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Liquid dosage forms filling

After being used to contain the blood of martyrs after death or to store the anointing oil of French monarchs, today ampoules are the first choice in packaging injectables. You create ampoules by melting the glass tube into the desired shape and seal them at the neck by melting the top of the glass tube. The only way for you to extract the contents from an ampoule is by breaking the glass at its breaking point, making it perfect for single dose applications only.

Ampoules

Your earliest memory of medicine is probably a jar of cough syrup with a plastic dosing spoon attached. Although widely produced as remedies for children, medicated syrups are also available for adults. Making cough syrup starts by dissolving active ingredients into a purified water and sugar solution. But it is the distinct flavorings and colorants that persist in people’s minds long after the illness is cured.

Cough syrup

The body produces earwax to protect the ear canal from microbial growth. But no one wants too much protection of this kind. Thankfully, simple solutions are available over the counter to medicate excess cerumen. Besides wax removal, eardrops and OTIC manufacturing provides an effective delivery technique to treat infections or administer anesthetic.

Eardrops

Eyedrops processing is quite literally a sight for sore eyes. There is no shortage of eye care products, from eyewashes to anesthetics to antibiotics. But formulating eyedrops is a complex affair with multiple safety checkpoints. Technological advances bring a pair of fresh eyes to manufacturing, ensuring higher-quality products for specialized applications.

Eyedrops

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Smelling is said to be the most underrated sense. But a congested nose quickly reminds us why it is important. Besides the loss of the olfactory function, nasal blockage leads to a dangerous buildup of pathogens in the airways. Nasal spray formulation is the science of mixing drugs and excipients to free your nasal passage. A few spritzes of the right recipe will bring back the scents of life.

Nasal spray

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

If you've ever heard the acronym WFI spoken, know that we're not talking about wireless technology to connect your computer. WFI stands for water for injection, a sterile water used as a solvent to dilute other solutions for injections to the body. Traditionally, WFI was only produced through the distillation process using water for injection equipment until other methods such as reverse osmosis, electrodeionization, and ultrafiltration were developed.

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Water for injection

Small foot print due to compact size(790 x 625 x 390mm

Can be programmed to operate automatically

Hygienic system where the product only comes in contact with the silicone tube

Filling capacity: 12 –15(100mL containers) per minute

Can be combined with Adelphi’s Accuramatic Peristaltic Dispensing Unit

Aseptic filling equipment is crucial for sensitive products, as they need to be filled into their primary packaging in an environment free from contamination caused by harmful bacteria, viruses, or other microorganisms. Choosing an aseptic filling solution requires consideration of the physical form of the product, the type of primary packaging, the volume to be dosed per package, and the production speed. Aseptic fillers are widely used for cleaning, filling, and sealing pre-sterilized vials, cartridges, ampoules, and syringes in the pharmaceutical industry. Aseptic filling is also used in the food industry to process for example, dairy products that need harmful bacteria's minimized, or ensure shelf-stable products that do not require refrigeration. In these industries, aseptic equipment is integrated into the production line for maximum isolation and sterilization. And, can either be configured as an automated or manual process, depending on standards that the products require.

Aseptic filling equipment

Pharmaceutical

Filling lines

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Connect directly with world leading manufacturers of filling lines equipment and find technology to build or improve your production line.

Filling &ndash; Making.com

Filling Lines Equipment - Making.com

Cannabinoids are natural compounds obtained from the Cannabis sativa plant. Delta-9-tetrahydrocannabinol or THC is a psychotropic substance. Cannabidiol, or CBD, is non-psychotropic and often used for nutraceutical purposes. Cannabinoid equipment extracts THC and CBD from the plant and prepares the substance for formulations that treat pain, nausea, anxiety, and inflammations. Cannabinoids are processed in various forms, including creams, capsules, and oils.

Cannabinoids

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Vials are difficult to fill individually through manual methods due to handling concerns such as accuracy in filling and possible spillage ofthe liquid

Benchtop piston filling equipment for vials in trays &ndash; Making.com

We open production technology to everyone

Making.com

Base model for filling ophthalmic liquids

Easy sterilization using H2O2

No product spillage or part-filled bottles

Integrated weighing and quality control

Built to cGMP and FDA standards

Sterile Filling Solutions

Liquid

Packaging

Process

R&amp;D

Batch

Continuous

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

Almost all manufacturers will require industrial storage systems and solutions at some point during their production process. The raw materials that go into your products need dedicated storage solutions to protect them from spoilage and contamination before they enter the manufacturing cycle. Storage usually refers to particular storage space. For example, having enough warehouse storage. Or clearing out a production facility for more floor space.  However, in this case, we are referring to the equipment and solutions that make storage manageable and easier. Such equipment includes solutions such as storage racks, pallet racks and shelving systems. These are just some of many storage options available to manufacturers. Advanced technology facilitates the management of heavy duty and high density tank and silo systems by automating the delivery system and linking it with the rest of the production line.

