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Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Industrial sampling equipment are systems that allow manufacturers to test (in other words to take a sample of) the products they are manufacturing. This process is generally implemented as a means of quality control but it can also be used as a mean to ensure that production processes adhere to certain regulatory standards. Quality control in your manufacturing process starts with precision sampling techniques. Automated systems deliver consistent samples at a pre-set rate for accurate testing and probing. Sampling technology uses a calibration system involving a series of sensors to extract the material at high levels of reliability.

Sampling

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Sampling is the process of aseptically drawing a sample from the process for analysis, without disturbing the bioprocess itself. The bioprocess needs to be carefully controlled by measuring important process variables and parameters. These parameters include pH, temperature, dissolved oxygen, foam/level, and agitation. The controllers use PID or auto-tuning adaptive control to measure and regulate the process parameters. The choice of a suitable controller depends on the identification of critical process variables.

Industrial

In the radiopharmaceutical industry, the need for precise dispensing and production of radioisotopes is critical. Handling radioactive materials involves challenges such as ensuring safety, maintaining sterility, and achieving accurate dosages. Facility managers must comply with strict regulatory requirements while optimizing productivity.
<h2>Automate dosing and sterilize with precision.</h2>
The Lu-177 N.C.A. Semiautomatic Production and Dispensing Plant by Comecer is a refined solution for producing and dispensing Lu-177. This system comprises two hot cells: one for the extraction and purification of Lu-177, and another for dispensing and terminal sterilization. The extraction cell features a tele-pliers and dose calibrator, protected with a fluoropolymer acid-proof coating, and supports the integration of a customer-specific module for separating 176Yb from 177Lu. It efficiently handles both liquid and solid wastes. The dispensing cell is equipped with tele-manipulators and an automated micro-pipettor module that allows for the semi-automatic dispensing of radioisotope micro-doses. The system features SIL-2 certified safety interlocks according to IEC 61508, ensuring high reliability. With productivity reaching 50 vials in 8 hours, including terminal sterilization, this plant offers both efficiency and safety in handling highly concentrated and corrosive substances.

Semiautomatic lu-177 production and dispensing plant

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Industrial extraction equipment unlocks the valuable compounds hidden away in natural materials. Automated extraction equipment is applied in the pharmaceutical and cosmetic industries to extract active compounds from medicinal plants or herbs. For example, extracting cannabinoids from cannabis plants. But the process is also fundamental to the food industry, recovering various components like aromas, oleoresins, and proteins.  Considerations for selecting suitable extraction technology include the type of plant material to be processed, the extract's heat sensitivity, and the production volume.

Extraction

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

Sterilization

liquid

solid

Batch

Radial flow chromatography processes require special attention and the right use of high-quality appliances in order to deliver upon specific laboratory requirements. This is where the bubble trap becomes an integral part of the process as it efficiently removes any unwanted gas or air bubbles in process fluids without providing areas where harmful bacteria could accumulate.
<h2>Bubble and gases bubble trap extractor</h2>
Bubble traps are an essential part of the pharmaceutical, food, and chemical industries that are responsible for the extraction of bubbles and gases from chromatographic processes and operations. Bubble traps are most often used in combination with Proxcys Radial Flow Chromatography columns or are simply installed inline onto piping, skids, or for stand-alone use via an expended foot.

The bubble traps are designed in accordance with customer requirement specifications and can range between volumes of 0.5L to 60L. Moreover, the bubble traps have various outlets and inlets that allow for the implementation of add-ons like an expanded feed for stand-alone use in laboratory environments. In general, the standard material of manufacturing is 316L stainless steel with a borosilicate glass cylinder. Additionally, onto the glass cylinder, a straight or at 90-degree elbow Tri-Clamp inlet and outlet to connect to piping are available for a wide range of process flows.

Still, it is completely optional to upgrade materials to a higher grade of steel. All of the materials that have been used come with the proper certifications for usage in pharmaceutical production.

Automated bubble traps for chromatography

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

In the food industry, as an example, during lab-testing and studies, chromatography columns are used to detect and quantify spoilage indicators such as pyruvic acid in milk. In such cases, it is essential to make use of chromatography columns that possess great industrial compatibility. Having a tolerance for errors like accidental air, flow, and pressure variations proves to be critical during such practices as this will increase the margin for error that could fail a study, allowing for a wider spectrum of tests to be successfully carried out.
<h2>Mini radial chromatography columns for virus validation</h2>
The mini radial chromatography columns by Proxcys are robust, resulting in exceptional industrial compatibility due to their large tolerance for errors, like the entry of air, flow, and pressure variations. They are used to closely mimic full-scale radial processes with smaller bed volumes ranging between 3 and 30 centimeters.

The design of the Mini Column comes with an integrated valved packing port that results in an improved column overall performance and easy handling. The clear acrylic cylinder provides the conditions to study the behavior of the resin and bed build up during the column packing.

