Technetium-99m generator production line
Streamline your radiopharmaceutical production with our solution, ensuring precise formulation, sterilization, and assembly of Technetium-99m generators, supported by advanced semi-automatic processes and comprehensive quality control measures for reliable outputs.
Processes and Assembles Tc-99m Generators
The TC-99m Generator Production Plant from Comecer is an advanced semi-automatic production line designed for crafting high-purity technetium-99m generators, primarily serving radiopharmaceutical manufacturers and nuclear medicine facilities. This system excels in integrating multiple stages, including formulation, sterilization, and quality control, into one streamlined process. Equipped with progressive shielding chambers, the plant ensures operator safety during operations ranging from high-activity Mo-99 bulk loading to final washing and quality checks. With a capacity of up to 250 generators in a 12-hour shift, it supports consistent batch processing. Enhanced by features like automatic Mo-99 dispensing and comprehensive QC verification, the plant maintains high standards aligned with GMP regulations. The double pass-through autoclave optimizes workflow, reducing downtime during maintenance. Tailored engineering support allows customization to meet specific operational demands, making it an adaptable asset in radiopharmaceutical production lines.
Benefits
- Enhances production efficiency with semi-automatic operation, reducing labor involvement.
- Ensures consistent product quality through 100% in-line quality control of Tc-99m generators.
- Increases safety for operators with comprehensive shielding during high-activity handling.
- Maintains uninterrupted workflow with automated Mo-99 formulation and dispensing.
- Minimizes downtime and maximizes reliability with double pass-through autoclave design.
- Applications
- Radiochemistry,Nuclear medicine,Radiopharmaceuticals
- End products
- Molybdenum-99 solution,Technetium-99m generators,Radioisotope generator columns
- Steps before
- Loading 99Mo bulk,Formulation of chemical parameters,Adjustment of solution parameters
- Steps after
- Sterilization,Quality control,Packing
- Input ingredients
- Mo-99 bulk,chemical parameters adjustment
- Output ingredients
- Tc-99m generators,sterilized generator columns,QC verified generators
- Market info
- Comecer is known for manufacturing advanced containment and isolation systems, particularly in the pharmaceutical and nuclear medicine sectors, with expertise in custom-engineered equipment, ensuring high safety and compliance standards.
- Number of working chambers
- 12
- Type of process
- Terminal sterilization
- Type of shielding
- Lead 150mm / Lead 100mm
- Automation systems available
- Automatic 99Mo formulation,Automatic filling of generator columns,Automatic washing of generator columns
- Productivity
- 250 generators in 12h,3 batch per week
- Automatic in-line QC
- 99Mo breakthrough during filling
- Loading capacity
- Loading from B(U) of the 99Mo bulk
- QC verification
- 100% QC verification of each generator
- Transfer system
- Double pass-through autoclave
- Process flow
- One-way transfer of the material
- Maintenance capability
- Reliability in case of autoclave maintenance
- Number of working chambers
- 12
- Batch vs. continuous operation
- Semi-automatic batch
- Type of process
- Terminal sterilization
- Automation level
- Automatic 99Mo formulation and filling
- QC verification
- 100% in-line QC
- Productivity
- 250 generators in 12h
- Shielding
- Lead 150mm / Lead 100mm
- Transfer method
- Double pass-through autoclave
- Number of working chambers
- 12
- Type of shielding
- Lead 150mm / Lead 100mm
- Automation systems
- Automatic 99Mo formulation
- Automation systems
- Automatic filling of generator columns
- Automation systems
- Automatic washing of generator columns
- Quality Control
- Automatic in-line QC for 99Mo breakthrough
- Shielding Chambers
- Progressive-shielding chambers
- Autoclave type
- Double pass-through autoclave