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Liquid Dosage Forms Mixing Equipment

After being used to contain the blood of martyrs after death or to store the anointing oil of French monarchs, today ampoules are the first choice in packaging injectables. You create ampoules by melting the glass tube into the desired shape and seal them at the neck by melting the top of the glass tube. The only way for you to extract the contents from an ampoule is by breaking the glass at its breaking point, making it perfect for single dose applications only.

Ampoules

Your earliest memory of medicine is probably a jar of cough syrup with a plastic dosing spoon attached. Although widely produced as remedies for children, medicated syrups are also available for adults. Making cough syrup starts by dissolving active ingredients into a purified water and sugar solution. But it is the distinct flavorings and colorants that persist in people’s minds long after the illness is cured.

Cough syrup

The body produces earwax to protect the ear canal from microbial growth. But no one wants too much protection of this kind. Thankfully, simple solutions are available over the counter to medicate excess cerumen. Besides wax removal, eardrops and OTIC manufacturing provides an effective delivery technique to treat infections or administer anesthetic.

Eardrops

Eyedrops processing is quite literally a sight for sore eyes. There is no shortage of eye care products, from eyewashes to anesthetics to antibiotics. But formulating eyedrops is a complex affair with multiple safety checkpoints. Technological advances bring a pair of fresh eyes to manufacturing, ensuring higher-quality products for specialized applications.

Eyedrops

Insulin is a hormone that controls blood glucose levels produced by the beta cells in the pancreas. As a medication, insulin was discovered by Frederick Banting and Charles Best in 1921, for which Banting was awarded a Nobel Prize in 1923. The insulin production process involves manipulating the biological precursor to insulin and cultivating it inside bacteria using specialized technology.

Insulin

Smelling is said to be the most underrated sense. But a congested nose quickly reminds us why it is important. Besides the loss of the olfactory function, nasal blockage leads to a dangerous buildup of pathogens in the airways. Nasal spray formulation is the science of mixing drugs and excipients to free your nasal passage. A few spritzes of the right recipe will bring back the scents of life.

Nasal spray

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

During crime scene investigations in any movie, you've probably seen forensic scientists collecting evidence and biological samples in small containers. Here, these are the vials, used to store medicines, especially in liquid form, or laboratory samples. Often made of glass or plastic, vials can be labeled as single-dose vials or sterilized and reused more than once. They are also available with various closure systems depending on the material and storage requirements.

Vials

If you've ever heard the acronym WFI spoken, know that we're not talking about wireless technology to connect your computer. WFI stands for water for injection, a sterile water used as a solvent to dilute other solutions for injections to the body. Traditionally, WFI was only produced through the distillation process using water for injection equipment until other methods such as reverse osmosis, electrodeionization, and ultrafiltration were developed.

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Water for injection

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IKA-pilot-technology-brochure.pdf

Every minute, your skin loses between 30,000 and 40,000 dead skin cells. This means losing millions of cells every day, which makes your skin look less glowing. Being a moisturizing agent, body lotion has the power to hydrate your skin and  give the glow back to it. Production involves water and oil phases, which you then mix with an emulsifier and blend until homogeneous. Preservatives are essential for any solution containing water for the prevention of microbial growth.

Body lotion

You can make emulsions by combining two immiscible liquids (oil and water, for example) in a suspension through the use of force. The use of emulsifiers is necessary to keep this mixture stable and permanent.

Emulsions

Did you know that in the 30s, cosmetic creams that contained radioactive material were booming on the market because they promised to reduce wrinkles? Thank God that's no longer the case. To make a cosmetic cream today, you need to create a stable mixture of oil and water and add an emulsifier to join these otherwise immiscible substances.

Cosmetic creams

The most significant decision when making ointments is likely to be the choice between automatic or semi-automatic processes for it. This impacts on individual phases of the ointment cream manufacturing process - the water phase and oil phase.

Ointment

The easiest and most commonly used method of making gels is mixing gelling agents with water to form a weakly cohesive internal structure. The gel production process is pretty linear and straightforward, from mixing hydrocolloids and water to labeling and sealing containers.

Gels

Sunscreen is an emulsion which can be either oil-in-water or water-in-oil. To create it, you must prepare an oil phase and a water phase separately, then mix and heat them. Homogenization is a key process to guarantee that the product will have the right consistency. When manufacturing sunscreen, give special attention to protection against UV filters.

Sunscreen

Cosmetic serums are a very light formulation with a high density of active ingredients dispersed in oil, water, or gel. This makes serums well suited to the delivery of vitamins, antioxidants, and anti-aging ingredients, but provide less moisturization and protection. Serum production is mainly divided into stages related to optimal mixing and preventing degradation of the active ingredients.