The use of the selected material in combination with the straight forward design eliminates the need for learning any time-consuming processes giving you the freedom to focus on further operations and testing.

Lab-scale radial chromatography columns for virus validation

The food and pharmaceutical industries require maintaining high levels of sanitations as well as logistical quality. The lifting equipment used in these industries thus need to be cleaned thoroughly and very frequently. You thus need a weighing scale that is both accurate, while being easy to move and maintain.


<h2>A flexible and easy to clean lifting scale solution</h2>
Alba’s Floor Scale Moveline is an upgraded version of their standard lifting model. It is a floor scale which makes the raising and repositioning of materials extremely effortless. It is equipped with a ramp to ease loading and unloading of materials. It has a load capacity of 300-1500 kg and can be customised to suit the dimensions of your products. It is also equipped with a free-standing platform. It is a simple and user-friendly scale which is easy to move giving you more flexibility to make the work process more efficient. It can be used at any point in the production process of food and pharmaceuticals where reliable measurement accuracy and hygiene is required.

Hygienic floor scale

Weighing

The food and pharmaceutical industries require maintaining high levels of sanitation as well as logistical quality. This entails frequent cleaning of weighing equipment to meet the required standards. You thus need a scale that is reliable, not too bulky while being easy to clean and maintain.


<h2>Simple and effortless cleaning of scale platform</h2>
Alba’s floor scale with lifting mechanism is configured for industries with high sanitary requirements. It is a simple, reliable calibration and extremely user-friendly weighing solution. It is equipped with a ramp which makes loading and unloading of the products very easy. It has a wide loading capacity ranging from 300-1500kg. Its readability is 50g, 100g, 200g and 500g. It can weigh products with 1000 x 1250 mm dimensions but is also customisable according to your needs.

The hygienic floor scale with lifting device makes cleaning of the scale extremely simple. Its lifting mechanism enables a quick and safe elevation of the weighing platform to enable cleaning below it. It can be used at any point in the production process of food and pharmaceuticals where reliable measurement accuracy and hygiene is required.

Hygienic floor scale with lifting device

A key requirement for cosmetic compressed powder products is that they maintain their compaction during packaging, transport and in use. A modern, reliable, and easy-to-use drop testing system is the ideal way to test new formulations in the lab, as well as line sampling to ensure continued quality.
<h2>Table-top pneumatic drop tester for cosmetic compacts</h2>
The DP drop tester from Lorenzato has been designed specifically for testing in the cosmetics industry.

Its small form factor and low weight make it easy to install and relocate. Manual adjustment of drop height is quick and easy, and the height adjustment refers from 0 to 500mm. Powder pans, compacts and godets from 20mm to 120mm can be tested.

Pneumatic actuators operator by manual control ensures an accurate and repeatable drop. The unit requires a single 6 bar air pressure for operation.

As standard, the DP’s dropping surface is supplied as steel but can also be specified in marble to suit your test requirements.

Drop tester for compacted powders

Industrial inspection equipment is used for checking compliance with health, safety, and quality control standards. For that reason, inspection systems are most commonly utilized in the food and pharmaceutical industry but, they are also used in other industries too. Inspection solutions are often integrated into a production process or production line. Visual inspection systems perform checks to detect variation in size, shape, and color and ensure the presence of labels and closures. Check-weigh systems help ensure that product packages are not under or over-filled. Metal detection systems can help guard against the presence of foreign objects in product containers and X-ray inspection equipment is used to detect physical defects and to ensure high quality package seal integrity.

Inspection

Drawing samples and testing them for conformity with preset quality standards allows manufacturing units to produce a consistent quality of the product. In a batch process, sample testing systems ensures that each batch meets the specified standards. In a continuous process, product and materials testing helps in the early identification of quality issues, saving significant time and resources, and preventing a sub-standard product from reaching the market. The selection of industrial testing equipment depends on the identification of key quality parameters. These parameters may include volume, weight, viscosity, hardness, particle size distribution, sterility, gauge and containment, among other parameters. Testing machinery need regular calibration to ensure that the parameters being tested are accurate. Some of the more common testing solutions include thermal imagers, scratch testers, optical inspectors and texture analyzers.

Testing

Continuous

Accurate sampling is a critical tool in the design and improvement of a large range of pharmaceutical bioprocesses. For maximum performance you need a robust and highly accurate automated sampling solution that delivers samples to your analysers 24/7 in real-time and can integrate with a large range of instrumentation.
<h2>Automated on-line sampler with increased reliability and ease of use</h2>
The Seg-Flow S3 from Flownamics is the latest generation in their line of automated samplers and has been built to deliver the perfect sampling solution for your most critical processes.

Designed for heavy-duty use, the Seg-Flow S3 has been engineered with increased robustness, featuring a highly durable powder-coated heavy-gauge steel construction. The integrated touchscreen GUI is bright and easy to use, with simple thumbnail navigation, and ideal for any lab environment. Bright LED lights offer “at a glance” status indication for easy monitoring.

