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Biotech Equipment

A bioreactor is an engineered system designed to support, automate and control a biologically active environment. The volume of the reactor, suitability for photosynthesizing organisms, level of scalability and control, and the type of installed sensors are all important considerations when choosing bioreactor equipment. Bioreactors are typically used for biomass such as cell culture, microbial culture, biopharmaceutical, and chemical development processes. They are also used for photosynthesizing commercial organisms such as algae and bacteria and fermentation applications.

Bioreactor systems

Sampling is the process of aseptically drawing a sample from the process for analysis, without disturbing the bioprocess itself. The bioprocess needs to be carefully controlled by measuring important process variables and parameters. These parameters include pH, temperature, dissolved oxygen, foam/level, and agitation. The controllers use PID or auto-tuning adaptive control to measure and regulate the process parameters. The choice of a suitable controller depends on the identification of critical process variables.

Biotech sampling and control

High-pressure homogenizers are used in bio-pharmacy applications to obtain intracellular components like enzymes and proteins from bacteria, fungi, and animal cells through cell rupture. They are also used in other biotech processes such as the production of nanoparticles for tissue engineering and in the development of new drugs, vaccines, antibiotics, and chemicals. The choice of a high-pressure homogenizer depends on the mixture to be processed, desired particle size distribution, and the type of force to be applied to the particles.

High pressure homogenizers

Monolithic columns allow fast, efficient, and reproducible separation of biomolecules such as proteins, plasmid DNA, antibodies, and viral particles, from samples taken at various stages during a bioprocess. Choosing a monolithic column involves considering the desired column volume and length, the flow rate through the column, construction of the housing, and interface to the HPLC equipment. Monolithic columns are used in the pharmaceutical process development for reaction monitoring, column fraction screening, and analysis of mother liquors and unstable analytes.

Monolithic columns

Single-use technologies are increasingly being used in the biotech industry due to lower costs, lower risk of cross-contamination, flexibility, and convenience. A single-use bioreactor uses disposable bags instead of a culture vessel to carry out the bioprocess. Using disposable bags, instead of reusable bioreactors, can help reduce the setup time and the time between production cycles. It also reduces sterilization demands for vessel reuse, leading to significant cost savings. In addition to single-use bags, single-use sensors are also employed for efficient and low-cost bioprocessing. Single-use applications are especially suitable for the production of biopharmaceutical products.

Single use systems

Chromatography systems

single-use-bioreactor-2

Single-use-bioreactor

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Healthcare products are goods or services used to improve, maintain or prevent the deterioration of health or ease the consequences of illness. Healthcare products include a wide range of goods, from hospital clothing, over plasters, wound care products and diagnostic devices. These products must be clean and contamination-free, which is achieved with strictly regulated healthcare equipment.

Healthcare products

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Batch

Especially designed for cell culture applications and research applications such as process optimization, screening studies, product optimization, scale up/scale down studies and for educational programs.


<h2>Easy to handle autoclavable glass bioreactor</h2>
Getinge Applikon offers glass autoclavable bioreactors for cell culture applications. The system is built according to the specific demands of a process using an extensive array of standard components. Because of the modularity and flexibility the user can always adapt the system to changed process demands. This results in low initial investment and low running costs. Available in 1, 2, 3, 5, 7, 15 and 20 liter volumes.

Autoclavable glass bioreactor

Biotech

liquid

For cell culture and microbial culture applications.


<h2>Adapt your systems to changed process demands</h2>
The Bio Clave from Getinge Applikon is an autoclavable stainless steel bioreactor which is versatile and easy to use system; offering economical alternatives to steam-in-place bioreactors and fermenters. The Bio Clave range combines the advantages of both, the steam-in place bioreactor (robust design and pressurizable) and the glass autoclavable bioreactors (flexibility and modularity).

Available in 20, 70 and 110 liter volumes. All systems are equipped with a top driven stirrer which can be either a magnetically coupled or a lipsealed stirrer system.

Autoclavable stainless steel bioreactor

The fermentation process stimulates enzymatic activity in organic substrates to transform their chemical composition. Fermentation is aided by storying the biomaterials in anaerobic environments, allowing the microorganisms to decompose their nutrient structures. The process is integral to some of the most popular products throughout time such as wine, beer, cheese, and kimchi. But besides the food sector, fermentation is also an important stage in the industrial manufacturing of chemicals, pharmaceuticals, and biofuels.

Fermentation

SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth applications. A photobioreactor with SSL light is especially suitable for plant growth applications in the laboratory scale and all photosynthesizing commercial organisms such as algae and bacteria.


<h2>Economical set-up for cultivating photosynthesizing organisms</h2>
Using Solid state lamps (SSL), Getinge Applikon has developed a light panel that can be used as add-on modules that are compatible with standard stirred tank and single-use bioreactors from Getinge Applikon. This Photobioreactor for Plant Growth, offers maximum flexibility and economical set-up for the cultivation of photosynthesizing organisms. The volume range covers 3 liters up to 20 liters autoclavable stirred tank bioreactors and 10 up to 50 litters single use bioreactors.

Photobioreactor for plant growth

Success with bioprocesses is all about controlling the environmental conditions controls so you can replicate processes consistently. Good insight and easy adjustment of pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation are crucial for any biopharmaceutical process.


<h2>Easy to use control for lab scale operation</h2>
The ez2-Control from Getinge Applikon is an easy to use control and measurement system for bioreactors and fermentors. The bioreactor control system offers high accuracy, a good insight and easy adjustment of pH, Temperature, dissolved Oxygen, Foam/Level and Agitation, which are crucial for any biopharmaceutical process.

The colour touch screen interface guides the user through the operation.  The adaptive control features allow the user to focus on the process while the controller keeps tight control on the important process parameters.

The new web-interface for ez2-Control with advanced user management option provides a clear overview of the bioprocess parameters. Also it allows back-ups, copies and predefined settings of configurations to be simply shared via USB.

The ez2-Control can be used to control a large variety of reaction environments: From autoclavable bioreactors, steam in place bioreactors, to Appliflex single use bioreactors, milipore Cell Ready single use bioreactors or HyClone SUB bioreactors.

Lab scale Bioreactor controller

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

When you are working with small bioreactors, starting from 50 ml volumes, you need a good insight and an easy adjustment of pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation.


<h2>Control system for small-scale bioreactors</h2>
MyControl from Getinge Applikon is the most advanced controller available for small-scale bioreactors, compatible with bioreactors ranging from 50 mL to 2,700 mL (working volume), and is easily convertible between microbial and cell culture configurations.

The built-in software interface allows you to access with a web browser via computer, tablet or smartphone, so you can manage your entire laboratory with ease.

It is pre-configured and ready to use. Adding additional control loops, sensors, actuators, or external I/O is also fast and easy, so you will receive a system that meets your exact process specifications! Moreover, it is modular, so you can change your configuration options in the future as your experimental objectives.

One control system can control: 250 ml up to 1000 ml MiniBio bioreactors, 1L up to 3 liter Autoclavable bioreactors, 3 liter Cellready single use bioreactors.

Small-scale bioreactor controller

When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot and production scale; a scalable can come to represent a compelling solution to have. The required system has to allow a large number of inputs and outputs, synoptic displays, trending screens, alarms and much more.


<h2>Pilot scale to production bioreactor control system</h2>
Getinge Applikon i-Control is an easy-to-operate Scalable bioreactor controller and utility console. This scalable control solution is used to control processes in bioreactor systems from laboratory scale to pilot plant and production scale. The i-control from Getinge Applikon is a human interface color touch screen device used to control the most important parameters at a laboratory scale scenery.

