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Drum-Transfer-System

The essential objectives of containment systems are personnel protection and preventing the release of toxic or infectious material into the environment. Containment is also used to prevent a product or sample from contamination by the external environment. In the chemical and pharmaceutical industries, containment solutions are used to protect the personnel from the leaking of airborne particles of hazardous substances, as powders or liquids are handled or transferred during processing.

Containment

A loading system feeds your continuous or batch processing machine with the specified material or item in line with the flow of production. Loaders transfer the articles from one stage of preparation to the next with uniformity and accuracy.

Loading

Industrial feeding systems allows you to control the flow of solid bulk materials throughout the manufacturing line. After loading your material onto the vibrating hopper, a screw at the base drives it out in uniform doses to the next stage of processing. New feeding technologies are designed to deal with challenges of powders clumping together in the hopper (bridging and ratholing) that interrupt the outflow. Common feeder systems include centrifugal feeders, vibratory feeders as well as elevator, linear and pneumatic feeders.

Feeding

Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Healthcare products are goods or services used to improve, maintain or prevent the deterioration of health or ease the consequences of illness. Healthcare products include a wide range of goods, from hospital clothing, over plasters, wound care products and diagnostic devices. These products must be clean and contamination-free, which is achieved with strictly regulated healthcare equipment.

Healthcare products

Contained transfer systems are designed to safely transfer the product or waste items in or out of contained or sterile areas. Valves are used to regulate the flow in contained transfer systems. The choice of a suitable containment system depends on the form of source and target containers, the physical state of the product and the volume of the product to be transferred. These systems find applications in transferring pharmaceutical powders from drums to the process equipment, filling bulk chemicals in transportation bags or safely discharging them into mixing tanks.

Batch

Continuous

A high-performance transfer port system that combines ultimate safety, simplicity of operation, and ideal cleaning, used in pharmaceutical and biopharmaceutical manufacturing.
<h2>High-integrity locking system, preventing accidental containment breach</h2>
The Containment Transfer System (CTS) product range from Telstar Life-Sciences is a versatile combination of technologies that provides you with the flexibility to safely and securely transfer products in high containment environments. A number of sizes and design options are available to suit your containment requirements, security needs, and budget.

Contained transfer systems are specially designed as the safest method for transferring product/waste or items in or out of contained or sterile areas. Totally mechanical system (no power needed) with safety devices to prevent incorrect operations (not operator dependent) and with color indicators on the locking mechanism provide visual feedback of the transfer's port status.

Transfer system for high-containment environments

Conveyor systems are used for moving materials from one location to another. Considerations for choosing a suitable industrial conveying system include the nature of the product, its physical state, the desired conveying rate, and sensitivity of the product to heat and mechanical shock. Conveying equipment is used in the food, pharmaceutical, chemical, biomass, and mineral industries to move materials around a warehouse as well as to transport bulk powders, granules, and grains for processing and filling. These types of systems are usually automated and there is a wide variety of solutions to choose when it comes to the type of conveyor. Types include screw, gravity, chain, roller and belt conveyors.

Conveying

liquid

solid

Industrial

In the pharmaceutical industry, achieving both high yield and reliable tablet quality is critical. Traditional methods often fall short when dealing with complex shapes and rigorous production standards, leading to product loss and cross-contamination risks.
<h2>Enhanced tablet production with innovative compression system</h2>
The COMPRIMA by IMA is an advanced tablet press designed to overcome these challenges with its centrifugal force-driven powder feeding system. This system ensures accurate die filling without powder mix segregation, enabling high production speeds regardless of tablet shape. The processing area is isolated with seals and bellows to prevent contamination, and a Clean In Place (CIP) system allows for a fully automatic, validatable cleaning cycle. Suitable for high containment applications (OEL 5), it features glove ports and negative pressure within the processing area for operational safety. The COMPRIMA offers various models with capacities ranging up to 300,000 tablets per hour and is capable of handling round tablets of 5-17 mm and oblong tablets of 5-21.5 mm, with a compression force up to 80 kN.

Tablet press for high-quality pharmaceutical tablets

Filling lines are used extensively in all industries, such as food, pharmaceutical, chemical, and cosmetics, to accurately package different products into a container suitable for that product. Although the filling process is at the very end of the production line, it is no less important than the earlier steps. Last but not least, the idiom that dates back to 1382 when John Wyclif wrote the firste the laste, and the laste the firste, indicates just that the last things on a list are just as valuable as the previous ones. In this case, this idiom fits perfectly.

Filling

Pressing

Entry level

Pilot

When developing new products with unpredictable grinding properties, the need for flexible systems is paramount. Traditional setups may involve multiple mills and classifiers, taking up significant space and often reducing efficiency during production and research phases.
<h2>Integrate multiple grinding processes seamlessly</h2>
The Multiprocessing System by Hosokawa Alpine offers a versatile solution for flexible production and research requirements. This system integrates multiple mill types into a single compact unit, ideal for rapid changeovers and efficient space utilization. By allowing quick switching between various grinding and classifying modules, it supports small-batch R&D while maintaining compliance with GMP standards. The system is available in sizes ranging from small laboratory setups to large-scale production units. Key features include modular design, optimized dismantling for easy cleaning, and minimal documentation requirements. Ideal for industries such as food, chemicals, pharmaceuticals, and minerals, the Multiprocessing System ensures high flexibility, reduced investment costs, and ease of validation.

Multiprocessing system for flexible research and production

Classifying

Grinders use a spinning blade or rotating abrasive elements to reduce the size of various materials. The specifications, RPM and grit of the engineered grinder, will result in various particle sizes. As a result, what you want to make will determine the type of grinder you need. Grinding is used for improving the texture and flow properties of various products and to enhance the flavor of food products such as coffee, spices, sugar, nuts, sesame, poppy seeds, lentils, wheat, and rice. Choosing the right rotational speed, grinding elements, and processing power allow the grinding and shredding of a wide range of materials into coarse or fine powders. Popular types of heavy duty grinders in food processing include angle grinders, bench grinders and meat grinders.

