Vaccine Manufacturing Equipment
Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.
Which vaccines equipment do you need?
Ultra-fine dispersing machine for APIs and vaccines
Sterile Filtration System for GMP-grade products
High-frequency vibratory mixer
Acoustic cell retention system
Autoclavable glass bioreactor
Autoclavable stainless steel bioreactor
Photobioreactor for plant growth
Lab scale Bioreactor controller
Small-scale bioreactor controller
Scalable bioreactor controller
Dissolved Oxygen sensor
Steam-in-place bioreactor systems
Micro-Flask
Mini bioreactors
pH Sensor
Resonance Acoustic Mixer
Single-use bioreactor Appliflex
Single-use bioreactor CellReady 3L
Single use bioreactor Hyclone
Compact laboratory freeze dryer
Pilot freeze dryer for scale up
Multipurpose and R&D freeze dryer
Custom engineered freeze dryer
GMP freeze dryer
GMP laboratory freeze dryer
Purified water systems
Downflow booth
Sterility test isolators
Vertical laminar flow cabinet
Horizontal laminar flow benches
Compact horizontal laminar flow bench
Microbiological safety cabinet class II
Biosafety cabinet class II for cytotoxic medicines
Positive pressure isolator
Biological safety cabinet class III
Negative pressure isolator
Aseptic liquid filler for vials
3D disposable bags for bioprocesses
Disposable tank liners
Disposable manifold bags for bioprocesses
Normal flow filtration sets for bioprocesses
Disposable mixer bags for bioprocesses
Disposable pillow bags for bioprocesses
Biocompatible tubing for peristaltic pumps
Y sets tubing for bioprocesses
Disposable tubing for manifolds in bioprocesses
Filling and closing machine for parenterals
Automated single use tangential flow filtration system
Semi-automated tangential flow filtration system
Semi-automated normal flow filtration system
Bag holder and weighing platform for bioprocesses
Lab scale tangential flow filtration system
Lab scale normal flow filtration system
Automated dispensing system for bioprocesses
Single-use pressure sensor
Single-use conductivity sensor
Single-use temperature sensor
Automated cell culture clarification system
Sterile filling line for injectables
Start-up sterile filling line for injectables
Compact H2O2 disinfection system
Ethylene oxide sterilizer
24 fully controlled bioreactors in a microtiter format
Flexible automatic inspection machine for syringes
Distributor of samples to different devices
Packaging machine for syringes in trays
Vial sterilization tunnel
Vial filling machine
Syringe tub sterilizer
Nested syringe filling machine
Closed restricted access barrier system
Sterile compounding system
Single use bioreactor
Bioreactor software
Bioprocess control software
Optical Dissolved Oxygen Sensors
Complete bioreactor system
Pharmaceutical rotary labeling machine for vials
Labeling machine for ampoules
Form fill seal thermoforming machine for medical devices
Low speed Filler for large-volume parenterals
Lab-scale radial chromatography columns for virus validation
Pre-packed and pre-validated chromatography columns
Automated bubble traps for chromatography
Automatic forming and sealing blister machine for packing syringes
Aseptic filling machine for liquids and powders
Disposable isolator
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Select your vaccines process
Tell us about your production challenge
Vaccines are over-formulated to protect against potency loss
Vaccines start with the isolation of chemically defined media, but they come into being during formulation. The delicate development process stabilizes the separate components into a uniform mixture and prepares it for batch dosing. Cell cultures are often used in the development as well as formulation of Vaccines and has been that way for decades.
When it comes to producing vaccines, mixtures are typically over-formulated above the required potency. This method lowers yield but compensates for any possible degradation throughout the vaccine’s shelf-life.
Reduce vaccine moisture to max 3% with freeze-drying equipment
The process of lyophilization ensures that your biological formula remains stable along the cold chain. For this reason, freeze-dryers have become critical equipment in modern vaccine production.
Vaccine freeze-drying is a complex procedure involving three major steps. At the freezing stage, the solution solidifies with the formation of crystals. During the dehydration phase in a drying chamber, you subject the material to temperatures not exceeding -50 °C and forces water to sublimate. Finally, another round of drying releases any remaining moisture to between 1% and 3%.
Protect diluent from freezing or heating with cold chain storage
Before clinical trials and before the vaccine enters into the arms of patients, your lyophilized vaccines are reconstituted into liquid solutions using a diluent. World Health Organization guidelines warn that vaccine manufacturing is incomplete without the accompanying diluent.
Sterile water is often used as a diluent, but ingredients may contain a range of other substances such as sodium chloride, xanthan, or calcium carbonate. Whatever the composition, diluents must always be kept at temperatures between +2°C to +8°C.
Chromatography technology and mRNA techniques promise more accessible vaccines
Purification of the reaction mixture remains a challenge for large-scale vaccine development and production. But chromatography is emerging as an ideal purification technique for several biopharmaceuticals. Ligands in the chromatography columns form ‘hooks’ that filter out specific contaminants.
Vaccine manufacturers are taking advantage of this purification technique to reduce vaccine production’s financial and environmental costs. This method is attracting particular interest with the development of mRNA vaccines to combine a relatively simple manufacturing process with the high-yield capabilities of chromatography.
Packaging is a crucial step in vaccine production. This step is often forgotten about but is important in ensuring that the vaccines reach their final destination without getting damaged. But more importantly, safe packing means that the vaccines will reach patients without getting contaminated.