The seamless scale-ability saves time and money by offering a simple scale-up of a control strategy from research via pilot-plant to production. The simplicity of operation is one of the key features, allowing operation by cell biologists, and configurations to get adapted to changing process demands without the need of an engineer on-site.

Scalable bioreactor controller

Scaling-up from a laboratory scale to pilot plant and small scale production can be simplified with a consistent bioreactor design and the scalable control solutions. Depending on your desired output, you can choose between a bench scale or pilot plant systems.


<h2>Scale up with consistent bioreactor design</h2>
Getinge Applikon’s concept of modularity (using standard modules to customize the functions of the bioreactor) is extended to the stainless steel pilot plant bioreactors as well. For scaling-up purposes the range of the Bio Bench and Pilot Systems, designed and built to the latest standards on hygienic processing and CGMP and GAMP validation requirements, complements the laboratory-scale bioreactor systems.

Getinge Applikon offers CIP systems ranging from fully manual control to fully automated. The Standardized Steam-in-place bioreactor systems are available with approximately 140-liters volume and custom-built units can be supplied up to 2,000 liters total volume.

Steam-in-place bioreactor systems

When a screening study takes place, optimizing media process and working with microbial and cell cultures is quite common. Working with small volumes reduces media costs, which in consequence maximizes bench space and such factor would normally be considered a premium benefit.


<h2>Considerably small, real bioreactors</h2>
The MiniBio from Getinge Applikon is a range of bioreactors (250 ml, 500 ml and 1000 ml total volume) is a true scale down of the laboratory scale bioreactors in the 1 to 15-liter range. The Mini bioreactors systems have the same flexibility as the laboratory scale bioreactors, which means that the MiniBio systems can be customized to fit the demands of any process.

Mini bioreactors

A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, containing fewer parts compared with conventional bioreactors, so the initial purchasing and maintenance costs in the R+D process are reduced.


<h2>Rocking Single-Use Bioreactors from 10 up to 50 liter volume</h2>
The Single-use bioreactor Appliflex, from Getinge Applikon is a flexible bag bioreactor ideal for cell culture, specially the growth of animal cells like CHO cells, Hybridoma cell lines and insect cells like Sf-9, Sf-21 cells, also excellent working for the seeding of pre-seeding for larger cell cultivation systems.

Offering reliable measurement and control in rocking Single-Use Bioreactors from 10 up to 50-liter volume. The bag and sensors (pH, dissolved oxygen, T) are designed for single-use, in compliance with CE guidelines.

The control system (pH, DO, T, rpm) is formed by the standard Getinge Applikon ez-Control, which guarantees real-time measurement of pH, DO, T and rocking speed.

Single-use bioreactor Appliflex

A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture of cells, instead of a glass culture vessel, containing fewer parts compared with conventional bioreactors, this way the initial purchasing and maintenance costs are reduced.


<h2>3 liter single-use stirred tank bioreactor</h2>
The Single-use bioreactor CellReady 3L, from Getinge Applikon is a stirred tank bioreactor platform that works by eliminating the cleaning process, it is disposable, autoclave and assembles your traditional glass bioreactors, saving you downtime days, which sometimes represent quite a setback at the initial scale-up stage, due to the limited data available.

This Single-use bioreactor CellReady 3L, allows you to focus on experimentation and data analysis, getting you to faster conclusions.

The control system is formed by the standard Getinge Applikon ez-Controller, configured for a cell culture application, it measures and controls pH, temperature and dissolved oxygen (DO).

Single-use bioreactor CellReady 3L

A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead of a glass culture vessel, containing fewer parts compared with conventional bioreactors, so the initial purchasing and maintenance costs are reduced.


<h2>Bioreactor vessel with single-use contact surfaces for mixing</h2>
Getinge Applikon is an authorized integrator for the HyClone S.U.B. bioreactors. The Hyclone is a fully functional and unique tank bioreactor mixing system which provides overhead mixing while maintaining sterility and integrity. A re-usable outer support container also provides a mixer motor, heating/cooling, control unit for integration with an external control system and a mobile skid.

This bioreactor operating system enables to set-up and the application of your processes in a reduced time-to-market, going from R+D to production in the shortest time.

The main features of this unique equipment are scalability, for both larger and smaller volume systems for research and process development; alternative Sparging, the product is also supplied with an open pipe and (optional) micro porous “frit”.

Single-use Non-invasive Sensors, like the ez-Control is capable of measuring both classical sensors for pH and Dissolved Oxygen as well as Fluorophore type sensors.

The combination of ez-Control and HyClone S.U.B. offers the advantages of Single-Use Processing.

Single use bioreactor Hyclone

Manufacturers in the bioprocessing industries are increasingly turning to single-use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high-quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value-added tasks.


<h2>A disposable 3D bag for production bioprocess containment manufactured in strict cleanroom conditions</h2>
JM BioConnect is known for certified top of industry quality and customer service, including very short lead times. The company's disposable 3D bags use a film specifically developed by JM BioConnect to meet the needs of bio processors from laboratory to production plant scale.  The film, known as JMS Flex Film, is manufactured to the highest quality standards and has the highest clarity of any film used for bag manufacture.  It is manufactured under laminar flow conditions in the class 7 cleanroom.  The 3D bags are available in sizes from 50L to 3.500 L and include a completely inert polyethylene fluid contact layer.  They are resistant to damage caused by gamma sterilization, have very low oxygen permeability (.1cc/sqrM.bar.day), and are unsurpassed in clarity and flexibility.

3D disposable bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to disposable solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high-quality, single-use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value-added tasks.


<h2>A complete manifold system composed of  single-use components of the highest quality</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company's disposable tubing and containment solutions can be combined into complete manifold systems accommodating an entire upstream or downstream bioprocess.  The modular and interchangeable design of the disposable units including tubing, connectors, and bags, allow several bags to be connected to one another and to other supporting equipment such as pumps and filters according to the customer's needs.   These systems can be scaled from lab and pilot to full production plant needs.  All components used in the single-use manifold systems are fully compliant with cGMP regulations as well as 21CFR part 11.  They meet USP class 6 standards and are completely free from any animal-derived material.

Disposable manifold bags for bioprocesses

Bio-processors require reliable, high quality, easy to maintain, filtration equipment to ensure efficient processing and high-quality outputs. Selecting the right supporting equipment like filters and tubing eliminates potential variables that can make your upstream or downstream bioprocess unpredictable, and hinder production with high maintenance demand.


<h2>Modular filter sets with tubing and connections ready for integration into your bioprocess manifold system</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers filter sets that provide conveniently bundled filter housings, high-quality tube, and connectors in one package that is easy to install in your manifold system.  A wide variety of sizes and filter media options are available. The set is configured with the correct hose size and fitting style at the time of order so it is immediately ready for integration into your manifold system upon arrival. These Normal flow filtration sets for bioprocesses will prove to be a valuable acquisition.

Normal flow filtration sets for bioprocesses

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

Bioprocessors must use ingredients of known high quality and consistency.  Inconsistent or poor quality raw materials are often the cause of inefficient or failed processes.  Separation of mixtures of liquids with different densities or settling of liquids with suspended solids during storage or transport is often the cause of varying raw material quality and associated process issues.


