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Ensuring sterile liquid transfer during pharmaceutical manufacturing is crucial for maintaining product safety. The challenge lies in transferring fluids across sterile boundaries in environments like isolators or RABS without contamination.
<h2>Maintain sterility during liquid transfers</h2>
The AT-Port™ System by Aseptic Technologies is an alpha-beta aseptic liquid connection system designed to enable safe liquid transfer between different containment classification areas while ensuring sterility. Its core components include the Connector Port, and the Disposable Connector Devices, AT-Connector™ and AT-Connect™. The AT-Connector™ is suited for large volumes and can be used for up to five opening-closing operations, ensuring reliable, repeated use. The AT-Connect™ is ideal for precise, low volume transfers, maintaining sterility with seamless integration into aseptic filling lines. Made with silicone and thermoplastic elastomer (C-Flex®) tubing, it ensures all product contact points remain sterile. Distributed by Sartorius Stedim under the name Gammasart Aseptic Transfer Device (ATD™), this system is widely used in cGMP pharmaceutical formulation, fill & finish, and other critical liquid product handling applications.

Aseptic liquid transfer connection system

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

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In biopharmaceutical manufacturing, the integration of various systems for upstream and downstream processes such as cell culture and purification is crucial to maintain efficiency and product quality. Customizable solutions that cater to specific process needs are often required to meet stringent regulatory standards and production goals.
<h2>Integrate stainless steel and single-use systems</h2>
The Hybrid Bioprocess System from Austar offers a comprehensive solution incorporating both stainless steel and single-use systems for upstream and downstream bioprocessing. Designed to handle tasks such as media preparation, buffer preparation, cell culture, separation, purification, and aseptic transfer, this system ensures flexibility and customization according to client needs. By combining the technical benefits and cost advantages of stainless steel with single-use systems, it provides high-quality, low-cost solutions. The system includes hardware, consumables, automatic control, and validation services. Additionally, it supports the entire process from feasibility evaluation to project management services, making it a versatile option for biopharma operations.

Hybrid bioprocess system for cell culture and purification

Purification is the removal of contaminating substances and by-products to increase the level of purity of the desired substance. Considerations for choosing a suitable purification system in the industry, include the physical state of the mixture, the desired product, required level of purity, the type of mixture, heat sensitivity of the product, number of purification steps needed, and the production volume. Industrial purification systems are used for the production of pure water in the food pharmaceutical and biotech industries.

Purification

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

In the food and beverage industry, ensuring product microbiological stability is paramount. Processes must be capable of inactivating microorganisms that can lead to spoilage, while maintaining product quality and safety. High temperature sterilization methods are essential for heat-sensitive products.
<h2>Sterilize liquids using efficient heat transfer</h2>
The Alfa Laval Steritherm PHE is a premium plate sterilizer designed for heat-sensitive food, dairy, and beverage products. This pre-assembled, skid-mounted aseptic thermal module enhances product stability by inactivating unwanted microorganisms. Specific features include high temperature heat transfer and controlled holding times. The frame compresses stainless steel plates to form narrow channels for optimized heat transfer. The regenerative heat exchanger section pre-heats the product using direct energy recovery, reducing the need for additional heating and cooling media. The module supports automated Clean-In-Place (CIP), ensuring easy maintenance. The system offers flexibility with accurate 24/7 control and easy integration with aseptic tanks and filling machines.

Plate heat exchanger sterilizer for food products

Industrial cleaning equipment is used to wash or disinfect machinery and the production/warehouse area. It may also be used to sterilize the product, equipment, tools, floor or work surfaces and to purify or clean the product by removing impurities. Choosing a suitable cleaning system depends on the type of product or equipment to be cleaned, the sensitivity of the product to heat, pressure, and chemicals, and the level of sterility desired.

Cleaning

<span style="font-weight: 400">The heating process is a step of raising the temperature of food, pharma, cosmetics, and many other types of products. You may employ different heating solutions for this process, depending on the type of product you intend to manufacture. Selecting the appropriate heater machine for your product is quite important since various products require different ranges of temperatures and different ways of heat transfer using exchangers. Industrial heating equipment varies in two ways - the type of material it can process and the reaction you want to achieve.</span>

Heating

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Transfer Technologies

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Aseptic liquid transfer connection system

Hybrid bioprocess system for cell culture and purification

Plate heat exchanger sterilizer for food products

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