Seg-Flow S3 offers complete flexibility to match your sampling needs. It can simultaneously sample from between one and eight vessels or process streams with cell-free or cell-containing samples, and then deliver to up to four analyzers or fraction collectors.

The S3 will automatically clean and/or sterilize the sample lines after every collection, removing cross-contamination risk entirely.

For process monitoring, the S3 can export data to any OPC-enabled DCS, PLC or PC, allowing easy performance data monitoring and analysis.

A wide range of feed control strategies can be programmed into the sampler, including setpoint and gravimetric. The S3 can control 2 feed pumps per vessel.

Fully Automated On-Line Sampling for Bioprocesses

<span style="font-weight: 400;">For many bioprocesses, precise measurement of media flow rates is vital to process monitoring, additive delivery, filtration, sample delivery, and more. The use of a highly accurate automated flow rate measurement system that is also capable of controlling pumps can bring significant advantages to delivery quality and accuracy across processes.</span>
<h2>Accurate flow rate measurement and automatic pump control unit</h2>
<span style="font-weight: 400;">The Flow Reader from Flownamics is a highly accurate fluid flow rate sensor and pump controller.</span>

<span style="font-weight: 400;">Flow Reader features a patented dual sensor technology for outstanding accuracy down to as low as 0.01ml/minute.</span>

<span style="font-weight: 400;">The sensor operates by using sterile air bubbles injected into the fluid path. By tracking the leading edge of the bubble through a known volume past two discrete sensors, a high accuracy reading is obtained.</span>

<span style="font-weight: 400;">The read tube is gamma radiated and disposable and can be welded directly into your fluid path if required. </span>

<span style="font-weight: 400;">Flow Reader is then able to provide feedback to any pumping system capable of receiving 0-10V control inputs, including the Flownamics FP-101, eliminating the need for recalibrations.</span>

Fluid sensor technology for flow rate measurement

<span style="font-weight: 400;">In many biopharmaceutical or chemical development processes, lab work can be greatly enhanced by the availability of small form-factor, high-reliability accessory feed pumps purpose-designed for reliability and accuracy.</span>
<h2>Flexible, compact feed pump for lab environments</h2>
<span style="font-weight: 400;">The Flownamics FP-101 is an accessory feed pump that has been designed to be used with a wide range of applications such as automated bioreactor feedback control, continuous set point control, or manual feed additions.</span>

<span style="font-weight: 400;">The FP-101 has a 114DV flip-top four-roller pump head, which makes installing tubing quick and easy, saving time with setup.</span>

<span style="font-weight: 400;">Measuring only 9.5cm x 12cm x 16cm and weighing just 600g, this small-footprint pump is ideal for already crowded benchtops.</span>

<span style="font-weight: 400;">Enhanced features include one-button priming, user-set manual speed control via easy-to-use dial, or fully automatic remote control using 0-5V input.</span>

<span style="font-weight: 400;">FP-101 can be used with tubing from 0.5mm to 4.8mm internal diameter, and flow rates can be controlled from 0.1ml/min to 150ml/min</span>

Accessory feed pump for various applications

<span style="font-weight: 400;">Automatic sampling of reactor vessels requires careful fluid management to achieve cell-free sampling. In high-density cultures or highly viscous media, this becomes even more important. A self-calibrating fluid control module can be added to sampling probes and automatic samplers that overcome these challenges and provides consistent sample quality.</span>
<h2>Increased fluid management for automatic samplers</h2>
<span style="font-weight: 400;">The Flownamics Seg-Mod 202 is a self-calibrating fluidic module for high cell density cultures.</span>

<span style="font-weight: 400;">Seg-Mod 202 mounts easily to the Flownamics FISP probes used with the trendy Seg-Flow line of automated samplers and uses ultrasonic sensors for increased accuracy and reliability.</span>

<span style="font-weight: 400;">The Seg-Mod calculates the fluidic pull on the probe to ensure accurate cell-free sampling. When it detects an increase in viscosity, it will decrease flow rates to maintain sample quality.</span>

<span style="font-weight: 400;">The unit is completely scale-independent, and it’s been designed to work with vessels from any manufacturer at scales from the lab through to full production.</span>

Fluid sample-taking module for high cell density cultures

<span style="font-weight: 400;">The ability to expand your automatic sampling solution provides increased flexibility and improved return on investment for your system. The addition of a precise sample distributor with enhanced features allows samples to be sent to an extended range of analyzers or other equipment.</span>
<h2>Enhanced sample distribution accessory for Seg-Flow automated samplers</h2>
<span style="font-weight: 400;">The Flownamics Sample-Mod 300 is an enhanced accessory that complements the popular Seg-Flow line of automated samplers.</span>

<span style="font-weight: 400;">Sample-Mod 300 allows for distribution of samples to a further 4 devices using a single-use fluid path via a zero dead volume syringe. It’s been engineered to deliver maximum precision.</span>

