Depyrogenation tunnels for pharmaceutical containers
Ensure precise sterility and safety in pharmaceutical production with advanced depyrogenation tunnels, designed for high-speed continuous operations that optimize the washing, sterilization, and cooling of ampoules, vials, and larger bottles.
Sterilizes and Depyrogenates Pharmaceutical Containers
The DEPYR Depyrogenation Tunnel from Marchesini Group is an advanced solution for pharmaceutical and biotech industries, specifically designed to sterilize and depyrogenate ampoules, SVP vials, and larger bottles. Its fully integrated dry-heat sterilization system uses dedicated resistors and separate air loops for efficient cooling and sterilization, minimizing downtime and energy consumption. The symmetrical air recycling ensures consistent temperature distribution, while automatic pressure compensation guarantees precise process control and repeatability. With a handling capacity determined by the tunnel size and container type, DEPYR operates continuously at high speeds, ideal for large-scale production. Constructed with tubular stainless steel and equipped with easy-access panels, it supports GMP compliance and efficient maintenance. Optional customizations and engineering support are available to meet specific operational needs, ensuring seamless integration into existing production lines.
Benefits
- Ensures aseptic integrity by consistently sterilizing and depyrogenating containers.
- Minimizes energy use with an efficient dry-heat system featuring dual air loops.
- Enhances production efficiency with continuous, high-speed operation.
- Complies with GMP standards, supporting pharmaceutical production requirements.
- Simplifies maintenance and reduces downtime with accessible design and integrated components.
- Applications
- Parenterals,Biopharmaceuticals,Aseptic products,Pharmaceuticals
- End products
- Ampoules,Svp (small volume parenteral) vials,Larger bottles
- Steps before
- Ampoules Filling,Vials Filling,Syringes Handling,Syringes Assembling
- Steps after
- Cooling,Packing,Labelling,Inspection
- Input ingredients
- ampoules,Small Volume Parenteral (SVP) vials,larger bottles
- Output ingredients
- depyrogenated ampoules,depyrogenated vials,depyrogenated bottles
- Market info
- Marchesini is renowned for manufacturing high-quality packaging machinery for the pharmaceutical and cosmetics industries, offering innovative, customized solutions with advanced automation and technology.
- Construction Material
- Stainless steel
- Frame Design
- Tubular stainless steel
- Depyrogenation Process
- Dry-Heat Sterilization
- Temperature Distribution
- Symmetrical air recycling
- Cooling System
- 100% air recycling
- Airflow
- Integrated air extracting fan
- Pressure Compensation System
- Automatic
- Capacity Range
- Ampoules
- Output Rate
- Depends on tunnel size and containers
- Installation
- On-board design for quick installation
- Exhaust System
- Single exhaust duct required
- Cooling Temperature
- Very low glass temperature at exit
- Expansion Compensation
- Metal structure with no particle generation
- Resistors
- Dedicated for Dry-Heat cycle
- Cycle Start
- Quick start without chilled water draining
- Cycle End
- Forced cooling at the end of DH cycle
- Automation level
- PLC / SCADA
- Batch vs. continuous operation
- Batch / Inline Continuous
- Changeover time
- Minimal due to integrated design
- CIP/SIP
- CIP 121°C / SIP 135°C
- Cleaning method
- Manual / Easy Access for Cleaning
- Energy efficiency
- 0.5–2 kWh/kg moisture
- Symmetrical air recycling
- 50% left and 50% right side
- Air incorporation control
- Symmetrical recycling for stability
- Cooling and temperature control
- 100% air recycling in cooling chamber
- Quick installation
- Fully integrated on board design
- Pressure compensation systems
- Automatic with high overpressure
- Dry-Heat Sterilization cycle
- Dedicated resistors with double air loop
- Metal expansion compensation system
- No particle generation during heating
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Container size
- 1 ml - 500 ml
- Container type
- Ampoules / SVP vials / Bottles
- Machine Frame Material
- Tubular stainless steel
- Frame Design
- Hinged doors on front side and removable panels on maintenance side
- Access Panels
- Easy removable panels on the maintenance side
- Inspection Method
- Inspection glass doors on pre-heating and cooling chambers
- Footprint
- Integrated on board design
- Air Ducting
- Single exhaust duct required
- Air Recycling
- Symmetrical air recycling in hot chamber
- Cooling Chamber Design
- 100% air recycling
- Temperature Control
- Very constant temperature distribution
- Cooling Fan Installation
- On board
- Operation Access
- Accessible from 2 openable sides
- Control Panel Access
- Accessible from 2 openable sides
- Frame Material
- Tubular stainless steel
- Filter Installation
- Operator side
- Access Design
- Hinged doors,removable panels
- Cooling System
- 100% air recycling
- Pressure Compensation
- Automatic systems
- Temperature Control
- Symmetrical air recycling
- Sterilization Method
- Innovative Dry-Heat Sterilization
- Exhaust System
- Single exhaust duct with on-board fan