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Maker - Product Challenge

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Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need to be controlled, except where water for injection is required.


<h2>Fully compliant water purification in flexible executions</h2>
The purified water systems from Telstar Life-Sciences are specially designed to generate purified water in accordance with the International Pharmacopoeia specifications for Purified or Highly Purified water; and in full compliance with cGMP guidelines as per FDA and EMEA, EP, JP and USP requirements.

Offering two flexible outputs:  from 300 to 10,000 L/h with Oasys and from 100 to 10,000 L/h with Genesys. The Genesys system is designed to allow automatic hot water sanitization of the complete unit including the pipework feeding the purified water into the storage vessel, whereas the Oasys system works with chemical sanitization.

Purified water systems

Sensitive bioprocess applications requires equipment that will not interfere with the chemical and biological processes being carried out.  At the same time, production bioprocesses, in particular those that involve peristaltic pumping, require robust tubing not prone to wear or mechanical failures.  Traditional transfer tubing for these more rigorous ans sensitive bioprocesses often proves inadequate.


<h2>A robust biocompatible tube designed for longevity in production peristaltic pumping applications</h2>
JM BioConnect is known for certified top of industry quality and customer service including very short lead times.  The company offers tubing solutions specifically designed for use in peristaltic pumps in bioprocess production environments. The tubes are of the PharMed BPT brand and are completely bio-compatible and less permeable to gasses and vapors than traditional silicone tubes.  This makes the PharMed BPT tubes ideal for protecting sensitive biological processes like cell culture, fermentation, separation, synthesis, and purification.  At the same time, they have been formulated for enhanced flex and wear characteristics allowing trouble free used in peristaltic pumping applications.  The combination of these qualities increases the efficiency of the bio-production process by reducing down time from tubing failure without making any sacrifices in bio compatibility.

Biocompatible tubing for peristaltic pumps

Single use bags for biopharmaceutical process containment and liquid storage are being used with increasing frequency in the industry due to their convenience, efficiency, and inherent cleanliness.  Integration of single use bags into biopharmaceutical processes is a great way to reduce required maintenance, and improve the versatility of equipment without increasing risk of cross contamination.
<h2>A mobile, vertical bag holder with integrated scale compatible with bags from any manufacturer</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs. The company’s WeighStation system is a wheeled bag stand that works with single use bags from any manufacturer.  The system includes integrated load cells and local display which allow it to be used as a stand-alone scale or to be integrated into other Scilog processing platforms for metered dispensing and purification.  The system has a minimized footprint and superior mobility when compared to a traditional floor scale.  The mobility and use of single use bags allow this piece of equipment to support several processes in your facility rather than being dedicated to just one.

Bag holder and weighing platform for bioprocesses

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

Getinge Applikon is the only company that can take you from the initial screening stage to full-scale production using the same platform. This minimizes scale-up risks and guarantees the shortest time to market for your new product development.

How can single use in biotech be sustainable, if you think of all the waste it creates? This might raise questions regarding the environmental impact. Let’s compare the complete life cycle of single-use systems such as tubing, capsule filters, chromatography devices, and bioreactors to their multi-use counterparts in glass or stainless steel and look at the outcome.

<h2>The end-of-life impact of single use tech</h2>
A product life cycle assessment compared single-use technologies to traditional multi use systems on points like resource extraction, processing, manufacturing, all through the end of the product life. Additionally environmental impact factors such as carbon, energy and water footprint were evaluated to paint a complete sustainable picture. Although disposal and waste remains a concern, the study found that this was actually only 1% of the total impact on the environment. Once put into use single use equipment presented a significantly lower impact resulting in <a href="https://cdn.cytivalifesciences.com/dmm3bwsv3/AssetStream.aspx?mediaformatid=10061&amp;destinationid=10016&amp;assetid=16801">a smaller overall end-of-life impact</a>.
<h2>Single use eliminates the need for cleaning in between batches</h2>
The most pressing finding is that the impact of chemicals, high purity waters and heat for cleaning and sterilization in between production batches is very high. Take for example a <a href="https://making.com/equipment/single-use-bioreactor">single use bioreactor</a> as shown in the video below; No need for extensive cleaning before the culture is started or after it’s finished and reducing the risk of cross contamination. Innovative technology such as 3D printing allows to create customizable products, while (re)creating exact replicas and keep desired process environments steady. Now officially stated as the more sustainable choice makes us understand why single systems are on the rise.

[embed]https://www.youtube.com/watch?v=RfPgrgw_wT8[/embed]

Is single use biotech equipment the more sustainable option?

Pharmaceutical

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Find production technology for Vaccines purification, and connect directly with leading machine manufacturers worldwide

Vaccines purification

Which vaccines purification equipment do you need?

Purified water systems

Biocompatible tubing for peristaltic pumps

Bag holder and weighing platform for bioprocesses

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