<h2>A disposable vessel for liquids with an integrated, magnetically actuated, mixing pump for homogenizing contained liquids</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company's Jetmixer single use mixing system consists of a reusable mixing machine with a motor and magnetic power coupling and a single use bags with integrated mixing pumps.  When the bags are placed in the mixing machine, the pumps are acted on  by the magnetic power coupling and rotation is induced inside the bag without the need to open it.  The pumps draw fluid in vertically from the center of the bag and expel it horizontally along the bottom.  This sets up a current that continually sweeps the entire volume of the bag and mixes all the contained fluid.

Disposable mixer bags for bioprocesses

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>A disposable pillow bag for bioprocess containment manufactured in strict clean room conditions</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company's pillow bags use a film specifically developed by JM BioConnect to meet the needs of bioprocessors from laboratory to production plant scale.  The film, known as JMS Flex Film is manufactured to the highest quality standards and has the highest clarity of any film used for bag manufacture.  It is manufactured under laminar flow conditions in a class 7 clean room.  The pillow bags are available in sizes from 50mL to 50L and include a completely inert polyethylene fluid contact layer.  They are resistant to damage caused by gamma sterilization, have very low oxygen permeability (.1cc/sqrM.bar.day), and are unsurpassed in clarity and flexibility.

Disposable pillow bags for bioprocesses

Sensitive bioprocess applications requires equipment that will not interfere with the chemical and biological processes being carried out.  At the same time, production bioprocesses, in particular those that involve peristaltic pumping, require robust tubing not prone to wear or mechanical failures.  Traditional transfer tubing for these more rigorous ans sensitive bioprocesses often proves inadequate.


<h2>A robust biocompatible tube designed for longevity in production peristaltic pumping applications</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers tubing solutions specifically designed for use in peristaltic pumps in bioprocess production environments. The tubes are of the PharMed BPT brand and are completely bio-compatible and less permeable to gasses and vapors than traditional silicone tubes.  This makes the PharMed BPT tubes ideal for protecting sensitive biological processes like cell culture, fermentation, separation, synthesis, and purification.  At the same time, they have been formulated for enhanced flex and wear characteristics allowing trouble free used in peristaltic pumping applications.  The combination of these qualities increases the efficiency of the bio-production process by reducing down time from tubing failure without making any sacrifices in bio compatibility.

Biocompatible tubing for peristaltic pumps

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Manufactueres in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>High quality pre-assembled tubing splitters for convenient addition to your fluid transfer or manifold system</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The Company provides a line of pre-assembed high quality fluid transfer tubes for bioprocesses that is ready for integration into your system.  The Y-sets split one tubing line into to and are frequently used for connecting several single use bags together with supporting equipment making a manifold for an upstream or downstream bioprocess.  A wide variety of sizes and fitting styles is available.  Use of the pre-assembled Y-sets improves efficiency by avoiding the need to stock, track, and manually assemble a high number of smaller fittings and raw tube that make up the Y-set.  Maintenance time in your system will also be improved as damaged or worn sets can be replaced as a whole using the ready-made tube connections.

Y sets tubing for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs. Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>Disposable tubing manufactured under strict clean room and quality standards</h2>
JM BioConnect is known for top of industry certified quality and customer service including very short lead times. The company has developed a unique thermoplastic tubing known as Solmed TubeFelx 4502.  This tubing is made from TPE--the cleanest biologically compatible material and is manufactured in a completely controlled clean room environment.  It contains no animal derived ingredients or oils.  This tubing is weldable by all commercial tubing welders and sealers and can be sterilized by autoclave, gamma radiation, UV, and ETO processes.  It is suitable for use with peristaltic pumps and rated for pressure up to 3 bar.  The tubing is designed to be used to in conjunction with various other JM Bioconnect products to create process manifolds for both upstream and downstream bioprocesses.

Disposable tubing for manifolds in bioprocesses

Single use bags for biopharmaceutical process containment and liquid storage are being used with increasing frequency in the industry due to their convenience, efficiency, and inherent cleanliness.  Integration of single use bags into biopharmaceutical processes is a great way to reduce required maintenance, and improve the versatility of equipment without increasing risk of cross contamination.
<h2>A mobile, vertical bag holder with integrated scale compatible with bags from any manufacturer</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s WeighStation system is a wheeled bag stand that works with single use bags from any manufacturer.  The system includes integrated load cells and local display which allow it to be used as a stand-alone scale or to be integrated into other Scilog processing platforms for metered dispensing and purification.  The system has a minimized footprint and superior mobility when compared to a traditional floor scale.  The mobility and use of single use bags allow this piece of equipment to support several processes in your facility rather than being dedicated to just one.

Bag holder and weighing platform for bioprocesses

Weighing

Biopharmaceutical manufacturers require precisely known liquid quantities for testing and process development but time spent measuring and dispensing liquids in the laboratory is expensive and adds no value to the final product.  Use of an automated system for accurately dispensing liquids saves time and labor allowing laboratory personnel to focus on value added tasks.
<h2>High precision, high accuracy automated liquid dispensing with the touch of a button</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s LabTec system is an automated liquid dispensing system allowing up to 10 user defined dispensing volumes to be established and accurately repeated at the touch of a button.  Accuracy is improved while laboratory technician’s time is saved by avoiding the need to repeatedly measure liquid amounts.  Accuracy of better than 1% is typically achieved.  The system can dispense by volume, or when connected to an electronic balance, by weight and weight ratio.  Dispensing by weight provides enhanced accuracy while dispensing by weight ratio saves even more labor by automatically dispensing the correct amount of fluid based on the weight of substance already in the vessel.  In this way, accurate dilutions can be made without the technician having to carefully measure either substance.  A roughly measured sample of one substance is added to the vessel and the correct amount of diluent is automatically dispensed based on the user defined required weight ratio.  When used with the SciDoc Documentation system the LabTec also compiles, displays and documents up to 10 process parameters providing real-time information about the dispensing progress and status.

Automated dispensing system for bioprocesses

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

To purify a specific large biomolecule, for example IgM or a virus or virus-like particle, the first step is to screen the working conditions. Different mobile phases and column chemistries are then tested, according to the biochemical properties of that particular large molecule.
<h2>Efficiently identify, isolate and recover large biomolecules</h2>
The CIMmultus™ Purification Screening Kit from BIA Separations is intended to help scientists quickly discover the optimal stationary phase chemistry for their particular application.

The kit includes two different 1mL CIMmultus™ ion-exchange columns (QA and SO3) and one hydrophobic interaction chemistry column (OH).

By using one of the selected chemistries and applying proper working conditions, the user will be able to discover the combination that will result in appropriate purity and excellent recovery of their required large biomolecule.

Purification screening kit for large biomolecules

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

When undertaking a screening study, process development or optimisation study, you can speed up your project by growing and controlling multiple small cultures simultaneously. If time and reproducibility are critical for your project, you may consider investing in technology that will help you increase your efficiency in time and costs.


<h2>Independently control up to 24 bioreactors with one system</h2>
The Micro-matrix from Getinge Applikon is an high throughput fermentation and cell culture device which allows easy operation of 24 bioreactors in parallel. The micro-Matrix comes on a simple microtiter plate footprint, allowing independent control and measurements of the following:
<ul>
 	<li>pH,</li>
 	<li>temperature,</li>
 	<li>dissolved oxygen control, individually controlled by up to 4 separate gas additions, and</li>
 	<li>individual liquid additions.</li>
</ul>
The bioreactors are a true scale down of small scale bioreactors, giving all the functionality of their larger counterparts in a space-saving format. The accompanying software allows for simple comparisons of experimental cultures, and advanced controls such as time- and event-based control actions. The volume per bioreactor is 10ml (recommended working volume is 5ml).

