Tell us about your production challenge

A pre-filled syringe is a single-dose disposable syringe that is supplied loaded with the substance to be injected. By using a pre-filled syringe filling machine, you can have excellent dosage accuracy due to the exact filling of medications. During administration, safety from potential contaminants is also ensured as they are directly injected after opening.

What pre-filled syringes equipment do you need?

Semi-automatic forming and sealing blister machine

As a manufacturer of medical device, the packaging is a critical facto...

Automatic forming and sealing blister machine for packing syringes

Controlling contamination is on every manufacturer&#...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method of choice for the delivery of in...

Horizontal cartoner for pharmaceutical applications

Automatic cartoning for cosmetic or pharmaceutical products is a requ...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables ...

Vacuum mixer for suspensions

The production of high quality pharmaceuticals often requires mixing of suspensions and similar...

Shell and tube heat exchanger

Heating, cooling and tempering are important processes in the production of many products acro...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutical production is a dedicated Clea...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a vital step in the production of ...

Syringe tub sterilizer

A common challenge is how to transfer nested syringe tubs to the aseptic filling area without compromi...

Sterile compounding system

Hospitals and compounding centres have traditionally used manual aseptic compounding processes. A...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take carton blanks which are formed and...

Automatic cartoner for applications in pharma and cosmetics

For high capacity production of cosmetics and pharmaceutical...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed ...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorati...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic products are sold in protective and de...

Flexible automatic inspection machine for syringes

Manufacture of pre-filled syringes requires the highest quality inspec...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Microdosing machine for sterile powders

Fill sterile pharmaceutical powders into vials under aseptic conditions with a spee...

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Show more equipment
Contact us

Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
Contact us

Rising demand for sophisticated forms of drug delivery

Pre-filled syringes are gaining popularity over traditional syringes and vials and are considered one of the fastest-growing markets in drug delivery and pharmaceutical packaging industries. Pre-filled syringes address most of the issues from the traditional vial and syringe drug delivery such as less risk of contamination during administration as there is no need to draw out substances from a separate container and elimination of on-site vial cleaning and depyrogenation.

For healthcare providers, prefilled syringes provide the exact dosage for injection, preventing potential dosage error and offering quick and convenient drug administration. For pharmaceutical companies, pre-filled syringes eliminate drug overfill with its correct dosage. This means less waste of drugs and better efficiency in manufacturing since vials are usually overfilled to ensure that the transfer of drugs from vial to syringe is adequate.

Less contamination, safer application, from a material called Cyclo Olefin Polymer

Most prefilled syringes still use glass materials, but in some parts of the world like Japan, plastic-based materials are becoming more common due to their improved break resistance and less surface reaction from chemicals. New materials for syringes have been developed to improve safety from contamination using a material called Cyclo Olefin Polymer (COP) that looks and feels like glass but tougher.

It is tungsten-free, which means it has fewer chances of health hazard due to tungsten exposure – tungsten can cause nausea and irritation to the lungs, eyes, and skin. COP is resistant to delamination; its properties are retained at cryogenic temperatures and require no lubricants or processing aids. This material can also be sterilized with gamma, ethylene oxide, and steam.

Administration of vaccines: tried-and-tested or new-and-improved?

Typical delivery methods for vaccines use multi-dose vials especially in mass vaccination programs. However, with the pre-filled syringes gaining market share, there is a shift towards using pre-filled syringes rather than multi-dose vials for vaccines. Based on global data of evaluation of vaccine presentation, pre-filled syringes can save time in mass immunization clinics. A study conducted by Scheifele and colleagues in Canada shows that, for every 1000 vaccine doses, vials took 36 hours while pre-filled syringes only took 27 hours.

This means that man-hours charged for labor costs are significantly lowered by 25 to 33 percent. Other advantages of using pre-filled syringes include the reduction of vaccine waste as it removes the variation inherent in drawing from a vial. There is also an increase in the consistency of administrating medicines across all locations as some healthcare workers are more adept than others in drawing medicines from a vial.

Pre-filled syringe filling machine for bubble-free liquid contents

Pharmaceutical companies that manufacture complex biologics require less headspace by using the bubble-free filling method. This is done by a stoppering technique called vacuum placement. A vacuum is pulled in each syringe that causes a differential pressure. The pressure draws the plunger into the syringe, leaving minimal headspace between the product and the plunger.

Advantages of a bubble-free pre-filled syringe filling machine are dosing accuracy with the removal of air bubbles, assurance of sterility because of fewer chances of plunger movement during shipping, and biologic stability due to less oxygen content that can affect oxygen-sensitive drugs.

Let's talk about your project!

Try us and get in touch. Send us a message and we will try to reply within 24 hours or give us a call at +31 10 206 8000
Contact us
All your data is kept confidential