operation type

product format

Privacy Policy

User Agreement

Terms of Service

Default Confirmation

If too long

This form auto replies from Zendesk on submission
on Trigger ID: tbc
https://vekamafsupport.zendesk.com/agent/admin/triggers

Admin Notification

New submission from {form_title}

Messages backup

Notify Teammedia of submission

Submission from Making.com Ad Campaign

Maker - Product Challenge

Products

Technologies

About us

Changemakers

Ampoule filling Equipment

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

After being used to contain the blood of martyrs after death or to store the anointing oil of French monarchs, today ampoules are the first choice in packaging injectables. You create ampoules by melting the glass tube into the desired shape and seal them at the neck by melting the top of the glass tube. The only way for you to extract the contents from an ampoule is by breaking the glass at its breaking point, making it perfect for single dose applications only.

Ampoules

Fill liquid pharmaceutical, nutraceutical and cosmetic products in ampoules and bottles with volumes ranging from 2 to 500ml and with maximum speed of 12,000 units per hour.


<h2>Fill liquid products in ampoules and bottles with fast product change-over</h2>
The new and innovative Romaco Macofar LF 200 series are an efficient solution for the filling of liquids and are perfectly adjusted to the increasing market requirements. The systems working in the medium and high speed range are suitable for products with different flow properties. All models are very easy to operate and individually configurable. The high degree of automation optimizes the process safety and the overall equipment effectiveness.

It has a weight of 1900 to 3800kg and speed of 4500 to 12,000 units per hour depending on the machine configuration.

High-speed small volume liquid filler

Filling ampoules or vials with parenteral fluids are an essential matter for which you need to consider the highest levels of safety and reliability in the process.


<h2>Customisable Ampoule filling machine with the highest filling accuracy</h2>
Rota’s filling machines allow the filling from small scale batches to mass production with optimal performance range. Filling can be done for the ampoules and vials that are from 0.2 ml to 30 ml and can afford up to 24.000 per hour.

Ampoules are the perfect containers to store parenteral fluids and their filling demands rigidly controlled sterile conditions. Rota’s own rotary pumps guarantee high filling accuracy in continuous operation without re-adjustment. This Ampoule filling machine comes with an easy to handle approach when looking to clean and sterilise the filling system, whether manually or with automatic CIP/SIP systems.

Ampoule filling machine

For smaller-scale production of vials and syringes for the injectables market, sterile conditions and accurate metering are still required for filling, stopping and crimping a wide range of container sizes.
<h2>Fill vials and syringes in basic, yet flexible, configuration</h2>
The i-Dositecno MI-I is specially designed for sterile pharma filling, able to fill sterile liquid and powder in doses from 1 to 500 mls into vials and syringes.

3,000 units per hour can be produced for formats up to 80 mm diameter in simple configuration, while 6,000 units per hour can be attained for smaller units up to 26 mm diameter in a double configuration.

Filling is achieved by means of peristaltic, stainless steel rotary, ceramic rotary or CIP/SIP rotary pump. Stoppers are introduced by servo-driven pick and place, however, capsule introduction and crimping heads are controlled by pneumatics.

&nbsp;

Start-up sterile filling line for injectables

Inspect small batch production of ampoules, vials, or cartridges using automated machinery designed for large-scale production was not cost-effective. The latest technological advances have now made automatic inspection viable for smaller lines, increasing productivity for lower cost.
<h2>Flexible, high-quality fully automatic inspection for small production</h2>
The CMP SA6 has been designed specifically to bring the benefits of fully automated inspection to small batch production, in an adaptable and reliable package.

Able to handle liquid or freeze-dried products in vials, ampoules, and cartridges with diameters from 8mm up to 32mm, the CMP SA6 can accurately inspect up to 100 pcs/minute and runs on a standard single-phase 230V power for ease of installation.

In standard configuration, it will inspect for contamination by particles, fibers, and glass fragments as well as correct fill levels. Optional features include cosmetic control of the vessels, product color, printing, and leak testing.

Small automatic inspector for ampoules, vials, or cartridges

If you need to increase the efficiency of your manual inspection process for liquids or freeze-dried products without compromising quality, the latest generation of semi-automatic machines can deliver the productivity increase you need at a lower cost.
<h2>Flexible semi-automatic inspection solution for a wide range of vessels</h2>
The CMP SV inspection machine allows your operators to inspect the widest range of products, handling containers - including pre-filled syringes- from just 1ml capacity up to 1000ml.

