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Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.

Which liquid dosage forms equipment do you need?

Inline batch mixer for solids and liquids

Several issues often arise when your process requires batch-wise mixing of powde...

Dilution system for two or more liquids in one pass

Onsite dilution of liquid process ingredients has historically been a...

Laboratory liquid viewer for colored glass bottles

In the pharmaceutical industry, an inspection to detect any particulat...

Laboratory liquid viewer for transparent glass bottles

In the pharmaceutical industry, an inspection of liquids in vials ...

Laboratory liquid viewer

Impurities like hair, fibers or glass, sourced from the environment, equipment or packaging can cont...

Sachet Machine

If you want to pack into eye-catching 4-side sealed sachets between 40x50 mm and 250x200 mm in size, investing ...

Stickpack Machine

If you are looking to pack your product into stick packs from 17 x 40 mm to 100 x 200 mm in size, you may b...

Disposable tank liners

Manufacturers in the bioprocessing industries are increasingly turning to single use solutions for the...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Dispersing machine for very fine emulsions and suspensions

For continuous high performance mixing of solid and liquid ra...

Corundum disk mill

Wet milling and grinding of viscous liquids or pastes containing solid particles such as peanut butter,mus...

Continuous homogenizing system

Certain mixing tasks present unique challenges and manufacturers need equipment that is speci...

High accuracy homogenizing system

When extremely high accuracy is required in your recipe or formulation traditional mixing...

Continuous kneader

Effective mixing of highly viscous products with extremely high solids content can be difficult and the re...

Batch dispersing machine for bottom entry into vessels

When your process requires high performance mixing or dispersion b...

GMP homogenizing system

Manufacturers need production mixing equipment that is capable, flexible, and easy to maintain. Accur...

Dust-free continuous homogenizing system

Producers in a wide variety of industries benefit from equipment that can continuo...

Small-scale laboratory dispersing machine

Developing and validating new processes requires reliable and highly versatile e...

Pilot dispersing machine for testing and scale-up

Innovators in process development need laboratory equipment that helps ...

In-line laboratory dispersing machine

Innovators in a wide variety of industries need laboratory equipment on which process...

Agitator for medium viscosity media

Mixing fluids of medium viscosity for many production processes requires an agitator wi...

High-pressure homogenizer

When processes call for homogenized emulsions with extremely fine particle sizes the traditional t...

Sterile filling line for ophthalmics

Demanding very high standards, the ophthalmic market requires quality solutions for fi...

Start-up sterile filling line for ophthalmics

Commencing ophthalmic production requires sterile conditions and accurate me...

Benchtop peristaltic dispenser

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of ...

Benchtop piston filling equipment for vials in trays

Vials are difficult to fill individually through manual methods due ...

Manual ampoule filler

When filling ampoules is essential to avoid wetting the inside walls of the container, as it may affect...

Manual stoppering equipment for pre-filled syringes

Air present in the empty space of pre-filled syringes may prevent the...

Versatile checkweigher

This Versatile checkweigher is equipped with a highly versatile strain gauge load cell. It is also sui...

Small bottle checkweigher

Any small-diameter bottle, containing prescription medication or cosmetic applications, can be pro...

Dispersing machine for emulsions and suspensions

Equipment operating under the rotor/stator principal is often employed wh...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Colloid mill

For creating extremely fine emulsions and high quality dispersions a high pressure homogenizer is often chosen.  ...

Cone mill machine

When your raw materials include agglomorated suspensions of grainy or crystalline solids and your process n...

Horizontal kneader

For high viscosity products, better results and reduced process times can be achieved with kneading type r...

Vertical kneader

Production of highly viscous products with high solid content often benefits from kneading processes rather t...

Batch dispersing machine

Equipment operating under the rotor/stator principal is often employed when more traditional methods...

Batch dispersing machine for abrasive products

For mixing and dispersing tasks that cannot be completed by conventional st...

Cost-effective homogenizing and emulsifying system

Manufacturers need production mixing equipment that is capable, flexib...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Jet flow agitator for high-viscosity media

Processes including homogenization, dispersing, suspension, emulsification and ...

Agitator for low viscosity media

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale p...

Feeder with flexible wall hopper

The varying properties of dry powder products mean that specialized feeders are required fo...

Small feeder with flexible wall hopper

In many laboratory applications and production processes, smaller quantities of powd...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but tradit...

GMP chamber washer

The thorough cleaning of small product contact parts has always been chall...

GMP washer

In order to guarantee zero cross-contamination between production batches, the prop...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be place...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing ...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceutical...

Syrup preparation tank

Syrups and suspensions are typically produced under the same high-qual...

Labeling machine for ampoules

It’s essential for pharmaceutical companies to provide the highest quality ampoules to custom...

Benchtop ampoule opening and closing equipment

The procedure for opening or closing ampoules requires the handling of gas ...

Semi-automatic vial crimper

In a small production line, crimping vials manually can cause fatigue to the operator due to mul...
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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Use water or pure alcohol as a solution in the liquid dosage manufacturing process

The liquid dosage form is prepared by dissolving the active ingredient within a liquid vehicle to form a solution. Depending on the type of liquid vehicle used, you obtain either aqueous or non-aqueous solutions.

The aqueous solutions have water as the solvent, while the non-aqueous solutions have hydro-alcoholic (water and alcohol as solvents) and alcohol (only alcohol as solvent). Elixirs and tinctures are examples of hydro-alcoholic solutions. The concentration of alcohol in elixirs is 3%-25%, while the concentration of alcohol in tinctures is 25%-60%.

Apply size reduction to raw materials to facilitate solubility

Drops, syrups, elixirs, and draughts are monophasic liquid dosage forms, retaining the components in a single liquid phase. The APIs in most dosage forms of this type are weak acids or weak bases with low solubility properties. The formulation, therefore, requires adjustment of pH levels.

One method to improve solubility is by reducing the particle size of pharmaceutical powders. Using a mill or a spray drying system, grind the materials to 10 microns or less.

Apply gravimetric measurement in the liquid dosage manufacturing process

The volumetric measurement risks a high variability in liquids as the ingredients may be subjected to volume contraction or expansion.

The gravimetric method bypasses the effects of temperature and ambient forces acting on the ingredients. By measuring the density of the total contents, the technique gives a more reliable reading of the liquid dosage before filling and packing.

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