Serums

Hyaluronic acid is a natural lubricant found in all mammals. An effective humectant, its molecules can hold a thousand times their weight in water. However, hyaluronic acid extraction is a complex biotechnological process that requires a specialized manufacturing technique.

Hyaluronic acid

In 2009, billionaire Stanley Ho made the winning bid for a giant white truffle weighing 3.3 pounds during an auction. Price: $330,000. Looking at the price, there's no need to explain why truffles are called the diamonds of the kitchen. After harvesting, they are selected to be sold fresh or processed to make truffle products such as truffle cream. Truffle processing involves cleaning, cutting, grinding, cooking, packaging, and sterilizing.

Truffle cream

It's been estimated that we spend an average of 3,000 hours brushing our teeth. In fact, in our daily routine, toothpaste is something we use at least twice a day. Making toothpaste is a very straightforward process; just mix together water, abrasives, humectants, thickening and foaming agents, sweeteners, and flavors in the right amounts until you get a paste. Once you have added the colors, you can fill a tube with your colorful toothpaste and seal it before being shipped to stores.

Toothpaste

After shaving, anti-aging, with organic ingredients, for the feet... Lotions are many. They compose the skincare world, which has been growing in recent years. More consumers look for the benefits of products that promise to enhance well-being and self-care. Whether you want to help prevent wrinkles, provide vitamins or just hydrate your consumers’ skin, get your formula and select lotion making equipment to get started.

Lotion

Shampoo is a unique form of cleaning agent composed primarily of water and some form of surfactant. This surfactant provides the ability to bind oily substances for removal without leaving a residue, as traditional soaps might. The production process involves the batch mixing of its laboratory-defined formula, quality control, and filling stages.

Shampoo

A cosmetic foundation comes in a powder, cream, or liquid form. And did you know that the liquid form came about because women in the 30s and 40s didn't want to wear stockings? So to cover up their legs, they turned to leg makeup, which played an essential role in our liquid foundation formula. The foundation making process involves balancing the oil and water phase interactions during the formulation stage, mixing ingredients, and packaging using a liquid foundation filling machine.

Cosmetic foundation

Star-shaped, lavender-scented, yellow, green, in a dispenser, today’s hand soap comes in a variety of shapes, fragrances, and colors. But whatever type of soap you choose for your good hand-washing habits, the basis of all soap making is mixing animal fats or vegetable oils with an alkali - in this case, a strong base - in a kettle to produce a chemical reaction called saponification.

Hand soap

People have always loved butter. Suffice it to say that Ancient Norsemen were buried with it to take to the afterlife. It seems impossible but making butter is all about separation. First, you separate the raw milk to get the buttercream using a cream separator. After cooling, mixing and pasteurizing your buttercream, the churning process separates it into buttermilk and butter grains. Then, mix butter grains with salt and use a butter churner to mix the ingredients again, before shaping begins using butter molds. Which butter-making equipment can improve your process?

Butter

Cocoa butter is the fat product of cocoa liquor. It is an integral part of the chocolate-making process. To make cocoa butter, roast and process cocoa beans with the help of a cocoa butter production machine. After that, it undergoes continuous crushing – forming a rich liquid, known as cocoa liquor. You can finally press the liquid to extract cocoa butter.

Cocoa butter

To put into perspective, the average number of peanuts that you use to make a 12-ounce jar of peanut butter is 540 pieces. Peanut butter is widely used as a spread for most bread and biscuits. To make it, use raw peanuts and process them using peanut butter making machines.

Peanut butter

Tomato sauce is a popular ingredient for adding a sweet, slightly acidic touch of flavor to food and recipes. Sauce production involves cooking the tomatoes, removing the seeds and stems with a strainer, using a grinder or milling machine, and then further cooking to the desired consistency. Tomato sauce making equipment is used in industrial production to speed up the various preparation steps while maintaining the quality of the sauce.

Tomato sauce

Chili sauce is produced worldwide, but each is augmented by the cultural elements of where it is made. Most chili sauces consist primarily of chilis, though some preparations include tomato as the primary ingredient. Vinegar, sugar, and salt are added to the chili sauce making machinery, and the mixture is thickened mainly by cooking.

Chili sauce

Broth

Hummus processing begins by blending chickpeas, tahini, lemon juice and olive oil to create the simple yet versatile dip loved by so many around the world. To prove their love for hummus, the Lebanese, in 2010, made the largest plate of hummus that weighed over 10 tonnes! To produce hummus industrially, you need a hummus production line that includes processing equipment such as cookers, industrial grinders, pasteurizers and packaging equipment.

