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Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue. These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Which injectables equipment do you need?

High-speed aseptic injectable vial filling machine

Fill up to 24,000 vials per hour with pharmaceutical powders or liquid...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables ...

Pure steam generator

Pure steam is mainly used in the pharmaceutical industry and in biotechnology for sterilization, water f...

Purified water systems

Highly Purified water is used in the preparation of medicinal products where bacterial endotoxins need...

Horizontal laminar flow benches

HEPA filtered horizontal laminar airflow (crossflow) creates an ISO 14644-1 (Class 5) work a...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

Monobloc small volume liquid filler

These intermittent motion monobloc machines are designed for filling various liquids in...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method ...

Reverse Osmosis water filtration system

Reverse osmosis uses a partially permeable membrane to remove undesirable molecules...

Vapor compression distiller

Water for injections must be of highest achievable quality to eliminate the possibility of conta...

Water distillation system

Water used in pharmaceutical processes must meet high standards of regulatory bodies. These includ...

Pharmaceutical pure steam generator

Dry, saturated steam can be used to sterilise pharmaceutical manufacturing equipment, a...

API powders storage bottle

Users who prefer rigid storage over single-use pharma charge bags, require lightweight solutions ...

Entry-level filler for large-volume parenterals

Large volume parenterals are unit-dose containers that are larger than 100...

High-frequency vibratory mixer

Mixing liquid products by stirring method generates heat from friction and shear forces. This...

Continuous chocolate line with vertical ball mills

To mix and refine cocoa liquor, cocoa powder, sugar, and lecithin, sev...

Laboratory spiral jet mill

Ideal for the ultra-fine size reduction on a laboratory scale of dry materials up to Mohs' hardne...

Vertical scraper centrifuges

Vertical Bottom discharge Centrifuges work discontinuously, discharging the solids to the botto...

Vertical peeler centrifuge

A vertical peeler centrifuge is used to separate solids, usually to separate fine particles from ...

Active freeze dryer

Freeze-drying is used for dehydrating high-value products that are too sensitive for conventional drying ...

Laboratory scale active freeze dryer

The laboratory-scale active freeze-drying is used for dehydrating high-value products ...

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of...

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and "scale up" work.

Multipurpose and R&D freeze dryer

A multipurpose unit in the research and development field. Some of the most common applic...

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are design...

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in ac...

Saturated steam GMP laboratory autoclave

For processing a wide range of products: solid, porous and liquids in a laboratory...

Steam and air mixture sterilization autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Superheated water shower autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Ethylene oxide sterilization chamber

Designed for the terminal sterilization of temperature sensitive medical-health produc...

Dry heat depyrogenation oven

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and...

Electrical pure steam generator

Pure steam is defined as the steam which when condensed becomes WFI quality water in accorda...

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Transfer system for high-containment environments

A high-performance transfer port system that combines ultimate safety, ...

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Downflow booth

Provides the highest levels of operator protection from potentially harmful airborne contaminants generated dur...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

Vertical laminar flow cabinet

HEPA filtered vertical laminar airflow (down flow) creates an ISO 14644-1 (Class 5) work area ...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Compact blister machine

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

High-speed small volume liquid filler

Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottl...

Microdosing machine for sterile powders

Fill sterile pharmaceutical powders into vials under aseptic conditions with a spee...

Aseptic liquid filler for vials

Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.

Automatic washing machine for ampoules

Automatic washing machine designed for cleaning ampoules and achieving a maximum out...

Depyrogenation tunnels for ampoules, vials and bottles

Sterilize and depyrogenize ampoules, vials, bottles and similar gl...

Versatile checkweigher

This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also sui...

Small bottle checkweigher

Any small-diameter bottle, containing prescription medication or cosmetic applications, can be pro...

Ampoule filling machine

Filling ampoules or vials with parenteral fluids are an essential matter for which you need to consid...

Pharmaceutical bottles inspection machine

For the visual inspection of small to medium batch-sizes of vials, ampoules or b...

Magnetic agitator

Reliable mixing and agitation are essential to any quality production process that involves a fluid. This n...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

High containment split butterfly valve

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. ...

Feeder with flexible wall hopper

The varying properties of dry powder products mean that specialized feeders are required fo...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Ethylene oxide sterilizer

When medical devices like syringes, catheters, dialysis cartridges, plastic dressings and sutures ...

Flexible automatic inspection machine for syringes

Manufacture of pre-filled syringes requires the highest quality inspec...

Flexible automatic inspection machine for ampoules, vials, cartridges

If you are looking to improve the efficiency of y...

Small automatic inspector for ampoules, vials, or cartridges

Inspect small batch production of ampoules, vials, or cartr...

Semi-automatic inspection machine for ampoules, vials or cartridges

If you need to increase the efficiency of your manu...

Visual and HVLD inspection for ampoules, vials and cartridges

Do you need to improve the efficiency and capability of yo...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic produc...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are p...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pha...

Automatic cartoner for applications in pharma and cosmetics

For high capacity production...

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take ca...

Continuous pack cartoner

High volume automatic cartoning is vital for large scale production ...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but tradit...

GMP chamber washer

The thorough cleaning of small product contact parts has always been chall...

GMP washer

In order to guarantee zero cross-contamination between production batches, the prop...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be place...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing ...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceutical...

Rotary vial washing machine

When washing vial, ampoules, or cartridges for pharmaceutical pr...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a ...

Vial filling machine

The volume filling of vials, cartridges and syringes is a vital part of ...

Industrial vial capping machine

The high capacity production of pharmaceuticals delivered in...

