Vial filling for pharmaceuticals
Streamline your aseptic processing with vial filling machines that ensure sterile, precise, and efficient handling of liquid formulations, from vaccines to biologics, reducing contamination risks and maximizing production quality.
Processes and Stoppers Vials for Liquid Formulations
The vial filling and stoppering machine from groninger offers a cutting-edge solution for pharmaceutical and biopharmaceutical production lines. This equipment encompasses an integrated process for washing, sterilizing, filling, and stoppering vials, ensuring seamless operations from start to finish. Designed for a diverse range of liquid formulations, including vaccines, insulin, and monoclonal antibodies, it supports production outputs between 50 and 600 units per minute, accommodating both small and large batch operations.
Engineered for sterile areas and clean rooms, the machine adheres to cGMP requirements, integrating easily into your existing production line. The system features a quickconnect format changeover for minimal downtime, allowing tool-free transitions between different vial formats. Groninger’s vial filling machine is designed with 100% In-Process-Control (IPC) to maximize precision, coupled with smartfill technology to minimize product loss and achieve optimal efficiency.
This automated line can incorporate additional processes like freeze drying and external vial cleaning, enabling aseptic processing even to OEB5 or BSL2 levels. The equipment incorporates advanced technology like PUPSIT, CIP/SIP options, and a single-use fill path to avoid cross-contamination. It further offers flexibility in sealing with various rubber stoppers and push-fit closure systems like RayDyLyo®.
Constructed for durability and reliability, the machine can be tailored with materials like stainless steel to meet specific corrosion resistance needs. With compliance to EU GMP standards, the groninger vial filling and stoppering machine stands as a robust and adaptable choice for high-speed, automated pharmaceutical production.
Benefits
- Maximizes production efficiency with rapid format changeover and minimal downtime.
- Ensures product integrity and safety through 100% In-Process-Control and precise filling.
- Minimizes waste and product loss with smartfill technology.
- Adapts to diverse formulation needs, supporting a wide range of pharmaceuticals and cosmetics.
- Complies with cGMP standards, enhancing regulatory compliance and quality assurance.
- Applications
- Veterinary products,Biologics,Liquid formulations,Vaccines,Cell therapies,Cosmetics,Biopharmaceuticals,Gene therapies,Pharmaceuticals
- End products
- Covid-19 vaccines,Orphan drugs,Botox,Anti-aging serums,Insulin,Dna vaccines,Chemotherapeutic agents,Collagen-based creams,Hyaluronic acid fillers,Hepatitis b vaccines,Protein-based therapeutics,Moisturizers,Eye serums,Gene editing solutions,Oncolytic viruses,Monoclonal antibodies,Liposomal formulations,Interferons,Veterinary serums
- Steps before
- Glass Container Preparation,Vial Transport to Buffer,Camera Inspection for Defects,Sterile Tunnel Supply,Pre-Use-Post-Sterilization Integrity Test (PUPSIT)
- Steps after
- Tray Loading,External Cleaning,Product Coding,Freeze Drying,Re-stoppering
- Input ingredients
- glass containers,vaccines,biologics,cell and gene therapies,raw pharmaceutical materials,vial caps,rubber stoppers,pre-sterilized packaging containers
- Output ingredients
- filled vials,sealed vials,sterilized containers,labeled vials,packed trays
- Market info
- Groninger is known for its expertise in manufacturing high-quality filling and packaging machinery for the pharmaceutical, cosmetics, and consumer healthcare industries, with a strong reputation for innovation, precision engineering, and customer-focused solutions.
- Speed
- 50–600 units per minute
- Capacity
- 3,000–36,000 per hour
- Compliance
- cGMP requirements
- Filling accuracy
- Uncompromising accuracy
- Automation
- Automatic
- Material Compatibility
- Liquid formulations
- Cleanroom Compatibility
- Sterile areas or clean rooms
- Sterilization
- External or integrated
- CIP/SIP
- Clean-in-place or Sterilization-in-place
- In-Process-Control (IPC)
- 100% IPC
- Filling method
- Rotary piston pump,peristaltic pump,time pressure filling systems
- Changeover
- Quickconnect system
- External cleaning
- Integrated system for toxic products
- Closure Type
- Various rubber stoppers,push-fit systems
- Sealing
- Single-disc sealing principle
- Tray Loading
- Tiltable drawer system
- Automation level
- PLC / SCADA
- Batch vs. continuous operation
- Batch / Inline Continuous
- CIP/SIP
- CIP 121°C / SIP 135°C
- Changeover time
- Quick changeover with quickconnect
- Cleaning method
- CIP / SIP compatible
- Energy efficiency
- High energy efficiency
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Machine footprint
- Customizable
- Compact footprint
- Yes
- Control panel type
- Electronic / Touch screen
- Discharge method
- Automated / Bulk / Tray
- Tray loading system
- Pick,Place / Tiltable drawer
- Control panel type
- Touchscreen / HMI
- Integration possibilities
- SCADA / MES
- Quick changeover system
- Quickconnect
- Filling head options
- 1 to 8 heads
- Format adaptability
- Tool-free changeover
- Flexibility in container size
- Various vial sizes