Vial and syringe filling system for pharmaceuticals

Ensure aseptic precision in liquid formulation filling with a modular system designed for rapid turnaround and compliance with stringent regulatory standards, streamlining the production of sterile syringes and pre-filled vials.

Fills and Seals Aseptic Vials, Syringes, and Cartridges

The flexfill from groninger is a modular aseptic filling machine designed to streamline the production of sterile liquid pharmaceuticals. Its unique modular design allows for rapid deployment and customization, meeting medium production volumes for pharmaceutical manufacturers and CDMOs. The system efficiently handles debagging, transfer, opening, filling, closing, denesting, and sealing processes for vials, syringes, and cartridges. Featuring flexible filling systems, including rotary piston and peristaltic pumps, it accommodates a variety of product viscosities and oxygen-sensitive formulations, with optional gassing and vacuum capabilities. Compliant with major regulatory standards, flexfill ensures high process reliability with automated clamping, cutting, and In-Process-Control (IPC) to maximize output. The hygienic design supports fast cleaning, integrating into existing lines with ease and leveraging groninger’s high-end capping technology for minimized particle generation during sealing. Available with advanced camera systems for precise quality control, it meets GMP standards, providing pharmaceutical and biopharmaceutical manufacturers with a reliable solution for aseptic filling.

Benefits

  • Accelerates time to market with rapid deployment and modular customization.
  • Enhances product safety with aseptic no-touch transfer and controlled processing.
  • Increases production efficiency with automated IPC for optimal filling accuracy.
  • Simplifies integration and cleaning, supporting seamless line incorporation.
  • Ensures regulatory compliance, meeting GMP standards for pharmaceutical production.

General


Applications
Liquid formulations,Biopharmaceuticals,Aseptic products,Pharmaceuticals
End products
Ready-to-use cartridges,Sterile syringes,Injectable biologics,Ophthalmic solutions,Pre-filled vials,Iv solutions
Steps before
Debagging,No-touch transfer (NTT),Sorting of closures
Steps after
Denesting,Sealing,Transfer Module with tub reject handling
Input ingredients
vials,syringes,cartridges,ready-to-use containers,closures,stopper
Output ingredients
filled vials,filled syringes,filled cartridges,sealed vials,sealed syringes,sealed cartridges
Market info
Groninger is known for its expertise in manufacturing high-quality filling and packaging machinery for the pharmaceutical, cosmetics, and consumer healthcare industries, with a strong reputation for innovation, precision engineering, and customer-focused solutions.

Technical Specifications


Filling method
Rotary piston and/or peristaltic pump
Filling accuracy
Not specified
Filling speed
Not specified
Filling capacity
Medium production volumes
Automation
Automatic clamping and cutting
Pre-configured modules
Available
No-touch transfer
Grade A aseptic transfer
In-Process-Control (IPC)
For filling
Oxygen sensitive gassing
Available
Vacuum for high viscous products
Available
Sorting of closures
Feeding tracks
Hygienic design
Fast and easy cleaning
Standard gassing and vacuum functions
Available
Camera system for stopper presence
Available
Sealing process
Low particle generation
Crimp quality control
Camera tracking

Operating Characteristics


Automation level
High (PLC with customizable modules)
Batch vs. continuous operation
Batch and inline flexible
CIP/SIP
CIP compatible,hygienic design
Cleaning method
Easy cleaning operations
Changeover time
Quick with modular design
Energy efficiency
Balanced for operational cost reduction

Material Compatibility


Biological compatibility
Aseptic filling
Cleanability
Hygienic design for easy cleaning
Corrosive resistance
Suitable for polymer containers or cartridges
Abrasion resistance
High-end capping technology for low particle generation
Density/particle size
Low particle generation during sealing

Physical Characteristics


Modular design
Yes
Flexible filling system
Rotary piston and/or peristaltic pump
Aseptic transfer system
No-touch transfer (NTT) for ready-to-use containers

Custom Options


Modular machine concept
Pre-defined configuration
Pre-configured modules
Available for individual customization
Filling system type
Rotary piston and/or peristaltic pump
Gassing and vacuum functions
Standard options available
Camera systems
Stopper presence and orientation