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After being used to contain the blood of martyrs after death or to store the anointing oil of French monarchs, today ampoules are the first choice in packaging injectables. You create ampoules by melting the glass tube into the desired shape and seal them at the neck by melting the top of the glass tube. The only way for you to extract the contents from an ampoule is by breaking the glass at its breaking point, making it perfect for single-use applications only.

What ampoules equipment do you need?

Ampoule filling machine

Filling ampoules or vials with parenteral fluids are an essential matter for which you need to consid...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method of choice for the delivery of in...

Continuous pack cartoner

High volume automatic cartoning is vital for large scale production of cosmetic or pharmaceutical pr...

Horizontal cartoner for pharmaceutical applications

Automatic cartoning for cosmetic or pharmaceutical products is a requ...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables ...

Vacuum mixer for suspensions

The production of high quality pharmaceuticals often requires mixing of suspensions and similar...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutical production is a dedicated Clea...

Rotary vial washing machine

When washing vial, ampoules, or cartridges for pharmaceutical production there is often a trade-...

External vial washing machine

Exterior washing solutions for vials often suffer from high water consumption and low throughp...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a vital step in the production of ...

GMP laboratory freeze dryer

Freeze dryer designed for aseptic and small-scale production of high-value products.

Magnetic agitator

Reliable mixing and agitation are essential to any quality production process that involves a fluid. This n...

High capacity horizontal cartoner for pharmaceutical and cosmetic appliances

Cartoners take carton blanks which are fo...

Automatic cartoner for applications in pharmaceutical and cosmetics industry

For high capacity production of cosmetics...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed ...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorati...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic products are sold in protective and de...

Flexible automatic inspection machine for ampoules, vials or cartridges

If you are looking to improve the efficiency of...

Small automatic inspector for ampoules, vials, or cartridges

Inspect small batch production of ampoules, vials, or cartr...

Semi-automatic inspection machine for ampoules, vials or cartridges

If you need to increase the efficiency of your manu...

Visual and HVLD inspection for ampoules, vials and cartridges

Do you need to improve the efficiency and capability of yo...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Microdosing machine for sterile powders

Fill sterile pharmaceutical powders into vials under aseptic conditions with a spee...

Labeling machines for ampoules, vials and bottles

Labels for ampoules, vials and bottles are typically applied at the end...

Vial, ampoule or bottle inspection machine

For the visual inspection of small to medium batch-sizes of vials, ampoules or ...

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Compact blister machine

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...

Depyrogenation tunnels for ampoules, vials and bottles

Sterilize and depyrogenize ampoules, vials, bottles and similar gl...

Automatic washing machine for ampoules

Automatic washing machine designed for cleaning ampoules and achieving a maximum out...

Dosing machine for nonfree-flowing powders

Fill poorly flowing powders, dry syrups and similar substances into various gla...

Monobloc small volume liquid filler

These intermittent motion monobloc machines are designed for filling various liquids in...

High-speed small volume liquid filler

Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottl...

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are design...

Dry heat depyrogenation oven

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Types of ampoules: shapes that fit the standards

Based on the shape of their head from ISO standards, you can count three types of ampoules: straight-stem (form B), funnel type (form C), and sealed (form D). ISO 9187-1:2010 specifies materials, dimensions, capacities, performance and packaging requirements for three forms of glass ampoule for injectable pharmaceutical products.

Straight-stem ampoules and funnel-types have open ends for the customers to wash and sterilize before filling and sealing. Sealed ampoules instead have dome-shaped closed ends, which means that ampoules are supplied already sterilized. Customers have to open them with a sharp flame before filling them and then reseal them.

Ampoules also have different break systems. One point cut (OPC) refers to a small cut on the constriction of the ampoule and is paired with a colored dot mark for the position of the breaking cut. Color break ring (CBR) refers to an enamel ring applied around the constriction as a marker for the breaking cut. Scoring (SCO) refers to surface markings of the glass around the constriction part.

Plastic ampoules as a new possibility

Plastic ampoules are getting more popular in pharmaceutical companies. They are less costly to manufacture, easier to transport and store as they have better breaking resistance. Actually, they do not require tearing or cutting the top portion, because you can simply snap off the neck to open. Their manufacturing process offers more accurate dosages and prevents overfill of products, making it more efficient compared to glass.

Check the quality through ampoule inspection machine

Quality control for pharmaceutical products is a critical process. It requires multiple visual inspections to ensure that the products are not contaminated, and the packaging is intact and clean. You can opt for a fully automatic or semi-automatic inspection machine equipped with image sensors and magnifying cameras to check the correct fill level, detect contaminating particles, glass defects and container leakage.

Other options available for inspection machines include detecting product color using illumination and sensors, and container closure integrity using multiple cameras that check the position of the cap.

Color coding for identification

Have you ever noticed that ampoules have colored rings around their neck?
The colored rings are used as a code to identify the substance inside the ampoule. This makes it easier to sort them for the purposes of storage, labeling, and packaging. These rings are machine-readable for easier identification and printed by rotating discs using heavy-metal-free inks for safety reasons.

Between ampoules and vials

Ampoules are meant for single-use or single-dose applications since they are sealed at the neck with heat and you have to crack them open to extract the contents. With vials is another story. You only need to remove the caps or pierce the rubber stopper with a syringe. As for the content inside, ampoules store unstable chemical compounds and highly volatile elements while vials are for storing stable compounds.

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