Hummus

To produce condensed milk, you need to remove a large portion of the water content from the milk. Usually, you add sugar to it to create a sweet flavor. First, milk is standardized and pasteurized. Then, it goes through an evaporation process to remove the excess water content while sugar is added. After that, the mixture undergoes homogenization. The condensed milk is cooled and crystallized before being ready for packaging.

Condensed milk

Simple design for simple, safe, and smooth operation

All parts that come in contact with the product are 316L stainless steel

A broad range of tools available for optimized adaptation to a variety of mixing and stirring tasks

Infinitely adjustable rotation speed

Explosion-proof design

A high-shear mixer produces flow and shear in a fluid to help disperse separate phases. Choosing a shear mixer requires multiple considerations including the degree of dispersion and homogeneity required, the targeted time cycle, heating or cooling requirements, and the desired batch volume or flow rate. High shear mixers are used in the pharmaceutical industry for the production of syrups, creams, and ointments, in the chemical industry for the dispersion of pigments or other powders in a liquid medium, and in the food industry for the preparation of sauces and dressings.

High-shear mixers

Food

Pharmaceutical

Mixing Equipment

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

Connect directly with world leading manufacturers of Mixing equipment and find technology to build or improve your production line.

Mixing - Making.com

Industrial Mixing Equipment - Making.com

The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Cream

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Pharmaceutical powders provide longer shelf life and better stability than liquid dosage forms. But the processing of pharmaceutical powders is crucial for growing segments besides pharmacy. Functional foods and cosmetics formulated with active ingredients and excipients depend on powdered forms to fulfill their promises.

Pharmaceutical powder

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Ancient civilizations discovered that plant extracts were useful for the treatment of pathologies. The origin of plant extraction cannot be specifically verified, but we can infer that the earliest attempts at plant extraction were more intuitive than scientific. Today, the extraction of compounds is a precise process with plant extraction systems complimenting traditional knowledge.

Plant extracts

R&amp;D

Batch

liquid

The Turbotron RKG line from IKA is a simple and robust rotary agitator for lower viscosity fluids.

Reliably agitating fluids in open or pressure-less vessels in a laboratory or small scale production environment is often an important step in developing

Agitator for low viscosity media - Making.com

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The marketplace for finding innovative production technology

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IKA-process-technology-brochure.pdf

Basic robust design for simple and safe operation

Variety of drive options available for slow or variable speeds

Suitable for use with both pressurized and pressure-less vessels

Wide variety of tools available allow optimization for most mixing and dispersing tasks

All parts that contact the product are stainless steel

Liquid

The building blocks of matter have driven the imagination of philosophers, scientists, and artists for millennia. But, for manufacturers, these elements have a more concrete existence as powders. Powder processing technology conditions these primary materials to create a vast range of products, from chemicals and foods to pharmaceuticals and ceramics.

Powder

Process

The Turbotron line from IKA are agitators that satisfy a huge array of needs from a wide variety of processes.

Mixing fluids of medium viscosity for many production processes requires an agitator with a simple and proven reliable design while at the same time being

Agitator for medium viscosity media - Making.com

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ika-rototron-brochure-pdf

IKA-Rototron-brochure.pdf

Effective on media with a viscosity of 15,000 mPa*s

Fast mixing and dispersing results

Flexible installation features for use a wide variety of vessels

Avoids whirlpool action and minimizes air inclusions

Avoids sedimentation formation in the bottom of the containers when used to form suspensions

Agitated media mills stir the grinding media to break down the target material into ultra-fine particles. The grinding media generally consists of spherical metallic or ceramic beads that are stirred into action by the agitator. Agitated media mills are designed in both vertical and horizontal configurations. The choice of a suitable mill depends on the properties of the material to be processed, the particle size required, the production volume, and the desired grinding time.

Agitated media mills

An emulsifier is used to mix two immiscible liquids. Heating or cooling requirements during emulsification, overpressure or vacuum requirements, the need for wall scrapers, design of the mixing head, the viscosity of the liquids, and the desired droplet size are all important considerations when selecting an emulsifying system. Emulsifiers are typically used in the food industry for the production of batters, creams, and sauces, in the pharmaceutical and cosmetics industry for the production of creams and lotions, and in the chemical industry for the production of paint and other emulsions.

