Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue. These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

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Automatic medical forming and sealing blister machine for packing capsules and tablets

Product safety is very importa...

Semi-automatic forming and sealing blister machine

As a manufacturer of medical device, the packaging is a critical facto...

Benchtop peristaltic dispenser

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of ...

Laboratory liquid viewer for colored glass bottles

In the pharmaceutical industry, an inspection to detect any particulat...

Laboratory liquid viewer for transparent glass bottles

In the pharmaceutical industry, an inspection of liquids in vials ...

Manual stoppering equipment for pre-filled syringes

Air present in the empty space of pre-filled syringes may prevent the...

Aseptic filling machine for liquids and powders

Aseptic filling of containers such as vials, syringes, bottles, and cartri...

Individual item serialization equipment

Traceability is critical to quality assurance in the pharmaceutical sector. But ser...

Sterile Filtration System for GMP-grade products

Processing equipment used in industries regulated by GMP must ensure full...

Modular assembly line for healthcare products

Assembly setups need to be constantly rethought and reconfigured to adapt qu...

Ultra-fine dispersing machine for APIs and vaccines

Multi-staged rotor/stator mixers generate the high shear forces requi...

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Select your injectables process

drying injectables

mixing injectables

labeling injectables

formulation injectables

sterilization injectables

containment injectables

inspection injectables

dosing injectables

filling injectables

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When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!

What are you making?

Vaccines

Parenterals

Pre-filled Syringes

Vials

Ampoules

Pharmaceutical cartridges

Water for injection

Single-use bags

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Manufacturing parenteral formulations

Fragile molecules such as protein formulations would be destroyed using the alimentary canal and are therefore administered by injection. When making injectable formulations the drugs are stored in liquid or, if unstable at higher temperatures, lyophilized form. To ensure a stable active medium during storage and make the preparation isotonic with blood, liquid formulations combine active ingredients with a minimum amount of excipients such as solvents, solubilizers, suspending, and buffering agents, and antimicrobial preservatives.

Water for injections(WFI) is used as the vehicle for aqueous injections. For non-aqueous injections, fixed oils of vegetable origin are used as vehicles. Water for Injection is used in the preparation of medicines as a vehicle and sterilized water for injection is used when solving or diluting substances or preparations before use. WFI is obtained by distillation or reverse osmosis and meets all chemical requirements for PW (Purified Water) with an additional bacterial endotoxin parameter.

Lyophilized drugs allow storage at higher temperatures after freeze-drying is used to remove water from a liquid drug and create a solid powder or cake. In protein formulations, stabilizers are added to replace the water and preserve the molecule structure. Before administration, a lyophilized drug is reconstituted by combining a liquid diluent with the freeze-dried powder and mixing before injected into the body.

Vaccine development and production technology

Applikon Biotechnology is specialized in human vaccine production systems, as well as in systems for the production of therapeutic agents using both cell culture and microbial cultures.

Their advanced bioreactor systems can be used from the initial screening stage up to full-scale production using the same platform to minimize scale-up risks and guarantee a short time to market in product development.

Visual and high voltage leak detection (HVLD) inspection

Inspection of sealed glass vessels for contaminants, correct fill volume, sealing, and for example tip-cap effects or black spot particles. How convenient to cover all quality inspection requirements at once?

CMP Pharma’s NIKE-LT’s recirculation feature allows re-inspection following rejection by only one or two cameras (user selectable) which brings false rejection rates down reducing unnecessary wastage.

Sterile filling and packing of injectables

Sterile dosage forms must be free from any microorganisms, dust, fibers, and foreign particles, and should be isotonic. Although standards and legislation may differ worldwide there are several regulations to ensure the product or safe and effective new and generic drugs on the market such as USP/JP/EP standards and Current Good Manufacturing Processes (GMP) compliance.

Small-volume parenteral solutions (SVPs) are injections provided in containers 100 ml or less and can be designed for single and for multiple uses. A large volume parenteral (LVP) is a single-use unit dose container of greater than 100ml designed to carry fluids, calories, and electrolytes.

For light-sensitive substances, colored glass containers such as vials or ampoules are used. If possible containers are made transparent for easier visual inspection. Containers are made, as far as possible, from material that is sufficiently transparent to permit visual inspection. Closures are equipped with a firm seal to prevent the entry of microorganisms and other contaminants while permitting the withdrawal of a part of the whole of the contents without removal of the closure. Closures for multidose containers are sufficiently elastic to allow the puncture to reseal when the needle is withdrawn.

Equipment for making injectables in action

Applikon next generation in microbioreactors

Vial filling line

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Which injectables equipment do you need?

High-speed aseptic injectable vial filling machine

Sterile filling line for injectables

Start-up sterile filling line for injectables

Table top sterile filling line for injectables

Pure steam generator

Purified water systems

Horizontal laminar flow benches

Compact horizontal laminar flow bench

Monobloc small volume liquid filler

Packaging machine for syringes in trays

Reverse Osmosis water filtration system

Vapor compression distiller

Water distillation system

Pharmaceutical pure steam generator

API powders storage bottle

Entry-level filler for large-volume parenterals

High-frequency vibratory mixer

Continuous chocolate line with vertical ball mills

Laboratory spiral jet mill

Vertical scraper centrifuges

Vertical peeler centrifuge

Active freeze dryer

Laboratory scale active freeze dryer

Compact laboratory freeze dryer

Pilot freeze dryer for scale up

Multipurpose and R&D freeze dryer

Custom engineered freeze dryer

GMP freeze dryer

Saturated steam GMP laboratory autoclave

Steam and air mixture sterilization autoclave

Superheated water shower autoclave

Ethylene oxide sterilization chamber

Dry heat depyrogenation oven

Electrical pure steam generator

GMP laboratory freeze dryer

Restricted-access barrier systems

Aseptic barrier systems

Transfer system for high-containment environments

Glove tester

Half-suit tester

Downflow booth

Sterility test isolators

Vertical laminar flow cabinet

Microbiological safety cabinet class II

Biosafety cabinet class II for cytotoxic medicines

Positive pressure isolator

Biological safety cabinet class III

Negative pressure isolator

High-speed blister machine

Compact blister machine

Horizontal continuous motion cartoner

Horizontal intermittent motion cartoner

Vertical cartoner

Stretch bander

Case packer for cartons and bundles

High-speed small volume liquid filler

Microdosing machine for sterile powders

Aseptic liquid filler for vials

Automatic washing machine for ampoules

Depyrogenation tunnels for ampoules, vials and bottles

Versatile checkweigher

Small bottle checkweigher

Ampoule filling machine

Pharmaceutical bottles inspection machine

Magnetic agitator

Economic dispersing machine for emulsions and suspensions

Ultra-fine dispersing machine for emulsions and suspensions

Laboratory dispersing machine for low-viscous masses

High containment split butterfly valve

Feeder with flexible wall hopper

Small feeder with flexible wall hopper

Ethylene oxide sterilizer

Flexible automatic inspection machine for syringes

Flexible automatic inspection machine for ampoules, vials, cartridges

Small automatic inspector for ampoules, vials, or cartridges

Semi-automatic inspection machine for ampoules, vials or cartridges

Visual and HVLD inspection for ampoules, vials and cartridges

Microencapsulation system for your drug delivery system

Vertical cartoner for pharmaceutical applications