&nbsp;

24 fully controlled bioreactors in a microtiter format

Continuous

<span style="font-weight: 400;">An accurate, automated sampling of cultures is a key requirement in the development of biopharmaceuticals. For automated sampling across a larger number of bioreactors, a robust and reliable automated system is needed to accurately transfer bioprocess samples directly to a range of analytical devices while maintaining the highest levels of sterility. For medium-scale operations, a cost-effective and efficient system is required to improve process performance.</span>
<h2>Automated multiple bioreactor sampling</h2>
<span style="font-weight: 400;">The Flownamics Seg-Flow 4800 is a fully automated online sampling solution for up to 8 bioreactor vessels. Using unique FISP cell-free sampling probes, the Seg-Flow can deliver accurate samples to up to 4 analyzers.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">Rapid and accurate sampling is available for user-defined sample sizes from as little as 250 to 15 ml.</span>

<span style="font-weight: 400;">The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.</span>

<span style="font-weight: 400;">The Seg-Flow features a single-use fluid path from the vessel to the analyzer to reduce operating and maintenance costs. The sample line is automatically cleaned or sterilized after each sample. The user-friendly operating system means minimal training is required, and setup is straightforward.</span>

<span style="font-weight: 400;">The Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.</span>

Automatic sampling system for bioprocess monitoring

Industrial sampling equipment are systems that allow manufacturers to test (in other words to take a sample of) the products they are manufacturing. This process is generally implemented as a means of quality control but it can also be used as a mean to ensure that production processes adhere to certain regulatory standards. Quality control in your manufacturing process starts with precision sampling techniques. Automated systems deliver consistent samples at a pre-set rate for accurate testing and probing. Sampling technology uses a calibration system involving a series of sensors to extract the material at high levels of reliability.

Sampling

<span style="font-weight: 400;">Accurate sampling is vital for improving a wide variety of industrial, chemical, and biofuel processes. A sampling solution that provides  24/7 automated, real-time analyte monitoring, fraction collection, feed control, and data processing will allow increased process performance and development to maximize performance.</span>
<h2>Automated sampling for up to eight vessels</h2>
<span style="font-weight: 400;">The Flownamics Seg-Flow 8000i is a fully automated online sampling system that offers multiple process monitoring and control solutions designed for biofuel, chemical or industrial processes.</span>

<span style="font-weight: 400;">The Seg-Flow’s patented segmented online sampling technology means rapid and accurate sampling for up to 8 vessels and sample delivery to up to 4 analyzers and/or fraction collectors. It uses a chemically inert fluid path with automated cleaning or sterilizing after each sample. </span><span style="font-weight: 400;">A number of feed control options are available for maximum flexibility, and the Seg-Flow 8000i can control up to 2 pumps per vessel.</span>

<span style="font-weight: 400;">The 8000i is scaled independent and can be used with laboratory, pilot, or production vessels. It utilizes the unique FISP in-situ sampling probe, which provides an aseptic barrier between the vessel and the Seg-Flow system. </span><span style="font-weight: 400;">The Seg-Flow features a built-in touchscreen HMI, providing control over many samples and feed options. The easy-to-use system requires minimal training and allows parameters to be programmed within minutes.</span>

<span style="font-weight: 400;">The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.</span>

<span style="font-weight: 400;">Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.</span>

Online sampling system for larger scale bioprocesses

<span style="font-weight: 400;">Many bioprocesses require offline analysis of samples to monitor development and optimize performance. By using an automated fraction collector, the collection process can be accelerated and delivered with increased accuracy. Compatibility with automated reactor samplers is vital.</span>
<h2>Collect fractions from reactor vessels automatically</h2>
<span style="font-weight: 400;">The Flownamics FlowFraction is used in conjunction with the Flownamics Seg-Flow sampling systems. It allows the online collection of fractions from up to eight reactor vessels for further offline analysis of a range of bioprocesses.</span>

<span style="font-weight: 400;">The FlowFraction system is customizable to accommodate various tube types and sizes and can sample volumes from 250 µl to 50 ml. An added benefit is that vials can be equipped with a septum as a piercing option is available. For storage, racks in a range of standard sizes can be shipped with the FlowFraction, but custom rack sizes can also be produced to meet exact requirements.</span>

<span style="font-weight: 400;">A range of advanced options can be specified to meet your requirements perfectly, including temperature control modules featuring Peltier or water-based cooling systems. Using the options Seg-Flow Sample module, sample dilutions, and reagent additions can be performed before vial deposits.</span>

<span style="font-weight: 400;">Thanks to the included Flownamics WebFlow software, the interface allows easy control and data capture with minimal operator training. Maintenance time is reduced thanks to all internal fluid paths being self-cleaned after each sample.</span>

Online fraction collector for offline bioprocess analysis

<span style="font-weight: 400;">In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, and improve processes. This needs to be done in aseptic conditions. The risk of contaminating either the test sample or the reactor can be eliminated by using a dedicated sampling probe designed to operate with the range of sample ports in use across all scales of production.</span>
<h2>Risk-free sampling for use with bioreactor top ports</h2>
<span style="font-weight: 400;">The Flownamics FISP F-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 12mm or 19mm top ports from lab scale up to production.</span>

<span style="font-weight: 400;">FISP is a sterilizable 316 stainless steel carrier that is surrounded by a tubular, microporous membrane.</span>

<span style="font-weight: 400;">FISP has been designed to withstand the temperatures, pressures, and chemicals found in fermentation environments and is perfect for aerobic or anaerobic bacteria, yeast, fungi, algae, insect, and mammalian cell cultures. Its design provides risk-free sampling thanks to a sterile barrier provided by its 0.2-micron filter. It offers the flexibility of being able to be used for submerged feeding or adding sterile media.</span>

<span style="font-weight: 400;">Compatible with Clean in Place (CIP), Sterilize in Place (SIP), and autoclaving, the FISP is easy to maintain and intuitive to use, with no specialist training required.</span>

<span style="font-weight: 400;">The FISP has been developed to work seamlessly with the Flownamics Seg-Flow range of automated samplers for use in fully automated test scenarios.</span>

Sampling probe for bioreactor samples

Accurate sampling is a critical tool in the design and improvement of a large range of pharmaceutical bioprocesses. For maximum performance you need a robust and highly accurate automated sampling solution that delivers samples to your analysers 24/7 in real-time and can integrate with a large range of instrumentation.
<h2>Automated on-line sampler with increased reliability and ease of use</h2>
The Seg-Flow S3 from Flownamics is the latest generation in their line of automated samplers and has been built to deliver the perfect sampling solution for your most critical processes.

Designed for heavy-duty use, the Seg-Flow S3 has been engineered with increased robustness, featuring a highly durable powder-coated heavy-gauge steel construction. The integrated touchscreen GUI is bright and easy to use, with simple thumbnail navigation, and ideal for any lab environment. Bright LED lights offer “at a glance” status indication for easy monitoring.

Seg-Flow S3 offers complete flexibility to match your sampling needs. It can simultaneously sample from between one and eight vessels or process streams with cell-free or cell-containing samples, and then deliver to up to four analyzers or fraction collectors.

The S3 will automatically clean and/or sterilize the sample lines after every collection, removing cross-contamination risk entirely.

For process monitoring, the S3 can export data to any OPC-enabled DCS, PLC or PC, allowing easy performance data monitoring and analysis.

