Combisys filling and closing system for pharmaceutical containers

Ensure precise filling and closing of pharmaceutical liquids with a high-output system that integrates dosing, weighing, and inspection, enhancing your sterile production line’s efficiency and reliability.

Fills and Closes Liquid Pharmaceutical Containers

The FVC 50606 from Bausch+Ströbel is an automated CombiSys filling and closing machine, designed for high-precision aseptic processing in pharmaceutical and biotech settings. This system is distinguished by its modular design and capability to handle up to 12,000 containers per hour. It automates dosing, filling, and closing tasks with integrated dosing systems for maximum efficiency, minimizing waste with the Zero Reject Principle. The machine is equipped with 100% IPC at full output, meeting all relevant GMP and FDA compliance standards. Its robust design supports RABS and isolator environments to ensure sterile conditions. With easy-to-use operational controls and quick set-up times, it provides seamless integration into existing production lines. The CIP/SIP system ensures thorough cleaning between batches without manual disassembly, enhancing productivity and reducing downtime. Customizable options, including various dosing system configurations, offer tailored solutions to specific production requirements.

Benefits

  • Increases production capacity with automated multi-dosing systems.
  • Enhances process reliability in aseptic conditions with RABS compatibility.
  • Minimizes product waste with Zero Reject Principle.
  • Ensures compliance with GMP and FDA standards for pharmaceutical applications.
  • Reduces cleaning time and labor with integrated CIP/SIP system.

General


Applications
Liquid formulations,Blood plasma processing,Biopharmaceuticals,Aseptic solutions,Pharmaceuticals
End products
Blood plasma derivatives,Buffered saline solutions,Insulin vials,Vaccines,Monoclonal antibodies,Ophthalmic solutions,Liquid oral medications,Sterile injectable solutions
Steps before
Container preparation,Container sterilization,Upstream processing
Steps after
Crimp-Cap-Inspection,Re-stoppering,Re-capping,Downstream processing,Packing
Input ingredients
containers,syringes,product batch
Output ingredients
filled containers,filled syringes,rejected last container
Market info
Bausch Stroebel specializes in manufacturing high-quality pharmaceutical packaging and processing machinery, renowned for their precision, reliability, and innovation in filling and packaging lines for the pharmaceutical industry. They are respected for tailored solutions and advanced engineering.

Technical Specifications


Output Capacity
Up to 12,000 items/h
Container Diameter
7 - 30 mm
Container Height
35 - 100 mm
Syringes Volume
0.5 - 10 ml
Modular Design
Standardized components
Process Control
100% IPC
Automation
Automatic dosing and closing
Laminar Air Flow
Optimal
Loading System
Free-standing,calibrated load cells
Dosing System
Up to three dosing systems
Cleaning Method
CIP/SIP system
Airflow System
Suitable for RABS / isolator
Zero Reject Solutions
Re-stoppering,refilling,re-capping,crimp-cap inspection

Operating Characteristics


Working mechanism
CombiSys filling and closing
Integrated steps
Dosing and closing
CIP/SIP
CIP/SIP
Batch vs. continuous operation
Batch
Automation level
Automatic dosing and closing
Changeover time
Short set-up time
Cleaning method
CIP/SIP

Material Compatibility


Corrosive resistance (e.g. acids)
Yes
Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Container diameter
7 - 30 mm
Container height
35 - 100 mm
Syringe volume
0.5 - 10 ml

Physical Characteristics


Container diameter
7 - 30 mm
Container height
35 - 100 mm

Custom Options


Modular design
Standardized components
Dosing system
Up to 3 dosing systems
Integration with isolator
RABS / Isolator
Needle holder type
Freely positionable
Process control
100% IPC
Gripper system
Flexible container transport
Load cells
Free-standing,calibrated
Barrier system type
Passive/Active/Closed RABS
Setpoint correction
In situ
CIP/SIP capability
In place with no part removal