Grinding

Industrial separation equipment encapsulates the separation process which is to separate components of a liquid mixture, for recovering dissolved solids from liquids. The choice of a suitable technology depends on the identification of the key physical or chemical property, such as size, mass, density, or boiling point, which sets the product of interest apart from the rest of the components. Separation technology is widely used in the pharmaceutical and chemical industries for the isolation of active ingredients and high-purity chemicals. As well as in waste management and recycling industries.

Separation

Powder

In environments where the handling of hazardous or sensitive materials is critical, maintaining a controlled environment is essential. Contamination during the sampling, discharging, or packaging processes can compromise both operator safety and product integrity.
<h2>Ensures safe and contamination-free material handling</h2>
The containment system, developed by Comber under Heinkel, is used with Nutsche filter dryers. This system enables protected sampling, product discharge, packaging, and disposal of residual materials without exposing operators to harmful substances or risking product contamination. The system features an isolator (or glove box) connected via a flange to the filter dryer’s discharge stopper. This ensures that the materials handled remain enclosed, minimizing exposure and contamination risks. It is ideal for industries such as pharmaceuticals, chemicals, and fine chemicals where safety and purity are paramount. By incorporating this containment solution, facilities can achieve regulatory compliance, improve product yields, and ensure the safety of their staff.

Containment system for filter dryers

Discharging

Packaging

Industrial sampling equipment are systems that allow manufacturers to test (in other words to take a sample of) the products they are manufacturing. This process is generally implemented as a means of quality control but it can also be used as a mean to ensure that production processes adhere to certain regulatory standards. Quality control in your manufacturing process starts with precision sampling techniques. Automated systems deliver consistent samples at a pre-set rate for accurate testing and probing. Sampling technology uses a calibration system involving a series of sensors to extract the material at high levels of reliability.

Sampling

In pharmaceutical and food industries, secure and efficient storage and transportation of powders is critical. Meeting safety and contamination prevention standards is challenging without the right containment solutions.
<h2>Store and transport powders safely and efficiently</h2>
The stainless steel Intermediate Bulk Containers (IBCs) from Hanningfield Process Systems are designed to safely and securely transport, store, and handle powders and bulk materials. Featuring 316L stainless steel contact parts and FDA-compliant seals, these containers ensure high standards of hygiene and safety. With capacities ranging from 150 to 2000 litres, they offer flexibility for various process requirements. Custom design options are available to suit specific needs, including dust-tight charging and discharging methods, mobility with castors, and handling via forklift or post hoist. The robust construction with 304 stainless steel non-contact parts further enhances the durability and longevity of the containers.

Stainless steel intermediate bulk containers for pharmaceutical use

Handling

Almost all manufacturers will require industrial storage systems and solutions at some point during their production process. The raw materials that go into your products need dedicated storage solutions to protect them from spoilage and contamination before they enter the manufacturing cycle. Storage usually refers to particular storage space. For example, having enough warehouse storage. Or clearing out a production facility for more floor space.  However, in this case, we are referring to the equipment and solutions that make storage manageable and easier. Such equipment includes solutions such as storage racks, pallet racks and shelving systems. These are just some of many storage options available to manufacturers. Advanced technology facilitates the management of heavy duty and high density tank and silo systems by automating the delivery system and linking it with the rest of the production line.

Storage

In pharmaceutical or chemical industries, transferring sensitive powders safely and maintaining sterility are critical tasks. Ensuring both operator safety and the integrity of the product requires specialized equipment to mitigate contamination risks and handle potentially hazardous materials.
<h2>Ensure sterile powder transfer with split valve technology</h2>
The Sterisplit by Hanningfield Process Systems is a high-regulation split butterfly valve designed for the safe transfer of powders in sterile or potentially dangerous applications. It consists of two halves—active and passive—that mate to form a single valve, allowing powders to flow through while keeping the external surfaces clean. This design ensures that when undocked, the valve remains sterile and safe for handling. Made from stainless steel 1.4404 (AISI 316L), the Sterisplit is compliant with cGMP and EHEDG guidelines, and it is compatible with CIP (clean-in-place) systems. Applicable in processes involving dynamic substances, hormones, antibiotics, or toxic products, the Sterisplit provides reliable security for both the operator and the product. The device is available in various sizes (DN 50, DN 100, DN 150, DN 200, DN 250) and comes with FDA Certification, Material Certificate 3.1, and ATEX compliance.

Split butterfly valve for sterile powder transfer

In industries like pharmaceuticals and food processing, unloading sacks and bags often leads to dust emissions. Controlling this dust is crucial to maintain a safe and clean working environment, especially when handling fine and reactive powders.
<h2>Controls dust emissions during sack unloading</h2>
The Hanningfield sack tip station is a solution designed to empty sacks and bags efficiently while minimizing dust emissions. Operators lift the bag onto the station's shelf, pierce it, and allow the contents to flow into the downstream conveyor system. The unit features a dust extraction hood that protects the operator and the environment during this process. Constructed from 316L stainless steel for contact parts and 304 stainless steel for non-contact parts, this station meets FDA compliance. As an added benefit, the station can be customized with integrated dust extraction systems, like filters and fans. This is ideal for small-scale to large-scale applications in various industries including pharmaceuticals and food processing.

Dust-control sack tip station for industrial loading

Industrial cleaning equipment is used to wash or disinfect machinery and the production/warehouse area. It may also be used to sterilize the product, equipment, tools, floor or work surfaces and to purify or clean the product by removing impurities. Choosing a suitable cleaning system depends on the type of product or equipment to be cleaned, the sensitivity of the product to heat, pressure, and chemicals, and the level of sterility desired.

