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Vaccine Manufacturing Equipment

Find innovative production technology for making vaccines and connect directly with world-leading specialists.

Vaccine making equipment

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Which vaccines equipment do you need?

GMP dispersing machine for liquid formulations

GMP dispersing machine for liquid formulations

Multi-staged rotor/stator mixers generate the high shear forces required to …

Sterile Filtration System for GMP-grade products

Sterile Filtration System for GMP-grade products

Processing equipment used in industries regulated by GMP must ensure fully…

High-frequency vibratory mixer

High-frequency vibratory mixer

Mixing liquid products by stirring method generates heat from friction and shear forces. This …

Acoustic cell retention system

Acoustic cell retention system

Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh or…

Autoclavable glass bioreactor

Autoclavable glass bioreactor

Especially designed for cell culture applications and research applications such as process opt…

Autoclavable stainless steel bioreactor

Autoclavable stainless steel bioreactor

For cell culture and microbial culture applications.

Photobioreactor for plant growth

Photobioreactor for plant growth

SSL (Solid state lamps) plant light has unique and useful characteristics for plant growth a…

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Lab scale Bioreactor controller

Lab scale Bioreactor controller

Success with bioprocesses is all about controlling the environmental conditions controls so y…

Small-scale bioreactor controller

Small-scale bioreactor controller

When you are working with small bioreactors, starting from 50 ml volumes, you need a good …

Scalable bioreactor controller

Scalable bioreactor controller

When you are up-scaling bioprocesses, starting at the lab and going all the way to the pilot a…

Dissolved Oxygen sensor

Dissolved Oxygen sensor

The vast majority of all biotechnological processes are aerobic, where a microorganism or cell respond…

Steam-in-place bioreactor systems

Steam-in-place bioreactor systems

Scaling-up from a laboratory scale to pilot plant and small scale production can be simpli…

Micro-Flask

Micro-Flask

During the initial stages of scale-up, researchers often have limited data available with which they must decide on…

Mini bioreactors

Mini bioreactors

When a screening study takes place, optimizing media process and working with microbial and cell cultures is q…

pH Sensor

pH Sensor

pH is one of the most important parameters of cell-culture and fermentation processing in the biotech industry. New t…

Resonance Acoustic Mixer

Resonance Acoustic Mixer

Utilized when applying low-frequency and high-intensity acoustic energy to agitate microbial cultures…

Single-use bioreactor Appliflex

Single-use bioreactor Appliflex

A single-use bioreactor is a bioreactor with a disposable bag instead of a culture vessel, co…

Single-use bioreactor CellReady 3L

Single-use bioreactor CellReady 3L

A single-use bioreactor is quite simply a bioreactor with disposable vessel for culture o…

Single use bioreactor Hyclone

Single use bioreactor Hyclone

A single-use bioreactor is a bioreactor with a disposable vessel for culture of cells, instead …

Compact laboratory freeze dryer

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of …

Pilot freeze dryer for scale up

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and "scale up" work.

Multipurpose and R&D freeze dryer

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common applica…

Custom engineered freeze dryer

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are designe…

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GMP freeze dryer

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in acc…

GMP laboratory freeze dryer

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Purified water systems

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need …

Downflow booth

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated duri…

Sterility test isolators

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated fa…

Vertical laminar flow cabinet

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area a…

Horizontal laminar flow benches

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work ar…

Compact horizontal laminar flow bench

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space …

Microbiological safety cabinet class II

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection a…

Biosafety cabinet class II for cytotoxic medicines

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepar…

Positive pressure isolator

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indigen…

Stories about Vaccines

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Vaccines are over-formulated to protect against potency loss

Vaccines start with the isolation of chemically defined media, but they come into being during formulation. The delicate development process stabilizes the separate components into a uniform mixture and prepares it for batch dosing. Cell cultures are often used in the development as well as formulation of Vaccines and has been that way for decades.

When it comes to producing vaccines, mixtures are typically over-formulated above the required potency. This method lowers yield but compensates for any possible degradation throughout the vaccine’s shelf-life.

Reduce vaccine moisture to max 3% with freeze-drying equipment

The process of lyophilization ensures that your biological formula remains stable along the cold chain. For this reason, freeze-dryers have become critical equipment in modern vaccine production.

Vaccine freeze-drying is a complex procedure involving three major steps. At the freezing stage, the solution solidifies with the formation of crystals. During the dehydration phase in a drying chamber, you subject the material to temperatures not exceeding -50 °C and forces water to sublimate. Finally, another round of drying releases any remaining moisture to between 1% and 3%.

Protect diluent from freezing or heating with cold chain storage

Before clinical trials and before the vaccine enters into the arms of patients, your lyophilized vaccines are reconstituted into liquid solutions using a diluent. World Health Organization guidelines warn that vaccine manufacturing is incomplete without the accompanying diluent.

Sterile water is often used as a diluent, but ingredients may contain a range of other substances such as sodium chloride, xanthan, or calcium carbonate. Whatever the composition, diluents must always be kept at temperatures between +2°C to +8°C.

Chromatography technology and mRNA techniques promise more accessible vaccines

Purification of the reaction mixture remains a challenge for large-scale vaccine development and production. But chromatography is emerging as an ideal purification technique for several biopharmaceuticals.  Ligands in the chromatography columns form ‘hooks’ that filter out specific contaminants.

Vaccine manufacturers are taking advantage of this purification technique to reduce vaccine production’s financial and environmental costs. This method is attracting particular interest with the development of mRNA vaccines to combine a relatively simple manufacturing process with the high-yield capabilities of chromatography.

Packaging is a crucial step in vaccine production. This step is often forgotten about but is important in ensuring that the vaccines reach their final destination without getting damaged. But more importantly, safe packing means that the vaccines will reach patients without getting contaminated.

Processing steps involved in vaccines making

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