<span style="font-weight: 400;">The Sample-Mod enables sample dilution, including serial dilution, and allows for reagent addition for sample preparation. U</span><span style="font-weight: 400;">ltrasonic sensor for enhanced precision.</span>

Distributor of samples to different devices

<span style="font-weight: 400;">Accurate, sterile sample collection is vital across a range of biopharmaceutical, chemical, and industrial processes. To eliminate the risk of contaminating either the culture or the sample, specially designed probes developed to withstand fermentation environments can deliver accurate, cell-free samples for monitoring and development.</span>
<h2>Risk-free sampling for use with bioreactor side ports</h2>
<span style="font-weight: 400;">The Flownamics FISP D-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 25mm side ports from lab scale up to production.</span>

<span style="font-weight: 400;">At the heart of FISP is a fully sterilizable carrier that’s encompassed by a specially designed micro-porous membrane. This has been designed to cope with the most extreme fermentation environments, and it’s ideal for use with anaerobic and aerobic bacterial cultures, yeasts and fungi, and mammal and insect cells.</span>

<span style="font-weight: 400;">With a 0.2 micron filter, FISP’s sterile barrier means zero-risk samples can be taken. Its robust design also means it can easily be used to add media or feeding of cultures. </span><span style="font-weight: 400;">FISP is simple to use and requires no additional operator training. It’s also simple to sterilize and can be used as an autoclave and</span><span style="font-weight: 400;"> manual sampling process. FISP is fully compatible with the Seg-Flow range - Flownamics’ automated sampling products.</span>

Sampling probe suitable for fermenter samples

<span style="font-weight: 400;">In biopharmaceutical and chemical industries, sampling is vital to develop, maintain, and improve processes. This needs to be done in aseptic conditions. The risk of contaminating either the test sample or the reactor can be eliminated by using a dedicated sampling probe designed to operate with the range of sample ports in use across all scales of production.</span>
<h2>Risk-free sampling for use with bioreactor top ports</h2>
<span style="font-weight: 400;">The Flownamics FISP F-Series is a dedicated sampling probe capable of withdrawing sterile, cell-free samples from fermenters and bioreactors with 12mm or 19mm top ports from lab scale up to production.</span>

<span style="font-weight: 400;">FISP is a sterilizable 316 stainless steel carrier that is surrounded by a tubular, microporous membrane.</span>

<span style="font-weight: 400;">FISP has been designed to withstand the temperatures, pressures, and chemicals found in fermentation environments and is perfect for aerobic or anaerobic bacteria, yeast, fungi, algae, insect, and mammalian cell cultures. Its design provides risk-free sampling thanks to a sterile barrier provided by its 0.2-micron filter. It offers the flexibility of being able to be used for submerged feeding or adding sterile media.</span>

<span style="font-weight: 400;">Compatible with Clean in Place (CIP), Sterilize in Place (SIP), and autoclaving, the FISP is easy to maintain and intuitive to use, with no specialist training required.</span>

<span style="font-weight: 400;">The FISP has been developed to work seamlessly with the Flownamics Seg-Flow range of automated samplers for use in fully automated test scenarios.</span>

Sampling probe for bioreactor samples

<span style="font-weight: 400;">Many bioprocesses require offline analysis of samples to monitor development and optimize performance. By using an automated fraction collector, the collection process can be accelerated and delivered with increased accuracy. Compatibility with automated reactor samplers is vital.</span>
<h2>Collect fractions from reactor vessels automatically</h2>
<span style="font-weight: 400;">The Flownamics FlowFraction is used in conjunction with the Flownamics Seg-Flow sampling systems. It allows the online collection of fractions from up to eight reactor vessels for further offline analysis of a range of bioprocesses.</span>

<span style="font-weight: 400;">The FlowFraction system is customizable to accommodate various tube types and sizes and can sample volumes from 250 µl to 50 ml. An added benefit is that vials can be equipped with a septum as a piercing option is available. For storage, racks in a range of standard sizes can be shipped with the FlowFraction, but custom rack sizes can also be produced to meet exact requirements.</span>

<span style="font-weight: 400;">A range of advanced options can be specified to meet your requirements perfectly, including temperature control modules featuring Peltier or water-based cooling systems. Using the options Seg-Flow Sample module, sample dilutions, and reagent additions can be performed before vial deposits.</span>

<span style="font-weight: 400;">Thanks to the included Flownamics WebFlow software, the interface allows easy control and data capture with minimal operator training. Maintenance time is reduced thanks to all internal fluid paths being self-cleaned after each sample.</span>