Storage

liquid

Commencing ophthalmic production requires sterile conditions and accurate metering when filling and sealing eye-drop containers. Fill and cap eye-drop

Start-up sterile filling line for ophthalmics &ndash; Making.com

printable-sheet-specifications-xi-o-pdf

printable-sheet-specifications-XI-O.pdf

No spillage of product

Can handle aptar filtered capping

Satisfies pharmaceutical cGMP and FDA requirements

When looking for capping equipment, it is crucial to know first which type of capper your product requires. Do you want screw caps, twist-off caps, hand pumps, or push-pull caps on your bottle or container? If you require different cap types for format changeover times can be time-consuming. The bottle cap seals the top opening of a bottle to guard the product against leakage and spoilage and sterility and filling requirements depend on the nature of your product.

Capping

Dositecno XI-O is specially designed for laboratory installations and optimizes ophthalmic production with completely sterile, accurate filling and capping.

Demanding very high standards, the ophthalmic market requires quality solutions for filling a large range of bottle sizes, having different capping

Sterile filling line for ophthalmics &ndash; Making.com

Wide range of fill volumes (1-1000mL)

Accurate filling volume (+/-0.5%)

Hygienic system 

3 filling modes to choose from (braked stop, soft stop, stop with suck back)

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

When filling vials and ampoules, high standards of hygiene are required to avoid the risk of cross-contamination. Using a suitable hygienic pump, where

Benchtop peristaltic dispenser &ndash; Making.com

Small footprint due to compact size (210 x 105 x 345mm)

Precise filling due to centered needle position

Filling accuracy up to +/-0.5% reduces product waste

Used in conjunction with Adelphi Accuramatic Peristaltic Dispensing Unit

When filling ampoules is essential to avoid wetting the inside walls of the container, as it may affect the quality of the seal. Having a stable ampoule

Manual ampoule filler &ndash; Making.com

<h3>Use water or pure alcohol as a solution in the liquid dosage manufacturing process</h3>
The liquid dosage form is prepared by dissolving the active ingredient within a liquid vehicle to form a solution. Depending on the type of liquid vehicle used, you obtain <a href="https://ptcbtestprep.com/what-are-liquid-dosage-forms/" target="_blank" rel="noopener">either aqueous or non-aqueous</a> solutions.

The aqueous solutions have water as the solvent, while the non-aqueous solutions have hydro-alcoholic (water and alcohol as solvents) and alcohol (only alcohol as solvent). Elixirs and tinctures are examples of hydro-alcoholic solutions. The concentration of alcohol in elixirs is 3%-25%, while the concentration of alcohol in tinctures is 25%-60%.

Drops, syrups, elixirs, and draughts are monophasic liquid dosage forms, retaining the components in a single liquid phase. The APIs in most dosage forms of this type are <a href="https://www.gputtawar.edu.in/downloads/Monophasic%20Liquid%20Dosage%20Forms.pdf" target="_blank" rel="noopener">weak acids or weak bases</a> with low solubility properties. The formulation, therefore, requires adjustment of pH levels.

One method to improve solubility is by reducing the particle size of pharmaceutical powders. Using a mill or a spray drying system, <a href="https://www.gputtawar.edu.in/downloads/Monophasic%20Liquid%20Dosage%20Forms.pdf" target="_blank" rel="noopener">grind the materials to 10 microns</a> or less.

Apply size reduction to raw materials to facilitate solubility

The volumetric measurement risks a high variability in liquids as the ingredients may be subjected to volume contraction or expansion.

The gravimetric method bypasses the effects of temperature and ambient forces acting on the ingredients. By measuring the density of the total contents, the technique gives a more reliable reading of the liquid dosage before filling and packing.

Apply gravimetric measurement in the liquid dosage manufacturing process

Making Liquid Dosage Forms

Find production technology for making liquid dosage forms and connect directly with leading machine and equipment manufacturers worldwide.

Liquid dosage forms &ndash; Making.com

Liquid dosage forms production technology &ndash; Making.com

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The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

What's new in pharmaceutical packaging? During Pharmapack, we met Chantal Younes, Key Account Manager at Aptar CSP Technology, who introduced us to the

#Changemaker: Ready to protect your pharmaceutical products from moisture? &ndash; Making.com

#Changemaker: Ready to protect your pharmaceutical products from moisture?

Deborah

Sneeze, sniffle, blow your nose, repeat! During these winter months, this is the routine of millions of people a day. Nasal sprays can help us find relief

#Changemaker: the first, highly recyclable metal-free nasal spray pump &ndash; Making.com

#Changemaker: the first, highly recyclable metal-free nasal spray pump

Find production technology for Liquid dosage forms filling, and connect directly with leading machine manufacturers worldwide.

Liquid dosage forms filling

Which liquid dosage forms filling equipment do you need?

Benchtop piston filling equipment for vials in trays

Start-up sterile filling line for ophthalmics

Sterile filling line for ophthalmics

Benchtop peristaltic dispenser

Manual ampoule filler

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