A wide range of feed control strategies can be programmed into the sampler, including setpoint and gravimetric. The S3 can control 2 feed pumps per vessel.

Fully Automated On-Line Sampling for Bioprocesses

Single use, micro-bioreactors could be a good solution for replication processes, especially when they eliminate cross contamination and time-consuming cleaning. Moreover, they are small and portable for use in the field. However, it’s important to ensure the design is consistent if using multiple instruments for comparative work.


<h2>A Tailor-Made 3D Printed Alternative Micro-Bioreactor</h2>
AppliFlex ST disposable reactors from Getinge Applikon are customizable to individual requirements. Moreover, the company 3D prints its tailor-made single-use bioreactors, meaning it can accurately create a perfect clone at any time after completing the first order.

These bioreactors can be stirred, and the user can choose the type and number of impellers, liquid and gas additions, and sparger gas diffusers to create a bioreactor that suits their purpose. They could even design their own impeller and Getinge Applikon will create it.

The AppliFlex ST design caters for both cell culture at 500 millilitre / 3 litre volumes, and 500 millilitre microbial applications. The customisable design allows the user to specify their bioreactor, and therefore optimise the output. The fully removable top plate provides easy access to the product.

Single use bioreactor

Comprehensive upstream data acquisition and management are essential in the bioprocessing industry. That’s because you can’t be completely sure which historic information you may need in future. SCADA monitoring systems were not designed for laboratory precision. Research work needs more focussed information.


<h2>An Information System for All Stages of Bioreactor Operation</h2>
Lucullus PIMS bioreactor software from Getinge Applikon records the entire process from recipe planning through to automatic reporting and modelling. Phases covered between these points include reactor allocation, experiment design, media preparation, media component traceability, data analysis, and data mining.

This all-embracive approach is time-saving because all information is in a central Oracle database. There’s no need to export and import data between systems. Updating is a thing of the past because you always have the latest version at hand. Moreover, the same software produces accurate spreadsheets and graphs.

Advanced software is necessary to convert data from parallel bioreactor systems into useful information. Data management is key to research and process development in the pharmaceutical industry.

Bioreactor software

solid

Managing a large number of bioprocesses individually without automation is time-consuming, and there are possibilities of errors. Bioprocess control software moves this activity to the desktop and creates an activity log.


<h2>Bioprocess Control Software for R&amp;D Scale Bioreactors</h2>
Getinge Applikon’s V-Control bioprocess-control software is a scaled version of Emerson’s proven distributed control system. It simplifies process control, and data upscaling on a single platform. Moreover, organizations already using the DeltaV DCS at production scale have reliable, scaled information that’s easily transferred.

V-Control provides a turnkey solution that customizes to different situations. It has a user-friendly interface, and uses simple technology to minimize upscaling risks. Its easy-going technology and data transfer capabilities may reduce development costs and time-to-market.

This system is therefore ideal for a user wishing to compress start-up time, and work within an optimized DeltaV environment perfected for laboratory bioreactor systems. It is sufficiently flexible to accommodate a wide range of requirements. All hardware and software are pre-configured and ready to switch on.

Bioprocess control software

An autoclavable bioreactor establishes special conditions for a variety of applications, for example yeast and microbial cultivation. These conditions may include particular high and low pressures, and temperatures without which a particular chemical reaction or biological event cannot occur.


<h2>A Bundled Reactor for Yeast, Microbial and Mammalian Cell Cultivations</h2>
An EZ2 control bundle from Getinge Applikon is a complete bioreactor system containing everything needed to facilitate bioprocesses. The equipment is easy to set up, does not require special tools or skills, and is easy to learn to operate. Software for data acquisition is included.

Typical projects could include yeast and microbial culture, and also mammalian cultivation including suspension and anchorage-dependent cells. Continuous perfusion cultures are also a possibility, because everything down to silicon tubing, sample bottles and even spare parts are in the kit.

Getinge Applikon touched on all the details when designing its EZ2 system. The quiet agitation motor will hardly be noticed in a busy laboratory, while the sophisticated controller is simple to use thanks to an integrated touch screen. A USB port enables software updates without needing a service engineer.

The EZ2 bundled reactor range includes 2, 3, 5, 7, 15, and 20 litre total volume sizes for cell or microbial cultures.

Complete bioreactor system

Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh or membrane, you can have all the benefits from traditional devices without the inherent problems and limitations that come with them.


<h2>Non-clogging retention for high-density perfusion processes</h2>
The Getinge Applikon BioSep Acoustic cell retention system is a unique, cell retention device for high-density perfusion processes. The BioSep, based on the technology of acoustic resonance, is a non-fouling / non-clogging retention system. The BioSep can be applied in both R&amp;D (max. 1 L/day), process development and on production scale (1000 L/day).

Acoustic cell retention system

For accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic fermentations.


<h2>Very accurate characterization of the fermentation quality</h2>
The Anaerobic Fermentation Monitor from Getinge Applikon is a robust and user-friendly laboratory parallel bioreactor that allows for accurate comparisons of carbon conversion rates and yields for six simultaneous anaerobic fermentations.

It serves not only as the perfect screening machine for general research on anaerobic yeast fermentations, but also as a powerful, time saving tool for plant design and process optimization. A very accurate characterization of the fermentation quality can be obtained, without the need for highly educated laboratory staff, which is an important, money saving feature.

Anaerobic Fermentation Monitor

The vast majority of all biotechnological processes are aerobic, where a microorganism or cell responds to the liquid phase oxygen concentration in regulating its overall metabolism. Knowing the exact oxygen content in the working atmosphere is critical for your process.


<h2>DO2 Sensor optimized for bioprocesses</h2>
The Dissolved Oxygen sensor is a measuring device that informs about the dissolved oxygen in biotechnology processes, which is a basis for process optimization and control.

The AppliSens Low-Drift DO2 sensor from Getinge Applikon is specifically designed for long-term, stable, and accurate measurements in bioprocesses, such as fermentation and cell culture applications. Designed to withstand repeated sterilizations without failure.

The DO2 sensor has a titanium membrane module to minimize the measurement drift, and the available autoclave polarization module allows you to reduce start-up time for your cultures.

Dissolved Oxygen sensor

During the initial stages of scale-up, researchers often have limited data available with which they must decide on what to do next. High throughput, informative and predictive tools are necessary to cope with the number of cultures that must be done early on.


<h2>Cultivation in microtiter plates</h2>
The Micro-Flask system by Getinge Applikon, is a simple and powerful set of tools for improving the quality of experiments performed in micro-titer plates. Using a unique "sandwich cover" plate closure, it is possible to eliminate well-to-well variability in flasks, dramatically improve gas transfer in cultures, and achieve outstanding results from high-throughput experimentation.

The Micro bioreactor ensures that every microtiter plate is exposed to identical culture conditions. In addition to preventing cross-contamination during vigorous shaking, the sandwich covers also provide uniform diffusion paths for each well, virtually eliminating well-to-well variability.

Micro-Flask

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New technologies are emerging that warrant accurate measurement and improve durability even in high-temperature steam-sterilization processes.


<h2>Acidity sensor optimized for bioprocesses</h2>
The pH sensor from Getinge Applikon is constructed using FDA approved materials, like the non-toxic solid gel electrolyte. Furthermore this sensor has an internal pressure, which reduces cross contamination. The pH sensor is designed to withstand repeated sterilization cycles without failure.

pH Sensor

Utilized when applying low-frequency and high-intensity acoustic energy to agitate microbial cultures.