Online fraction collector for offline bioprocess analysis

<span style="font-weight: 400;">Accurate sampling is vital for improving a wide variety of industrial, chemical, and biofuel processes. A sampling solution that provides  24/7 automated, real-time analyte monitoring, fraction collection, feed control, and data processing will allow increased process performance and development to maximize performance.</span>
<h2>Automated sampling for up to eight vessels</h2>
<span style="font-weight: 400;">The Flownamics Seg-Flow 8000i is a fully automated online sampling system that offers multiple process monitoring and control solutions designed for biofuel, chemical or industrial processes.</span>

<span style="font-weight: 400;">The Seg-Flow’s patented segmented online sampling technology means rapid and accurate sampling for up to 8 vessels and sample delivery to up to 4 analyzers and/or fraction collectors. It uses a chemically inert fluid path with automated cleaning or sterilizing after each sample. </span><span style="font-weight: 400;">A number of feed control options are available for maximum flexibility, and the Seg-Flow 8000i can control up to 2 pumps per vessel.</span>

<span style="font-weight: 400;">The 8000i is scaled independent and can be used with laboratory, pilot, or production vessels. It utilizes the unique FISP in-situ sampling probe, which provides an aseptic barrier between the vessel and the Seg-Flow system. </span><span style="font-weight: 400;">The Seg-Flow features a built-in touchscreen HMI, providing control over many samples and feed options. The easy-to-use system requires minimal training and allows parameters to be programmed within minutes.</span>

<span style="font-weight: 400;">The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.</span>

<span style="font-weight: 400;">Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.</span>

Online sampling system for larger scale bioprocesses

<span style="font-weight: 400;">An accurate, automated sampling of cultures is a key requirement in the development of biopharmaceuticals. For automated sampling across a larger number of bioreactors, a robust and reliable automated system is needed to accurately transfer bioprocess samples directly to a range of analytical devices while maintaining the highest levels of sterility. For medium-scale operations, a cost-effective and efficient system is required to improve process performance.</span>
<h2>Automated multiple bioreactor sampling</h2>
<span style="font-weight: 400;">The Flownamics Seg-Flow 4800 is a fully automated online sampling solution for up to 8 bioreactor vessels. Using unique FISP cell-free sampling probes, the Seg-Flow can deliver accurate samples to up to 4 analyzers.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">Rapid and accurate sampling is available for user-defined sample sizes from as little as 250 to 15 ml.</span>

<span style="font-weight: 400;">The internal Flow-Web web server logs data and information for each vessel or stream independently and allows viewing and control from any PC or mobile device.</span>

<span style="font-weight: 400;">The Seg-Flow features a single-use fluid path from the vessel to the analyzer to reduce operating and maintenance costs. The sample line is automatically cleaned or sterilized after each sample. The user-friendly operating system means minimal training is required, and setup is straightforward.</span>

<span style="font-weight: 400;">The Sefg-Flow’s highly flexible operating software can be tailored to your specific applications. It allows data to be saved in spreadsheet format or automatically exported to other software. System status and reporting can be quickly checked from any device with a browser and internet access.</span>

Automatic sampling system for bioprocess monitoring

<span style="font-weight: 400;">An accurate and sterile sampling of cultures is vital throughout the biopharmaceutical development process. For constant, accurate monitoring, a reliable automated system is needed that transfers bioprocess samples directly from bioreactors to a range of analytical devices without intervention while maintaining the highest levels of sterility. For small-scale development, the availability of a more cost-effective entry-level system brings large economic advantages.</span>
<h2>Affordable automated bioreactor sampling</h2>
<span style="font-weight: 400;">The Seg-Flow 1200 Automated Bioreactor Sampling System from Flownamics is an economical alternative to the larger Seg-Flow 4800. It is available in two models, the Seg-Flow 1200 and the Seg-Flow 1200 Plus.</span>

<span style="font-weight: 400;">Segmented flow technology allows rapid and accurate low volume samples to be taken from reactor vessels containing aerobic or anaerobic bacterial cultures and yeast, fungi, algae, insect, animal, and mammalian cell cultures. Samples can be either cell-containing or cell-free.</span>

<span style="font-weight: 400;">By incorporating a disposable, single-use flow path, the Seg-Flow 1200 is easy to use and requires little maintenance and no specialist operator training.</span>

<span style="font-weight: 400;">Samples can be collected from up to 2 reactors and delivered to 2 analyzers or collectors. Built-in expansion capability means this can be extended to 4 reactors with the Sample Module.</span>

<span style="font-weight: 400;">Integrated control functions such as an automated feed from an at-line glucose measurement can be quickly and easily implemented.</span>

<span style="font-weight: 400;">The Seg-Flow 1200 can be used with small laboratory vessels right up to large full-scale production vessels with 12, 19, and 25 mm models.</span>

<span style="font-weight: 400;">The unique Flownamics FISP filter probe used in the Seg-Flow 1200 ensures a sterile, cell-free sample can be taken from any vessel.</span>

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Entry-level automated online sampling system

