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After being used to contain the blood of martyrs after death or to store the anointing oil of French monarchs, today ampoules are the first choice in packaging injectables. You create ampoules by melting the glass tube into the desired shape and seal them at the neck by melting the top of the glass tube. The only way for you to extract the contents from an ampoule is by breaking the glass at its breaking point, making it perfect for single dose applications only.

Which ampoules equipment do you need?

Automatic washing machine for ampoules

Automatic washing machine designed for cleaning ampoules and achieving a maximum out...

Compact laboratory freeze dryer

Particularly suitable for research centers requiring greater freeze drying capacity. Some of...

Pilot freeze dryer for scale up

Designed for biological, pharmaceutical and food products formulation and "scale up" work.

Custom engineered freeze dryer

For either bulk format or liquid in vials, ampoules or syringes, the Lyomega units are design...

GMP freeze dryer

Designed to perform clinical trials, pilot, and small scale or large scale industrial drying processes, in ac...

Superheated water shower autoclave

Specially designed for sterilizing large batches of parenteral solutions.

Dry heat depyrogenation oven

Specially designed for the drying and sterilization of glass containers, vials or ampoules, and...

Compact horizontal laminar flow bench

HEPA filtered horizontal laminar airflow (cross-flow) creates an optimized free space...

Microbiological safety cabinet class II

This handy device offers the most advanced features in product-operator protection ...

Biosafety cabinet class II for cytotoxic medicines

For the manipulation of hazardous substances utilized during the prepa...

Positive pressure isolator

Ideal for products which have no biological risk but require high sterile conditions.

Biological safety cabinet class III

Specially designed for the handling of microbiological agents, when working with indige...

Ampoule filling machine

Filling ampoules or vials with parenteral fluids are an essential matter for which you need to consid...

Pharmaceutical bottles inspection machine

For the visual inspection of small to medium batch-sizes of vials, ampoules or b...

Labeling machines for pharmaceutical bottles

Labels for ampoules, vials and bottles are typically applied at the end of th...

Sterile filling line for injectables

Sterile filling of liquids and powders for the pharmaceutical and cosmetic industries ...

Start-up sterile filling line for injectables

For smaller-scale production of vials and syringes for the injectables marke...

Table top sterile filling line for injectables

Where a compact solution is required for filling vials for the injectables ...

Flexible automatic inspection machine for syringes

Manufacture of pre-filled syringes requires the highest quality inspec...

Flexible automatic inspection machine for ampoules, vials, cartridges

If you are looking to improve the efficiency of y...

Small automatic inspector for ampoules, vials, or cartridges

Inspect small batch production of ampoules, vials, or cartr...

Semi-automatic inspection machine for ampoules, vials or cartridges

If you need to increase the efficiency of your manu...

Visual and HVLD inspection for ampoules, vials and cartridges

Do you need to improve the efficiency and capability of yo...

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic produc...

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are p...

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons fo...

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pha...

Automatic cartoner for applications in pharma and cosmetics

For high capacity production...

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take ca...

Packaging machine for syringes in trays

Pre-dosed syringes are rapidly becoming the method ...

Continuous pack cartoner

High volume automatic cartoning is vital for large scale production ...

GMP chamber washer

The thorough cleaning of small product contact parts has always been chall...

Rotary vial washing machine

When washing vial, ampoules, or cartridges for pharmaceutical pr...

Vial sterilization tunnel

Sterilization of vials, ampoules and syringes before filling is a ...

External vial washing machine

Exterior washing solutions for vials often suffer from high wa...

Cleaning and sterilization systems

An increasingly vital part of high quality pharmaceutica...

Horizontal cartoner for pharmaceutical applications

Automatic cartoning for cosmetic or p...

Benchtop ampoule opening and closing equipment

The procedure for opening or closing ampoules requires the handling of gas ...

Benchtop peristaltic dispenser

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of ...

Laboratory liquid viewer for transparent glass bottles

In the pharmaceutical industry, an inspection of liquids in vials ...

Laboratory liquid viewer

Impurities like hair, fibers or glass, sourced from the environment, equipment or packaging can cont...

Manual ampoule filler

When filling ampoules is essential to avoid wetting the inside walls of the container, as it may affect...

Pharmaceutical data management software

A typical pharmaceutical production handles numerous work flow activities like mana...
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Types of ampoules: shapes that fit the standards

Based on the shape of their head from ISO standards, you can count three types of ampoules: straight-stem (form B), funnel type (form C), and sealed (form D). ISO 9187-1:2010 specifies materials, dimensions, capacities, performance and packaging requirements for three forms of glass ampoule for injectable pharmaceutical products.

Straight-stem ampoules and funnel-types have open ends for the customers to wash and sterilize before filling and sealing. Sealed ampoules instead have dome-shaped closed ends, which means that ampoules are supplied already sterilized. This is done prior to the ampoule going through their respective filling and sealing machines.  Customers have to open them with a sharp flame before filling them and then reseal them.

Ampoules also have different break systems. One point cut (OPC) refers to a small cut on the constriction of the ampoule and is paired with a colored dot mark for the position of the breaking cut. Color break ring (CBR) refers to an enamel ring applied around the constriction as a marker for the breaking cut. Scoring (SCO) refers to surface markings of the glass around the constriction part.

Plastic ampoules as a new possibility

Plastic ampoules are getting more popular in pharmaceutical companies. They are less costly to manufacture, easier to transport and store as they have better breaking resistance. Actually, they do not require tearing or cutting the top portion, because you can simply snap off the neck to open. Their manufacturing process offers more accurate dosages and prevents overfill of products, making it more efficient compared to glass.

Check the quality through ampoule inspection machine

Quality control for pharmaceutical products is a critical process. It requires multiple visual inspections to ensure that the products are not contaminated, and the packaging is intact and clean. You can opt for a fully automatic or semi-automatic inspection machine equipped with image sensors and magnifying cameras to check the correct fill level, detect contaminating particles, glass defects and container leakage.

Other options available for inspection machines include detecting product color using illumination and sensors, and container closure integrity using multiple cameras that check the position of the cap.

Color coding for identification

Have you ever noticed that ampoules have colored rings around their neck?
The colored rings are used as a code to identify the substance inside the ampoule. This makes it easier to sort them for the purposes of storage, labeling, and packaging. These rings are machine-readable for easier identification and printed by rotating discs using heavy-metal-free inks for safety reasons.

Difference between ampoules and vials

Ampoules are meant for single-use or single-dose applications since they are sealed at the neck with heat and you have to crack them open to extract the contents. With vials it is another story. You only need to remove the caps or pierce the rubber stopper with a syringe. As for the content inside, ampoules store unstable chemical compounds and highly volatile elements while vials are for storing stable compounds.

Specialised machinery for ampoule production

When it comes to the full production of making ampoules, specialised machines and manufacturing processes need to be followed. For example, all ampoule production lines and machinery should be made from high quality stainless steel. This is because the contents simply cannot be contaminated. The production process also includes the use of an ampoule filler, for liquid filling as well as Labeling machines and heating stations for sealing the glass.

Processing steps involved in ampoules making

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