The machine can operate with ampoules, vials or cartridges from 8mm to 78mm in diameter, with a maximum height of 120mm, giving you great flexibility across product ranges.

Featuring high output LED lighting and a high quality magnifying viewer, the CMP SV allows operators to inspect product for contaminating particles, correct fill level, cosmetic issues including any printing, plunger inspection (for cartridges), glass defects and more.

The SV can handle up to 100 pcs/minute, and the containers are rotated to allow the inspector to assess each one before deciding on any rejections.

Semi-automatic inspection machine for ampoules, vials or cartridges

Do you need to improve the efficiency and capability of your inspection and quality control process?High volume inspection of sealed glass vessels is crucial, not only for contaminants, but also correct fill volume, correct sealing, cosmetic appearance and more. Multiple inspection machinery to cover all your quality inspection requirements adds costs and increases production times. The latest combination inspection products offer a one-stop quality solution.
<h2>High speed visual inspection and high voltage leak detection (HVLD) machine</h2>
CMP Pharma's NIKE-LT is the latest generation in pharmaceutical inspection machinery for vial, ampoules and cartridges.

Able to handle vessel capacities from as little as 1ml up to 30ml, the NIKE-LT uses high resolution cameras and the latest LED technology to achieve best-in-class visual inspection. The novel recirculation feature allows re-inspection following rejection by only one or two cameras (user selectable) which brings false rejection rates down reducing unnecessary wastage.

Standard inspection processes built in are for correct fill level and detection of contamination particles, fibres or glass fragments. Optional additional inspection modules allow for cosmetic control (position of cap, shape, height, etc), product colour, glass defects and leak testing.

Visual and HVLD inspection for ampoules, vials and cartridges

When you fill ampoules it is essential to avoid wetting the inside walls of the container, as it may affect the quality of the seal. Having a stable ampoule holder with a well-aligned and precise liquid-filling device makes it possible for you to fill the ampoule without any contact with the walls, thus ensuring the seal’s quality of the ampoule.
<h2>Stable holder and precise liquid filling mechanism for ampoules</h2>
The Ampoule Filling Jig, from Adelphi, is a hand-operated ampoule-filling device. This unit is designed for holding small neck containers like ampoules and filling them up through a centered needle. The needle is small enough to fit ampoules without being in contact with the inside wall. It comes with a predetermined stop to make sure the end of the filling needle is at the correct level when raising the holder. The holder of the unit is custom-made based on the size of the ampoules or containers to be used. This unit is used in conjunction with Adelphi’s Accuramatic Peristaltic Dispensing Unit which pumps the liquid through the tubing.

Manual ampoule filler

When you fill vials and ampoules, high standards of hygiene are required to avoid the risk of cross-contamination. Using a suitable hygienic pump, where the liquid only comes into contact with a disposable tube, can help you reduce the contamination risk.
<h2>Pumping liquids into vials and ampoules without the risk of contamination</h2>
The Accuramatic Peristaltic Dispensing Unit from Adelphi is a hygienic peristaltic pump that can fill bottles, vials, and ampoules with volumes ranging from 1 to 1000ml. It can fill containers at a maximum rate of 36ml per second and a filling accuracy of +/-0.5 %. The unit can be operated by hand, foot switch, or programmed to cycle automatically with a delay of up to 10 seconds between fills. The system features 3 filling modes (braked stop, soft stop, stop with suck back) of your choice. This machine can be used in conjunction with Adelphi’s XYZ Distributor for filling vials and bottles or Ampoule Filling Jig for filling ampoules.

Benchtop peristaltic dispenser

For operations needing efficient filling and capping of small to medium-sized containers, ensuring accuracy and minimizing downtime is essential. Maintaining product integrity and optimizing space can present challenges in limited production environments.
<h2>Fill and cap efficiently with precise control</h2>
The Response Monobloc 250 Filler & Capper, from Adelphi Manufacturing, is engineered for fast and accurate filling and capping of bottles, jars, and screw-top vials. Capable of processing up to 35 containers per minute and handling fill volumes ranging from 3ml to 250ml, it ensures exceptional accuracy up to ±0.25%, thus reducing waste. Constructed from 316L stainless steel and PTFE, it complies with both pharmaceutical and food industry standards. Its compact design maximizes workspace, and its intuitive HMI touch screen controls are user-friendly, making operations straightforward. The Quick-Strip design facilitates rapid changeover between different container sizes, minimizing downtime and enhancing efficiency. The system also incorporates the Response Benchtop Filler, which can be detached for independent use if required.