<span style="font-weight: 400;">For safe and convenient delivery of liquid nitrogen a robust and portable solution is paramount. This wheeled transport tank provides ease of use and operator safety for the supply of liquid nitrogen as a cryogen for long-term storage of samples in cryogenic freezers.</span>


<h2>Portable and robust storage tank that’s simple to use</h2>
<span style="font-weight: 400;">With a large 230 litre capacity, the CC230LP-SB liquid nitrogen supply tank is suitable for use in a wide range industries.</span>

<span style="font-weight: 400;">Featuring a robustly constructed wheeled platform with integrated handle, the unit is easy to move to exactly where it’s needed by only one operator.</span>

<span style="font-weight: 400;">Operating at 22psi (151.7kPa) this insulated unit has a class-leading evaporation rate of only 2% per day, reducing wastage and improving your operational efficiency.</span>

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Cryogenic industrial gases transportation supply tank

Industrial cooling equipment varies according to the consistency and temperature conversion demands the material you are handling, but the process typically involves heat exchange treatment as your products are conveyed through a cooling chamber equipped with extraction fans or circulating water. Temperature control is a crucial aspect of your commercial production and cooling systems are applied to a range of industries.

Cooling

Freezing

Handling

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

Almost all manufacturers will require industrial storage systems and solutions at some point during their production process. The raw materials that go into your products need dedicated storage solutions to protect them from spoilage and contamination before they enter the manufacturing cycle. Storage usually refers to particular storage space. For example, having enough warehouse storage. Or clearing out a production facility for more floor space.  However, in this case, we are referring to the equipment and solutions that make storage manageable and easier. Such equipment includes solutions such as storage racks, pallet racks and shelving systems. These are just some of many storage options available to manufacturers. Advanced technology facilitates the management of heavy duty and high density tank and silo systems by automating the delivery system and linking it with the rest of the production line.

Storage

<span style="font-weight: 400;">For biotech and pharmaceutical cryopreservation, liquid nitrogen vapor storage provides a cost-effective and efficient solution where shorter-term storage is required. Vapor phase freezers provide easier access to the stored samples and provides higher levels of user protection from contact with the liquid nitrogen.</span>


<h2><b>Superior temperature stability with ease of access</b></h2>
<span style="font-weight: 400;">The Custom BioGenic Systems EV10 EcoVapor Liquid Nitrogen Freezer provides access to cost-effective and efficient liquid nitrogen vapor storage. Liquid nitrogen is pooled in the bottom of the freezer and a patent-pending custom engineered vapor insert enables superior temperature uniformity in the -180°C range. Because there is no liquid in the storage area it minimises risks involved with contact with liquid nitrogen.</span>

<span style="font-weight: 400;">The unit is controlled by the Custom BioGenic Systems Model 2200 controller. This unit features a dual temperature display and auto-fill capabilities that is fully software driven for automatic operation.</span>

<span style="font-weight: 400;">The EV10 features a lightweight, lockable, lift-off lid for easy unrestricted access to samples. The unit offers a capacity of 45 litres, with a maximum usable internal storage height of 737mm and internal diameter of 559. This generous sizing combines to enable the storage of up to 10,725 2ml vials using 5 mini racks.</span>

Liquid nitrogen vapor storage freezer

<span style="font-weight: 400;">Remove the risks of cross-contamination and liquid nitrogen handling by adopting a freezer system that does not bring the coolant in direct contact with your samples. Increase storage space for the same footprint as a traditional freezer and improve access to samples without affecting the internal temperature and benefit from industry-leading temperature gradient.</span>


<h2><b>Liquid nitrogen freezer solution that removes risks of cross-contamination</b></h2>
<span style="font-weight: 400;">Suitable for a wide range of biotech and pharmaceutical uses, the Custom BioGenic Systems V1500-AB Isothermal Liquid Nitrogen Freezer provides nitrogen storage temperatures but without the need to bring samples into direct contact with the coolant. A patented jacket design means that liquid nitrogen surrounds the entire chamber whilst keeping the storage area completely clean and dry, allowing for exceptionally low temperatures throughout the unit.</span>

<span style="font-weight: 400;">As well as removing cross-contamination risk associated with collant contact, the V1500-AB also reduces health and safety risks associated with filling traditional freezers with liquid nitrogen as there is no splash risk.</span>

<span style="font-weight: 400;">Because the nitrogen is not introduced directly into the freezing chamber this allows the entire volume to be used for storage. The units will allow storage of a wide range of containers including aluminum and stainless steel square and vertical racks, mini racks, canister and frame systems, vials, boxes and canisters or cassettes.</span>

<span style="font-weight: 400;">The unit comes as standard with the respected Custom BioGenic Systems 2301 controller which handles auto filling and full monitoring of the unit, including alarms and data recording. The combination of controller and freezer design means the V1500-AB has an industry leading temperature gradient that averages -193°C inside the storage area.</span>

