Integrated vial filling system for aseptic and toxic pharmaceuticals
Minimize product loss and ensure high sterility in vial filling while handling aseptic and toxic products with precision and speed.
Fills, Decontaminates, and Seals Vials Aseptically
The integra Integrated Vial Filling and Isolator Technology System from groninger combines precise vial filling with the latest isolator technology for aseptic and toxic pharmaceutical applications. This system is engineered to enhance safety and efficiency, featuring SKANFOG decontamination for maintaining sterility. Designed for biopharmaceutical and biotech industries, it processes up to 400 vials per minute across a range of 2R to 100H vials, ideal for products like vaccines and monoclonal antibodies. The system’s automation and integration capabilities include servo motor adjustments, rapid changeovers, and stopper repositioning to minimize downtime and product loss. The integra’s compact design is compliant with GMP and allows full monitoring and control through advanced PLC systems, ensuring the highest standards in safety and operational efficiency. Available with options for stainless steel construction, the system also incorporates user-friendly elements like easy access for cleaning and maintenance through its ergonomic design. With comprehensive engineering support, groninger ensures that the integra adapts seamlessly into existing production lines for pharmaceutical manufacturers and CMOs.
Benefits
- Minimizes product loss with precise filling and stopper repositioning functions.
- Shortens changeover times by 50% with efficient format part design.
- Enhances operational safety with fully automated HEPA filter changes.
- Increases productivity by processing up to 400 vials per minute.
- Maintains sterility and compliance with integrated SKANFOG decontamination technology.
- Applications
- Toxic products,Aseptic products,Biotech products,Biopharmaceuticals,Pharmaceuticals
- End products
- Monoclonal antibody vials,Cytotoxic drug vials,Insulin vials,Protein therapeutics vials,Antiviral drug vials,Cancer treatment vials,Sterile oncology medication vials,Biologic drug vials,Vaccine vials
- Steps before
- Washing,Sterile preparation
- Steps after
- Stopper setting,Crimping,External washing,Packing
- Input ingredients
- vials,aseptic products,toxic products,2R-100H Vials,filling volume 1-100ml
- Output ingredients
- filled vials,up to 400 vials per minute
- Market info
- Groninger is known for its expertise in manufacturing high-quality filling and packaging machinery for the pharmaceutical, cosmetics, and consumer healthcare industries, with a strong reputation for innovation, precision engineering, and customer-focused solutions.
- Output
- up to 400 vials per minute
- Processing range
- 2R-100H Vials
- Filling volume
- 1-100 ml per vial
- In-Process-Control (IPC)
- 100%
- Residual oxygen content
- Minimum of =1%
- Vacuum-free line
- For toxic products
- Cycle time
- 1 hour < 1 ppm with SKANFOG® technology
- NANOX® catalyst technology
- 0.1 ppm
- HEPA filter system
- Automated and safe change (“FIPA”)
- Filling method
- groninger smartfill technology
- Machine design depth
- 650 mm
- Automation level
- PLC/SCADA
- Batch vs. continuous operation
- Batch / Inline Continuous
- CIP/SIP
- CIP 121°C / SIP 135°C
- Changeover time
- Short
- Cleaning method
- CIP / Manual
- Energy efficiency
- Minimized product loss,waste
- Process monitoring
- 100% In-Process-Control (IPC)
- User-friendliness
- Single-side operation
- SKANFOG technology
- Fast H2O2 cycle
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Container size and shape
- 2R-100H Vials
- Filling volume
- 1-100 ml per vial
- Product compatibility
- Bulk vial filling
- Filling method
- Volumetric / Gravity
- Stopper system
- Repositioning function
- Decontamination technology
- SKANFOG
- Line configuration
- Integrated Vial Filling Machine
- Machine footprint
- Compact design
- Control panel type
- Fully automated panel control
- Compact footprint
- Single-side operation and setup
- Machine depth
- 650 mm
- Discharge method
- Filter cartridge system with HEPA filters
- Control panel type
- Fully automated panel control
- Filter system
- HEPA filters with automated change
- Integration possibilities
- Interfaces between groninger and SKAN lines
- Machine design
- Compact design for easy access
- Mechanical stopper setting function
- Yes
- Servo motor configuration
- Adjustable walking beam
- Smartfill technology
- Minimum product loss via groninger smartfill
- SKANFOG decontamination technology
- Integrated with shortest cycle times
- Stopper transport bowl
- Integrated sorting device