archive tax-process theme-making woocommerce-js customize-support

newpack_aseptic-ffs-machine-for-coffee-creamer_fm200_1_picture

Newpack_Aseptic FFS machine for coffee creamer_FM200_1_picture

Aseptic Filling Equipment

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Milk can be consumed as a stand-alone product (whole, low-fat or skim) or can be the starting point for food industry products such as cheese, butter, yogurt, condensed milk, and ice cream. In order to process milk and other dairy products, you need specialized dairy production equipment which then encapsulates different processes such as pasteurization, homogenization, and fermentation.

Dairy

Cannabinoids are natural compounds obtained from the Cannabis sativa plant. Delta-9-tetrahydrocannabinol or THC is a psychotropic substance. Cannabidiol, or CBD, is non-psychotropic and often used for nutraceutical purposes. Cannabinoid equipment extracts THC and CBD from the plant and prepares the substance for formulations that treat pain, nausea, anxiety, and inflammations. Cannabinoids are processed in various forms, including creams, capsules, and oils.

Cannabinoids

Fruit pulp is a mass of pressed fresh fruit not meant for immediate consumption. Production of fruit pulp avoids wasting food and preserves the flavors and nutrient value of the fruit product. Processed fruit pulp is an ingredient in beverages, sauces, baby foods, jellies, smoothies, and bakery products.

Tradition and manufacturing procedures dictate the distinction between fruit juice, puree, and pulp. Still, naming and labeling are complex and depend on regulations, type of fruit, texture, consistency, preservation methods, and sugar or solid content (measured in Degrees Brix). Depending on your desired output, there are various fruit pulper machines for different stages of production that make the process quicker and more efficient.

Fruit pulp

Healthcare products are goods or services used to improve, maintain or prevent the deterioration of health or ease the consequences of illness. Healthcare products include a wide range of goods, from hospital clothing, over plasters, wound care products and diagnostic devices. These products must be clean and contamination-free, which is achieved with strictly regulated healthcare equipment.

Healthcare products

Aseptic filling equipment is crucial for sensitive products, as they need to be filled into their primary packaging in an environment free from contamination caused by harmful bacteria, viruses, or other microorganisms. Choosing an aseptic filling solution requires consideration of the physical form of the product, the type of primary packaging, the volume to be dosed per package, and the production speed. Aseptic fillers are widely used for cleaning, filling, and sealing pre-sterilized vials, cartridges, ampoules, and syringes in the pharmaceutical industry. Aseptic filling is also used in the food industry to process for example, dairy products that need harmful bacteria's minimized, or ensure shelf-stable products that do not require refrigeration. In these industries, aseptic equipment is integrated into the production line for maximum isolation and sterilization. And, can either be configured as an automated or manual process, depending on standards that the products require.

Continuous

Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottles with volumes ranging from 2 to 500ml and with maximum speed of 12,000 units per hour.


<h2>Fill liquid products in ampoules and bottles with fast product change-over</h2>
The new and innovative Romaco Macofar LF 200 series are an efficient solution for the filling of liquids and are perfectly adjusted to the increasing market requirements. The systems working in the medium and high speed range are suitable for products with different flow properties. All models are very easy to operate and individually configurable. The high degree of automation optimizes the process safety and the overall equipment effectiveness.

It has a weight of 1900 to 3800kg and speed of 4500 to 12,000 units per hour depending on the machine configuration.

High-speed small volume liquid filler

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

<span style="font-weight: 400">At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with </span><span style="font-weight: 400">chemicals or hazardous substances since they can be potentially dangerous to human health. </span>

Packing

liquid

These intermittent motion monobloc machines are designed for filling various liquids into glass or plastic containers with an output of up to 12000 vials per hour.


<h2>Flexibly fill liquid into glass or plastic containers of any shape</h2>
The Romaco Macofar LVI can be equipped with volumetric syringes or peristaltic pumps for filling liquids into glass or plastic containers of any shape. It is an intermittent motion monobloc liquid filling machine with one closing station. The series includes 3 machines models: (1) Monobloc with two integrated closing groups, (2) Monobloc with one closing group separated from the filling area, (3) an In-line solution.

They are suitable for filling a variety of liquids and can be supplied with closing stations capable of handling a wide range of closures such as droppers, spray pumps, press-on plugs, alu-ROPP, plastic screw cap (including child proof) and many others. LVI can also be designed to fill and apply rubber stoppers for injectable vial.

Monobloc small volume liquid filler

Fill sterile pharmaceutical powders into vials under aseptic conditions with a speed of up to 18,000 vials per hour.


<h2>Leading Microdosing machine for the sterile filling of powder into vials</h2>
The Romaco Macofar Micro 6, 9 and 18 are machines suitable for filling sterile pharmaceutical powders into vials under aseptic conditions. The Micro range of intermittent motion machines offers mechanical speeds ranging from 9,000 to 18,000 vials per hour. The powders are filled using a vacuum / pressure system. The cylindrical glass vials are then sealed with a rubber stopper.

Microdosing machine for sterile powders is designed for cGMP compliance and thanks to its balcony design, they are considered to be a leading powder micro-dosing machine.

Microdosing machine for sterile powders

solid

Fill poorly flowing powders, dry syrups and similar substances into various glass or plastic bottles with any type of closure.


<h2>Fill non free-flowing powders into a variety of bottles</h2>
The Romaco Macofar macrodosers MT 6 and F 4/PC are continuous motion powder filling machines suitable for dosing non free-flowing powders into all types of glass or rigid plastic bottles and the subsequent sealing with any type of closure (pilfer-proof, screw caps, press-on caps etc.). Powder dosing is performed by vacuum-pressure. The dosing disc has individually adjustable pistons, complete with suitable filtration material made of stainless steel mesh with a porosity that can vary according to the type and granulometry of the powder. The continuous motion operation minimizes powder loss and assures a high filling accuracy. A modular and flexible design allows a fast changeover.

Dosing machine for nonfree-flowing powders

Compact modular aseptic filler of vials with parenteral medicines and freeze-dried products.


<h2>Aseptic liquid filling solution suitable for liquid or lyophilized products</h2>
The Romaco Macofar VF Series is the ideal solution for filling vials with liquid parenteral drugs in advanced aseptic conditions and is suitable for liquid or lyophilized products. The machines, due to their compact, modular and versatile design are easily integrated into any line configuration; such as center room, through wall, connection to downstream capping machine, to a tray loader or to a freeze-dryer automatic loading system.

Aseptic liquid filler for vials, are positively conveyed throughout all the stations of the process. The machines are easy to clean, allow quick removal and repeatable assembly of size parts for change-over and sanitization operations. An automatic lateral adjustment of the linear transport system according to vials diameter is provided to minimize change-over time.

