Pilot-scale bioreactors for bioprocess scale-up

Bridge the gap between experimentation and large-scale production with pilot-scale bioreactors, mastering precise environmental control and adaptable configurations for seamless and reliable bioprocess scale-up.

Facilitates Fermentation and Customizes Bioprocesses

The pilot-scale bioreactors from n!Biomachines are an indispensable tool for biopharmaceutical companies, biotechnology firms, and nutraceutical manufacturers seeking precision in scale-up processes. These bioreactors provide a critical bridge from lab-scale experimentation to commercial production, ensuring consistency in products such as monoclonal antibodies, vaccines, and probiotic supplements. With volumes ranging from 200 to 5000 liters, they accommodate a wide range of applications, including cultivated meat and alternative protein sources. Equipped with advanced control systems, including the AUXO V® technology, they allow for meticulous environmental parameter manipulation to optimize growth conditions. The modular design supports extensive integration into existing workflows and allows for tailored configurations to meet specific production needs. Constructed from long-lasting materials, these units offer robust performance in demanding bioprocesses and include advanced sensor technology for real-time monitoring. Cleaning and maintenance are streamlined with options for CIP/SIP systems, ensuring operational efficiency while minimizing downtime. Each unit can be customized with software and hardware options to fit exact processing requirements, while ensuring compliance with industry standards for safety and quality.

Benefits

  • Ensures seamless scale-up with precise control systems, maintaining product consistency.
  • Adapts to specific process needs with customizable configurations, enhancing production flexibility.
  • Minimizes downtime with easy-clean systems, reducing labor and maintenance costs.
  • Improves efficiency with real-time monitoring, optimizing growth conditions and preventing failures.
  • Facilitates integration into existing operations, streamlining workflow and enhancing productivity.

General


Applications
Alternative protein sources,Fermented products,Nutraceuticals,Biopharmaceuticals,Enzymes,Cultivated meat
End products
Lab-grown beef,Quorn,Vaccines,Plant-based chicken,Vegan cheese,Amylase,Monoclonal antibodies,Probiotic supplements,Vitamin-enhanced supplements,Proteases,Lactase,Soy-based yogurt,Tofu,Tempeh
Steps before
Laboratory-scale experimentation,Small-scale experiments,Process development
Steps after
Scale-up to commercial production,Bioprocessing scale-up,Nutritional and health product formulation
Input ingredients
cell culture media,microorganisms,nutrients,bioprocess fluids
Output ingredients
bioproducts,cultivated meat,proteins,biomaterials
Market info

Technical Specifications


Capacity
200–5000 liters
Control System
Advanced control systems
Customization
Highly customizable design
AUXO V® Technology
Precision environmental control
Integration Capabilities
Extensive integration
Sensor Technology
Advanced sensor technology
Impellers
Shear stress optimization for cell types
CIP/SIP System
Available upon request
Monitoring System
Automated monitoring and alert
Component Design
Component-based design

Operating Characteristics


Scale-up capability
200 to 5000 liters
Advanced control systems
Precise manipulation of environmental parameters
Customization
Modular components and flexible configurations
Integration capabilities
Designed to fit into existing workflows
Automation level
AUXO V® control systems
CIP/SIP
Available upon request
Sensor technology
High-quality sensors for accurate,real-time monitoring
Cleaning method
Easy-clean and self-cleaning mechanisms
Changeover time
Component-based design for simplified upgrades

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Physical Characteristics


Tank capacity
200–5000 liters
Control panel type
Intuitive interfaces
Modularity
Modular components
Discharge method
Customizable input/output options
Material usage
Long-lasting materials
Easy-clean systems
Self-cleaning mechanisms or easy disassembly

Custom Options


Control panel type
Intuitive interface
Integration capabilities
Customizable input/output options
Software
Customizable interfaces
Modular design
Flexible configurations
Impellers
Optimized for different organisms