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Maker - Product Challenge

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Vaccine drying Equipment

Industrial drying machines are designed to remove moisture from your product. But the drying process must cater to variations in the state of matter and molecular structure of the input material. Industrial dryer technology exploits the modes of heat transfer (convection, conduction, radiation, evaporative cooling) to control the moisture content.

Drying

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Particularly suitable for research centers requiring greater freeze drying capacity. Some of the most common applications are galenic formulation, freeze drying experimentation, aliquot preservation, taxidermy, experimental food and so on.


<h2>The laboratory freeze dryer that is easy-to-use</h2>
The LyoAlfa from Telstar Life-Sciences is a compact laboratory freeze dryer. It comes as a console and is mounted on casters which make it easy to install. The unit is very flexible, allowing for the simultaneous freeze drying of bottles, vials or bulk products through the connection of different manifold systems or a chamber.

It is available in two models LyoAlfa 6 -50, with a final condenser temperature of -50 ºC; and LyoAlfa 6 -80, with a final condenser temperature of -80 ºC. This enables a higher freeze drying speed and is much more suitable for working with biological samples or products with very low eutectic or collapse points.

Compact laboratory freeze dryer

Designed for biological, pharmaceutical and food products formulation and "scale up" work.


<h2>Best performance for technology transfer activities and work in advanced R&amp;D Centers</h2>
The LyoBeta from Telstar Life-Sciences is a freeze drying unit for biological, pharmaceutical and food products formulation and "scale up" work, facilitating transfer technology to the R&amp;D centers and production. It is a high performance unit with a GLP design that allows for performing the entire freeze drying process fully automatically as well as accurately monitoring it. Very easy to clean, stainless steel chamber, condenser and plates; includes industrial components, such as sensors, vacuum pump, exchangers, etc.

Some of the most common applications are production in pilot plants, functional food research, preservation of diagnosis kits, small batches for clinical trials and so on.

Pilot freeze dryer for scale up

A multipurpose unit in the research and development field. Some of the most common applications are galenic formulation, freeze drying experimentation, taxidermy, underwater archaeology, aliquot preservation,  diagnosis and other research.


<h2>Start your research with this multipurpose high-performance device</h2>
The LyoQuest laboratory, multipurpose and R&amp;D freeze dryer from Telstar Life-Sciences has been designed as a multipurpose unit for the research and development field. It is a small freeze dryer, more compact than most but in spite of its small size, its capacity is quite unbeatable. A state-of-the-art control system and a range of specially designed accessories make the LyoQuest a benchmark in its category.

The unit's design offers the best performance in the least possible space. Suitable for laboratories: compact and easy to install, solidly designed laboratory equipment. On a functional level, cooling management ensures optimum performance.

Multipurpose and R&D freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are designed for freeze drying high value products, such as: vaccines, cytostatics, antibiotics, biologicals, hormones, active ingredients, reactives, etc.


<h2>Integrated and customized solution for pharmaceutical production</h2>
The Lyomega from Telstar Life-Sciences offers design flexibility to tackle all the requirements for each project. Customization capabilities cover a wide range of engineered solutions, including two-door pass-through design and sub-doors for product loading and unloading at a constant level. Internal or external condenser systems can also be configurated in a horizontal or vertical position, adjacent to or below the chamber. Refrigeration systems range through a double stage or cascade reciprocating compressor, screw compressor or liquid nitrogen and a full range of customized CIP systems are also available.

Custom engineered freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in accordance with the strictest GMP and Regulatory standards and in line with the latest freeze drying technology trends.


<h2>The right balance between specification, quality, cost and lead-time</h2>
The Lyonomic Series from Telstar Life-Sciences are state of the art freeze-drying systems, designed and engineered modularly to provide a comprehensive range of standard models and in-factory options.

Telstar freeze drying shelf inner channel design ensures high product homogeneity during the freezing, primary and secondary drying stages. The SCADA supervisory, control and data acquisition system designed by Telstar, allows the user to readily interpret the machine's operation and obtain information on the process required for decision making and batch reporting, all in compliance with FDA 21 CFR part 11 electronic record guidelines.

GMP freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.


<h2>Industrial freeze dryer in a compact envelope</h2>
Lyotris from Telstar Life-Sciences is a lab scale production freeze dryer designed for the production of small batches of high-value pharmaceutical products. With a 1m2 loading surface and capacity for approximately 1,600 10R-type vials or 30 liters of bulk product. It has been specially designed for aseptic production in vials or in bulk and its novel fascia and door design provides easy isolator integration.

