Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.

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Select your liquid-dosage-forms process

dispersing liquid-dosage-forms

emulsifying liquid-dosage-forms

filling liquid-dosage-forms

mixing liquid-dosage-forms

cleaning liquid-dosage-forms

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Vaccines

Insulin

Softgel capsules

Parenterals

Vials

Ampoules

Pharmaceutical cartridges

Water for injection

Pharmaceutical syrup

Eyedrops

Nasal spray

Eardrops

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Use water or pure alcohol as a solution in the liquid dosage manufacturing process

The liquid dosage form is prepared by dissolving the active ingredient within a liquid vehicle to form a solution. Depending on the type of liquid vehicle used, you obtain either aqueous or non-aqueous solutions.

The aqueous solutions have water as the solvent, while the non-aqueous solutions have hydro-alcoholic (water and alcohol as solvents) and alcohol (only alcohol as solvent). Elixirs and tinctures are examples of hydro-alcoholic solutions. The concentration of alcohol in elixirs is 3%-25%, while the concentration of alcohol in tinctures is 25%-60%.

Apply size reduction to raw materials to facilitate solubility

Drops, syrups, elixirs, and draughts are monophasic liquid dosage forms, retaining the components in a single liquid phase. The APIs in most dosage forms of this type are weak acids or weak bases with low solubility properties. The formulation, therefore, requires adjustment of pH levels.

One method to improve solubility is by reducing the particle size of pharmaceutical powders. Using a mill or a spray drying system, grind the materials to 10 microns or less.

Apply gravimetric measurement in the liquid dosage manufacturing process

The volumetric measurement risks a high variability in liquids as the ingredients may be subjected to volume contraction or expansion.

The gravimetric method bypasses the effects of temperature and ambient forces acting on the ingredients. By measuring the density of the total contents, the technique gives a more reliable reading of the liquid dosage before filling and packing.

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Which liquid dosage forms equipment do you need?

Inline batch mixer for solids and liquids

Dilution system for two or more liquids in one pass

Laboratory liquid viewer for colored glass bottles

Laboratory liquid viewer for transparent glass bottles

Laboratory liquid viewer

Sachet Machine

Stickpack Machine

Disposable tank liners

Economic dispersing machine for emulsions and suspensions

Dispersing machine for very fine emulsions and suspensions

Corundum disk mill

Continuous homogenizing system

High accuracy homogenizing system

Continuous kneader

Batch dispersing machine for bottom entry into vessels

GMP homogenizing system

Dust-free continuous homogenizing system

Small-scale laboratory dispersing machine

Pilot dispersing machine for testing and scale-up

In-line laboratory dispersing machine

Agitator for medium viscosity media

High-pressure homogenizer

Sterile filling line for ophthalmics

Start-up sterile filling line for ophthalmics

Benchtop peristaltic dispenser

Benchtop piston filling equipment for vials in trays

Manual ampoule filler

Manual stoppering equipment for pre-filled syringes

Versatile checkweigher

Small bottle checkweigher

Dispersing machine for emulsions and suspensions

Ultra-fine dispersing machine for emulsions and suspensions

Colloid mill

Cone mill machine

Horizontal kneader

Vertical kneader

Batch dispersing machine

Batch dispersing machine for abrasive products

Cost-effective homogenizing and emulsifying system

Laboratory dispersing machine for low-viscous masses

Jet flow agitator for high-viscosity media

Agitator for low viscosity media

Feeder with flexible wall hopper

Small feeder with flexible wall hopper

Portable IBC washer

IBC bin washer and dryer

CIP system for bulk tanks

GMP chamber washer

GMP washer

Loading basket for GMP washer

Entry-level chamber washer

Bulk chamber washer

Syrup preparation tank

Labeling machine for ampoules

Benchtop ampoule opening and closing equipment

Semi-automatic vial crimper

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