Cleaning

Manual

In aseptic manufacturing environments, safely and efficiently transporting heavy or fragile loads can be challenging. Operators often face restricted space and require equipment that ensures precise and ergonomic handling to maintain productivity and product integrity.
<h2>Facilitates safe and precise load handling.</h2>
The DPTE® Transfer Trolley from Getinge offers a power-assisted design for managing loads within confined spaces, enhancing operator safety and process efficiency. It features precision motors for fine-tuned positioning, programmable memory functions for alignment restoration, and multi-directional castors for mobility. With adjustable height and memorizable positions, the trolley aids in speeding up manual processes in aseptic zones. Its compatibility with DPTE-BetaBag® and DPTE® Beta containers allows for quick changeovers within two minutes. The trolley's compact footprint, coupled with a lifting capacity of up to 60 kg and a lifting interval of 900 mm to 1800 mm, makes it a versatile tool for various applications. The system includes push-button controls and a cable remote control for ease of use.

Ergonomic transfer trolley for beta bags and containers

In pharmaceutical production, transferring sterile or toxic materials between different containment areas poses significant challenges. Contamination risks and maintaining sterile conditions are critical concerns that need to be addressed to ensure safety for both the operator and the product.
<h2>Enable secure bi-directional material transfer</h2>
The DPTE® Beta Containers by Getinge offer a reliable solution for transferring materials in and out of barrier systems without breaking containment. These containers are available in stainless steel or polyethylene and ensure safe, contamination-free transfers in life science applications. The system uses an Alpha part interacting with a Beta part, each fitted with a door, lock, and sealing function. These containers can be sterilized using autoclave, gamma irradiation, or H2O2 bio-decontamination methods, making them suitable for a wide range of sterilization processes. Optional racks and accessories enhance the versatility and usability of the containers, enabling secure loading and unloading. The containers are compatible with the Getinge DPTE® Alpha flange, ensuring a leak-tight and reliable transfer process.

Reusable containers for sterile and toxic material transfer

Industrial sterilization processes are employed in different industries to completely eliminate all living microorganisms from the final product. For instance, in food processing, sterilization equipment is used to produce a stable product with a long shelf-life by eradicating harmful bio-contaminants. Instead, in the medical field, sterilization technologies aim to prevent the transmission of microbes to patients by sterilizing all the tools and medical devices that come in contact with the patient. Most sterilization equipment, such as autoclaves, employs high-temperature pressurized steam to destroy bacteria and disinfect surfaces from spores. Other methods include radiation sterilization or using chemicals such as hydrogen peroxide for disinfection.

Sterilization

Unloading

In pharmaceutical production, ensuring the sterility of components transferred into aseptic environments is critical. Challenges include avoiding contamination during transfer and meeting strict regulatory requirements while maintaining high productivity.
<h2>Enables contamination-free component transfer</h2>
The DPTE-BetaBag® from Getinge provides a single-use, sterile transfer solution based on the DPTE® System. This system utilizes a secure Alpha-Beta port mechanism to ensure an airtight transfer, significantly reducing the risk of biological and particulate contamination. Available in various materials and sizes, including Tyvek, PE/EVOH/PE, and Polyurethane, the DPTE-BetaBag® can handle different sterilization methods like gamma, steam, and ethylene oxide. Notably, the bags are assembled in ISO 5 and ISO 7 environments for ultra-clean production, and they come pre-validated to comply with international standards. This makes them ideal for applications in aseptic filling, component transfer, and environmental monitoring in pharmaceutical and biotechnological industries.

Sterile transfer bags for aseptic production

In sterile or hazardous environments, maintaining containment and preventing contamination during the transfer of materials is crucial. Situations such as cleanroom operations, filling lines, or isolator applications need a reliable method to ensure safety and sterility.
<h2>Ensure contamination-free transfer</h2>
The DPTE®-XS Alpha Port by Getinge is a robust solution designed for safe and leak-tight transfer in aseptic or toxic working areas. Featuring a manual 60° rotation to connect Alpha and Beta parts, this port ensures that openings and closures do not compromise sterility or containment. Its lip seals provide a validated, air-tight connection, establishing it as the industry standard for reliable and safe transfer processes. Widely applicable in processes such as liquid and component transfer, waste disposal, and environmental monitoring, the DPTE®-XS Alpha Port is validated to meet rigorous international regulations, thereby assuring quality and safety in diverse industrial applications.

Aseptic transfer port for secure bi-directional transfer

When dispensing pre-sterile liquids, it is crucial to maintain a sterile environment to prevent contamination by airborne bio-burden. Ensuring that the liquid remains uncontaminated during the transfer and measurement process is a key challenge.
<h2>Maintains sterility during liquid dispensing</h2>
The Liquid Dispensing Isolator by Fabtech is designed to safely measure and dispense pre-sterile liquids into smaller containers. This system ensures sterility through the use of inline sterile filters and VHP (Vaporized Hydrogen Peroxide) decontamination. Built with SS 316L stainless steel, the isolator features ISO 5 Grade A laminar airflow for an aseptic environment. The standard configuration includes a pass box with two glove ports and a main chamber with four glove ports, along with a glove integrity tester. The system offers customizable ergonomics, multiple chamber configurations, integration options for on-demand process equipment, and online particle counters. It also supports password protection for different authorization levels.

Liquid dispensing isolator for sterile environments

Decontamination

Dispensing

Industrial filtration equipment separates solid matter from liquid by using a filter medium. The filter allows only the fluid to pass through but retains the solid matter. The choice of filtration equipment depends on the particle size, the consistency of the mixture, and the nature of your product.

