Injectables Equipment

Find innovative production technology for making injectables and connect directly with world-leading specialists.

Injectables
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Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue. These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Which injectables equipment do you need?

High-speed aseptic injectable vial filling machine

High-speed aseptic injectable vial filling machine

Fill up to 24,000 vials per hour with pharmaceutical powders or liquids…

Sterile filling line for injectables

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries r…

Start-up sterile filling line for injectables

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables market…

Table top sterile filling line for injectables

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables m…

Pure steam generator

Pure steam generator

Pure steam is mainly used in the pharmaceutical industry and in biotechnology for sterilization, water fo…

Purified water systems

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need …

Horizontal laminar flow benches

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work ar…

Compact horizontal laminar flow bench

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space …

Monobloc small volume liquid filler

Monobloc small volume liquid filler

These intermittent motion monobloc machines are designed for filling various liquids int…

Packaging machine for syringes in trays

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method of choice for the delivery of inj…

Reverse Osmosis water filtration system

Reverse Osmosis water filtration system

Reverse osmosis uses a partially permeable membrane to remove undesirable molecules,…

Vapor compression distiller

Vapor compression distiller

Water for injections must be of highest achievable quality to eliminate the possibility of contam…

Water distillation system

Water distillation system

Water used in pharmaceutical processes must meet high standards of regulatory bodies. These include…

Pharmaceutical pure steam generator

Pharmaceutical pure steam generator

Dry, saturated steam can be used to sterilise pharmaceutical manufacturing equipment, an…

API powders storage bottle

API powders storage bottle

Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions f…

Entry-level filler for large-volume parenterals

Entry-level filler for large-volume parenterals

Large volume parenterals are unit-dose containers that are larger than 100m…

High-frequency vibratory mixer

High-frequency vibratory mixer

Mixing liquid products by stirring method generates heat from friction and shear forces. This …

Continuous chocolate line with vertical ball mills

Continuous chocolate line with vertical ball mills

To mix and refine cocoa liquor, cocoa powder, sugar, and lecithin, seve…

Laboratory spiral jet mill

Laboratory spiral jet mill

Ideal for the ultra-fine size reduction on a laboratory scale of dry materials up to Mohs' hardnes…

Vertical scraper centrifuges

Vertical scraper centrifuges

Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the bottom…

Vertical peeler centrifuge

Vertical peeler centrifuge

A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from s…

Active freeze dryer

Active freeze dryer

Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying p…

Laboratory scale active freeze dryer

Laboratory scale active freeze dryer

The laboratory-scale active freeze-drying is used for dehydrating high-value products t…

Compact laboratory freeze dryer

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of …

Pilot freeze dryer for scale up

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and "scale up" work.

Multipurpose and R&D freeze dryer

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common applica…

Custom engineered freeze dryer

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are designe…

GMP freeze dryer

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in acc…

Saturated steam GMP laboratory autoclave

Saturated steam GMP laboratory autoclave

For processing a wide range of products: solid, porous and liquids in a laboratory …

Steam and air mixture sterilization autoclave

Steam and air mixture sterilization autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Superheated water shower autoclave

Superheated water shower autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Ethylene oxide sterilization chamber

Ethylene oxide sterilization chamber

Designed for the terminal sterilization of temperature sensitive medical-health product…

Dry heat depyrogenation oven

Dry heat depyrogenation oven

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and …

Electrical pure steam generator

Electrical pure steam generator

Pure steam is defined as the steam which when condensed becomes WFI quality water in accordan…

GMP laboratory freeze dryer

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Restricted-access barrier systems

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an isol…

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When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Manufacturing parenteral formulations

Fragile molecules such as protein formulations would be destroyed using the alimentary canal and are therefore administered by injection. When making injectable formulations the drugs are stored in liquid or, if unstable at higher temperatures, lyophilized form. To ensure a stable active medium during storage and make the preparation isotonic with blood, liquid formulations combine active ingredients with a minimum amount of excipients such as solvents, solubilizers, suspending, and buffering agents, and antimicrobial preservatives.

Water for injections(WFI) is used as the vehicle for aqueous injections. For non-aqueous injections, fixed oils of vegetable origin are used as vehicles. Water for Injection is used in the preparation of medicines as a vehicle and sterilized water for injection is used when solving or diluting substances or preparations before use. WFI is obtained by distillation or reverse osmosis and meets all chemical requirements for PW (Purified Water) with an additional bacterial endotoxin parameter.

Lyophilized drugs allow storage at higher temperatures after freeze-drying is used to remove water from a liquid drug and create a solid powder or cake. In protein formulations, stabilizers are added to replace the water and preserve the molecule structure. Before administration, a lyophilized drug is reconstituted by combining a liquid diluent with the freeze-dried powder and mixing before injected into the body.

Vaccine development and production technology

Applikon Biotechnology is specialized in human vaccine production systems, as well as in systems for the production of therapeutic agents using both cell culture and microbial cultures.

Their advanced bioreactor systems can be used from the initial screening stage up to full-scale production using the same platform to minimize scale-up risks and guarantee a short time to market in product development.

Visual and high voltage leak detection (HVLD) inspection

Inspection of sealed glass vessels for contaminants, correct fill volume, sealing, and for example tip-cap effects or black spot particles. How convenient to cover all quality inspection requirements at once?

CMP Pharma’s NIKE-LT’s recirculation feature allows re-inspection following rejection by only one or two cameras (user selectable) which brings false rejection rates down reducing unnecessary wastage.

Sterile filling and packing of injectables

Sterile dosage forms must be free from any microorganisms, dust, fibers, and foreign particles, and should be isotonic. Although standards and legislation may differ worldwide there are several regulations to ensure the product or safe and effective new and generic drugs on the market such as USP/JP/EP standards and Current Good Manufacturing Processes (GMP) compliance.

Small-volume parenteral solutions (SVPs) are injections provided in containers 100 ml or less and can be designed for single and for multiple uses.  A large volume parenteral (LVP) is a single-use unit dose container of greater than 100ml designed to carry fluids, calories, and electrolytes.

For light-sensitive substances, colored glass containers such as vials or ampoules are used. If possible containers are made transparent for easier visual inspection. Containers are made, as far as possible, from material that is sufficiently transparent to permit visual inspection. Closures are equipped with a firm seal to prevent the entry of microorganisms and other contaminants while permitting the withdrawal of a part of the whole of the contents without removal of the closure. Closures for multidose containers are sufficiently elastic to allow the puncture to reseal when the needle is withdrawn.

Equipment for making injectables in action

Applikon next generation in microbioreactors

Vial filling line

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