External vial washing machine

Exterior washing solutions for vials often suffer from high wa...

Aseptic automatic vial filling machine

Current and future developments in pharmaceuticals i...

Aseptic vial cap sealing machine

Aseptic production methods are at the heart of the latest d...

Aseptic automatic vial washing machine

The production of the latest high value pharmaceuticals often requires aseptic handl...

Automatic vial tray loader

In modern pharmaceutical production, end-line processes are often...

Nested syringe filling machine

Increasingly, pre-sterilized Ready To Use (RTU) nested vials,...

Closed restricted access barrier system

Pharmaceutical production techniques often require ...

Vacuum mixer for suspensions

The production of high quality pharmaceuticals often requires m...

Purified water storage tank

Many pharmaceutical and cosmetic production lines require holdin...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutica...

Horizontal cartoner for pharmaceutical applications

Automatic cartoning for cosmetic or p...

Labeling machine for BFS containers

The pharmaceutical sector is unquestionably one of the major industries that rely on th...

Pharmaceutical rotary labeling machine for vials

Small, cylindrical-shaped glass bottles or vials are mainly used for vacc...

Low speed Filler for large-volume parenterals

Large-volume parenteral bottles are usually manufactured with a resin that c...

Automatic forming and sealing blister machine for packing syringes

Controlling contamination is on every manufacturer's...

Clinical trial lab sealer for a laminar airflow bench

When running small production for clinical trials, stability studie...

Automatic medical forming and sealing blister machine for packing capsules and tablets

Product safety is very importa...

Semi-automatic forming and sealing blister machine

As a manufacturer of medical device, the packaging is a critical facto...

Benchtop peristaltic dispenser

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of ...

Laboratory liquid viewer for colored glass bottles

In the pharmaceutical industry, an inspection to detect any particulat...

Laboratory liquid viewer for transparent glass bottles

In the pharmaceutical industry, an inspection of liquids in vials ...

Manual stoppering equipment for pre-filled syringes

Air present in the empty space of pre-filled syringes may prevent the...

Aseptic filling machine for liquids and powders

Aseptic filling of containers such as vials, syringes, bottles, and cartri...

Individual item serialization equipment

Traceability is critical to quality assurance in the pharmaceutical sector. But ser...

Sterile Filtration System for GMP-grade products

Processing equipment used in industries regulated by GMP must ensure full...

Modular assembly line for healthcare products

Assembly setups need to be constantly rethought and reconfigured to adapt qu...

Ultra-fine dispersing machine for APIs and vaccines

Multi-staged rotor/stator mixers generate the high shear forces requi...
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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Manufacturing parenteral formulations

Fragile molecules such as protein formulations would be destroyed using the alimentary canal and are therefore administered by injection. When making injectable formulations the drugs are stored in liquid or, if unstable at higher temperatures, lyophilized form. To ensure a stable active medium during storage and make the preparation isotonic with blood, liquid formulations combine active ingredients with a minimum amount of excipients such as solvents, solubilizers, suspending, and buffering agents, and antimicrobial preservatives.

Water for injections(WFI) is used as the vehicle for aqueous injections. For non-aqueous injections, fixed oils of vegetable origin are used as vehicles. Water for Injection is used in the preparation of medicines as a vehicle and sterilized water for injection is used when solving or diluting substances or preparations before use. WFI is obtained by distillation or reverse osmosis and meets all chemical requirements for PW (Purified Water) with an additional bacterial endotoxin parameter.

Lyophilized drugs allow storage at higher temperatures after freeze-drying is used to remove water from a liquid drug and create a solid powder or cake. In protein formulations, stabilizers are added to replace the water and preserve the molecule structure. Before administration, a lyophilized drug is reconstituted by combining a liquid diluent with the freeze-dried powder and mixing before injected into the body.

Vaccine development and production technology

Applikon Biotechnology is specialized in human vaccine production systems, as well as in systems for the production of therapeutic agents using both cell culture and microbial cultures.

Their advanced bioreactor systems can be used from the initial screening stage up to full-scale production using the same platform to minimize scale-up risks and guarantee a short time to market in product development.

Visual and high voltage leak detection (HVLD) inspection

Inspection of sealed glass vessels for contaminants, correct fill volume, sealing, and for example tip-cap effects or black spot particles. How convenient to cover all quality inspection requirements at once?

CMP Pharma’s NIKE-LT’s recirculation feature allows re-inspection following rejection by only one or two cameras (user selectable) which brings false rejection rates down reducing unnecessary wastage.

Sterile filling and packing of injectables

Sterile dosage forms must be free from any microorganisms, dust, fibers, and foreign particles, and should be isotonic. Although standards and legislation may differ worldwide there are several regulations to ensure the product or safe and effective new and generic drugs on the market such as USP/JP/EP standards and Current Good Manufacturing Processes (GMP) compliance.

Small-volume parenteral solutions (SVPs) are injections provided in containers 100 ml or less and can be designed for single and for multiple uses.  A large volume parenteral (LVP) is a single-use unit dose container of greater than 100ml designed to carry fluids, calories, and electrolytes.

For light-sensitive substances, colored glass containers such as vials or ampoules are used. If possible containers are made transparent for easier visual inspection. Containers are made, as far as possible, from material that is sufficiently transparent to permit visual inspection. Closures are equipped with a firm seal to prevent the entry of microorganisms and other contaminants while permitting the withdrawal of a part of the whole of the contents without removal of the closure. Closures for multidose containers are sufficiently elastic to allow the puncture to reseal when the needle is withdrawn.

Equipment for making injectables in action

Applikon next generation in microbioreactors

Vial filling line

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