Aseptic liquid filler for vials

When looking for capping equipment, it is crucial to know first which type of capper your product requires. Do you want screw caps, twist-off caps, hand pumps, or push-pull caps on your bottle or container? If you require different cap types for format changeover times can be time-consuming. The bottle cap seals the top opening of a bottle to guard the product against leakage and spoilage and sterility and filling requirements depend on the nature of your product.

Capping

Filling ampoules or vials with parenteral fluids are an essential matter for which you need to consider the highest levels of safety and reliability in the process.


<h2>Customisable Ampoule filling machine with the highest filling accuracy</h2>
Rota’s filling machines allow the filling from small scale batches to mass production with optimal performance range. Filling can be done for the ampoules and vials that are from 0.2 ml to 30 ml and can afford up to 24.000 per hour.

Ampoules are the perfect containers to store parenteral fluids and their filling demands rigidly controlled sterile conditions. Rota’s own rotary pumps guarantee high filling accuracy in continuous operation without re-adjustment. This Ampoule filling machine comes with an easy to handle approach when looking to clean and sterilise the filling system, whether manually or with automatic CIP/SIP systems.

Ampoule filling machine

Any pre-filled syringe can be filled and closed with this fast and easy machine that helps in manual handling as well as for fully automated conveying of the tubs.


<h2>A processing machine for nested and pre-sterilized syringes</h2>
Rota has decades of experience as a supplier for the pharmaceutical industry. This processing machine for nested and per-sterilized syringes is a translation and integration of Rota’s experience for meeting the customer needs.

They main feature is the use of latest servo motor technology. Serial kinematics robotics (SCARA) and advanced control programming allow the precise execution of each individual processing step. It is provided with automated systems for de-bagging, lid and fleece inlay removal. The machine capacity covers a range of up to 22.000 syringes per hour.

Filling and closing machine for parenterals

Bagging is the process of packaging measured portions of a product into bags that protect it from spoilage, enable easy and safe transportation, and secure the product against tampering and pilferage. The choice of bagging equipment depends on the desired mass or volume per bag, the flow characteristics of the product, and bag construction and design. Bags vary in size from small sachets to bulk flexible containers. Bagging systems are often the last processing step that is generally integrated into a production line.

Bagging

Fill up to 24,000 vials per hour with pharmaceutical powders or liquids under aseptic conditions.


<h2>High speed sterile vial filling with 100% integrated check-weighing.</h2>
The Romaco Macofar MicroMaxX is an indexed motion microdosing machine for the dosing of sterile powders into glass vials in sterile environment, by means of vacuum/pressure system and subsequent closure with rubber stoppers. The aseptic injectable vial filling machine offers mechanical speeds ranging from 6,000 to 24,000 vials per hour.  The vacuum filling, first in class dosing system available on the market, highly reliable and largely validated, can be complemented with peristaltic pumps to perform liquid filling.

The machine can be configured with in-line, high speed, TARE/GROSS 100% check-weighing system, representing the perfect machine to process the most valuable and critical products of the customer. MicroMaxX is conceived to comply with the latest GMP regulations, thus meeting market’s highest quality requirements and Romaco customers’ needs.

High-speed aseptic injectable vial filling machine

Batch

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries requires flexible automation to accommodate format changes and optimize production. Also, vial sizes can range from 0.1 ml to 500 ml and syringes from 0.1 ml to 20 ml.
<h2>Fill, stop and crimp syringes and vials of all sizes</h2>
XI-I is specially designed by i-Dositecno for pharma filling, able to fill sterile liquid and powder in doses from 1 to 500 mls into vials and syringes.

4,000 units per hour can be produced for formats up to 80 mm diameter in a simple configuration, while 7,000 units per hour can be attained for smaller units up to 26 mm diameter in a double configuration.

Filling is by means of peristaltic pump, stainless steel rotary pump, ceramic rotary pump or CIP/SIP rotary pump. Stoppers are introduced by pick and place and capsule introduction and crimping are also completely servo driven.

&nbsp;

Sterile filling line for injectables

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Almost all manufacturers will require industrial storage systems and solutions at some point during their production process. The raw materials that go into your products need dedicated storage solutions to protect them from spoilage and contamination before they enter the manufacturing cycle. Storage usually refers to particular storage space. For example, having enough warehouse storage. Or clearing out a production facility for more floor space.  However, in this case, we are referring to the equipment and solutions that make storage manageable and easier. Such equipment includes solutions such as storage racks, pallet racks and shelving systems. These are just some of many storage options available to manufacturers. Advanced technology facilitates the management of heavy duty and high density tank and silo systems by automating the delivery system and linking it with the rest of the production line.

Storage

Demanding very high standards, the ophthalmic market requires quality solutions for filling a large range of bottle sizes, having different capping methods, at varying speeds.
<h2>Optimize ophthalmic production with completely sterile, accurate filling and capping</h2>
The i-Dositecno XI-O is specially designed for laboratory installations and its 8 filling heads are able to dose 1 to 500 ml of ophthalmic liquids at speeds of up to 7,000 bottles per hour for bottles as small as 26 mm diameter.

Totally built in AISI 304 stainless steel, the XI-O handles all the special materials requirements for this market and can work with plastic, pre-sterilized eye-dropper bottles or full servo solutions that can be sterilized inline (with CIP/SIP equipment and H2O2) or by means of an autoclave.

Filling options include peristaltic, stainless steel rotary, ceramic rotary or CIP/SIP rotary pumps.

&nbsp;

Sterile filling line for ophthalmics

Commencing ophthalmic production requires sterile conditions and accurate metering when filling and sealing eye-drop containers.
<h2>Fill and cap eye-drop bottles with high-quality rotary filler</h2>
The MI-O series by i-Dositecno is designed for start-up installations and is able to fill larger bottles of up to 80 mm diameter at speeds of 3,000 bottles per hour and smaller bottles, up to 26 mm diameter, at rates of up to 6,000 bottles per hour.

With up to 4 heads, it can dose 1 to 500 ml of ophthalmic liquids into the bottles. Filling options include peristaltic, stainless steel rotary, ceramic rotary or CIP/SIP rotary pumps. Totally built in AISI 304 stainless steel, the dispensing nozzles are smooth with the special rugosity required for handling sterile products.

Caps are introduced by servo-controlled pick and place and then screwed on using a pneumatic system. The quality detection system rejects any empty or partly filled bottles as well as any uncapped bottles.

