Injectables Equipment
Which injectables equipment do you need?
High-speed aseptic injectable vial filling machine
Sterile filling line for injectables
Start-up sterile filling line for injectables
Table top sterile filling line for injectables
Pure steam generator
Purified water systems
Horizontal laminar flow benches
Compact horizontal laminar flow bench
Monobloc small volume liquid filler
Packaging machine for syringes in trays
Reverse Osmosis water filtration system
Vapor compression distiller
Water distillation system
Pharmaceutical pure steam generator
API powders storage bottle
Entry-level filler for large-volume parenterals
High-frequency vibratory mixer
Continuous chocolate line with vertical ball mills
Laboratory spiral jet mill
Vertical scraper centrifuges
Vertical peeler centrifuge
Active freeze dryer
Laboratory scale active freeze dryer
Compact laboratory freeze dryer
Pilot freeze dryer for scale up
Multipurpose and R&D freeze dryer
Custom engineered freeze dryer
GMP freeze dryer
Saturated steam GMP laboratory autoclave
Steam and air mixture sterilization autoclave
Superheated water shower autoclave
Ethylene oxide sterilization chamber
Dry heat depyrogenation oven
Electrical pure steam generator
GMP laboratory freeze dryer
Restricted-access barrier systems
Aseptic barrier systems
Transfer system for high-containment environments
Glove tester
Half-suit tester
Downflow booth
Sterility test isolators
Vertical laminar flow cabinet
Microbiological safety cabinet class II
Biosafety cabinet class II for cytotoxic medicines
Positive pressure isolator
Biological safety cabinet class III
Negative pressure isolator
High-speed blister machine
Compact blister machine
Horizontal continuous motion cartoner
Horizontal intermittent motion cartoner
Vertical cartoner
Stretch bander
Case packer for cartons and bundles
High-speed small volume liquid filler
Microdosing machine for sterile powders
Aseptic liquid filler for vials
Automatic washing machine for ampoules
Depyrogenation tunnels for ampoules, vials and bottles
Versatile checkweigher
Small bottle checkweigher
Ampoule filling machine
Pharmaceutical bottles inspection machine
Magnetic agitator
Economic dispersing machine for emulsions and suspensions
Ultra-fine dispersing machine for emulsions and suspensions
Laboratory dispersing machine for low-viscous masses
High containment split butterfly valve
Feeder with flexible wall hopper
Small feeder with flexible wall hopper
Ethylene oxide sterilizer
Flexible automatic inspection machine for syringes
Flexible automatic inspection machine for ampoules, vials, cartridges
Small automatic inspector for ampoules, vials, or cartridges
Semi-automatic inspection machine for ampoules, vials or cartridges
Visual and HVLD inspection for ampoules, vials and cartridges
Microencapsulation system for your drug delivery system
Vertical cartoner for pharmaceutical applications
High capacity cartoner for pharmaceutical applications
Horizontal cartoner for pharma and cosmetics
Pharmaceutical and cosmetic industry products cartoner
Automatic cartoner for applications in pharma and cosmetics
High-capacity horizontal cartoner for pharma and cosmetics appliances
Continuous pack cartoner
Portable IBC washer
IBC bin washer and dryer
CIP system for bulk tanks
GMP chamber washer
GMP washer
Loading basket for GMP washer
Entry-level chamber washer
Bulk chamber washer
Rotary vial washing machine
Vial sterilization tunnel
Vial filling machine
Industrial vial capping machine
External vial washing machine
Aseptic automatic vial filling machine
Aseptic vial cap sealing machine
Aseptic automatic vial washing machine
Automatic vial tray loader
Nested syringe filling machine
Closed restricted access barrier system
Vacuum mixer for suspensions
Purified water storage tank
Cleaning and sterilization systems
Horizontal cartoner for pharmaceutical applications
Labeling machine for BFS containers
Pharmaceutical rotary labeling machine for vials
Low speed Filler for large-volume parenterals
Automatic forming and sealing blister machine for packing syringes
Clinical trial lab sealer for a laminar airflow bench
Automatic medical forming and sealing blister machine for packing capsules and tablets
Semi-automatic forming and sealing blister machine
Benchtop peristaltic dispenser
Laboratory liquid viewer for colored glass bottles
Laboratory liquid viewer for transparent glass bottles
Manual stoppering equipment for pre-filled syringes
Aseptic filling machine for liquids and powders
Individual item serialization equipment
Sterile Filtration System for GMP-grade products
Modular assembly line for healthcare products
Ultra-fine dispersing machine for APIs and vaccines
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Select your injectables process
Tell us about your production challenge
Manufacturing parenteral formulations
Fragile molecules such as protein formulations would be destroyed using the alimentary canal and are therefore administered by injection. When making injectable formulations the drugs are stored in liquid or, if unstable at higher temperatures, lyophilized form. To ensure a stable active medium during storage and make the preparation isotonic with blood, liquid formulations combine active ingredients with a minimum amount of excipients such as solvents, solubilizers, suspending, and buffering agents, and antimicrobial preservatives.
Water for injections(WFI) is used as the vehicle for aqueous injections. For non-aqueous injections, fixed oils of vegetable origin are used as vehicles. Water for Injection is used in the preparation of medicines as a vehicle and sterilized water for injection is used when solving or diluting substances or preparations before use. WFI is obtained by distillation or reverse osmosis and meets all chemical requirements for PW (Purified Water) with an additional bacterial endotoxin parameter.
Lyophilized drugs allow storage at higher temperatures after freeze-drying is used to remove water from a liquid drug and create a solid powder or cake. In protein formulations, stabilizers are added to replace the water and preserve the molecule structure. Before administration, a lyophilized drug is reconstituted by combining a liquid diluent with the freeze-dried powder and mixing before injected into the body.
Vaccine development and production technology
Applikon Biotechnology is specialized in human vaccine production systems, as well as in systems for the production of therapeutic agents using both cell culture and microbial cultures.
Their advanced bioreactor systems can be used from the initial screening stage up to full-scale production using the same platform to minimize scale-up risks and guarantee a short time to market in product development.
Visual and high voltage leak detection (HVLD) inspection
Inspection of sealed glass vessels for contaminants, correct fill volume, sealing, and for example tip-cap effects or black spot particles. How convenient to cover all quality inspection requirements at once?
CMP Pharma’s NIKE-LT’s recirculation feature allows re-inspection following rejection by only one or two cameras (user selectable) which brings false rejection rates down reducing unnecessary wastage.
Sterile filling and packing of injectables
Sterile dosage forms must be free from any microorganisms, dust, fibers, and foreign particles, and should be isotonic. Although standards and legislation may differ worldwide there are several regulations to ensure the product or safe and effective new and generic drugs on the market such as USP/JP/EP standards and Current Good Manufacturing Processes (GMP) compliance.
Small-volume parenteral solutions (SVPs) are injections provided in containers 100 ml or less and can be designed for single and for multiple uses. A large volume parenteral (LVP) is a single-use unit dose container of greater than 100ml designed to carry fluids, calories, and electrolytes.
For light-sensitive substances, colored glass containers such as vials or ampoules are used. If possible containers are made transparent for easier visual inspection. Containers are made, as far as possible, from material that is sufficiently transparent to permit visual inspection. Closures are equipped with a firm seal to prevent the entry of microorganisms and other contaminants while permitting the withdrawal of a part of the whole of the contents without removal of the closure. Closures for multidose containers are sufficiently elastic to allow the puncture to reseal when the needle is withdrawn.