Cell culture bioreactor for mabs and vaccines
Optimize your biopharmaceutical production with advanced cell culture capabilities, ensuring rapid scale-up from R&D to cGMP manufacturing for critical therapies like vaccines and monoclonal antibodies.
Facilitates Scalable Cell Culture Processes
The Ambr® 15 Cell Culture Bioreactor System from Sartorius is tailored for streamlined R&D and biopharmaceutical manufacturing. It employs high-throughput parallel processing, optimizing cell culture development through a reproducible scale-down format. Ideal for producing monoclonal antibodies and vaccines, it supports batch, fed-batch, and perfusion modes. With a capacity to efficiently handle multiple cell lines, it’s PLC-controlled for seamless integration into existing workflows. The system’s Flexsafe® RM bags ensure robust single-use operations, made from chemically resistant polyethylene film. Compliance with industry standards makes it suitable for GMP environments. Maintenance is simplified with integrated systems for automated validation and cleaning. Customization options, including modular expansion, offer engineering support tailored to specific project needs.
Benefits
- Enhances scalability with high-throughput, parallel processing capabilities.
- Minimizes time-to-market through efficient, reproducible cell culture development.
- Lowers operational costs with single-use, maintenance-free components.
- Ensures process reliability in GMP settings with robust compliance and validation systems.
- Reduces resource consumption with optimized energy and material usage.
- Applications
- Vaccines,Monoclonal antibodies,Biosimilars,Biopharmaceuticals,Cell and gene therapy,Recombinant proteins
- End products
- Gardasil,Avastin,Pfizer-biontech covid-19 vaccine,Neupogen,Aduhelm,Zynteglo,Bevacizumab biosimilar,Luxturna,Moderna covid-19 vaccine,Rituximab,Trastuzumab biosimilar,Cervarix,Epogen,Herceptin,Humira
- Steps before
- Clone selection,Process optimization,Media preparation,Buffer preparation
- Steps after
- Process modeling and control,Analytical measurement,Purification,Sterile filtration
- Input ingredients
- cell lines,media,buffers,reagents,microcarriers,plasmids,recombinant human albumin,growth factors,cytokines,buffer solutions
- Output ingredients
- monoclonal antibodies (mAbs),vaccines,recombinant proteins,biosimilar molecules,cell density,biomass
- Market info
- Sartorius AG is renowned for manufacturing high-precision laboratory and bioprocess equipment. They specialize in filtration, fermentation, and cell cultivation systems, known for their innovation and reliability in the pharmaceutical and biotech industries.
- Bioreactor Type
- Single-use / Multi-parallel / Stainless Steel
- Cell Culture Process Type
- Batch / Fed-batch / Perfusion
- Scale
- R,D / Pilot / cGMP Manufacture
- Volume Range
- 1 L to 200 L
- Automation
- Reproducible Scale-Down
- Measurement Capabilities
- Online Glucose,Lactate,Off-gas,Viable Biomass
- Film Type
- Polyethylene Film (Flexsafe®)
- Mixing Capability
- Low Shear / Specialist Mixing
- Microcarrier Use
- Suspension / Adherent Cultures
- Design
- Classic Stirred-Tank
- Disposability
- Single-use / Autoclavable / In-situ Sterilizable
- Predictive Process Modeling
- Available
- Rocking Motion
- Up to 200 L
- Working mechanism
- Stirred-tank,rocking motion
- Batch vs. continuous operation
- Batch,fed-batch,perfusion
- Automation level
- Manual / PLC / SCADA
- CIP/SIP
- Single-use,autoclavable,in-situ sterilizable
- Scale conversion
- Seamless
- Mixing capabilities
- Low shear,specialist mixing
- Compliance,material
- Single-use,polyethylene film
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Compact footprint
- Specialist mixing capabilities
- System type
- Single-use,autoclavable,in-situ sterilizable
- Control panel type
- Advanced analytical capabilities
- Bioreactor volume range
- 15 ml to 200 L (Ambr® systems)
- Discharge method
- Seamless scale conversion to single-use or stainless steel
- Control panel type
- Touchscreen / HMI display
- Integration possibilities
- SCADA / PLC systems
- Bioreactor system configurations
- Single-use / Stainless Steel / Modular
- Scale flexibility
- Micro to Large Scale Transfer
- Mixing strategies
- Stirred-tank / Rocking motion