&nbsp;

Start-up sterile filling line for ophthalmics

For smaller-scale production of vials and syringes for the injectables market, sterile conditions and accurate metering are still required for filling, stopping and crimping a wide range of container sizes.
<h2>Fill vials and syringes in basic, yet flexible, configuration</h2>
The i-Dositecno MI-I is specially designed for sterile pharma filling, able to fill sterile liquid and powder in doses from 1 to 500 mls into vials and syringes.

3,000 units per hour can be produced for formats up to 80 mm diameter in simple configuration, while 6,000 units per hour can be attained for smaller units up to 26 mm diameter in a double configuration.

Filling is achieved by means of peristaltic, stainless steel rotary, ceramic rotary or CIP/SIP rotary pump. Stoppers are introduced by servo-driven pick and place, however, capsule introduction and crimping heads are controlled by pneumatics.

&nbsp;

Start-up sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables market, sterile conditions and high-quality metering still need to be maintained.
<h2>Space-saving fill, stop and crimp line for vials</h2>
The table top BI-I from i-Dositecno can fill sterile liquid and powders in doses from 1 to 500 mls into vials, as well as specialized micro-dosing.

It can produce up to 2.000 units per hour for injectable vials from 2R to 500H as well as install rubber stoppers ranging from 12 mm to 32 mm and alu-caps 12 mm to 32 mm in size.

Filling is achieved by means of a peristaltic pump or a servo auger filler for micro-dosing which can meter as little as 0.150g. Stoppers are introduced by pneumatic pick and place and alu-caps loaded by chute, with crimping performed by pneumatics.

&nbsp;

Table top sterile filling line for injectables

<span style="font-weight: 400;">Filling and capping bottles and pots for food, chemical and cosmetics industries using separate machines is expensive and inefficient.A better solution is a combined monoblock unit, that will save space and cost, whilst increasing product throughput, even on multi-product lines.</span>
<h3><b>Monoblock combined filling and sealing machine</b></h3>
<span style="font-weight: 400;">EFM Monoblock filling machine is an easy-to-use, multi-purpose machine designed for filling and capping of containers with lids or pressure caps. Featuring a touchscreen system, the machine is easy to operate and allows simple readout and storage of all function information.</span>

<span style="font-weight: 400;">EFM’s design philosophy is to provide adaptable machines suitable for a range of industries. The Monoblock filling machine can be used with a wide variety of filling methods, including digital flow metering, piston pumps, peristaltic pumps, and more.</span>

<span style="font-weight: 400;">For the sealing process, a choice of methods is available including manual positioning of lids, or use of a fully automated cap supply system that uses pick and place. Final tightening can be by magnetic capping, servo capping, pressure capping or pilfer proof capping, to suit your requirements.</span>

Compact monoblock filler

<span style="font-weight: 400;">For larger production runs of food, non-food and cosmetics industries, where accuracy and volume of filling is required, a fully-automated vessel filling solution that works seamlessly with your line is vital. Ease of operation and precision control over fill volume of a large spectrum of liquids provides maximum flexibility for multi-product environments.</span>


<h3>Flexible high-volume flowmeter solution</h3>
<span style="font-weight: 400;">The EFM F-Series is a fully customisable, high accuracy, high volume filling machine. Capable of operating with a wide spectrum of liquids, the F-Series is available in 2,4,6, or 8 head versions. The high efficiency supply pump transfers product directly to the flow meter, where it’s then sent in compressed tubes to the fill valves, which are servo-controlled for accuracy of placement.</span>

<span style="font-weight: 400;">Fitted with electromagnetic flow meters by default, the EFM F-Series can also be supplied with mass flow meters for use with non-water-based product. It can also be fitted with conductivity measurement where required.</span>

<span style="font-weight: 400;">The F-Series is made primarily of stainless steel, and it’s designed to be easily and quickly disassembled for cleaning.</span>

Flowmeter filler

<span style="font-weight: 400;">In many food, chemicals and cosmetic industry processes it is vital to have a quick, accurate and reliable filling and sealing solution that can handle a wide variety of liquid types, including high viscosity and foaming products, into a range of bottle types.</span>


<h2><b>High capacity filler and capper capable of handling wide range of product</b></h2>
<span style="font-weight: 400;">The EFM Inline Monoblock Linear Filling and Capping series is available in both flowmeter and servo piston configurations to suit your exact requirements. Able to operate at up to 2,600 bottles per hour and fill volumes up to 30,000ml depending on model configuration, the Inline Monoblock is constructed in the Netherlands using all stainless steel and standardised components for longevity and ease of maintenance. Remote support from EFM engineers is also available for full peace of mind.</span>

<span style="font-weight: 400;">All variants features Siemens PLC and touchscreen controls, and all product contact points are of 316 stainless steel construction for longer life even when used with corrosive product. A polycarbonate safety casing gives superior protection and allows for excellent visibility for monitoring the filling and capping cycle. The capping module features high-torque sealing and a self-contained Detect and Reject operation to confirm the integrity of the seal, ensuring product quality.</span>

<span style="font-weight: 400;">The flowmeter variants are fitted with Endress &amp; Hauser Mag or Mass flowmeters, and both flowmeter and servo piston versions feature bottle counting, individual centering detection and automated filling bridge height adjustment.</span>

In-line monoblock linear filler &amp; capper

<span style="font-weight: 400;">For the stand-alone capping of bottles of up to 2.5litre capacity you need a robust and flexible machine with high speed and accuracy. Used in the beverage and chemicals industries, bottle cappers need to be reliable and fast, and for maximum flexibility need to be able to deal with a range of caps.</span>


<h2><b>Fully automated standalone capper for bottles up to 2.5 litre</b></h2>
<span style="font-weight: 400;">The EFM range of Multi-Head Capping machines offer maximum flexibility together with impressive performance. These all-stainless machines feature Siemens PLC and full touchscreen controls for accuracy and ease of use. The use of standardised components throughout from high-quality manufacturers increases longevity and reduces the downtime for any maintenance. The gravity-fed cap sorter and magnetic torque head provide high levels of reliability.</span>

<span style="font-weight: 400;">Able to handle a wide range of caps types, including screw caps, push ons, non-vacuum twist-offs and pilfer proof, the EFM multi-head range includes variants able to operate from 4,000 bottles per hour up to 9,000 bottles per hour with the 8 head unit.</span>

<span style="font-weight: 400;">Flexible options include screw infeed, second cap sorter for extremely quick changeovers, torque verification and Detect and Reject system for full capping verification. The units are also available with an optional remote support package direct from the manufacturer.</span>

Multi-head capper

<span style="font-weight: 400;">For food and non-food liquid products that are high foam or have a high viscosity a specialist filling solution is required. Whether filling jars, cans, bottles, top-downs or bowls, the filling machine needs to offer high levels of accuracy and reliability whilst being able to operate at high volumes.</span>