Liquid nitrogen freezer for safe and dry storage of your samples

<span style="font-weight: 400;">For maximum value, a high-pressure homogenizer that’s suitable for both laboratory and pilot/small scale pharmaceutical production is the ideal choice. Full control over all process elements and 100% scalability coupled with cost-effective electric operation offers substantial cost-savings over alternative options.</span>
<h2>Cost-effective unit suited for both laboratory and pilot use</h2>
<span style="font-weight: 400;">The Mini DeBEE from BEE International is hydraulically driven homogenizer that is suitable for both laboratory use and in pilot plants or in small-scale production. Offering the highest process intensity available in its class, it will disrupt the toughest cells with the highest yield, or obtain the smallest particle size.  </span>

<span style="font-weight: 400;">With proprietary modular homogenising cell, the Mini DeBEE offers completely independent control of pressure, flow, cavitation, impact, shear and process duration. The minimal sample size of only 10ml makes it an excellent choice for R&amp;D and lab work. Because it guarantees 100% scalability, it can easily be transferred to pilot operations, or the machine itself can also be used for small-scale and batch production, offering continuous flow of up to 15 litres per hour.</span>

<span style="font-weight: 400;">PLC control with digital interface means simple operation and monitoring, with user-adjustable operating pressure from 2,000 to 45,000 PSI. Coupled with a wide range of options, this makes the Mini DeBEE suitable for application in the pharmaceutical, biotech, chemicals, cosmetics and food industries.</span>

Pilot high pressure homogenizer

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

Milling machines are used to reduce the size of material by cutting, crushing, or grinding it. The choice of industrial milling equipment depends on the industry and the materials to work with. Besides, there is a significant difference between those aimed to remove layers from metal or other materials workpieces and those designed to reduce particle size for materials that come in bulk.

Milling

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

<span style="font-weight: 400;">Offering lab-scale to small pharmaceutical production scale output for in one unit means maximum cost-benefit when acquiring a homogenizer. Capable of achieving a range of processes including cell disruption, particle size reduction, creating stable nano/micro emulsions and working with polymers and liposomes, this benchtop scale unit can operate at up to 15 litres per hour capacity, yet still offer lab quality results.</span>
<h2>Air-operated, compact, bench-top homogenizer suitable for a broad range of applications</h2>
<span style="font-weight: 400;">The Micro DeBEE from BEE International is a compact, laboratory-scale homogenizer that can also be used for small-scale production. This is an air-powered unit that can process as little as a single 5ml sample, up to as much as 15L per hour, offering exceptional flexibility.</span>

<span style="font-weight: 400;">Features that make it an excellent R&amp;D machine include maximum pressure of 45,000 PSI/3100 bar (at 150 PSI, 55 CFM). In addition, the back pressure can reach 5,000 PSI/350 bar, but this is adjustable to your specific process.</span>

Micro DeBEE is simple in operating, and exceptionally easy to maintain and clean (with no disassembly required), adding further to the value proposition.

High pressure air powered laboratory homogenizer

<span style="font-weight: 400;">It’s vital that small units for experimentation can scale up with 100% accuracy. Ease of use, reliability and simple maintenance means increased work efficiency, and rapid cleaning and suitability for sanitary uses increase flexibility and improve return on investment.</span>
<h2>Cost-effective benchtop homogenizer with reliable and consistent process for R&amp;D</h2>
<span style="font-weight: 400;">The Nano DeBEE from BEE International is a market-leader in laboratory-scale homogenizers. Designed for maximum flexibility, the Nano DeBEE can be used for a range of procedures including cell disruption, particle size reduction, nano/micro emulsions and nano/micro dispersions. Despite the minimum sample size of only 5ml, the results obtained from the DeBEE are guaranteed 100% scalable to production processes.</span>

<span style="font-weight: 400;">Offering excellent value for money, the Nano DeBEE can operate at up to 45,000 PSI of pressure and yet it is simple to clean and maintain and it’s suitable for sanitary applications where required. A further major benefit is that DeBEE will provide new staff training for the lifetime of the product.</span>

High pressure electric laboratory homogenizer

To purify a specific large biomolecule, for example IgM or a virus or virus-like particle, the first step is to screen the working conditions. Different mobile phases and column chemistries are then tested, according to the biochemical properties of that particular large molecule.
<h2>Efficiently identify, isolate and recover large biomolecules</h2>
The CIMmultus™ Purification Screening Kit from BIA Separations is intended to help scientists quickly discover the optimal stationary phase chemistry for their particular application.

The kit includes two different 1mL CIMmultus™ ion-exchange columns (QA and SO3) and one hydrophobic interaction chemistry column (OH).

By using one of the selected chemistries and applying proper working conditions, the user will be able to discover the combination that will result in appropriate purity and excellent recovery of their required large biomolecule.

Purification screening kit for large biomolecules

When developing a pDNA purification process for eventual transfer into production, efficient examination and selection of protocols is critical.
<h2>Develop plasmid purification procedures quickly</h2>
BIA Separations' CIMmultus™ HiP2 Plasmid Process Pack™ is intended to help scientists easily develop their pDNA purification process and transfer it to production.