Emulsifying

Homogenization is the process of reducing particle size in mixtures to improve the consistency, uniformity, and stability of the product. The choice of a homogenizer depends on the nature of the product, desired particle size, the physical state of the ingredients, and pressure requirements during the process. Homogenization is widely used in the biotech industry for cell lysis and in the pharmaceutical industry for the emulsification of creams and ointments; it also finds applications in the cosmetics and food industries for improving the consistency and uniformity of various products.

Homogenization

IKA's Rototron RTS is a line of jet flow agitators that accelerate mixing processes without many of the issues from traditional equipment.

Processes including homogenization, dispersing, suspension, emulsification and dissolving benefit with the addition of a dispersing rotor/stator system to

Jet flow agitator for high-viscosity media - Making.com

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ika-magic-plant-brochure-pdf

IKA-Magic-Plant-brochure.pdf

Complete discharge either through a valve at the bottom or tilting the vessel

Specialized stirrer geometry

Conical shaped vessel allows processing of extremely small batches when necessary

Better mixing and drying can be achieved by tilting the mixing vessel in the process

The intensity of the mixing and stirring effect is adjustable to meet the needs of your process

Research and development work often requires the production of small and ultra-small batches. Laboratory mills allow limited production of experimental batches without the need for interrupting work on production machines. Typical applications of laboratory mills include new product development, process improvement, and quality control work. The choice of a suitable laboratory mill depends on your milling technique requirement, the batch size range, and the nature of the product that needs to be processed.

Laboratory mills

Chemical

Biopharmaceuticals are drugs in which the active substance is manufactured or extracted from biological origin materials. They are usually produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Also known as biomanufacturing, they are used to either treat or diagnose and prevent a patient’s medical condition or disease. Biopharmaceuticals are typically complex macromolecules administered by injection or infusions, and examples include vaccines, serums, and insulin.

Biopharmaceuticals

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Dispersing systems are used to produce emulsions of two immiscible liquids or dispersions of solid particles in a liquid medium. The mixers generally operate on the rotor/stator principle and apply a high shear force on the suspended particles to break them down. The choice of a dispersion mixer depends on the physical state of the material being dispersed, the continuous or batch nature of the process, desired particle size, and the viscosity of the mixture. Dispersion mixers are widely used in the food industry for the dispersion of solid ingredients in oil or water and in the coatings industry for the dispersion of pigments.

Dispersing

The Magic PLANT series is a laboratory dispersing machine designed to address many of the issues and difficulties previously associated with mixers of this size.

Laboratory mixers have not always been easy to work with.  Getting all the product out of the mixing vessel, and mixing small batches were not as easy as

Laboratory dispersing machine for low-viscous masses - Making.com

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Yogurt makers start with raw milk from animals like cows and goats and produce yogurt by standardizing milk, reducing fat content and increasing total solids before pasteurizing to remove harmful bacteria. After pasteurization, the milk undergoes homogenization to make it smoother and more consistent. The milk then receives yogurt cultures, and the product undergoes a fermentation process. Finally, you can cool and refrigerate the yogurt and prepare it for packing.

Yogurt

Flexibility and ease of use--one machine suits many applications and a wide variety of processes

Easy conversion between specialized functional modules and reliable scale-up to production sized machines

Uses a low-maintenance mechanical seal

Functions at high temperatures

Operates in pressurized and vacuum conditions

IKA's Processs-Pilot is a versatile inline laboratory dispersing machine designed for reliable scale up.

Innovators in a wide variety of industries need laboratory equipment on which processes and products can be developed and reliably scaled up to

In-line laboratory dispersing machine - Making.com

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Achieve dispersion results up to 50% quicker than with traditional stirrers

Design for reliable and predictable  process scale up to production level machines

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

IKA's Labor-Pilot is a versatile and compact inline laboratory dispersing machine designed for reliable scale-up.

Innovators in process development need laboratory equipment that helps their ideas be reliably scaled up to production.  For dispersion equipment, this

Pilot dispersing machine for testing and scale-up - Making.com

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Everything tastes like porridge, the saying goes. That may be an exaggeration, but in theory, reaction flavors could make everything taste the same. Thankfully, flavorists and chemists in the flavor industry are more inventive than that, and colorful process flavors treat our taste buds to a broad palette of sensations, flavors and aromas.

Liquid Dosage Forms Mixing Equipment

Which liquid dosage forms mixing technology do you need?

Agitator for low viscosity media

Agitator for medium viscosity media

Jet flow agitator for high-viscosity media

Laboratory dispersing machine for low-viscous masses

In-line laboratory dispersing machine

Pilot dispersing machine for testing and scale-up

Dilution system for two or more liquids in one pass

Dust-free continuous homogenizing system

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