Filler and capper for bottles and jars

In pharmaceutical manufacturing, precise and efficient filling and closing of ampoules is critical to ensure product quality and sterility. Traditional methods can be time-consuming and prone to errors, impacting production workflows and increasing risk of contamination.
<h2>Enhances filling accuracy and operational efficiency</h2>
The Type 502/503 by Bausch Group is a compact unit designed for the filling and closing of ampoules. The system features a maximum output of 6,000 containers per hour and uses a transport star wheel for smooth, continuous transfer of ampoules to the working stations. Two-piece, valveless dosing pumps deliver precise dosing with an accuracy of up to +/- 0.05%. The ampoules are continuously rotated to minimize product foaming and to ensure an evenly heated ampoule stem, resulting in a perfectly formed dome. Vials are sealed with rubber stoppers fed from a vibrating bowl. This system is optimized for use under laminar flow, Restricted Access Barrier Systems (RABS), or isolators. It can be employed as a standalone unit or integrated into a production line.

Filling and closing system for ampoules

In the pharmaceutical industry, accurately filling and securely closing ampoules is crucial to maintain product integrity and avoid contamination. Switching between ampoules and vials can be time-consuming without versatile technology.
<h2>Effortlessly fill and close ampoules</h2>
The Type 504/505/506 series from Bausch Advanced Technology Group is designed to fill and close both open and pre-sealed ampoules with efficiency and precision. Featuring a rotary style, this system ensures smooth and gentle transport, minimizing the risk of product foaming and improper sealing. The PLC control and user-friendly touchscreen interface facilitate easy operation. Additionally, the system allows quick changeovers from ampoules to vials, optimizing production workflows. Capable of handling up to 24,000 containers per hour, this system is well-suited for high-scale pharmaceutical operations.

Ampoule filling and closing system

In the pharmaceutical industry, achieving high throughput while maintaining accuracy and safety is crucial. For operations requiring flexible solutions capable of accommodating different container sizes without the need for size parts changes, specialized filling and closing systems are essential.
<h2>Automate precise dosing and closing of containers</h2>
The CombiSys filling and closing system, model FVC 50606 by Bausch+Ströbel, offers an advanced solution for pharmaceutical filling operations. Designed for high flexibility, the system's grippers enable broad working ranges without changing size parts. It automates dosing and closing with high precision, ensuring 100% in-process control (IPC) at full output. The modular design with standardized components allows easy and centralized operation. Supporting up to three dosing systems, it can process up to 12,000 containers per hour with diameters ranging from 7 to 30 mm and heights from 35 to 100 mm, including syringes of 0.5 to 10 ml. Configurable for use in Restricted Access Barrier Systems (RABS) or isolators, it ensures high process reliability. Bausch+Ströbel's CombiSys machine stands out for its optimal laminar air flow, low-particle closure feed, and pharmaceutical-grade design. Additionally, the system features free-standing, calibrated load cells and benefits from short set-up times and compact design.

Combisys filling and closing system for pharmaceutical containers

Producing pharmaceutical, cosmetic, or other liquid products often requires precise filling and secure closing of plastic bottles. Ensuring an effective and accurate method for this process is crucial, especially when dealing with large-scale production where quality and consistency are paramount.
<h2>Automatically sort, fill, and close plastic bottles</h2>
The FVK 50400 is an intermittent motion system by Bausch+Ströbel, designed for fully automatic sorting, filling, and closing of plastic bottles. This system employs a walking beam to gently transport the containers through the work area. It features a dosing station outfitted with four rotary piston pumps, ensuring precise liquid filling. Alternatively, the machine can be equipped with peristaltic pumps. The closing stations can handle droppers, screw caps, snap-on caps, and multi-dose dispensers. This machine offers 100% In-Process Control (IPC) at full capacity and processes up to 10,000 items per hour. Container diameters range from 14.25 to 30 mm, and heights from 30 to 67 mm. The product-carrying parts are sterilizable and autoclavable, maintaining optimal laminar air flow, thus satisfying stringent pharmaceutical standards.

Filling and closing solution for plastic bottles

In pharmaceutical manufacturing, stringent standards for asepsis and containment are essential when processing intravenous (IV) bags. Traditional methods can involve significant human intervention, increasing the risk of contamination and errors.
<h2>Provides high-speed aseptic filling for Iv bags.</h2>
The automatic aseptic filling line for IV bags from Comecer is a high-speed, turnkey solution capable of processing various IV bag formats in both small and large batches. Using isolation technology from start to finish, it guarantees asepsis and containment, minimizing human intervention. The system includes in-line integrity testing and can handle bags ranging from 50 ml to 1 liter without requiring format part changes. It manages up to 2300 pieces per hour with either peristaltic or volumetric integration and incorporates LAF isolation technology along with a built-in VPHP decontamination system. Primarily used in the pharmaceutical industry, this filling line ensures complete separation between the process and the operator.