<h2>Enhances oxygenation and bulk mixing for bacterial and fungi cultures</h2>
The Resonance Acoustic Mixer, from Getinge Applikon is a highly-efficient orbital-shaker replacement that dramatically enhances oxygenation and bulk mixing for bacterial and fungi cultures. Combined with the patented Oxy-Pump® stopper, oxygen transfer rates up to 6-fold higher than orbital-shaken cultures can be achieved. The Resonance Acoustic Mixer is an indispensable product for any cutting-edge biological laboratory.

Resonance Acoustic Mixer

Filling of transportation bags and discharging them into mix tanks or reactor vessels is often a source of contamination and there potential exposure of personnel to harmful substances.  Inadequate measures to avoid these issues often slow production and reduce profitability.  Experienced biopharmaceutical manufacturers know that equipment designed for general industry use often falls short and rigid containment and transfer solutions for the biotech industry are often awkward and inefficient. Producers that embrace flexible solutions designed specifically for the challenges of our industry will find an advantage over competitors.


<h2>A fast and clean flexible powder transfer system</h2>
ILC Dover is an industry leader in contained material handling solutions for high-tech manufacturers and end users including NASA. The company's EZ BioPac is a single use solution to contamination free powder transfer for the bioprocessing and pharmaceutical industries.  The system consists of a rigid polypropylene stand with an integrated plastic bag.  The stand holds the bag in an open funnel shape for filling and doubles as a lifting point when the bag is ready to be emptied from the bottom.  The bag is oversized and includes enough material to fold back over the stand during filling to protect the stand from any spillage during filling.  The funnel shape of the supported bag in the filling configuration allows for easy manual addition and subtraction of material to ensure accurate fill weights.  A charge neck at the bottom is clamped to your reactor vessel or fill the tank for discharging and a system of clamps is used to manually control material flow and seal the bag for disposal after it is empty.  Isolation of the contained material is thus maximized, greatly reducing cross-contamination of the powder by substances from the work area, and of the work area by the handled powder.

Flexible contained handling of powder transfer bags

Bagging is the process of packaging measured portions of a product into bags that protect it from spoilage, enable easy and safe transportation, and secure the product against tampering and pilferage. The choice of bagging equipment depends on the desired mass or volume per bag, the flow characteristics of the product, and bag construction and design. Bags vary in size from small sachets to bulk flexible containers. Bagging systems are often the last processing step that is generally integrated into a production line.

Bagging

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Handling

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for their production infrastructure needs.  Experienced producers know that the flexibility, cleanliness, and convenience of high quality single use equipment increase process efficiency by reducing operator maintenance and cleaning activities, allowing them to focus on more value added tasks.


<h2>A disposable liner for reusable rigid vessels that avoids contamination while eliminating required cleaning</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times. The company's disposable tank liners are constructed from a 350 micron thick LDPE film with a completely inert fluid contact layer similar to that in JM BioConnect's other disposable bag products using JMS Flex Film.  The  film used in the tank liners is thicker and manufactured to a 3D shape to better fit the restraining vessel, but it has similarly low extractable and leachable compounds and is excellently suited for media and buffer preparation in support of subsequent bioprocesses.  Typical use is to install the tank liner into a cylindrical vessel and fill with liquid.  A powder is then added and mixed to create a buffer or media for subsequent bioprocess.  After mixing, the contained fluid can be pumped or drained out and the tank liner disposed of.  The process can begin again with the installation of a new tank liner and no required cleaning of the vessel.  Liners are also available with a bottom end drain port and supporting hoses and fittings to meet the customer's needs.

Disposable tank liners

Tangential Flow Filtration is an essential to the biopharmaceutical processing industry. An efficient, controlled, and documented, TFF process helps producers in the product development, process development, and production phases and experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this equipment is always a good decision.
<h2>Fully automated Tangential Flow Filtration with all single use wetted components</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s SciPure 200 system is a fully automated, single use TFF system with electronic HMI and specialized software. All wetted components of the system including sensors are single-use consumable items. The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance. The system responds to sensor feedback to maintain user-defined transmembrane pressure and flow rates simultaneously.

Automated single use tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical processing industry.  An efficient, controlled, and documented, TFF process helps producers in the product development, process development, and production phases and experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this equipment is always a good decision.


<h2>Semi-Automated Tangential Flow Filtration with all single use wetted components</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s SciPure 150 system is a semi-automated, single-use TFF system with electronic HMI and specialized software.  All wetted components of the Semi-automated tangential flow filtration system including sensors are single-use consumable items.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The Semi-automated tangential flow filtration system responds to sensor feedback to maintain user-defined trans membrane pressure or process flow rates.

Semi-automated tangential flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing industry to prepare liquids and solutions for further processing.  A wide variety of commercially available filters are used and efficient and consistent processing often requires careful control of the filtration process parameters.  Experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this equipment is always a good decision.
<h2>Semi-Automated Normal Flow Filtration with all single use wetted components</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciPure 140 system is a semi automated, single use NFF system with electronic HMI, PID pump control, and specialized software.  All wetted components of the system including sensors are single-use consumable items.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined constant rate or constant pressure filtration process parameters.

Semi-automated normal flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical processing industry.  An efficient, controlled, and documented, lab scale TFF process helps producers in the product development and process development phases and experienced biopharmaceutical producers know that investment in automation and maintenance reduction of this laboratory equipment simplifies development work and speeds implementation of new products and processes.
<h2>Semi-Automated Tangential Flow Filtration for the laboratory</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s PureTec system is a semi automated, TFF system with electronic HMI and specialized software.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined transmembrane pressure or process flow rates.  Disposable pressure sensors are included on the permeate, retentate, and feed lines.  An integrated electronic scale for permeate monitoring, magnetic stirrer, and programmable peristaltic pump are also included allowing completely unattended TFF processing to user specified parameters.  With the addition of the SciDoc documentation package 15 filtration parameters can be calculated, displayed, and documented providing the information and control you need for maximized yield.

Lab scale tangential flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing industry to prepare liquids and solutions for further processing.  A wide variety of commercially available filters are used and efficient and consistent processing often requires careful control of the filtration process parameters and behavior of the filter medium used.  Experienced biopharmaceutical producers know that laboratory testing and documentation of NFF processes prior to implementation at a production scale is an important step in developing an efficient process.
<h2>Semi-Automated Normal Flow Filtration for the laboratory</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s FilterTec system is a semi automated, NFF system with electronic HMI and specialized software.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined filter back pressure or filtrate flow rates.  A disposable pressure sensors and integrated electronic scale are included as well as a programmable peristaltic pump allowing completely unattended NFF processing to user specified parameters.  With the addition of the SciDoc documentation package 15 filtration parameters can be calculated, displayed, and documented providing the information and control you need for developing an optimized NFF process.

Lab scale normal flow filtration system

Biopharmaceutical manufacturers are increasingly making use of Single-use pressure sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate pressure sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the bio pharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciPres system is single use pressure sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your bio pharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  They are accurate to +/- .02 bar at maximum allowable pressure of 4.1 bar.

Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitation including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of bio-pharmaceutical process equipment.  They can also be integrated with the Sci-Pres monitor for stand-alone monitoring of up to three pressure sensor inputs.