<h2><b>Servo-controlled piston filling machine for high viscosity liquids</b></h2>
<span style="font-weight: 400;">The EFM Servo Piston range of filling machines has been designed specifically for use with high viscosity and high foam liquids in the food, chemical and cosmetics sectors. Featuring robust all-stainless construction and high quality Siemens PLC and touchscreen control, the Servo Piston variants offer accurate and reliable fills at up to 5,200 bottle per hour.</span>

<span style="font-weight: 400;">Featuring standardised components for ease of maintenance and minimal downtime, the EFM servo piston machines are designed to handle volume ranges from 15cc up to 1,100cc depending on configuration.</span>

<span style="font-weight: 400;">For speciality products there are a wide range of options and upgrades available, including heated product tank, product agitators and nitrogen injection.</span>

<span style="font-weight: 400;">Constructed in the Netherlands, EFM also offers an optional remote support service for complete peace of mind.</span>

Servo controlled filler

<span style="font-weight: 400;">For the stand-alone capping of bottles of up to 30 litre capacity for smaller-scale production you need a robust and flexible machine with high accuracy. Used in the beverage and chemicals industries, bottle cappers need to be reliable and fast, and for maximum flexibility need to be able to deal with a range of caps.</span>


<h2><b>Flexible single-head capping machine for smaller-scale production lines</b></h2>
<span style="font-weight: 400;">The EFM range of single head capping machines offer maximum flexibility together with impressive performance for smaller scale production lines. These all-stainless machines feature Siemens PLC and full touchscreen controls for accuracy and ease of use. The use of standardised components throughout from high-quality manufacturers increases longevity and reduces the downtime for any maintenance. The gravity-fed cap sorter and magnetic torque head provide high levels of reliability.</span>

<span style="font-weight: 400;">Able to handle a wide range of caps types, including screw caps, push ons, non-vacuum twist-offs and pilfer proof, the EFM single-head range includes a standard edition able to cap up to 2,200 bottles per hour, and a servo-controlled edition capable of up to 2,600 bottles per hour.</span>

<span style="font-weight: 400;">Featuring a star wheel positioner as standard, the machine is able to fill bottle of up to 2.5 litres. However, by specifying the option using gates larger packages from 5 up to 30 litres can be filled by this machine, providing great flexibility.</span>

<span style="font-weight: 400;">Other options include high torque sealing, torque verification and Detect and Reject system for full capping verification. The units are also available with an optional remote support package direct from the manufacturer.</span>

Single head capper

<span style="font-weight: 400;">Current and future developments in pharmaceuticals increasingly rely on aseptic production methods, particularly involving cutting-edge gene and cell therapies or in the production of potent or cytotoxic products. Traditional aseptic practices are notoriously slow and unsuited to modern manufacturing. A cutting-edge aseptic vial filling solution combines complete containment with maximum throughput, dramatically increasing line efficiency.</span>
<h2>Robotic vial filler for aseptic pharmaceutical production lines</h2>
<span style="font-weight: 400;">The Steriline RVFM Robotic Vial Filling Machine is a highly advanced aseptic filling solution for today’s modern pharmaceuticals. It has been specifically designed for campaign production of high-value products using complete containment technology.</span>

<span style="font-weight: 400;">At the heart of the RVFM is an anthropomorphic VHP compatible robot from world leaders in automation STÄUBLI. The robot handles all vial transport operations within the enclosure.</span>

<span style="font-weight: 400;">The RVFM can be specified with a wide range of options to match your requirements exactly. Examples include peristaltic or volumetric piston pump dosing systems, and the option to handle single-use disposables. It offers nitrogen flushing before and during stoppering as standard.  An additional capping module can be specified to be located on the same monobloc, powered by an additional STÄUBLI robot. This option provides a complete aseptic filling and closing system in one unit.</span>

<span style="font-weight: 400;">Quality is assured by means of a 100% IPC or statistical check weighing system placed directly under the filling nozzles, with feedback to the dosing pumps. This allows for an instant refill to target weight for any underfilled vials at the point of filling. There is no waste during product path priming. This “zero reject” philosophy is extended to the capper - the RVFM will repeat operations when detecting any missing stoppers or caps, further saving product waste. </span>

<span style="font-weight: 400;">With a capacity of up to 6,000 pcs/h, the RVFM can handle vials from 2R to 100H with the highest levels of accuracy and in completely aseptic conditions. RVFM has been engineered not only to meet or exceed all the requirements of cGMP, GAMP, and 21CFR Part11 but also to operate with minimal downtime, boosting production efficiency.</span>

Aseptic automatic vial filling machine

<span style="font-weight: 400;">Aseptic production methods are at the heart of the latest development in pharmaceuticals in key areas such as cell and gene therapies or in the manufacture of particularly potent or toxic product. Existing aseptic production practices are slow and inefficient, and unsuited to modern practices. A state-of-the-art aseptic vial capping and sealing solution delivers complete aseptic containment with increased throughput volume, dramatically improving efficiency of production of these high-value products.</span>
<h2>Robot vial sealer/capper for aseptic pharmaceuticals production</h2>
<span style="font-weight: 400;">The Steriline RVCM Robotic Vial Capping Machine is a highly advanced aseptic capping solution for today’s cutting-edge pharmaceuticals. It has been specifically engineered for the campaign production of high-value product that requires complete containment. </span><span style="font-weight: 400;">With a capacity of up to 6,000 pcs/h, the RVCM uses a superb anthropomorphic VHP compatible robot from industry-leaders STÄUBLI to handle all vial transport.</span>

<span style="font-weight: 400;">4 capping heads operate simultaneously to provide maximum efficiency while minimising errors. The RVCM has been engineered using a “zero rejection” philosophy. This means that where the machine detects a missing cap or stopper the vial is recapped, not rejected. This reduces wastage of high-value product to near zero.</span>

<span style="font-weight: 400;">Throughout the capping process, the RVCM continuously monitors for the presence of viable and non-viable particles. It has been engineered to meet or exceed all relevant cGMP, GAMP and 21CFR Part11 requirements. </span><span style="font-weight: 400;">As part of a complete aseptic production system the RVCM can be added to the same monobloc as the Steriline RVFM, providing you with a self-contained and complete aseptic vial filling and capping solution.</span>