Automatic aseptic filling line for Iv bags

In the pharmaceutical and healthcare industries, precision packaging is crucial for maintaining product integrity and ensuring accurate dosing. Challenges include handling small doses, maintaining sterility, and achieving high production speeds without compromising quality.
<h2>Package pharmaceuticals efficiently with multiple lanes</h2>
The PHS-100 from Enflex (part of the Coesia Group) is an intermittent stick pack system designed to meet stringent pharmaceutical and healthcare packaging requirements. The system operates with up to 24 lanes, allowing for speeds up to 1800 stick packs per minute (spm). This high-capacity throughput ensures efficient production while maintaining precise packaging standards. It is particularly suitable for OTC, other pharmaceutical and healthcare applications, and prescription packaging. The PHS-100’s design addresses challenges such as sterility and accuracy, ensuring each pack is consistent. Furthermore, the system offers easy switching between different batch sizes, optimizing flexibility for various production needs.

Intermittent stick pack machine for pharma and healthcare

In the pharmaceutical industry, precise bag forming is crucial for creating IV bags and other prescription applications. Ensuring a reliable and efficient forming process can significantly reduce waste and maintain product integrity, especially when dealing with liquid products that require sterile and accurate packaging solutions.
<h2>Enable zero waste bag forming</h2>
The BF Forming System from GF (Coesia Group) is designed to efficiently termoform polypropylene (PP) IV bags for pharmaceutical applications. The fully automatic system operates intermittently, ensuring precise forming and sealing with minimal material waste. Its modular design allows for the integration of additional features such as tube ultrasonic sealing, peelable sealing for multi-chamber bags, and accessory insertion. With zero waste in both film and tube materials, the system maintains a high standard for environmental sustainability. Operating at a maximum air pressure of 8 bar, the machine runs at an operating noise level of 75 dB, ensuring a conducive production environment.

Bag forming system for pharmaceutical industry

Filling injectable solutions accurately is critical in pharmaceutical and healthcare industries. This process requires precise control to ensure sterility, quality, and safety of the product. Challenges include maintaining sterile conditions, managing various container types, and ensuring exact fill levels.
<h2>Fill, stopper, and seal containers efficiently</h2>
The NVF Series from GF (Coesia Group) is designed for the sterile and nonsterile filling of injectable solutions into both glass and plastic cylindrical containers. This filling system stands out for its ability to handle a variety of container types with high precision, ensuring that each container is accurately filled and securely stoppered. The NVF series supports aseptic processing, making it suitable for critical pharmaceutical applications. With its integration capabilities, it can be combined with depyrogenation tunnels, rotary washing machines, and optical inspection machines to form a complete, streamlined filling line. The machine maintains rigorous standards for sterility and product integrity, making it ideal for injectable solutions in the pharma and healthcare sectors.

Sterile and nonsterile filling for injectable solutions

In the pharmaceutical, cosmetic, and food industries, ensuring product quality throughout the entire filling process is essential. Problems such as underfilling, overfilling, faulty closures, and label errors can lead to significant disruptions and potential safety issues.
<h2>Ensure quality with precise fill level and closure checks</h2>
The HEUFT SPECTRUM II VX is an advanced full container inspection system designed for the rigorous demands of the pharmaceutical, cosmetic, and food industries. It inspects containers such as vials, flacons, ampoules, pots, and shampoo bottles for fill level accuracy of both powdery and liquid contents. The device also checks closures and labels, identifying faults with specialized sensor, camera, and ultrasonic technologies. Automated sampling ensures representative quality assurance. This modular system offers exceptional efficiency by distributing the production flow onto multiple lanes and accurately rejecting faulty containers. The integration of the HEUFT NaVi user guidance ensures ease of operation, and the HEUFT reflexx A.I. real-time image processing minimizes false rejection rates. HEUFT SYSTEMTECHNIK GmbH developed this system to support precise, reliable, and comprehensive full container inspection.