Filtration

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

Handling toxic powders during industrial processes requires a safe and contained transfer system to prevent contamination and ensure operator safety. Efficient and secure transfer methods are essential in environments where powder containment is critical.
<h2>Securely transfer powders with advanced containment</h2>
The Drum Dock Station by De Dietrich is designed for the safe and contained transfer of powders from drums into other processing systems. Utilizing DIT® Drum Iris Technology, this station allows operators to handle reactive or toxic powders with minimal exposure and contamination risks. The station is available in single and double chamber configurations, providing varying levels of containment, up to OEB 6. The body is constructed from high-grade materials such as AISI 304, AISI 316, and HASTELLOY C-22, ensuring durability and compatibility with different chemical processes. The integration with multiple powder transfer systems, including the De Dietrich Powder Pump, enhances its flexibility. Additionally, features like pneumatic lifters for drum inversion, customizable glove ports, and a double Push-Push H14 filtration unit for maintaining negative pressure during the transfer process make it suitable for high-containment applications in industries such as pharmaceuticals and fine chemicals.

Powder handling drum dock station

In medical and nuclear facilities, managing radioactive waste safely is critical to ensure compliance with safety standards and protect personnel from radiation exposure. Effective containment solutions must be implemented to address the disposal challenges faced in these environments.
<h2>Provide secure shielding and easy waste management</h2>
The WC-303 is a shielded, movable waste container designed specifically for radioactive waste. Manufactured by Comecer, it is made of stainless steel and designed to fit standard blue plastic hospital containers. The radioactive waste is placed inside the plastic container under the waste container's opening, which is then covered by a shielded lid. The container is equipped with a foot-pedal operated lid for hands-free operation and a lockable door to ensure safety and security. It offers 3mm thick lead shielding (Pb) and measures 340x420x650 mm (internal dimensions) with external dimensions of 410x450x810 mm. Weighing 100 kg, the WC-303 ensures that radioactive waste is contained safely and securely.

Shielded waste container for radioactive materials

When handling and dispensing radiopharmaceuticals, maintaining a sterile environment and ensuring radiation safety is critical. Challenges include minimizing contamination risks and precise dosage control while adhering to stringent CGMP guidelines.
<h2>Ensures sterile and shielded dispensing of syringes</h2>
The THECLA by Comecer is a class A shielded isolator featuring an integrated dispensing system specifically designed for handling radiopharmaceuticals such as 68Ga. It offers a laminar flow over the entire main chamber to maintain sterile conditions. The isolator includes a semi-automatic syringe dispensing system and a class B pre-chamber for material introduction. Key features include a dose calibrator with a measurement range up to 2 Ci and compartments for 68Ge/68Ga generator housing and dose calibration. The compact and essential design allows it to fit in confined spaces with maintenance access from the front wall. Compliance with CGMP guidelines ensures a high standard of safety and efficacy in radiopharmaceutical preparation and dispensing.

Shielded isolator for radiopharmaceutical syringe dispensing

In the radiopharmaceutical industry, handling irradiated materials requires stringent safety measures and precise operations. The manipulation of solid targets during the production and dispensing of radiopharmaceuticals must adhere to current GMP guidelines to ensure safety and efficiency.
<h2>Handle and dispense irradiated materials safely</h2>
The SPECT Production Hot Cell by Comecer is a comprehensive system designed for the safe manipulation of irradiated materials. It includes seven hot cells connected by a transfer system called the 'Conveyor'. The cells feature shielding of 75 to 150 mm of lead and PVC working chambers. The lineup consists of various hot cells specialized for different tasks: a Receiving Hot Cell for receiving targets, a Recovery Hot Cell for storing materials, three Chemistry Hot Cells for synthesizing radiopharmaceuticals, and two Automatic Dispensing Systems equipped with robotic arms for precise calibration and dispensing. The system handles isotopes such as Tl-201 and Ga-67 and ensures seamless transfer of materials between different cells.

Hot cell system for solid target manipulation in radiopharma

Blending

Dosing systems are a line of hoppers, feeders, filling machines, and checkweighers that operate in sync to dispense materials accurately. Dosing is an essential feature of the packaging process, whether you’re filling shampoo bottles or tea bags. But dosing equipment is critical for formulations, too, particularly in the pharmaceutical and chemical industries. Imprecise dosing may cause quality degradation in the best-case scenario. In the worst scenario, it creates serious health risks.

Dosing

In the field of nuclear medicine and radiopharmacy, handling radioactive materials with precision and safety is crucial. Medical professionals often face the challenge of ensuring proper shielding from radiation while maintaining ease of use for procedures involving syringes.
<h2>Provide ergonomic radiation shielding for syringes</h2>
The PST Series by Comecer is a tungsten syringe shield specifically designed to enhance safety and usability in radiopharma applications. This series features a tungsten construction, offering effective radiation shielding. The ergonomic notch in the central part of the shield makes syringe handling effortless, reducing user fatigue. Available in models suitable for 5ml and 10ml syringes, the PST Series offers internal diameters of 13.9mm and 16.5mm respectively, with external diameters of 27.5mm and 33mm. These shields are compact with lengths of 60mm and 85mm, ensuring that they provide significant protection without being cumbersome. Users can choose the model that best fits their specific syringe needs, thereby optimizing both radiation protection and functional usability.

Tungsten syringe shield for radiopharma applications

In modern pharmaceutical and biotech industries, ensuring the sterility of drug products during the filling process is paramount. Challenges such as contamination risks and the need for compliance with stringent regulatory standards require advanced solutions.
<h2>Enable aseptic filling with high precision</h2>
The Comecer SuperTrak PHARMA8™ is an advanced sterile filling system designed for aseptic environments. This system integrates asynchronous conveyance technology within Comecer's isolator to maintain Grade A air quality in operation, reducing particle generation due to minimal moving components. It supports the filling of vials, syringes, bags, cartridges, combination products, ampules, dry powder processing, and pills. The system's speed can reach up to 2.5 m/s with acceleration up to 30 m/s², providing high-speed sterile filling while ensuring product sterility and operator safety. It meets cGMP, FDA, CE, and UL regulatory requirements and is equipped with handling gloves and integrated hydrogen peroxide generators (VPHP) for optimal cleanliness. Supplier: Comecer.

