Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.
Which liquid dosage forms equipment do you need?
Inline batch mixer for solids and liquids
Dilution system for two or more liquids in one pass
Laboratory liquid viewer for colored glass bottles
Laboratory liquid viewer for transparent glass bottles
Laboratory liquid viewer
Disposable tank liners
Economic dispersing machine for emulsions and suspensions
Dispersing machine for very fine emulsions and suspensions
Corundum disk mill
Continuous homogenizing system
High accuracy homogenizing system
Batch dispersing machine for bottom entry into vessels
GMP homogenizing system
Dust-free continuous homogenizing system
Small-scale laboratory dispersing machine
Pilot dispersing machine for testing and scale-up
In-line laboratory dispersing machine
Agitator for medium viscosity media
Sterile filling line for ophthalmics
Start-up sterile filling line for ophthalmics
Benchtop peristaltic dispenser
Benchtop piston filling equipment for vials in trays
Manual ampoule filler
Manual stoppering equipment for pre-filled syringes
Small bottle checkweigher
Dispersing machine for emulsions and suspensions
Ultra-fine dispersing machine for emulsions and suspensions
Cone mill machine
Batch dispersing machine
Batch dispersing machine for abrasive products
Cost-effective homogenizing and emulsifying system
Laboratory dispersing machine for low-viscous masses
Jet flow agitator for high-viscosity media
Agitator for low viscosity media
Feeder with flexible wall hopper
Small feeder with flexible wall hopper
Portable IBC washer
IBC bin washer and dryer
CIP system for bulk tanks
GMP chamber washer
Loading basket for GMP washer
Entry-level chamber washer
Bulk chamber washer
Syrup preparation tank
Labeling machine for ampoules
Benchtop ampoule opening and closing equipment
Semi-automatic vial crimper
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Use water or pure alcohol as a solution in the liquid dosage manufacturing process
The liquid dosage form is prepared by dissolving the active ingredient within a liquid vehicle to form a solution. Depending on the type of liquid vehicle used, you obtain either aqueous or non-aqueous solutions.
The aqueous solutions have water as the solvent, while the non-aqueous solutions have hydro-alcoholic (water and alcohol as solvents) and alcohol (only alcohol as solvent). Elixirs and tinctures are examples of hydro-alcoholic solutions. The concentration of alcohol in elixirs is 3%-25%, while the concentration of alcohol in tinctures is 25%-60%.
Apply size reduction to raw materials to facilitate solubility
Drops, syrups, elixirs, and draughts are monophasic liquid dosage forms, retaining the components in a single liquid phase. The APIs in most dosage forms of this type are weak acids or weak bases with low solubility properties. The formulation, therefore, requires adjustment of pH levels.
One method to improve solubility is by reducing the particle size of pharmaceutical powders. Using a mill or a spray drying system, grind the materials to 10 microns or less.
Apply gravimetric measurement in the liquid dosage manufacturing process
The volumetric measurement risks a high variability in liquids as the ingredients may be subjected to volume contraction or expansion.
The gravimetric method bypasses the effects of temperature and ambient forces acting on the ingredients. By measuring the density of the total contents, the technique gives a more reliable reading of the liquid dosage before filling and packing.