Tell us about your production challenge

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Which vaccines equipment do you need?

Ultra-fine dispersing machine for APIs and vaccines

Multi-staged rotor/stator mixers generate the high shear forces requi...

Sterile Filtration System for GMP-grade products

Processing equipment used in industries regulated by GMP must ensure full...

High-frequency vibratory mixer

Mixing liquid products by stirring method generates heat from friction and shear forces. This...

Acoustic cell retention system

Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh o...

Autoclavable glass bioreactor

Especially designed for cell culture applications and research applications such as process op...

Autoclavable stainless steel bioreactor

For cell culture and microbial culture applications.

Photobioreactor for plant growth

SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth ...

Lab scale Bioreactor controller

Success with bioprocesses is all about controlling the environmental conditions controls so ...

Small-scale bioreactor controller

When you are working with small bioreactors, starting from 50 ml volumes, you need a good...

Scalable bioreactor controller

When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot ...

Dissolved Oxygen sensor

The vast majority of all biotechnological processes are aerobic, where a microorganism or cell respon...

Steam-in-place bioreactor systems

Scaling-up from a laboratory scale to pilot plant and small scale production can be simpl...

Micro-Flask

During the initial stages of scale-up, researchers often have limited data available with which they must decide o...

Mini bioreactors

When a screening study takes place, optimizing media process and working with microbial and cell cultures is ...

pH Sensor

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New ...

Resonance Acoustic Mixer

Utilized when applying low-frequency and high-intensity acoustic energy to agitate microbial culture...

Single-use bioreactor Appliflex

A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, c...

Single-use bioreactor CellReady 3L

A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture ...

Single use bioreactor Hyclone

A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead...

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of...

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and "scale up" work.

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common applic...

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are design...

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in ac...

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need...

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

Aseptic liquid filler for vials

Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.

3D disposable bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single-use so...

Disposable tank liners

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for the...

Disposable manifold bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to dispos...

Normal flow filtration sets for bioprocesses

Bio-processors require reliable, high quality, easy to maintain, filtration e...

Disposable mixer bags for bioprocesses

Bioprocessors must use ingredients of known high quality and consistency.  Inconsist...

Disposable pillow bags for bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to single us...

Biocompatible tubing for peristaltic pumps

Sensitive bioprocess applications requires equipment that will not interfere wi...

Y sets tubing for bioprocesses

Manufactueres in the bioprocessing industries are increasingly turning to single use solution...

Disposable tubing for manifolds in bioprocesses

Manufacturers in the bioprocessing industries are increasingly turning to ...

Filling and closing machine for parenterals

Any pre-filled syringe can be filled and closed with this fast and easy machin...

Automated single use tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutica...

Semi-automated tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical proce...

Semi-automated normal flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing in...

Bag holder and weighing platform for bioprocesses

Single use bags for biopharmaceutical process containment and liquid st...

Lab scale tangential flow filtration system

Tangential Flow Filtration is an essential to the biopharmaceutical processing...

Lab scale normal flow filtration system

Normal Flow Filtration is frequently used the biopharmaceutical processing industry...

Automated dispensing system for bioprocesses

Biopharmaceutical manufacturers require precisely known liquid quantities for...

Single-use pressure sensor

Biopharmaceutical manufacturers are increasingly making use of Single-use pressure sensors to enh...

Single-use conductivity sensor

Biopharmaceutical manufacturers are increasingly making use of single-use conductivity sensor...

Single-use temperature sensor

Biopharmaceutical manufacturers are increasingly making use of single-use temperature sensors ...

Automated cell culture clarification system

Efficient harvest from the bioreactor is essential to any successful cell cult...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Compact H2O2 disinfection system

Dry fogging provides safe, effective microbiological cleaning of critical areas in biotech,...

Ethylene oxide sterilizer

When medical devices like syringes, catheters, dialysis cartridges, plastic dressings and sutures ...

24 fully controlled bioreactors in a microtiter format

When undertaking a screening study, process development or optimis...

Flexible automatic inspection machine for syringes

Manufacture of pre-filled syringes requires the highest quality inspec...

Distributor of samples to different devices

The ability to expand your automatic sampling ...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method ...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a ...

Vial filling machine

The volume filling of vials, cartridges and syringes is a vital part of ...