High quality sterile filling system

In research and development settings, ensuring the safety and precision of handling sensitive materials is crucial. Challenges include maintaining a contaminant-free environment and protecting operators from exposure to hazardous substances.
<h2>Ensures safe and accurate dispensing</h2>
The Dispensing Custom R&D Isolator by Comecer operates at negative pressure relative to the laboratory, offering a controlled environment for the safe handling and dispensing of materials. This isolator features hinged front view panels with inflatable seals for easy access and secure isolation. It includes circular and oval glove flanges made of polypropylene, which facilitate material handling without compromising safety. A communication door allows seamless material transfer between chambers, while the integrated drainage sanitary tank and sloped working plane ensure efficient waste management. The isolator’s connectivity options include predispositions for WFI, PW, compressed air, vacuum, nitrogen, and various other utilities. It is also equipped with an internal filter and drying system, making it ideal for pharmaceutical and radiopharmaceutical applications.

Custom r&d isolator for precise dispensing operations

In pharmaceutical manufacturing, transferring powder ingredients while ensuring containment and sterility can be a challenge. This is especially true for manufacturers who need to transfer ingredients between process steps or different facilities frequently.
<h2>Facilitates safe and sterile powder transfers</h2>
The ChargePoint® single use valve passive (SUP) is designed for pharmaceutical manufacturers who require an economic and contained powder transfer system. Functioning as the passive mating half of the ChargePoint Split Butterfly Valve system, it ensures high containment and sterility performance, reducing the need for cleaning, maintenance, and validation. Manufactured with FDA and USP Class VI compliant plastic, the SUP is lightweight and cost-effective for single-use purposes. It is produced in an ISO6 cleanroom environment and can be gamma sterilized for aseptic processing. Available as part of a complete package with the ChargeBag® PE-S, it offers seamless integration with optional tri-clamp connections or direct welding to ChargeBags. ChargePoint Technology provides an accessory GMP cover to secure the passive and connected container, ensuring product integrity during storage or transit.

Single use valves for powder transfer

Industrial disinfection equipment use antimicrobial agents to destroy microorganisms found on machines, floors, walls, and other surfaces. In industry, disinfection of machinery and the production area is important to prevent product contamination which may lead to spoilage and health hazards for workers and the consumer. The choice of industrial cleaning equipment depends on the level of disinfection needed, the sanitizing agent, the size of the area or objects to be treated, and the suitable method of treatment such as sterilization, pasteurization, exposure to ultraviolet light, or chemical fogging.

Disinfection

The process of forming allows you to shape your products homogeneously. Forming machines are fed the manufactured material in bulk and cut it down to specification, so the process takes place between formulation of the mass and the packaging of the final item.

A special class of this equipment – Form, Fill, and Seal Machines (FFS) – creates bags and pouches from flat material such as plastic sheets, fills them with your designated product, and seals them.

Forming

In pharmaceutical and other regulated industries, handling and transferring bulk powders efficiently and safely is crucial. Challenges like space optimization, contamination prevention, and compliance with industry standards require specialised containers designed to meet these specific needs.
<h2>Streamline bulk powder handling and transfer</h2>
The PuroVaso® plastic containers, by Chargepoint Technology, are devised to address the inefficiencies associated with traditional plastic charge bottles and stainless steel vessels. These containers range from 1 litre to 50 litres, offering the largest selection of plastic container sizes, which ensures that you can select the right volume for your batch size. The square bottle geometry maximizes facility space and reduces equipment stack-up heights, effectively lowering storage and transportation costs. Intelligent design features include moulded side profiles for easy clamping with the PuroGrab™. The containers come with 4” and 6” tri-clamp neck fittings, allowing compatibility with a variety of valve options. Available in different PE materials, they cater to various needs such as anti-static properties and UV protection. The rotational moulding process guarantees a crevice-free internal surface, and batch numbers are moulded in for full traceability. The materials used are suitable for gamma irradiation sterilization, ensuring compliance with sterilization standards. These containers are both reusable and recyclable, making them a sustainable choice.

Plastic containers for bulk powder transfer

During powder transfer operations in pharmaceutical or chemical processing, maintaining clean and efficient containment is crucial. Minimizing product loss and avoiding exposure to dust are common challenges that need to be addressed.
<h2>Ensures clean and accurate powder dispensing</h2>
The Dispensing Funnel from Chargepoint Technology is a specialized funnel designed for precise and clean powder dispensing through ChargePoint® valves. This funnel enhances containment performance and ensures accurate filling of transfer bags or containers. It directs powder cleanly through the valve, minimizing product loss and reducing dust exposure. Constructed from 316L Stainless Steel, the funnel is compatible with valve sizes ranging from DN50mm (2”) to DN150mm (6”). Typically used within a dispensing isolator, the funnel legs sit to the side of the open valve disc, ensuring that powder does not come into direct contact with the valve during the transfer. This results in a clean transfer process, providing an additional safety factor. By enabling the use of more basic valve designs, the Dispensing Funnel can eliminate the need for more advanced systems.

Powder dispensing funnel

In chemical and pharmaceutical manufacturing, safely transferring bulk powder materials while minimizing dust and contamination is critical. Traditional methods often expose workers to dust particulates and increase the risk of cross-contamination.
<h2>Ensures safe and dust-free powder transfer</h2>
The ChargePoint® DiscLock™ is a high-containment split butterfly valve designed for the secure transfer of bulk powder materials. Featuring a patented locking system, it seals the disc halves together, minimizing dust exposure and contamination risks. This valve operates within ChargePoint's PharmaSafe range, providing validated containment levels down to 1µg/m³ with the standard model and down to 0.1µg/m³ with the PharmaSafe® pro option. It eliminates the need for secondary barrier containment systems and cumbersome personal protective equipment (PPE), thus streamlining operations. The system's robust design ensures a reliable disc-to-disc containment seal, even under high mechanical stress, making it suitable for handling poorly flowing and high-value products. The valve's automatic operation, integrated with the optional PowerDock™ feature, furthers operational efficiency by providing easy raise and lowering mechanisms. Additionally, its low-profile design requires minimal space within new or existing setups, making it versatile for various manufacturing environments.

