostat® STR single-use bioreactors, known for their classic stirred-tank design.
Benefits
- Supports a variety of cell lines and processes
- Advanced monitoring and control systems
- Seamless scalability from research to production
- Compliance with regulatory standards
- Robust and reliable single-use materials