Aseptic vial cap sealing machine

<span style="font-weight: 400;">Increasingly, pre-sterilized Ready To Use (RTU) nested vials, cartridges and syringes are the preferred packaging option for modern pharmaceuticals. Because of this popularity, there are a wide variety of next types available, and traditional filling solutions are either unable to adapt to different nests, or require a long downtime in order to changeover. A modern, aseptic, fully flexible nest filling line offers rapid return on investment by being able to handle a wide variety of nests with minimum downtime and high throughput volumes. </span>
<h2>Robotic Nest Filling Machine for high-volume production</h2>
<span style="font-weight: 400;">The Steriline RNFM Robotic Nest Filling Machine is a complete combination line for the filling of RTU nested vials, syringes and cartridges. It offers the ultimate flexibility by being able to handle all currently available nest types, and is fully customisable with options including semi-automatic or manual debagging station, manual tub handling, volumetric or peristaltic dosing pumps, and the handling of single use disposables.</span>

<span style="font-weight: 400;">With a throughput of up to 18,000 pcs/h, the RNFM is the centrepiece of a modern high capacity campaign production system. Fully aseptic, it’s suitable for applications requiring oRABS, cRABS or Isolators.  </span><span style="font-weight: 400;">Tub handling is completely automated as standard, including Tyvek lid and insert removal, using an industry-leading STÄUBLI anthropomorphic VHP compatible robot. Nest handling throughout the filling and capping process is also carried out with high-grade STÄUBLI robots.</span>

<span style="font-weight: 400;">To allow maximum flexibility, the RNFM is able to handle a full range of liquid product, from water-like through to high viscosity. For the latter, vacuum assisted filling is available to ensure perfect results. </span><span style="font-weight: 400;">To enable rapid changeovers, fully electronic adjustment is available from the HMI to adjust for different container sizes. This quick changeover reduces downtime significantly.</span>

Nested syringe filling machine

With the production of dairy products such as butter in mini portions or natural jam and fruit puree with a low sugar content, the manufacturing process must meet certain hygiene standards. An FFS machine can be the right call in this case, as the production in the FFS machine takes place in a protected environment where the level of contamination is reduced. An added benefit of this machine is that it saves time by combining three production process steps – forming, filling and sealing – in one.


<h2>Thermoforming machine that forms, fills and seals cups</h2>
The Thermoforming machine designed by Newpack (Alimenta Group), is a horizontal Form-Fill-Seal machine that forms a container, fills it with the product of choice and then seals it in one single process. The machine can handle different food types from liquids to semi liquids, even high viscosity ones, such as milk based creams, butter, margarine, mayonnaise and more.

The Newpack Thermoforming machine is adjusted according to the product to be processed to meet demands regarding for example shelf life. Newpack customises the shape and size of the cup in accordance with manufacturer’s end product requirements. Depending on the needed hygiene levels, there are different machine versions: Standard, High-Clean, Ultra-Clean and Aseptic. For products such as butter, margarine and soft cheese, which are less sensitive to food poisoning microorganisms, a High-Clean or Ultra-Clean can be selected.

Starting from a reel of a thermoformable plastic film, Newpack Thermoforming machine forms the bottom of the container according to a pre-established shape, by heating the plastic film and shaping it through a mould. At this point, cups are automatically filled by a cup filling station. Based on the product to be packed and the shape of the cup, the filling system type changes. Afterwards, the machine applies a lid on each cup with heat sealing. When the cups arrive to the cutting station, they’ll be cut and separated. Newpack Thermoforming machine keeps the space between the lid and the top of the contents (headspace) inside the container to a minimum. It helps to reduce the risk of oxidation, while extending the shelf life of the product.

Machine capacity depends on the product and the volume of the cup; generally speaking, 9,000 - 15.000 c/h is the minimum production capacity.

High-clean FFS machine for butter in mini portions

The process of forming allows you to shape your products homogeneously. Forming machines are fed the manufactured material in bulk and cut it down to specification, so the process takes place between formulation of the mass and the packaging of the final item.

A special class of this equipment – Form, Fill, and Seal Machines (FFS) – creates bags and pouches from flat material such as plastic sheets, fills them with your designated product, and seals them.

Forming

In the food industry, from a microbiological point of view, different types of foods are subject to the growth of food poisoning microorganisms. For this reason, clean room conditions are required when they are processed. However, there are some products such as ketchup, mayonnaise, dip sauces, or jam/honey, that don’t require a special controlled environment, as they are considered low-risk foods. Adhering always to the hygiene standards, these products can be processed in a FFS machine with a standard environment which could be the right cost/benefit solution for mini portions production.


<h2>A thermoforming solution customizing cup shape and size</h2>
The Thermoforming machine designed by Newpack (Alimenta Group), is a horizontal Form-Fill-Seal machine that forms a container, fills it with a product and then seals it in a single process. The machine handles food products from liquids to semi liquids, even high viscosity ones like jam, honey, spreadable chocolate, dip sauces, and more.

The Thermoforming machine is adjusted to the demands of the product to be processed and its demands in regard to shelf life. Newpack customises the shape and size of the cup in accordance with manufacturer’s end product requirements. Depending on hygiene levels, Newpack has different versions: Standard, High-Clean, Ultra-Clean and Aseptic. For products such as jam, spreadable chocolate, ketchup, mayonnaise and dip sauces, that are not sensitive to the growth of food poisoning microorganisms, a Standard version is suggested.

Starting from a reel of thermoformable plastic film, the Newpack Thermoforming machine forms the bottom of the container according to a pre-established shape, by heating the plastic film and shaping it through a mould. At this point, cups are automatically filled by a cup filling station. Based on the product to be packed and the shape of the cup, the filling system type changes. Afterwards, the machine applies a lid on each cup by heat sealing it. When cups arrive to the cutting station, they’re cut and separated.

Machine capacity depends on the product and volume of the cup; generally speaking, 9,000 - 15.000 c/h is the minimum production capacity.

Standard FFS machine for spreads and sauces in mini portions

Thermoforming

UHT products (ultra high temperature processing) such as sterilized milk, are products where all microorganisms are destroyed and shelf life is extended thanks to this specific heating process. To ensure a continued product sterility and an extended shelf life, aseptic packaging is required. An aseptic FFS machine is indispensable to prevent reinfection. Packaging material is sterilized before the filling process and the end-product is sealed in an aseptic environment free of micro-organisms.


<h2>Aseptic filling and packaging solution prevents contamination</h2>
The thermoforming machine designed by Newpack (Alimenta Group), is a horizontal Form-Fill-Seal machine that forms a container, fills it with a product and seals it, in one single process. The machine handles UHT food products from liquids to semi liquids such as dairy products, not carbonated soft drinks, energy drinks, tea and more.

Newpack Thermoforming machine is adjusted to meet the needs of the products to be filled and its shelf life. Newpack customises the shape and size of the cup in compliance with manufacturers end product. Depending on the desired hygiene level, Newpack has different versions: Standard, High-Clean, Ultra-Clean and Aseptic. For products such as UHT milk or coffee creamer that need very high hygiene standards and sterile conditions, the Aseptic version is suggested.