High containment powder transfer valve for bulk material

During the production of highly potent active pharmaceutical ingredients (HPAPIs) and other sensitive materials, maintaining a high level of containment is crucial. Traditional transfer methods often result in contamination risks and exposure hazards that compromise both product integrity and worker safety.
<h2>Ensure safe and efficient powder transfer</h2>
The ChargePoint PharmaSafe® containment valve uses split butterfly valve technology to tackle contamination and exposure issues during high-potency powder transfers. Designed to meet GMP and product quality standards, this valve range includes models with varying containment levels, such as PharmaSafe, PharmaSafe® pro, and PharmaSafe® excel. These valves are validated according to ISPE SMEPAC guidelines, achieving containment levels down to nanogram standards without requiring additional seals, vacuum, or extraction. Users can handle poorly flowing and high-value products while reducing the need for secondary barrier containment and cumbersome personal protective equipment (PPE). The valve operates by docking the active and passive units, sealing the interfaces, and allowing controlled, contamination-free material transfer.

High containment powder transfer valve

In pharmaceutical manufacturing, maintaining purity and efficiency during powder transfer processes is crucial. Challenges include contamination prevention and ensuring optimal flow for various powders, granulates, and components.
<h2>Maximize product flow and ensure sterile processing</h2>
The ChargeBottle® M by Chargepoint Technology is a robust stainless steel container designed for sterile powder transfer. Its optimal cone shape ensures maximum product flow and yield. Compatible with autoclave and automatic lifting hoist systems, this container supports sterilized in place (SIP) applications, making it suitable for aseptic processing. The container is available in volumes ranging from 2L to 20L with connection sizes from DN50 to DN150. Fabricated from 316L stainless steel or Alloy 22, it complies with the European Pressure Equipment Directive and has a pressure rating up to 6 bar (87 psi), including full vacuum. Optional features include vibration devices and handle grips for enhanced usability.

Stainless steel container for powder transfer

In pharmaceutical and biotechnological production, maintaining sterility and cleanliness of equipment is imperative. Contamination of product contact surfaces can lead to product recalls or production halts. Ensuring thorough, contained cleaning of these surfaces is a critical challenge faced by these industries.
<h2>Ensures contained cleaning of bottles and containers</h2>
The Bottle Wash Station is designed to provide thorough cleaning of ChargePoint passive units and connected containers. It features a penetrating WIP lance that allows the safe coupling and uncoupling of passive units in a contained manner. This lance, enclosed in flexible PTFE bellows, moves up and down to wash valve and disc faces as well as the inside of process containers. Additionally, it incorporates a drain connection, ensuring the efficient removal of wash fluids. With the option for manual or automatic operation, this station supports different operational needs. Constructed from 304 stainless steel, it offers durability and compliance with industry standards.

Bottle cleaning station for controlled environments

In pharmaceutical and biotech industries, ensuring sterility during the transfer of sensitive ingredients or small components is critical. Maintaining the integrity of sterile areas while processing toxic powders or high-value products can be challenging without appropriate equipment.
<h2>Enhance sterility assurance with aseptic transfer</h2>
The ChargePoint AseptiSafe® range of aseptic split butterfly valves provides enhanced sterility assurance for handling sensitive ingredients and small components. These valves offer advanced sterilization options such as autoclave and SIP (steam-in-place), making them ideal for installation in higher-grade cleanrooms with Isolator/RABS or existing LAF systems. The SIP method ensures sterilization prior to material transfer, maintaining the critical area integrity and minimizing the need for cumbersome personal protective equipment. With features such as in-board ports for clean Grade A air and remote filter/fan units, these valves are designed for high containment dust control and efficient transfer. ChargePoint Technology ensures that these valves meet GMP requirements and optimize the processing of poorly flowing, high-value products.

Aseptic transfer valve for sterility assurance

When working with ChargePoint Active valves in a GMP environment, ensuring the containment integrity when the valve is not actively in use is necessary. Contamination of valve disc interfaces can compromise the integrity of future processes and lead to potential safety hazards.
<h2>Maintain and protect valve containment integrity</h2>
The Active GMP plug by ChargePoint Technology is designed to protect the valve disc of an active unit when not in use. Made from HDPE and sealed with an EPDM O-Ring, the plug prevents contamination by locking securely inside the valve. It is suitable for ChargePoint valve sizes ranging from DN50 (2 inches) to DN300 (12 inches). The Active GMP plug is essential for maintaining containment, thus protecting both the users and the environment, while also preserving the value of the valve and the products being transferred. This practical solution is built for ease of use, ensuring high standards in GMP environments.

Active Gmp plug for valve containment

Pharmaceutical production environments often need efficient and reliable methods for handling RTU (Ready-to-Use) containers to maintain sterility and streamline processes. Traditional methods can involve significant manual labor and risks of contamination or breakage, especially when dealing with high volumes.
<h2>Automates tub de-bagging and de-nesting efficiently</h2>
The CombiSys machine DDC 90106 from Bausch+Ströbel is equipped with three work stations for the automatic de-bagging and de-nesting of tubs. The first station heats the adhesive around the tub to remove the lid and liner simultaneously by suction, disposing both into a bin integrated within the base for simple disposal. The second station handles tub de-nesting, and the third station uses compact holders to extract RTU containers from the nest by suction, transferring them to the next process step without glass-to-glass contact. The DDC 90106 supports up to 12,000 items per hour, with container diameters ranging from 7 to 30 mm and heights from 35 to 100 mm. It is specifically designed for pharmaceutical applications, ensuring optimal laminar airflow and easy, centralized operation.