Syringe tub sterilizer

A common challenge is how to transfer nested syringe tubs to the asept...

Nested syringe filling machine

Increasingly, pre-sterilized Ready To Use (RTU) nested vials,...

Closed restricted access barrier system

Pharmaceutical production techniques often require ...

Sterile compounding system

Hospitals and compounding centres have traditionally used manual ...

Single use bioreactor

Single use, micro-bioreactors could be a good solution for replication processes, especially when they ...

Bioreactor software

Comprehensive upstream data acquisition and management are essential in the bioprocessing industry. That...

Bioprocess control software

Managing a large number of bioprocesses individually without automation is time-consuming, and t...

Optical Dissolved Oxygen Sensors

Sufficient oxygen is critical to the success of processes like cell culture and fermentatio...

Complete bioreactor system

An autoclavable bioreactor establishes special conditions for a variety of applications, for exam...

Pharmaceutical rotary labeling machine for vials

Small, cylindrical-shaped glass bottles or vials are mainly used for vacc...

Labeling machine for ampoules

It’s essential for pharmaceutical companies to provide the highest quality ampoules to custom...

Form fill seal thermoforming machine for medical devices

Form Fill Seal thermoforming machines are those that produce pac...

Low speed Filler for large-volume parenterals

Large-volume parenteral bottles are usually manufactured with a resin that c...

Lab-scale radial chromatography columns for virus validation

In the food industry, as an example, during lab-testing and...

Pre-packed and pre-validated chromatography columns

In chromatography, you must always take into account the apparatus th...

Automated bubble traps for chromatography

Radial flow chromatography processes require special attention and the right use...

Automatic forming and sealing blister machine for packing syringes

Controlling contamination is on every manufacturer's...

Aseptic filling machine for liquids and powders

Aseptic filling of containers such as vials, syringes, bottles, and cartri...

Disposable isolator

Pharmaceutical powders need to be contained in the strictest conditions. But handling powders and cleanin...
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Stories about Vaccines

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Vaccines are over-formulated to protect against potency loss

Vaccines start with the isolation of chemically defined media, but they come into being during formulation. The delicate development process stabilizes the separate components into a uniform mixture and prepares it for batch dosing. Cell cultures are often used in the development as well as formulation of Vaccines and has been that way for decades.

When it comes to producing vaccines, mixtures are typically over-formulated above the required potency. This method lowers yield but compensates for any possible degradation throughout the vaccine’s shelf-life.

Reduce vaccine moisture to max 3% with freeze-drying equipment

The process of lyophilization ensures that your biological formula remains stable along the cold chain. For this reason, freeze-dryers have become critical equipment in modern vaccine production.

Vaccine freeze-drying is a complex procedure involving three major steps. At the freezing stage, the solution solidifies with the formation of crystals. During the dehydration phase in a drying chamber, you subject the material to temperatures not exceeding -50 °C and forces water to sublimate. Finally, another round of drying releases any remaining moisture to between 1% and 3%.

Protect diluent from freezing or heating with cold chain storage

Before clinical trials and before the vaccine enters into the arms of patients, your lyophilized vaccines are reconstituted into liquid solutions using a diluent. World Health Organization guidelines warn that vaccine manufacturing is incomplete without the accompanying diluent.

Sterile water is often used as a diluent, but ingredients may contain a range of other substances such as sodium chloride, xanthan, or calcium carbonate. Whatever the composition, diluents must always be kept at temperatures between +2°C to +8°C.

Chromatography technology and mRNA techniques promise more accessible vaccines

Purification of the reaction mixture remains a challenge for large-scale vaccine development and production. But chromatography is emerging as an ideal purification technique for several biopharmaceuticals.  Ligands in the chromatography columns form ‘hooks’ that filter out specific contaminants.

Vaccine manufacturers are taking advantage of this purification technique to reduce vaccine production’s financial and environmental costs. This method is attracting particular interest with the development of mRNA vaccines to combine a relatively simple manufacturing process with the high-yield capabilities of chromatography.

Packaging is a crucial step in vaccine production. This step is often forgotten about but is important in ensuring that the vaccines reach their final destination without getting damaged. But more importantly, safe packing means that the vaccines will reach patients without getting contaminated.

Processing steps involved in vaccines making

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