Starting from a reel of thermoformable plastic film, the Newpack Thermoforming machine forms the bottom of the container according to a pre-established shape, by heating the plastic film and shaping it through a mould. At this point, cups are automatically filled by a cup filling station. Based on the product and the shape of the cup, the filling system type changes. Afterwards the machine applies a lid on each cup by heat sealing it. When cups arrive to the cutting station, they’re cut and separated.

The Aseptic version sterilizes both the plastic film that will form the product container and the lid, with hydrogen peroxide to prevent bacterial contamination. The process takes place in a tunnel which is also filled with the sterile air. Scrapers will remove hydrogen peroxide residue from the packaging material. After washing, the filling system is sterilized with a steam cycle and then kept in aseptic conditions through sterile air at positive pressure.

The machine capacity depends on the product and the volume of the cup; generally speaking, for 10-15ml cup standard configuration, 30,000 c/h is the minimum production capacity while for 100ml and more the minimum production capacity is approx. 9000 c/h.

Aseptic FFS machine for UHT products

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of cross-contamination. Using a suitable hygienic pump, where the liquid only comes into contact with a disposable tube, can help reduce the contamination risk.
<h2>Pumping liquids intovials and ampoules without the risk of contamination</h2>
The Accuramatic Peristaltic Dispensing Unit from Adelphi is a hygienic peristaltic pump that can fill bottles, vials, and ampoules with volumes ranging from 1 to 1000mL. It can fill containers at a maximum rate of 36mL per second and a filling accuracy of+/-0.5%. The unit can be operated by hand, foot switch, or programmed to cycle automatically with a delay of up to 10 seconds between fills. The system features 3 filling modes(braked stop, soft stop, stop with suck back) of your choice. This machine can be used in conjunction with Adelphi’s XYZ Distributor for filling vials and bottles or Ampoule Filling Jig for filling ampoules.

Benchtop peristaltic dispenser

Vials are difficult to fill individually through manual methods due to handling concerns such as accuracy in filling and possible spillage ofthe liquid product. From a production standpoint, a liquid filling system with an automatic nozzle can help manufacturers to fill the vials accurately and quickly enough to meet production demands while minimizing waste.
<h2>Filling small vials automatically using a multi-directional movable nozzle</h2>
The XYZ Distributor from Adelphi is asemi-automatic liquid filling machine for bottles,vials, ampoules, and nested syringes that are loaded in trays.The system features a three-axis filling operation where the nozzle can move horizontally and vertically for greater precision.It can also accommodate containers with a maximum height of 200mm and a minimum neck diameter of 6-8mm. The system can be operated by hand and foot pedal switch or programmed to automatically cycle the filling process. The unit comes with silicone tubing where your liquid product flows through without any contact from other moving parts of the system to avoid cross-contamination. The entire system can be placed on a small workbench due to its compact dimensions (790 x 625 x 390mm).It has a quick and efficient filling rate of up to 36mL per second.

Benchtop piston filling equipment for vials in trays

When filling ampoules is essential to avoid wetting the inside walls of the container, as it may affect the quality of the seal. Having a stable ampoule holder with a well-aligned and precise liquid filling device makes it possible to fill the ampoule without any contact with the walls, thus ensuring the seal’s quality of the ampoule.
<h2>Stable holder and precise liquid filling mechanism for ampoules</h2>
The Ampoule Filling Jig, from Adelphi, is a hand-operated ampoule filling device. This unit is designed for holding small neck containers like ampoules and filling them up through a centered needle. The needle is small enough to fit ampoules without being in contact with the inside wall of them. It comes with a predetermined stop to make sure the end of the filling needle is at the correct level when raising the holder. The holder of the unit is custom-made based on the size of the ampoules or containers to be used. This unit is used in conjunction with Adelphi’s Accuramatic Peristaltic Dispensing Unit which pumps the liquid through the tubing.

Manual ampoule filler

Small and medium-sized manufacturers with manual filling processes often have to deal with inaccurate filling levels. Plus, the process is time-consuming. They know that an automated system can be expensive when scaling-up. Moreover, they don't need the level of output that a fully automatic system can provide. Switching to a semi-automatic system will ease the scaling-up process, giving consistently reliable fills at a higher production rate.
<h2> Filling bottles, jars, vials or tubes using interchangeable nozzles</h2>
The Response Benchtop Filler from The Adelphi is a pneumatically driven, volumetric filling machine having a versatile filling head design. It can be used for different products from pharma, food and cosmetic industry such as oils, gels, creams, sauces or peanut butter. It is available in single or twin-head configurations, with a wide range of nozzles, including cut-off nozzles for a clean fill with no dripping.

The versatile unit can be set to a single shot or continuous operation, filling at an average of 20 to 40 containers per minute. The filling speed can be adjusted according to the product characteristics. It can fill volumes of 5ml to 1000ml, with an accuracy up to ±0.25%. (superior to the industry average of ±1%).

Semi-automatic filler

Bottling equipment draws a measured quantity of your drink, food, or formulation from a holding tank and fills it into bottles. These bottles usually need to be checked, capped, labeled, and sealed for distribution. Bottling solutions differ in product metering system, sterilization level, and bottle type and sealing system depending on your production scale and product format and regulations. Bottling systems are utilized in a variety of industries. For example, in the food and beverage industry as well as in cosmetics and pharma.

Bottling

Increasing consumer demand forces production lines, especially packaging, to invest in different machines to adapt to the variety of products coming from the pharmaceutical, food, and cosmetic industries and thus keep up with demand. To fulfill the rising production demand investing in a flexible automatic system that can be assembled or disassembled to accommodate and fit the product and production requirements would further increase efficiency and reduce running costs.
<h2>Automatic filling line for bottles, jars, tubes, vials</h2>
The Response Automation Base from The Adelphi is a filling machine that incorporates up to 4 Adelphi Response Benchtop Filler, which can also be used as stand-alone pieces of equipment when required. It has logic controls for gating and sensing systems, thus giving consistent and reliable fills in each cycle. Pneumatic cut-off nozzles ensure a clean fill with no dripping, thereby maintaining a hygienic production environment.

Variable speed conveyor with adjustable guides and rails facilitates handling of a variety of products. The automatic filler has the capacity to fill volumes of 5ml to 1L, with a fill accuracy of up to ±0.25% (superior to the industry average of ±1%). Its fast-filling ability can give a highly productive output at up to 60 containers per minute, i.e. up to 29,000 containers per 8-hour shift.

Up to four head automatic filling machine

Pharmaceutical and chemical products may be toxic or prone to contamination from environmental exposure. When filling them up in drums, it is best to have a system that can provide proper containment to avoid contamination as well as the formation of dust particles.


