Automatic linear filling stoppering system for large volume vials

Ensure precise vial filling and secure sealing with a high-speed system designed for aseptic conditions, streamlining your process from filling to inspection, while minimizing contamination risk.

Fills, Stopers, and Caps Vials Efficiently

The LFS-8 Phoebus from Siempharma is a linear filling and stoppering machine designed for seamless integration into aseptic production lines in pharmaceutical, nutraceutical, and cosmetic sectors. It efficiently handles liquid and lyophilized products in vial formats up to 500 ml, with two machine cycles capable of processing vials up to 1000 ml. The LFS-8 utilizes an intermittent motion system with format-based scroll or carrying rake for precise vial transport, synchronizing movements to eliminate nozzle adjustments. Its compact design features an integrated alu-capping station, though optional installation on a separate RC-100/200 LADON is available. Dosage is managed by volumetric or peristaltic pumps, ensuring accurate filling. A rubber stopper system allows for complete or partial stoppering, with a built-in rejection device for faulty vials. Constructed from AISI 304 stainless steel and compliant with GMP standards, the machine is designed for easy cleaning and compliant with Industry 4.0 standards. User-friendly HMI ensures quick configuration and operation, while compliance with CFR21 part 11 / EU ANNEX 11 facilitates regulatory adherence.

Benefits

  • Enhances production efficiency by precisely filling and stoppering with minimal manual intervention.
  • Reduces contamination risk through aseptic integration, ensuring high product safety standards.
  • Increases flexibility by handling a wide range of vial sizes and liquid types seamlessly.
  • Minimizes operational costs with a built-in faulty vial rejection system to prevent waste.
  • Facilitates regulatory compliance with GMP and Industry 4.0 standards.

General


Applications
Pharmaceutical solutions,Liquid formulations,Nutraceutical solutions
End products
Insulin vials,Reconstituted antibiotic liquids,Vitamin supplement vials,Essential oil vials,Protein supplement liquids,Herbal extract vials,Probiotic liquid suspensions,Vaccine vials,Allergy medication vials,Lyophilized pharmaceutical powders
Steps before
Aseptic preparation,Vial cleaning,Liquid formulation
Steps after
Capping,Quality control,Packing
Input ingredients
vials,liquid products,lyophilized products,rubber stoppers
Output ingredients
filled vials,stoppered vials,capped vials
Market info

Technical Specifications


Filling volume
Up to 500 ml
Handling capacity
Vials up to 1000 ml
Dosing groups
Up to 8 groups
Automation
PLC-controlled
Material
AISI 304 stainless steel
Safety
Safety guards with interlock switches
Cleaning
Designed for easy cleaning
Regulatory compliance
CFR21 part 11 / EU ANNEX 11 ready
Industry Standard
Industry 4.0 compliant
Vial transport
Format-based scroll or carrying rake

Operating Characteristics


Working mechanism
Linear intermittent motion
Integrated steps
Filling and stoppering
CIP/SIP
CIP / Manual
Automation level
PLC-controlled
Batch vs. continuous operation
Batch
Changeover time
Easy change size parts
Cleaning method
Easy cleaning

Material Compatibility


Biological compatibility
FDA approved materials
Cleanability
Easy to clean design
Corrosive resistance (e.g. acids)
AISI 304 stainless steel
Abrasion resistance
High durability components

Product type Characteristics


Container type
Vials
Filling purpose
Liquid or lyophilized products
Vial size/volume
Small up to large volume vials (500 ml)

Physical Characteristics


Machine footprint
Compact design with stainless steel frame
Frame material
AISI 304 stainless steel
Screens/doors
Transparent with safety interlock switches
Contact material
FDA or other approved materials

Custom Options


Control panel type
Touch Screen HMI
Integration possibilities
oRABS / cRABS / Isolator
Nozzle adjustment
Eliminated need for adjustment
Dosing groups
Up to 8 dosing groups
Handling capacity
Up to 1000 ml vials