Sterilization in place fermentor for bioprocess applications

Optimize your fermentation processes with seamless integration of sterilization, sampling, and control, achieving precision and customization in microbial and cell culture production.

Facilitates Bioculture Sterilization and Harvesting

The MSJ and MPF Series from Marubishi Bioengineering are engineered-to-order fermentors tailored for diverse bioprocessing needs in the biotechnology and pharmaceutical industries. These fermentors are distinguished by their ability to perform sterilization in place using live steam, ensuring contamination-free operations for producing high-quality bioproducts such as monoclonal antibodies, recombinant proteins, and biofuels.

Available in sizes ranging from 10 to over 10,000 liters, these systems cater to both research and industrial-scale operations. They feature graphic touch panels and automated control systems, allowing seamless integration and streamlined operations including sterilization, sampling, and precise agitation. The fermentors accommodate various culture types—microbial, mammalian, and recombinant DNA—backed by Marubishi’s extensive experience.

Built with mechanical seal technology, these fermentors optimize energy usage and sterility. Offered with options for pH, DO, and airflow monitoring, they support a wide array of applications from R&D labs to large-scale production facilities. Marubishi provides comprehensive engineering support for custom configurations, ensuring compatibility with GMP standards and ease of maintenance with flexible cleaning systems.

Benefits

  • Enhances operational efficiency with automated sterilization and sampling processes.
  • Minimizes contamination risks with in-place sterilization using live steam.
  • Accommodates scaling needs, from R&D to industrial production, with customizable vessel sizes.
  • Reduces energy usage through variable-speed agitation and optimized control systems.
  • Complies with stringent GMP standards, ensuring regulatory adherence and product safety.

General


Applications
Microbial cultures,Biofuels,Cell cultures,Nutraceuticals,Biopharmaceuticals,Enzymes,Dna recombinant
End products
Biodiesel,Vaccines,Bioethanol,Monoclonal antibodies,Liposomal supplements,Lactase enzyme,Amylase enzyme,Yogurts,Recombinant proteins,Protein therapeutics,Probiotics
Steps before
Seed culture preparation,Scaling down test,Determining culture conditions
Steps after
Sampling,Harvesting,Transfer to the next process
Input ingredients
seed culture,microbes,mammalian cells,DNA recombinant,cell mass
Output ingredients
protein,culture medium,harvested cells,processed biomass
Market info
Marubishi Bioengineering is known for its expertise in manufacturing high-quality bioreactors and fermentation systems for the biotechnology and pharmaceutical industries, reputed for their precision-engineering and customization to meet specific client requirements.

Technical Specifications


Vessel Size
10,20,30,50,70,90,100,up to 10,000+ Liters
Sterilization Method
Sterilization in place with live steam
Agitation System
Top or bottom entry driving
Control Panel
Graphic touch panel
Automation
Automated operating procedures
Temperature Control
Available
Agitation Speed Control
Available
Optional Measurement/Control Items
pH,DO,anti-foaming,air flow rate
Mechanical Seal Technology
For agitator shaft seal

Operating Characteristics


Automation level
Manual / PLC
CIP/SIP
SIP with live steam
Cleaning method
SIP / Manual
Batch vs. Continuous Operation
Batch
Integrated Steps
Sterilization,Sampling,Harvesting,Transfer

Physical Characteristics


Fermentor vessel size
10,20,30,50,70,90 L
Fermentor vessel size
100 L to 10,000 L
Fermentor vessel size
Custom sizes over 10,000 L
Agitation system entry point
Top / Bottom
Control panel type
Graphic touch panel

Custom Options


Fermentor vessel sizes
10,20,30,50,70,90L
Fermentor vessel sizes for large scale
100L to 10,000L
Agitation system
Top or bottom entry driving
Control items
Temperature,agitation speed
Optional measurement/control items
pH,DO,anti-foaming,air flow rate
Automation system
Automated sterilization,sampling,harvesting
System integration
Hardware and software customizability
Customized design and manufacturing
Available for > 10 kilo liters
Graphical touch panel
For operation ease