Pharmaceutical lyophilization for large-scale production
Ensure precision in pharmaceutical freeze drying with controlled nucleation, reducing cycle times and enhancing product uniformity for critical drug formulations.
Processes Pharmaceuticals with Controlled Lyophilization
The LYOVAC Pharma Freeze Dryer from GEA specializes in industrial-scale lyophilization for pharmaceuticals, ensuring uniform processing of delicate formulations like vaccines and protein-based drugs. Using a unique shelf design and controlled nucleation technology, it offers precise freezing, drying, sublimation, and desorption. This equipment integrates seamlessly with automatic loading and unloading systems, minimizing contamination risks and optimizing throughput. It supports the production of lyophilized products in varied formats, achieving high consistency and efficiency. Engineered with solvent and energy-saving capabilities, the LYOVAC meets GMP standards and is available with options for customization, including material choices for compliance with pharmaceutical regulations.
Benefits
- Enhances product uniformity and quality with controlled nucleation technology.
- Shortens drying times, improving production efficiency and throughput.
- Minimizes contamination risks with automated loading and unloading systems.
- Adapts easily to existing systems with customizable configurations.
- Ensures regulatory compliance with GMP standards.
- Applications
- Pharmaceuticals,Freeze-dried products,Lyophilized products,Biopharmaceuticals,Potent pharmaceuticals,Pharmaceutical formulations
- End products
- Hormone therapies,Vaccines,Protein-based drugs,Antibodies,Monoclonal antibodies,Freeze-dried antibiotics,Enzyme formulations,Freeze-dried plasma,Oncological drugs,Lyophilized injectables
- Steps before
- Solution preparation,Filling vials,Cooling
- Steps after
- Packaging,Sterilization,Inspection and quality control
- Input ingredients
- Output ingredients
- Market info
- GEA is known for its expertise in engineering innovative and sustainable equipment and solutions, focusing on sectors such as food, beverages, pharmaceuticals, and energy, with a reputation for quality, efficiency, and advanced technological applications in industrial processing.
- Production Area
- 1–60 m²
- Condenser Capacity
- More than 1000 kg
- Arrangement
- Single or multiple floors
- Automation
- State-of-the-art with virtual servers
- Refrigeration
- Compressors,LN2,natural refrigerants
- Shelf Design
- Ensures high drying rates and uniform results
- Drying Stages
- Freezing,primary drying,secondary drying
- Nucleation Temperature
- –5 to –20 °C
- Controlled Nucleation
- LYOSPARK® technology
- Process Stages
- Freezing,Primary Drying,Secondary Drying
- Process Time
- Less than a year for Fast Track delivery
- CIP/SIP
- Quick subprocess turnaround times
- Loading and Unloading System
- Automatic (ALUS®)
- Containment Options
- Isolators,Cleanrooms,RABS
- Processing Capabilities
- Highly potent,solvent processing
- Ice Crystal Nucleation
- Controlled with LYOSPARK®
- CIP/SIP
- CIP 121°C / SIP 135°C
- Batch vs. continuous operation
- Batch
- Automation level
- State-of-the-art automation options with virtual servers
- Changeover time
- Quick subprocess turnaround times
- Biological compatibility
- Yes
- Cleanability
- CIP/SIP compliant
- Corrosive resistance (e.g. acids)
- Stainless steel construction
- Pharmaceutical lyophilizer
- LYOVAC® Pharma Freeze Dryer
- Machine footprint
- 1–60 m²
- Production area size
- 1–60 m²
- Condenser capacity
- More than 1000 kg
- Shelf design
- Unique for high drying rates and uniform results
- Condenser orientation
- Under drying chamber/side/behind
- System arrangement
- Single-floor or multiple-floor
- Freeze Dryer Arrangement
- Single or Multiple Floors