Tell us about your production challenge

Some of the vaccines in use today were originally developed decades ago. But advances in research and vaccine manufacturing equipment provide immunizations from bacterial and viral diseases to more people every year. The Covid-19 pandemic highlights the urgent need to scale up the production of vaccines and ensure a reproducible manufacturing environment.

What vaccines equipment do you need?

Lab scale Bioreactor controller

Success with bioprocesses is all about controlling the environmental conditions controls so ...

Pharmaceutical rotary labeling machine for vials

Small, cylindrical-shaped glass bottles or vials are mainly used for vacc...

Automated bubble traps for chromatography

Radial flow chromatography processes require special attention and the right use...

Pre-packed and pre-validated chromatography columns

In chromatography, you must always take into account the apparatus th...

Lab-scale radial chromatography columns for virus validation

In the food industry, as an example, during lab-testing and...

Compact H2O2 disinfection system

Dry fogging provides safe, effective microbiological cleaning of critical areas in biotech,...

Complete bioreactor system

An autoclavable bioreactor establishes special conditions for a variety of applications, for exam...

Single use bioreactor

Single use, micro-bioreactors could be a good solution for replication processes, especially when they ...

Bioprocess control software

Managing a large number of bioprocesses individually without automation is time-consuming, and t...

Optical Dissolved Oxygen Sensors

Sufficient oxygen is critical to the success of processes like cell culture and fermentatio...

Bioreactor software

Comprehensive upstream data acquisition and management are essential in the bioprocessing industry. That’...

24 fully controlled bioreactors in a microtiter format

When undertaking a screening study, process development or optimis...

Autoclavable glass bioreactor

Especially designed for cell culture applications and research applications such as process op...

Mini bioreactors

When a screening study takes place, optimizing media process and working with microbial and cell cultures is ...

Small-scale bioreactor controller

When you are working with small bioreactors, starting from 50 ml volumes, you need a good...

Vial filling machine

The volume filling of vials, cartridges and syringes is a vital part of the production of a wide range o...

Closed restricted access barrier system

Pharmaceutical production techniques often require isolation of compounds and chemi...

Disposable tank liners

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for the...

Autoclavable stainless steel bioreactor

For cell culture and microbial culture applications.

pH Sensor

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New ...

Photobioreactor for plant growth

SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth ...

Steam-in-place bioreactor systems

Scaling-up from a laboratory scale to pilot plant and small scale production can be simpl...

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common ap...

Acoustic cell retention system

Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh o...

Scalable bioreactor controller

When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot ...

Single-use bioreactor CellReady 3L

A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture ...

Single use bioreactor Hyclone

A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead...

Resonance Acoustic Mixer

Utilized when applying low-frequency and high-intensity acoustic energy to agitate microbial cultures.

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

Single-use pressure sensor

Biopharmaceutical manufacturers are increasingly making use of single disposable equipment to enh...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Automated single use tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutica...

Single-use conductivity sensor

Biopharmaceutical manufacturers are increasingly making use of single disposable equipment to...

Single-use temperature sensor

Biopharmaceutical manufacturers are increasingly making use of single disposable equipment to ...

Lab scale tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical processing...

Dissolved Oxygen sensor

The vast majority of all biotechnological processes are aerobic, where a microorganism or cell respon...

Micro-Flask

During the initial stages of scale-up, researchers often have limited data available with which they must decide o...

Single-use bioreactor Appliflex

A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, c...

Automated cell culture clarification system

Efficient harvest from the bioreactor is essential to any successful cell cult...

Disposable tubing for manifolds in bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to ...

3D disposable bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single-use so...

Disposable manifold bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to dispos...

Normal flow filtration sets for bioprocesses

Bio-processors require reliable, high quality, easy to maintain, filtration e...

Disposable mixer bags for bioprocesses

Bioprocessors must use ingredients of known high quality and consistency.  Inconsist...

Disposable pillow bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single us...

Biocompatible tubing for peristaltic pumps

Sensitive bioprocess applications requires equipment that will not interfere wi...

Y sets tubing for bioprocesses

Manufactueres in the bioprocessing industries are increasingly turning to single use solution...

Semi-automated tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical proce...

Semi-automated normal flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing in...

Bag holder and weighing platform for bioprocesses

Single use bags for biopharmaceutical process containment and liquid st...

Lab scale normal flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing industry...

Automated dispensing system for bioprocesses

Biopharmaceutical manufacturers require precisely known liquid quantities for...

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of...

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in ac...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Vaccines are over-formulated to protect against potency loss

Vaccines start with the isolation of chemically defined media, but they come into being during formulation. The delicate process stabilizes the separate components into a uniform mixture and prepares it for dosing.

Mixtures are typically over-formulated above the required potency. This method lowers yield but compensates for any possible degradation throughout the vaccine’s shelf-life.

Reduce vaccine moisture to max 3% with freeze-drying equipment

The process of lyophilization ensures that your biological formula remains stable along the cold chain. For this reason, freeze-dryers have become critical equipment in modern vaccine manufacturing.

Vaccine freeze-drying is a complex procedure involving three major steps. At the freezing stage, the solution solidifies with the formation of crystals. During the dehydration phase in a drying chamber, you subject the material to temperatures not exceeding -50 °C and forces water to sublimate. Finally, another round of drying releases any remaining moisture to between 1% and 3%.

Protect diluent from freezing or heating with cold chain storage

Before going into the arms of patients, your lyophilized vaccines are reconstituted into liquid solutions using a diluent. World Health Organization guidelines warn that vaccine manufacturing is incomplete without the accompanying diluent.

Sterile water is often used as a diluent, but ingredients may contain a range of other substances such as sodium chloride, xanthan, or calcium carbonate. Whatever the composition, diluents must always be kept at temperatures between +2°C to +8°C.

Chromatography technology and mRNA techniques promise more accessible vaccines

Purification of the reaction mixture remains a challenge for large-scale vaccine production. But chromatography is emerging as an ideal purification technique for several biopharmaceuticals.  Ligands in the chromatography columns form ‘hooks’ that filter out specific contaminants.

Vaccine manufacturers are taking advantage of this purification technique to reduce vaccine production’s financial and environmental costs. This method is attracting particular interest with the development of mRNA vaccines to combine a relatively simple manufacturing process with the high-yield capabilities of chromatography.

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