Allowing developers to select only the relevant parts of the recommended protocol that best fits their needs, the pack saves time and money on all scales.

The CIMmultus™ HiP2 Plasmid Process Pack™ contains one weak anion-exchange (DEAE) and one hydrophobic (C4 HLD) column and a protocol describing the purification procedure of specific plasmids.

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Plasmid process pack for your pDNA purification process

Samples taken at various process steps need to be analysed quickly and accurate results delivered, without affecting the state or condition of the original sample.
<h2>Understand a bioprocess through real-time monitoring</h2>
CIMac™ Analytical Columns from BIA Separations are short bed, high performance monolithic columns offering all the advantages of CIM® monolithic technology. They are primarily intended for fast, efficient, and reproducible separations of biomolecules like large proteins, plasmid DNA, and viral particles.

Small volume and short column length allow operation at high volumetric flow rates (from 1 to 30 column volumes/min), enabling product quantity and purity information to be available in just a few minutes.

The CIMac™ Analytical Columns are pre-packed in dedicated stainless steel housings and allow user-friendly connections to HPLC equipment, hence they can be effectively used for both the in-process and final control of various samples from different purification processes.

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Short bed monolithic columns for analytics

Chromatographic monolithic columns for working with large proteins, viruses, VLPs and pDNA require the high structural strength and contamination protection usually provided by expensive medical grade stainless steel.
<h2>Separate complex biomolecules using strong, versatile multi-use columns</h2>
CIMmultus™ disposable monolithic columns from BIA Separations have the structural integrity and leachable profile of medical grade stainless steel, but the process economics of a single or multi-use device.

With the introduction of composite materials into an epoxy-based housing and the application of USP Class VI Parylene C coating to the entire column surface, CIMmultus™ columns offer safety and high performance.

CIMmultus™ columns can be used at any step in the separation process and, with their 2 µm flow-through channels allowing convective mass transfer, make a perfect choice for the purification of viruses, VLPs, plasmids, antibodies, PEGylated proteins and other large biomolecules.

Disposable monolithic columns

Biopharmaceutical manufacturers require precisely known liquid quantities for testing and process development but time spent measuring and dispensing liquids in the laboratory is expensive and adds no value to the final product.  Use of an automated system for accurately dispensing liquids saves time and labor allowing laboratory personnel to focus on value added tasks.
<h2>High precision, high accuracy automated liquid dispensing with the touch of a button</h2>
Scilog is focused on improving the quality and efficiency of customers’ processes in the biopharmaceutical industry through enhancements and automation of sensing, filtration and other processing needs.  The company’s LabTec system is an automated liquid dispensing system allowing up to 10 user defined dispensing volumes to be established and accurately repeated at the touch of a button.  Accuracy is improved while laboratory technician’s time is saved by avoiding the need to repeatedly measure liquid amounts.  Accuracy of better than 1% is typically achieved.  The system can dispense by volume, or when connected to an electronic balance, by weight and weight ratio.  Dispensing by weight provides enhanced accuracy while dispensing by weight ratio saves even more labor by automatically dispensing the correct amount of fluid based on the weight of substance already in the vessel.  In this way, accurate dilutions can be made without the technician having to carefully measure either substance.  A roughly measured sample of one substance is added to the vessel and the correct amount of diluent is automatically dispensed based on the user defined required weight ratio.  When used with the SciDoc Documentation system the LabTec also compiles, displays and documents up to 10 process parameters providing real-time information about the dispensing progress and status.

Automated dispensing system for bioprocesses

Biotech sampling and control

As an alternative to conventional fuels, biogas is produced from the processing of biomass resources as an industrial feedstock. Biogas is a renewable and local energy source that contributes to sustainable heat and power production. Besides making use of agricultural wastes such as crop and forest residues and animal manure, biogas production converts organic wastes from industrial and municipal waste to energy. This is usually achieved by implementing the anaerobic digestion process in biogas plants.

Biogas

Cell culture has been, over a little more than 100 years, an important method of research in laboratories. But medicine developments aside, we wonder if even the most positive of idealists could have also believed that cell cultures and tissue culture would possibly change the way – and what – we eat. From the lab to the dining table, there’s cell culture equipment to make even the unimaginable possible.

Cell cultures

What does a $300,000 burger taste like? Meat. The first lab-grown burger took two years and 20,000 strands of muscle tissue to produce. But with rapid advances in cultivated meat processing technology, non-animal meat alternative products can now take a lot shorter to prepare. And cost much less.

Cultivated meat

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

Ancient civilizations were using yeast as it naturally occurred in bread-making and brewing. But yeast processing equipment wasn't developed and fully commercialized until the end of the 18th century. Today, this industrialized micro-organism is critical in producing biofuels and other products beyond food and drinks.

Yeast

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