Automatic tub de-bagging and de-nesting solution

<span style="font-weight: 400">The heating process is a step of raising the temperature of food, pharma, cosmetics, and many other types of products. You may employ different heating solutions for this process, depending on the type of product you intend to manufacture. Selecting the appropriate heater machine for your product is quite important since various products require different ranges of temperatures and different ways of heat transfer using exchangers. Industrial heating equipment varies in two ways - the type of material it can process and the reaction you want to achieve.</span>

Heating

In pharmaceutical manufacturing, thorough and consistent cleaning of containers such as vials, bottles, and ampoules is crucial to maintain product integrity and comply with stringent industry regulations. Traditional cleaning methods may fall short in effectively handling diverse container types and sizes, particularly those that are non-stable.
<h2>Ensure pharmaceutical-grade cleaning of containers</h2>
The FAW cleaning machines from Bausch Stroebel are designed specifically for wet cleaning of vials, bottles, ampoules, and similar containers. They gently convey containers through the work area in an intermittent flow, using a pressure-controlled rinsing and spraying system to ensure optimal cleaning. Various cleaning media can be utilized in any chosen order, preventing mixing through a well-configured line system. These machines are suitable for pharmaceutical applications requiring strict adherence to standards. Models like the FAW1005 and FAW1120 can handle up to 12,000 and 13,300 items per hour, respectively, accommodating containers with diameters ranging from 7.5 mm to 95 mm and heights from 22 mm to 250 mm. The system also offers a range of optional features, including water recycling, container-optimized cleaning needles (ECOwash system), and oil-free air supply. The FAW series meets GMP requirements and FDA guidelines (21 CFR Part 11) and can be customized for enhanced efficiency and compliance.

Vial and bottle cleaning system for pharmaceutical use

Ensuring aseptic conditions during the transfer of components into cleanrooms or isolators in pharmaceutical production is critical. Cross-contamination can significantly impact product safety and efficacy, necessitating advanced sterilization methods.
<h2>Decontaminate outer surfaces using pulsed Uv light</h2>
The Type 411, Puv-A-Tech™ from Bausch Group, is designed for sterile transfer by using pulsed ultraviolet radiation light to decontaminate outer surfaces. This enclosed chamber reaches up to a 6-log reduction within 5-30 seconds of exposure. Placed as a pass-through into cleanrooms or isolators, it maintains process containment by allowing components to be loaded by either an operator or robotic arm. The entire cycle, including loading, exposure, and unloading, completes within 20-60 seconds, ensuring the complete decontamination of the unit's interior and components. Post-cycle, components are ready for further processing. Available as both stand-alone and in-line models, the chamber provides 100% verification on every cycle, ensuring reliability.

Sterile transfer chamber for pharmaceutical components

Handling bulk materials often involves transferring contents between containers or bins and other processing equipment. This can produce dust, posing a contamination risk and requiring additional cleaning steps.
<h2>Ensure dust-free transfers with minimal manual effort</h2>
The AZO Docking Collar is designed to enable dust-free docking of containers and bins in the bulk-materials processing industry. Its patented shape and pliable material create a secure, dust-free connection between containers and downstream inlet pieces such as dosing screws and fall pipes, without using mechanically or pneumatically moved parts. This simple construction not only ensures easy handling but also facilitates fast mounting and dismounting, boosting overall operational efficiency. Made from food-grade rubber, it meets high hygiene standards, making it suitable for applications in industries that require stringent cleanliness. The construction allows straightforward cleaning, reducing downtime and maintenance efforts.

Dust-free docking collar for containers and bins

During product transfer in pharmaceutical and biopharma settings, sealing packages safely and effectively is crucial. The goal is to prevent contamination and ensure that packages remain secure under various conditions.
<h2>Seal packages with high-strength Pa material ties</h2>
The closure system from Austar is designed for contained sealing of product packages during transfers, using a continuous liner or BIBO. Made from high-strength PA material, this system boasts a high melting point and resistance to common solvents. It features a double-locking mechanism for safety and reliability. The included clamping and shearing tools ensure stable and verifiable sealing performance. The cutting section remains tight and flat, minimizing dust exposure. Additionally, the system supports special tamper-proof labels that enable destructive opening only. The toolset includes crimping pliers, cutting tools, a bag opener, and sealing labels.

Closure system for aseptic containment

Sealing

In the pharmaceutical industry, producing non-sterile active pharmaceutical ingredients (APIs) often involves challenges like dust containment, precise material handling, and operator safety during processing and packaging. Effective systems are required to manage these aspects, especially for highly toxic or flammable materials.
<h2>Ensure safe and efficient Api production</h2>
The non-sterile API production line by Austar provides a comprehensive solution for manufacturing powder and solid pharmaceutical formulations. The closed feeding system in the chemical synthesis workshop ensures a dust-free process, reducing labor intensity and minimizing environmental impact from vaporized organic solvents. Depending on the material properties and feed amounts, different systems are available, including Closed Unloading Stations for FIBCs, Dust-free Feeding Stations for small bags, and Containment Reactor Feeding Systems for highly toxic and flammable materials. The BPC and Intermediate Quantitative & Packaging System handles crushing, sieving, metal detection, and automatic measurement in a closed environment, enhancing weight accuracy and reducing manual labor. For highly-active and highly-toxic materials, the combined filtration dryer and isolator provide an OEB3-OEB5 compliant closed packaging system, ensuring operator safety and higher product yield.