Single-use pressure sensor

Biopharmaceutical manufacturers are increasingly making use of single-use conductivity sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate electrolyte conductivity and temperature sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciCon system is single use temperature and conductivity sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your biopharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  For conductivity they are accurate to +/- 2.5 mS of full range with range of 1 uS/cm to 200 mS/cm.  For temperature effective range is 4 -50 C with an accuracy of +/- 0.5 C.  Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitization including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of biopharmaceutical process equipment.  They can also be integrated with the SciCon monitor for stand-alone monitoring and automated documentation using the SciDoc software package.

Single-use conductivity sensor

Biopharmaceutical manufacturers are increasingly making use of single-use temperature sensors to enhance efficiency, make equipment more versatile for use in a variety of processes, and decrease risk of cross contamination. Today even sensing technology enjoys the convenience and maintenance savings of disposable technology.
<h2>Accurate temperature sensing in a preprogrammed, easy set up, disposable package</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s SciTemp system is single use temperature sensor that is easy to use, pre-calibrated, and ready for plug-and-play integration into your biopharmaceutical production process.  The sensors are barcoded for traceability, medical grade, and NIST traceable.  Their effective temperature measurement range is -40 to 150 C with an accuracy of +/- 0.5 C in the 4 to 70 C range.  Five sizes are available accommodating flow rates from 1 L/min to 60 L/min.  These sensors are compatible with may commonly used types of sanitization including, NaOH, NaCl, formaldehyde, autoclaving, and gamma irradiation.  Scilog has extensive experience developing single use sensors and these can be found used in a wide variety of biopharmaceutical process equipment.  They can also be integrated with the SciTemp monitor for stand-alone monitoring of up to two temperature sensor inputs.

Single-use temperature sensor

Efficient harvest from the bioreactor is essential to any successful cell culture process but is often labor intensive as laboratory personnel closely monitor and adjust filtration process parameters.  Experienced bioprocessors know that investment in automation of the harvest process yields higher quality, enhanced safety, and better efficiency, giving them an edge over competitors.
<h2>Walk-away automation of your cell culture harvest process</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s HarvestClear filtration system is a combination of Scilog’s fluid handling technology and pressure sensing with a single use filtration manifold optimized to clarify high cell density bioreactor outputs.  Three sizes are available to accommodate bioreactor outputs from 1L to 20L.  The fluid handling system is based on an automated laboratory scale NFF system with electronic HMI and specialized software.  The system’s pre-installed software allows user selectable limits and alarms for safe, consistent process performance without constant operator attendance.  The system responds to sensor feedback to maintain user-defined filter back pressure or filtrate flow rates.  A disposable pressure sensors and optional integrated electronic scale are included as well as a programmable peristaltic pump allowing completely unattended NFF processing of bioreactor outputs to user specified parameters.  Filter manifolds are provided in a gamma-irradiated sterile and pre-flushed state ready for use.  Once the user defined parameters are entered, the system can run unattended freeing personnel to focus on other tasks.

Automated cell culture clarification system

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA require the high structural strength and contamination protection usually provided by expensive medical grade stainless steel.
<h2>Separate complex biomolecules using strong, versatile multi-use columns</h2>
CIMmultus™ disposable monolithic columns from BIA Separations have the structural integrity and leachable profile of medical grade stainless steel, but the process economics of a single or multi-use device.

With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ columns offer safety and high performance.

CIMmultus™ columns can be used at any step in the separation process and, with their 2 µm flow-through channels allowing convective mass transfer, make a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other large biomolecules.

Disposable monolithic columns

Samples taken at various process steps need to be analysed quickly and accurate results delivered, without affecting the state or condition of the original sample.
<h2>Understand a bioprocess through real-time monitoring</h2>
CIMac™ Analytical Columns from BIA Separations are short bed, high performance monolithic columns offering all the advantages of CIM® monolithic technology. They are primarily intended for fast, efficient, and reproducible separations of biomolecules like large proteins, plasmid DNA, and viral particles.

Small volume and short column length allow operation at high volumetric flow rates (from 1 to 30 column volumes/min), enabling product quantity and purity information to be available in just a few minutes.

The CIMac™ Analytical Columns are pre-packed in dedicated stainless steel housings and allow user-friendly connections to HPLC equipment, hence they can be effectively used for both the in-process and final control of various samples from different purification processes.

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Short bed monolithic columns for analytics

Dry fogging provides safe, effective microbiological cleaning of critical areas in biotech, pharmaceutical and other industries where the highest levels of sterility are required. Let's find out if this compact disinfection system can serve you.


<h2>Thoroughly decontaminate exposed surfaces</h2>
The DosyMist by SolidFog uses H2O2 atomisation under controlled release to provide airborne decontamination and hinder the spread of bacterial growth on surfaces, filters, materials and equipment. A small, easy to manoeuvre unit made of medical grade stainless steel, the DosyMist digitally tracks its operation using Siemens PLC control for consistency of results. Designed to operate effectively on areas from 2 to 100 m³, this system has applications in the agri-food and pharmaceutical industries, health facilities, public and industrial premises and
research laboratories.

Compact H2O2 disinfection system

Industrial cleaning equipment is used to wash or disinfect machinery and the production/warehouse area. It may also be used to sterilize the product, equipment, tools, floor or work surfaces and to purify or clean the product by removing impurities. Choosing a suitable cleaning system depends on the type of product or equipment to be cleaned, the sensitivity of the product to heat, pressure, and chemicals, and the level of sterility desired.

Cleaning

Industrial disinfection equipment use antimicrobial agents to destroy microorganisms found on machines, floors, walls, and other surfaces. In industry, disinfection of machinery and the production area is important to prevent product contamination which may lead to spoilage and health hazards for workers and the consumer. The choice of industrial cleaning equipment depends on the level of disinfection needed, the sanitizing agent, the size of the area or objects to be treated, and the suitable method of treatment such as sterilization, pasteurization, exposure to ultraviolet light, or chemical fogging.

Disinfection

Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

Sterilization

<span style="font-weight: 400;">Biotech and pharmaceutical development programs often require a mixing method that achieves both particle size reduction and complete cell lysis. When piloting production systems, it’s vital that you have complete control over the pressure to accommodate all cell types, and that the results of testing are completely scalable to full production.</span>
<h2>High-pressure homogenizer offering all configurations</h2>
<span style="font-weight: 400;">The DeBEE 2000 from BEE International is a complete pilot solution for high pressure homogenization in a highly compact format. Offering user-adjustable pressure control from 5,000 to 45,000 psi, the unit is suitable for a wide range of pharmaceutical and biotechnology applications and its modular design means lower costs of maintenance and repair.</span>

<span style="font-weight: 400;">This pilot unit also offers a wide range of options to suit all process and budget requirements, including Dual Feed, Dual Jet, control of cavitation, shear and impact and secondary additive feed for particle synthesis.</span>

<span style="font-weight: 400;">PLC control and HMI touch screen provide simple monitoring, and the unit is designed to be easily cleaned (Clean in Place) and portable.</span>

High pressure pilot homogenizer

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

<span style="font-weight: 400;">For any industrial pharmaceutical process that relies on high pressure homogenization it’s vital that the equipment used is robust enough to cope with the demands of continuous operation. More than this, modern production demands high levels of process control and automation, as well as seamless integration with plant controls and providing results that satisfy the highest regulatory demands.</span>
<h2>Homogenizer offering the highest level of automation, compliance and capacity</h2>
<span style="font-weight: 400;">The DeBEE 4000 series from BEE International is the company’s top-of-line homogenizing solution for high performance situations. Designed from the ground up to achieve the best results as efficiently as possible, the DeBEE 4000 uses DeBEE’s proprietary homogenization technology for unequalled results, coupled with a hydraulically driven vertical intensifier pumps with a slow stroke rate to provide higher pressure and higher process intensity, all with lower maintenance costs.</span>