<h2>Controlled loading of powdered products in drums and bags</h2>
The Drum Filling system from Dec, is a solution for safe and controlled loading of pharmaceutical and chemical products in drums and bags. The system is equipped with a glovebox to enable the operator to connect the liners within a sealed environment. It allows contamination-free filling of drums of various sizes under high containment (less than 1 microgram per cubic meter). With its small footprint, the unit can be installed in remote spaces in case of limited height clearance under the equipment. The system can be equipped with optional load cells for added filling accuracy. The unit is easy to clean (CIP) and simple to install. It is available in various materials depending on the product application.

&nbsp;

Drum filling system

Dosing of powder products must be done in a continuously controlled manner to provide a precise amount of the product in every batch while avoiding the risk of altering the characteristics of the powder due to electrostatic charging.


<h2>Precise dosing of powders by volume using calibrated chambers</h2>
The PFL Powderflex from Dec, is a powder dosing system capable of moving small and medium quantities of powder at a rate of a few hundred grams per hour up to 200 kg/h. The system can extract powder from any container and convey it to long distances, around 50m or longer, without affecting the characteristics of the powder. It is equipped with two calibrated chambers with a flat filter and controlled through vacuum and pressure by a valve system for consistent volume dosing. The combined effect of vacuum and pressure alternately fills and empties the chambers at a high frequency. The powder volume flow rate can be adjusted by adapting the volume of the chamber or by changing the frequency of the operation. With its simple design, the unit is easy to clean (CIP – Clean-In-Place).

Powder dosing system

Aseptic filling of containers such as vials, syringes, bottles, and cartridges is required in pharmaceutical industries to ensure minimal risk of contamination caused by different microorganisms. This helps avoid product defects that may also lead to consumer health and safety concerns. Precise filling for each type of container should also be addressed to maximize yield while minimizing waste.


<h2>Tailor-made aseptic filling of vials, bottles, and syringes</h2>
The DecFill from Dec offers an automated aseptic system solution for various filling processes in production lines of different capacities. The system is specifically designed for the required application of filling products whether in liquid or powder form. It can also be configured to handle different containers such as vials, syringes, bottles, cartridges, and even special containers like Dual Chamber Syringes (DCS). The system can be built with all the required modules for an easy format changeover with minimum impact on production capacity. Through its tailor-made design, the filling process is more accurate and prevents overfilling or spilling, leading to increased production and less product waste. Other features that can be added to the system include stopper, cap, and needle placement of tubes and syringes.

Aseptic filling machine for liquids and powders

Active pharmaceutical ingredients demand high handling standards to prevent cross-contamination. Moreover, the processing of materials creates risks to occupational safety and health, especially where highly potent APIs are involved. But, while formulas may be kept separate during processing, loading them into different bagging machines leads to production inefficiencies.
<h2>Modular big bag filling equipment for powdered process bulk materials</h2>
Big Bag Filling station from Dec Group is a universal solution for the direct filling of big bags .  The station integrates into other process equipment like mixers or driers with gravity-assisted filling. In cases where headroom is limited, the station can be modeled for remote-filling instead. Here,  powder transfer technology moves the materials through a valve system for correct dosing.

The holding frame is either painted steel or stainless steel and has a big bag loop holder with a fast-release mechanism. The Big Bag Filling station includes a range of other solutions, including sieving, milling, metal detection and separation, sampling, weighing, and precise dispensing. The equipment uses a standard pallet jack for easy installation of pallets.

Big bag filling machine

Liners for powder handling across industries must prevent contamination of materials to comply with GMP. But individual bag or drum filling systems cannot guarantee complete sterilization standards during bag removal and exchange. Moreover, they may lead to concerns about operator safety.
<h2>Liner system for bag and drum filling of powders with high containment level</h2>
CLS Continuous Liner System from Dec Group offers complete solutions for packaging different powder materials into bags and drums. Depending on the liner and cartridge dimensions, the system carries folded bags up to 80 meters. Its filling head can be installed directly at the discharge outlet of the machine or on a support frame with load cells for weighing. Moreover, the liner is attached to the support clips for safe bag detachment.

The liner is produced in a clean ISO 5 environment with the option of γ-irradiated cartridges for sterile use. It can be delivered pre-folded in various sizes and supplied in a PE bag.

Additional features include rollers for heavy loads, a breather vent filter, and a precise dispensing mechanism through the inertisation of liner and dosing device. The system integrates into other process equipment like mixers, dryers, or powder transfer systems.

&nbsp;

Contamination free filling system

Weighing

Pharmaceutical powders in metered doses demand maximum filling precision. This is particularly challenging with materials in the micro-gram range. Fine powders may exhibit complex behaviors that develop into a bottleneck in the production line.
<h2>High precision multiple powder dosing in the mg range</h2>
µPTS from Dec Group is a patented technology offering precision dosing of minimal powder weights at a fast turnover. The PTS technology performs powder dosing from a &lt;1 mg in less than a second and with an accuracy rate reaching 2% RSD. The hopper is designed for powders with challenging flow properties to facilitate the powder transfer process. The system does not have an integrated filter, and it can dose ultra-fine and sticky materials.

The solution employs vacuum technology to transfer the powder to the calibrated chamber. Before dosing, the µPTS automates vial charging, positioning, and taring. The measured dose is then ejected using a piston and weighed ahead of filling. A linear motor may be regulated in a closed loop with a weighing device to change the volume automatically.

&nbsp;

Powder micro-dosing system

Balancing speed and accuracy in powder dosing is crucial to fulfilling production viability. But, in the case of small powder quantities, achieving that repeatability manually can slow down the manufacturing process.
<h2>Fast and precise dosing technology for small quantities of powders</h2>
FlexPTS from Dec Group is a powder dosing system based on PTS technology that can handle materials in the 100 – 200 mg range. The dosing operation takes between 0.5 to 2 seconds with an accuracy of up to 3% RSD. Additionally, the system integrates a filter in the upper portion.

Weight-setting is done through an intuitive HMI panel, but it can be programmed for repeatability with automatic volume adjustment. Powders are transferred through vacuum technology to a calibrated chamber that may be either constant or variable. The material is then followed by pressure-assisted vial filling. Special-purpose pinch valves used at the inlet and outlet enable rapid dosing.

The FlexPTS includes an additional feature of a mini-robotic platform for drug delivery. It is also suitable for charging in a pressurized process involving high temperature or humidity and even a corrosive environment.

