Combisys filling and closing system for pharmaceutical containers
Ensure precise filling and closing of pharmaceutical liquids with a high-output system that integrates dosing, weighing, and inspection, enhancing your sterile production line’s efficiency and reliability.
Fills and Closes Liquid Pharmaceutical Containers
The FVC 50606 from Bausch+Ströbel is an automated CombiSys filling and closing machine, designed for high-precision aseptic processing in pharmaceutical and biotech settings. This system is distinguished by its modular design and capability to handle up to 12,000 containers per hour. It automates dosing, filling, and closing tasks with integrated dosing systems for maximum efficiency, minimizing waste with the Zero Reject Principle. The machine is equipped with 100% IPC at full output, meeting all relevant GMP and FDA compliance standards. Its robust design supports RABS and isolator environments to ensure sterile conditions. With easy-to-use operational controls and quick set-up times, it provides seamless integration into existing production lines. The CIP/SIP system ensures thorough cleaning between batches without manual disassembly, enhancing productivity and reducing downtime. Customizable options, including various dosing system configurations, offer tailored solutions to specific production requirements.
Benefits
- Increases production capacity with automated multi-dosing systems.
- Enhances process reliability in aseptic conditions with RABS compatibility.
- Minimizes product waste with Zero Reject Principle.
- Ensures compliance with GMP and FDA standards for pharmaceutical applications.
- Reduces cleaning time and labor with integrated CIP/SIP system.
- Applications
- Liquid formulations,Blood plasma processing,Biopharmaceuticals,Aseptic solutions,Pharmaceuticals
- End products
- Blood plasma derivatives,Buffered saline solutions,Insulin vials,Vaccines,Monoclonal antibodies,Ophthalmic solutions,Liquid oral medications,Sterile injectable solutions
- Steps before
- Container preparation,Container sterilization,Upstream processing
- Steps after
- Crimp-Cap-Inspection,Re-stoppering,Re-capping,Downstream processing,Packing
- Input ingredients
- containers,syringes,product batch
- Output ingredients
- filled containers,filled syringes,rejected last container
- Market info
- Bausch Stroebel specializes in manufacturing high-quality pharmaceutical packaging and processing machinery, renowned for their precision, reliability, and innovation in filling and packaging lines for the pharmaceutical industry. They are respected for tailored solutions and advanced engineering.
- Output Capacity
- Up to 12,000 items/h
- Container Diameter
- 7 - 30 mm
- Container Height
- 35 - 100 mm
- Syringes Volume
- 0.5 - 10 ml
- Modular Design
- Standardized components
- Process Control
- 100% IPC
- Automation
- Automatic dosing and closing
- Laminar Air Flow
- Optimal
- Loading System
- Free-standing,calibrated load cells
- Dosing System
- Up to three dosing systems
- Cleaning Method
- CIP/SIP system
- Airflow System
- Suitable for RABS / isolator
- Zero Reject Solutions
- Re-stoppering,refilling,re-capping,crimp-cap inspection
- Working mechanism
- CombiSys filling and closing
- Integrated steps
- Dosing and closing
- CIP/SIP
- CIP/SIP
- Batch vs. continuous operation
- Batch
- Automation level
- Automatic dosing and closing
- Changeover time
- Short set-up time
- Cleaning method
- CIP/SIP
- Corrosive resistance (e.g. acids)
- Yes
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Container diameter
- 7 - 30 mm
- Container height
- 35 - 100 mm
- Syringe volume
- 0.5 - 10 ml
- Container diameter
- 7 - 30 mm
- Container height
- 35 - 100 mm
- Modular design
- Standardized components
- Dosing system
- Up to 3 dosing systems
- Integration with isolator
- RABS / Isolator
- Needle holder type
- Freely positionable
- Process control
- 100% IPC
- Gripper system
- Flexible container transport
- Load cells
- Free-standing,calibrated
- Barrier system type
- Passive/Active/Closed RABS
- Setpoint correction
- In situ
- CIP/SIP capability
- In place with no part removal