<span style="font-weight: 400;">Featuring a PLC with bespoke HMI software and full-colour touch screen, the DeBEE 4000 offers easy access to several features including security modes and authorisations, integrations with plant controls using network data gathering, and dynamic visual schematics for at-a-glance system status and component parameters.</span>

<span style="font-weight: 400;">The DeBEE 4000 features a fully sanitary design making it ideal for pharmaceutical and biotech production, as well as use in the chemical industries.</span>

High pressure industrial homogenizer

<span style="font-weight: 400;">For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot/small scale pharmaceutical production is the ideal choice. Full control over all process elements and 100% scalability coupled with cost-effective electric operation offers substantial cost-savings over alternative options.</span>
<h2>Cost-effective unit suited for both laboratory and pilot use</h2>
<span style="font-weight: 400;">The Mini DeBEE from BEE International is hydraulically driven homogenizer that is suitable for both laboratory use and in pilot plants or in small-scale production. Offering the highest process intensity available in its class, it will disrupt the toughest cells with the highest yield, or obtain the smallest particle size.  </span>

<span style="font-weight: 400;">With proprietary modular homogenising cell, the Mini DeBEE offers completely independent control of pressure, flow, cavitation, impact, shear and process duration. The minimal sample size of only 10ml makes it an excellent choice for R&amp;D and lab work. Because it guarantees 100% scalability, it can easily be transferred to pilot operations, or the machine itself can also be used for small-scale and batch production, offering continuous flow of up to 15 litres per hour.</span>

<span style="font-weight: 400;">PLC control with digital interface means simple operation and monitoring, with user-adjustable operating pressure from 2,000 to 45,000 PSI. Coupled with a wide range of options, this makes the Mini DeBEE suitable for application in the pharmaceutical, biotech, chemicals, cosmetics and food industries.</span>

Pilot high pressure homogenizer

<span style="font-weight: 400;">Remove the risks of cross-contamination and liquid nitrogen handling by adopting a freezer system that does not bring the coolant in direct contact with your samples. Increase storage space for the same footprint as a traditional freezer and improve access to samples without affecting the internal temperature and benefit from industry-leading temperature gradient.</span>


<h2><b>Liquid nitrogen freezer solution that removes risks of cross-contamination</b></h2>
<span style="font-weight: 400;">Suitable for a wide range of biotech and pharmaceutical uses, the Custom BioGenic Systems V1500-AB Isothermal Liquid Nitrogen Freezer provides nitrogen storage temperatures but without the need to bring samples into direct contact with the coolant. A patented jacket design means that liquid nitrogen surrounds the entire chamber whilst keeping the storage area completely clean and dry, allowing for exceptionally low temperatures throughout the unit.</span>

<span style="font-weight: 400;">As well as removing cross-contamination risk associated with collant contact, the V1500-AB also reduces health and safety risks associated with filling traditional freezers with liquid nitrogen as there is no splash risk.</span>

<span style="font-weight: 400;">Because the nitrogen is not introduced directly into the freezing chamber this allows the entire volume to be used for storage. The units will allow storage of a wide range of containers including aluminum and stainless steel square and vertical racks, mini racks, canister and frame systems, vials, boxes and canisters or cassettes.</span>

<span style="font-weight: 400;">The unit comes as standard with the respected Custom BioGenic Systems 2301 controller which handles auto filling and full monitoring of the unit, including alarms and data recording. The combination of controller and freezer design means the V1500-AB has an industry leading temperature gradient that averages -193°C inside the storage area.</span>

Liquid nitrogen freezer for safe and dry storage of your samples

Industrial cooling equipment varies according to the consistency and temperature conversion demands the material you are handling, but the process typically involves heat exchange treatment as your products are conveyed through a cooling chamber equipped with extraction fans or circulating water. Temperature control is a crucial aspect of your commercial production and cooling systems are applied to a range of industries.

Cooling

Freezing

Almost all manufacturers will require industrial storage systems and solutions at some point during their production process. The raw materials that go into your products need dedicated storage solutions to protect them from spoilage and contamination before they enter the manufacturing cycle. Storage usually refers to particular storage space. For example, having enough warehouse storage. Or clearing out a production facility for more floor space.  However, in this case, we are referring to the equipment and solutions that make storage manageable and easier. Such equipment includes solutions such as storage racks, pallet racks and shelving systems. These are just some of many storage options available to manufacturers. Advanced technology facilitates the management of heavy duty and high density tank and silo systems by automating the delivery system and linking it with the rest of the production line.

Storage

<span style="font-weight: 400;">For biotech and pharmaceutical cryopreservation, liquid nitrogen vapor storage provides a cost-effective and efficient solution where shorter-term storage is required. Vapor phase freezers provide easier access to the stored samples and provides higher levels of user protection from contact with the liquid nitrogen.</span>


<h2><b>Superior temperature stability with ease of access</b></h2>
<span style="font-weight: 400;">The Custom BioGenic Systems EV10 EcoVapor Liquid Nitrogen Freezer provides access to cost-effective and efficient liquid nitrogen vapor storage. Liquid nitrogen is pooled in the bottom of the freezer and a patent-pending custom engineered vapor insert enables superior temperature uniformity in the -180°C range. Because there is no liquid in the storage area it minimises risks involved with contact with liquid nitrogen.</span>

<span style="font-weight: 400;">The unit is controlled by the Custom BioGenic Systems Model 2200 controller. This unit features a dual temperature display and auto-fill capabilities that is fully software driven for automatic operation.</span>

<span style="font-weight: 400;">The EV10 features a lightweight, lockable, lift-off lid for easy unrestricted access to samples. The unit offers a capacity of 45 litres, with a maximum usable internal storage height of 737mm and internal diameter of 559. This generous sizing combines to enable the storage of up to 10,725 2ml vials using 5 mini racks.</span>

Liquid nitrogen vapor storage freezer

<span style="font-weight: 400;">An accurate and sterile sampling of cultures is vital throughout the biopharmaceutical development process. For constant, accurate monitoring, a reliable automated system is needed that transfers bioprocess samples directly from bioreactors to a range of analytical devices without intervention while maintaining the highest levels of sterility. For small-scale development, the availability of a more cost-effective entry-level system brings large economic advantages.</span>
<h2>Affordable automated bioreactor sampling</h2>
<span style="font-weight: 400;">The Seg-Flow 1200 Automated Bioreactor Sampling System from Flownamics is an economical alternative to the larger Seg-Flow 4800. It is available in two models, the Seg-Flow 1200 and the Seg-Flow 1200 Plus.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">By incorporating a disposable, single-use flow path, the Seg-Flow 1200 is easy to use and requires little maintenance and no specialist operator training.</span>

<span style="font-weight: 400;">Samples can be collected from up to 2 reactors and delivered to 2 analyzers or collectors. Built-in expansion capability means this can be extended to 4 reactors with the Sample Module.</span>

<span style="font-weight: 400;">Integrated control functions such as an automated feed from an at-line glucose measurement can be quickly and easily implemented.</span>

<span style="font-weight: 400;">The Seg-Flow 1200 can be used with small laboratory vessels right up to large full-scale production vessels with 12, 19, and 25 mm models.</span>

<span style="font-weight: 400;">The unique Flownamics FISP filter probe used in the Seg-Flow 1200 ensures a sterile, cell-free sample can be taken from any vessel.</span>

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