High-speed powder dosing system

Dosing multiple powders in a batch process is time inefficient, especially when handling small quantities of materials. But dose precision is a more important consideration, leading manufacturers to give up on speed to preserve accuracy.
<h2>Precise powder dosing equipment with multiple filling capacity</h2>
sPTS from Dec Group provides for dosing of small, regulated amounts of powder at a predetermined frequency. Based on PTS technology, it allows small powder quantities for separate applications to be dosed simultaneously. The system has a dosing range of &gt;100 g and runs at a speed of 5 to 20 seconds. The technology operates with an accuracy of up to 5% RSD.

In the powder dosing operation, a fixed volume calibrated chamber is firstly filled under vacuum and then emptied under pressure. The sPTS system contains a filtration membrane in the upper section. As per the requirement of the packaging machines, this compact system can be mounted in a battery to fill multiple points concurrently.

Accurate multiple dosing system for powders

Aseptic filling equipment

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

After being used to contain the blood of martyrs after death or to store the anointing oil of French monarchs, today ampoules are the first choice in packaging injectables. You create ampoules by melting the glass tube into the desired shape and seal them at the neck by melting the top of the glass tube. The only way for you to extract the contents from an ampoule is by breaking the glass at its breaking point, making it perfect for single dose applications only.

Ampoules

First commercially sold baby food was created by Henri Nestlé when he combined cow milk with sugar and grains. Baby food industry has since grown to offer everything from whole wheat infant cereals to ramen-flavored baby food. From infant formula to fruit puree, choosing the baby food processing equipment is related to the type of baby food you want to make.

Baby Food

Chocolate fillings

Chocolate milk is a beverage containing milk flavored with chocolate powder or chocolate syrup. Cocoa powder, sweetener, sugar, and carrageenan are mixed with the milk and then pasteurized. As cocoa powder has a higher density than milk, carrageenan is used as a thickening agent to prevent cocoa powder from settling to the bottom.

Chocolate milk

To produce condensed milk, you need to remove a large portion of the water content from the milk. Usually, you add sugar to it to create a sweet flavor. First, milk is standardized and pasteurized. Then, it goes through an evaporation process to remove the excess water content while sugar is added. After that, the mixture undergoes homogenization. The condensed milk is cooled and crystallized before being ready for packaging.

Condensed milk

Your earliest memory of medicine is probably a jar of cough syrup with a plastic dosing spoon attached. Although widely produced as remedies for children, medicated syrups are also available for adults. Making cough syrup starts by dissolving active ingredients into a purified water and sugar solution. But it is the distinct flavorings and colorants that persist in people’s minds long after the illness is cured.

Cough syrup

The body produces earwax to protect the ear canal from microbial growth. But no one wants too much protection of this kind. Thankfully, simple solutions are available over the counter to medicate excess cerumen. Besides wax removal, eardrops and OTIC manufacturing provides an effective delivery technique to treat infections or administer anesthetic.

Eardrops

Eyedrops processing is quite literally a sight for sore eyes. There is no shortage of eye care products, from eyewashes to anesthetics to antibiotics. But formulating eyedrops is a complex affair with multiple safety checkpoints. Technological advances bring a pair of fresh eyes to manufacturing, ensuring higher-quality products for specialized applications.

Eyedrops

Glycerine is a water-soluble liquid mix of alcohol and sugar. It is a by-product of the oil and fats industry that offers added value to various industries. There are three ways to process it: transesterification, saponification, and fat splitting (hydrolysis). In 2020 these 3 forms of glycerine production reached around 4 million metric tons, with a global market of $1.68 billion.

Glycerine

<span style="font-weight: 400;">Any coffee-drinker can agree that a cup of coffee in the morning can brighten up their day. As the most convenient way of making coffee, many people choose to make coffee at home. Whether you want to make Moka coffee or filtered coffee, you need ground coffee that is grind appropriately for the coffee brewing method of your choice. These ground coffee are manufactured by roasting and grinding processes. </span>

Ground coffee

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Mayonnaise is created by blending oil with eggs, and then flavoring with vinegar, mustard, herbs, and spices. The eggs are a natural emulsifier that creates a uniform mixture. Ingredients are pumped into mayonnaise manufacturing equipment. First, a dynamic mixer maintains the desired level of emulsification of the mixture, which then moves on to packaging and bottling once reaching a satisfactory consistency.

Mayonnaise 

Mineral water is mother nature’s cocktail of dissolved solids. The concentration of essential chemicals in the water makes it an excellent source of nutrients and electrolytes. Although your bottled product retains most of the properties present at its natural condition, the water still needs some help before it can be safely consumed.

Mineral water

Smelling is said to be the most underrated sense. But a congested nose quickly reminds us why it is important. Besides the loss of the olfactory function, nasal blockage leads to a dangerous buildup of pathogens in the airways. Nasal spray formulation is the science of mixing drugs and excipients to free your nasal passage. A few spritzes of the right recipe will bring back the scents of life.

Nasal spray

The most significant decision when making ointments is likely to be the choice between automatic or semi-automatic processes for it. This impacts on individual phases of the ointment cream manufacturing process - the water phase and oil phase.

Ointment

Oleochemicals

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

A pre-filled syringe or PFS is a single-dose disposable syringe that is supplied loaded with the substance to be injected. By using a pre-filled syringe filling machine, you can have excellent dosage accuracy due to the exact filling of medications. During administration, safety from potential contaminants is also ensured as they are directly injected after opening. To further minimize the risk of contamination, pre-filled syringes are often filled and sealed in a sterile environment using stainless steel equipment.

Pre-filled Syringes

<em>“How clean does my equipment needs to be?” </em>That's what manufacturers often wonder about in order to meet the high sterilization standards the pharmaceutical industry demands. Lending manufacturers helping hand have been single-use bags, also known as disposable, first introduced in the late 1990s. They immediately gained popularity because they reduce the risk of cross-contamination, minimalize cleaning and sterilization demands, and require a low capital cost.

Single-use bags

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

If you've ever heard the acronym WFI spoken, know that we're not talking about wireless technology to connect your computer. WFI stands for water for injection, a sterile water used as a solvent to dilute other solutions for injections to the body. Traditionally, WFI was only produced through the distillation process using water for injection equipment until other methods such as reverse osmosis, electrodeionization, and ultrafiltration were developed.

&nbsp;

Water for injection

Connect directly with world leading manufacturers of Aseptic filling equipment and find technology to build or improve your production line.

Aseptic Filling Equipment - Making.com

Home

We open production technology to everyone

Making.com

https://making-tst.imgix.net/2022/12/makingCopy.png

operation type

product format

Privacy Policy

User Agreement

Terms of Service

Default Confirmation

If too long

This form auto replies from Zendesk on submission
on Trigger ID: tbc
https://vekamafsupport.zendesk.com/agent/admin/triggers

Aseptic Filling Equipment

Which aseptic filling equipment equipment do you need?