Full container inspection for pharma and food industries

In the pharmaceutical industry, ensuring the integrity and quality of each product container is critical. Failures in fill levels, closure tightness, and labeling can lead to costly recalls and compliance issues. An automated, precise, and comprehensive inspection system is needed to mitigate these risks.
<h2>Ensures quality with automated checks and rejections</h2>
The HEUFT PRIME is a compact full product inspection system designed specifically for the pharmaceutical, cosmetic, and care product industries. What sets the HEUFT PRIME apart are its integrated detection technologies that can inspect fill levels, closure presence and position, and label adherence. Infrared, high-frequency, and X-ray technologies enable precise fill level detection for both transparent and opaque containers. The closure detection module identifies missing, misaligned, or leaking closures with special sensor and optical technologies. Label checks are conducted using sensors that exploit the reflection characteristics of the container surface and label material. In addition, the HEUFT PRIME employs a serial fault detection mechanism to prevent recurring issues from affecting entire batches. Its high degree of automation, coupled with the audiovisual HEUFT NaVi user guidance system, makes it user-friendly. Furthermore, the system supports network-based documentation and remote maintenance for enhanced quality management.

Compact full product inspection system for pharmaceuticals

In pharmaceutical manufacturing, ensuring the integrity of injectable solutions is critical. Ampoules must be filled with precise quantities of liquid and sealed to prevent contamination and tampering.
<h2>Ampoule filling and sealing with high accuracy</h2>
The STERIFILL from IMA is an advanced ampoule filling and sealing system designed for pharmaceutical applications. It supports both opened (type B and C) and closed (type D) ampoules and can be equipped with up to 10 dosing pumps to meet medium to high production needs. Driven by brushless motors, STERIFILL ensures precise and gentle movements. The machine's compact design and unidirectional air flow facilitate easy cleanability and maintenance. Additionally, STERIFILL can integrate with LAF hood systems, RABS, or isolator enclosures for enhanced safety. The system also features a user-friendly HMI with Siemens touch screen and allows tool-free size changeovers to accommodate different ampoule or vial sizes. STERIFILL is available as a stand-alone unit or as part of a complete processing line.

Ampoule filling and sealing system

overhead-view-medical-equipments-blue-backdrop

overhead-view-healthcare-products-on-blue-surface

#Changemaker: Ampoule dispensing made (too) easy

Making.com is a new online platform that helps makers find production technology quicker by grouping it around the products they make.

Ampoules are an excellent solution for storing unstable elements in pharmaceutical products. But breaking the ampoule cleanly and keeping the contents from spilling is a drawback.

Or so we thought until we came across <a href="https://packsys.de/en/">PACKSYS</a>.

Tim Lebaudy showed us a smart ampoule dispenser that cuts open any breaking system with minimal effort. More importantly, the module doubles as an applicator for accurate and spill-free administration.

The range of applicators includes spray pumps, roll-ons, and dabbers, making this device the ultimate ampoule dispensing system.

And it’s not just us thinking that. This solution was declared the winner of the Packaging Innovation Awards at <a href="https://www.linkedin.com/company/pharmapack-europe-event/" data-attribute-index="3" data-entity-hovercard-id="urn:li:fs_miniCompany:10977210" data-entity-type="MINI_COMPANY">Pharmapack Europe</a>.

A pre-filled syringe or PFS is a single-dose disposable syringe that is supplied loaded with the substance to be injected. By using a pre-filled syringe filling machine, you can have excellent dosage accuracy due to the exact filling of medications. During administration, safety from potential contaminants is also ensured as they are directly injected after opening. To further minimize the risk of contamination, pre-filled syringes are often filled and sealed in a sterile environment using stainless steel equipment.

Pre-filled Syringes

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

Automatic visual inspection of vials, ampoules, and syringes is a well-known and established industrial practice.

However, when it comes to small scale, it’s a different matter.



The Dutch company <a href="https://www.luoautomation.com/" target="_blank" rel="noopener">LUO</a> has used all its knowledge and passion for technology to develop automated visual inspection machines for small-scale pharmaceutical companies.

The company aims to help and support healthcare professionals to relieve the labor-intensive and time-consuming task of manual visual inspection of liquids for pharmaceutical applications. Their tabletop inspection machine can inspect up to 1.000 containers per hour.

#Changemaker: Automated visual inspection for pharmaceutical applications. Small scale companies, are you in?

Pharmaceutical

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Find production technology for Ampoule filling, and connect directly with leading machine manufacturers worldwide

Ampoule filling

Ampoule filling - Making.com

https://making-tst.imgix.net/2020/02/AMPOULS.png

Home

The marketplace for finding innovative production technology

Making.com

https://making-tst.imgix.net/2022/12/makingCopy.png