The GMP laboratory freeze dryer comes with all  the necessary components for an automatic cleaning (CIP) and steam sterilization (SIP) processes, filter integrity testing (WIT) and also incorporates an advanced SCADA system which includes Telstar's patented ‘Lyometrics' system; providing advanced real-time information on the freeze-drying process.

GMP laboratory freeze dryer

Stabilizing biopharmaceutical products often requires a reliable method to increase shelf life. Traditional preservation techniques may not suffice, especially when dealing with high-value products such as vaccines, antibiotics, or hormones.
<h2>Efficiently stabilizes high-value biopharmaceuticals</h2>
The LYOFAST by IMA is an industrial freeze dryer specifically designed for the biopharmaceutical industry. Unlike conventional systems, LYOFAST uses IMA Life’s patented FUSION™ technology to achieve higher quality and process reliability. The FUSION™ shelves are lighter and more resistant, facilitating optimal heat transfer. Supporting a shelf cooling capability down to -55°C and a condenser cooling range down to -75/120°C, the LYOFAST system accommodates various chamber geometries (cylindrical or rectangular) and configurations, making it suitable for bulk formats or liquid forms in vials, ampoules, or syringes. The system also features a two-stage reciprocating semi-hermetic, water-cooled refrigeration system, and vacuum measurements using an active Pirani type gauge. Its modular design compresses project timelines and reduces lead-times while offering significant cost savings.

Industrial freeze dryer for biopharmaceuticals

In the pharmaceutical industry, scaling from laboratory development to full-scale production often involves complex processes that require precise control of conditions. One critical phase is freeze drying, which stabilizes products by removing moisture under low temperatures and pressure.
<h2>Optimize freeze drying from lab to production</h2>
The Lyofast Mini by IMA is a compact freeze dryer designed to bridge the gap between laboratory development, pilot testing, and industrial production. This system is adept at processing initial scale-up batches to test the robustness of freeze drying processes, helping to understand future technology requirements for large-scale production. The Lyofast Mini is equipped with four different configurations, ranging from 1 to 2.8 square meters of shelf area. It features CIP/SIP (Clean-in-Place/Sterilize-in-Place) capabilities, a slot door for RABS/isolator integration, and variable shelf interdistance. Automatic stoppering pressure control and redundant shelf inlet temperature probes ensure consistent and reliable operation. Additionally, it incorporates the Lyomaster compact SCADA system for comprehensive process control. This system is particularly suitable for biotech customers and small-scale production, providing commercial value by reducing energy requirements and downstream production costs.

Pilot freeze dryer for pharmaceutical applications

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

Getinge Applikon is the only company that can take you from the initial screening stage to full-scale production using the same platform. This minimizes scale-up risks and guarantees the shortest time to market for your new product development.

How can single use in biotech be sustainable, if you think of all the waste it creates? This might raise questions regarding the environmental impact. Let’s compare the complete life cycle of single-use systems such as tubing, capsule filters, chromatography devices, and bioreactors to their multi-use counterparts in glass or stainless steel and look at the outcome.

<h2>The end-of-life impact of single use tech</h2>
A product life cycle assessment compared single-use technologies to traditional multi use systems on points like resource extraction, processing, manufacturing, all through the end of the product life. Additionally environmental impact factors such as carbon, energy and water footprint were evaluated to paint a complete sustainable picture. Although disposal and waste remains a concern, the study found that this was actually only 1% of the total impact on the environment. Once put into use single use equipment presented a significantly lower impact resulting in <a href="https://cdn.cytivalifesciences.com/dmm3bwsv3/AssetStream.aspx?mediaformatid=10061&amp;destinationid=10016&amp;assetid=16801">a smaller overall end-of-life impact</a>.
<h2>Single use eliminates the need for cleaning in between batches</h2>
The most pressing finding is that the impact of chemicals, high purity waters and heat for cleaning and sterilization in between production batches is very high. Take for example a <a href="https://making.com/equipment/single-use-bioreactor">single use bioreactor</a> as shown in the video below; No need for extensive cleaning before the culture is started or after it’s finished and reducing the risk of cross contamination. Innovative technology such as 3D printing allows to create customizable products, while (re)creating exact replicas and keep desired process environments steady. Now officially stated as the more sustainable choice makes us understand why single systems are on the rise.

[embed]https://www.youtube.com/watch?v=RfPgrgw_wT8[/embed]

Is single use biotech equipment the more sustainable option?

Pharmaceutical

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Find production technology for Vaccine drying, and connect directly with leading machine manufacturers worldwide

Vaccine drying

Vaccine drying - Making.com

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