Horizontal vacuum paddle dryer for sensitive pharmaceutical ingredients

Achieve precise drying and mixing of sensitive materials with a design that ensures cleanability, sterility, and compliance with stringent cGMP and FDA guidelines.

Dries and Mixes Sensitive Materials Efficiently

The COMBER Pharmadry® Series PH 50 – PH 4000 vacuum paddle dryer from HEINKEL Group is designed to tackle the challenges of processing sensitive materials across various industries, including pharmaceuticals and fine chemicals. This equipment excels in drying and mixing operations, using a fully welded agitator design and minimal build depth to ensure excellent cleanability and accessibility. With a processing capacity between 50 to 4,000 liters, it supports both batch and pilot operations, making it ideal for products like APIs, protein isolates, and metallic pigments.

The Pharmadry® meets stringent cGMP and FDA guidelines, including options for aseptic and steam sterilizable versions. It boasts a double mechanical seal, which is externally interchangeable, enhancing ease of maintenance. Constructed from stainless steels and high-performance alloys like Hastelloy C 22, it is suitable for environments requiring high corrosion resistance. The equipment’s PLC-controlled system allows seamless integration with existing lines, enhancing operational efficiency through automation. A built-in CIP system ensures contamination-free cleaning, while optional features like a vacuum system with condenser further optimize energy use.

Benefits

  • Enhances product purity with efficient drying and mixing tailored for sensitive materials.
  • Ensures compliance with industry standards, reducing regulatory risks.
  • Simplifies cleaning and maintenance through a fully welded, CIP-compatible design.
  • Minimizes operational disruptions with robust, externally interchangeable mechanical seals.
  • Accommodates diverse materials with corrosion-resistant alloy options.

General


Applications
Surface coating,Fine chemicals,Chemical products,Metal recycling,Food products,Pharmaceuticals
End products
Amino acids,Flavor enhancers,Powdered milk,Metal powders,Agricultural chemicals,Active pharmaceutical ingredients (apis),Metallic pigments,Protein isolates,Excipients,Instant coffee,Specialty polymers,Vitamin e supplements
Steps before
Purification,Emulsification,Grinding
Steps after
Sterilization,Packing
Input ingredients
freely flowing pharmaceutical ingredients,fine chemicals
Output ingredients
dried pharmaceutical ingredients,dried fine chemicals
Market info
Heinkel (Comber) is renowned for manufacturing industrial engineered-to-order equipment, specializing in filtration, centrifugal, and mixing solutions. They are recognized for their precision engineering, quality, and ability to tailor solutions for pharmaceutical and chemical industries.

Technical Specifications


Usable volume
50 – 4,000 liters
Design temperature
-10 to 150°C (14 to 302°F)
Design pressure
-1 to +6 barg (FV to 90 psig)
Material
Stainless steels,Hastelloy C 22,Alloy 59,Titanium
Sealing materials
PTFE gaskets,O-Rings in FFKM or FEP encapsulated
Heated areas
All product wetted components
Cycle time
Minimal drying times
Automation
PLC-controlled
Cleaning method
CIP systems,steam sterilizable
Agitator type
Paddle,entirely welded design

Operating Characteristics


Batch vs. continuous operation
Batch
CIP/SIP
CIP systems with simple validation
Automation level
PLC with HMI interface
Cleaning method
Excellent cleanability using CIP systems
Changeover time
Minimal due to good accessibility
Working mechanism
Vacuum paddle dryer

Material Compatibility


Cleanability
Excellent with CIP systems
Corrosive resistance (e.g. acids)
Stainless steels,Nickel based alloys
Biological compatibility
FDA and cGMP compliant materials
Abrasion resistance
Good with Hastelloy C 22 or Alloy 59

Physical Characteristics


Agitator design
Entirely welded,without bolts
Agitator support
Supported at the rear
Build depth
Minimal
Accessibility
Very good for inspection and cleaning
Design pressure
-1 to +6 barg (FV to 90 psig)
Design temperature
-10 to 150°C (14 to 302°F)
Usable volume
50 – 4,000 liters
Material options
Stainless steels,Nickel alloys,Titanium
Footprint
Compact
Seal type
Double mechanical,externally interchangeable
Heating
All product wetted components

Custom Options


Control panel type
HMI with touch screen
Integration possibilities
Interface for DCS
Sealing type
Double mechanical seal,externally interchangeable
Material options
Stainless steels,Nickel based alloys,Titanium
Agitator design
Entirely welded,no bolts,pockets,rounded edges
Cleaning systems
CIP systems
Process separation
Separating wall between process and mechanical areas