Non-sterile Api production line for powder and solid formulations

Sieving machines are available in various designs such as linear sieves, tumbler sieves, and vibrating sieves each employing a different sieving action. The choice of a suitable sieving machine depends on the desired particle size distribution, required amplitude and frequency of vibrations, and the physical state of the mixture. Sieving machines are used for removing dust from granular products and for grading grains. They are also used for the classification of granular material and the separation of solids from a slurry mix in the food processing industries.

Sieving

While handling highly toxic or pharmacologically active drugs, maintaining a controlled and safe environment is crucial. Workers need systems that ensure containment to avoid cross-contamination and exposure, meeting different operational exposure bands and ensuring sterile conditions.
<h2>Ensures safe, sterile environments for toxic drug handling</h2>
The glove box isolator from Austar provides a flexible solution for maintaining controlled environments under adjustable positive or negative pressure. Equipped with HEPA filters for both inlet and exhaust air, it can filter and collect air containing toxic dust, ensuring protection for operators and the environment. The system supports laminar air flow for sterile processes, and can be customized to work with material transfer systems like RTP, continuous bag devices, or split butterfly valves. Capable of meeting OEB3 to OEB5 containment levels, this isolator also offers the option of SMEPAC testing to verify system performance in actual use cases.

High containment isolator for toxic and active drug handling

Drawing samples and testing them for conformity with preset quality standards allows manufacturing units to produce a consistent quality of the product. In a batch process, sample testing systems ensures that each batch meets the specified standards. In a continuous process, product and materials testing helps in the early identification of quality issues, saving significant time and resources, and preventing a sub-standard product from reaching the market. The selection of industrial testing equipment depends on the identification of key quality parameters. These parameters may include volume, weight, viscosity, hardness, particle size distribution, sterility, gauge and containment, among other parameters. Testing machinery need regular calibration to ensure that the parameters being tested are accurate. Some of the more common testing solutions include thermal imagers, scratch testers, optical inspectors and texture analyzers.

Testing

Ensuring sterile liquid transfer during pharmaceutical manufacturing is crucial for maintaining product safety. The challenge lies in transferring fluids across sterile boundaries in environments like isolators or RABS without contamination.
<h2>Maintain sterility during liquid transfers</h2>
The AT-Port™ System by Aseptic Technologies is an alpha-beta aseptic liquid connection system designed to enable safe liquid transfer between different containment classification areas while ensuring sterility. Its core components include the Connector Port, and the Disposable Connector Devices, AT-Connector™ and AT-Connect™. The AT-Connector™ is suited for large volumes and can be used for up to five opening-closing operations, ensuring reliable, repeated use. The AT-Connect™ is ideal for precise, low volume transfers, maintaining sterility with seamless integration into aseptic filling lines. Made with silicone and thermoplastic elastomer (C-Flex®) tubing, it ensures all product contact points remain sterile. Distributed by Sartorius Stedim under the name Gammasart Aseptic Transfer Device (ATD™), this system is widely used in cGMP pharmaceutical formulation, fill & finish, and other critical liquid product handling applications.

Aseptic liquid transfer connection system

Transfer

In pharmaceutical production, coating tablets containing high-potency active pharmaceutical ingredients (HPAPIs) requires stringent containment to ensure operator safety and compliance with occupational exposure limits.
<h2>Ensures operator safety and compliant coating processes</h2>
The SECURECOAT 125 by ACG is designed to safely coat tablets containing oncological, cytotoxic, biopharmaceutical, hormonal, and other high-potency drugs, ensuring operator safety and compliance with occupational exposure band (OEB) 4 standards. This system provides complete containment during product charging and discharging through bins and split valves. Its vacuum-based sampling mechanism allows contained sampling throughout operation. Uniquely designed baffles ensure effective tablet rolling, matching the mixing and coating efficiency of the SMARTCOATER X•ONE baffles, and are easy to clean. Strategically positioned washing nozzles simplify washing, while the wash-in-place (WIP) rack guarantees thorough cleaning of inaccessible areas. The advanced X•ONE command and control system, compliant with ATEX, GAMP 5, and 21 CFR Part 11, allows intuitive, secure monitoring and control. Suitable for batches up to 125 liters, the SECURECOAT 125 is ideal for pharmaceutical applications requiring stringent containment measures.

Containment tablet coater for high-potency pharmaceuticals

To coat your consumer products with color or taste-enhancing substances, specialized technologies are available that ensure all the contents are individually and evenly covered. The process starts with loading your goods onto rotating drums, exposing the products to spray nozzles that treat them with your prescribed coating formula.

Coating

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

Industrial washing systems are used to clean and disinfect a variety of items in research and manufacturing facilities. Industrial washers use solvents and cleaning agents with mechanical action to remove deposits and residues from stainless steel machinery components, empty containers, and other soiled surfaces. The selection of an industrial or commercial washer depends on the type of items and surfaces to be cleaned, the type of deposits/residue that is typically present, whether drying is required after rinsing and the level of sterilization necessary. Manufacturers will have cleaning specifications and as a result, require washers to be engineered to meet these specs.

Washing

From GMP and HSE perspective material transfer is critical for chemical and pharmaceutical formulations. Risky substances, such as high-potency API, cadmium in batteries or other substances increase the complexity of processes, particularly in regard to safety. Containment solutions are, therefore, crucial for applications like powder handling during feeding, metering, discharge or even sampling.


<h3>Dispense, transfer and contain sampling ingredients with a single-use valve system</h3>
Andocksysteme developed a passive-passive split butterfly valve to discharge hazardous substances safely and reliably. The AVAX valve system meets the occupational exposure limits of ≤ 1 µg/m³ (OEB 5 requirements).

The hygienic components comply with the specific requirements of pharmaceutical and biopharmaceutical standards produced in a cleanroom environment. The solutions are also suitable for sterile applications.

The AVAX valve applies the bayonet coupling method to ensure superior containment performance during dispensing and handling.
This containment interface can be optionally be pre-fitted with different bag volumes and executions as complete product transfer solution serving different process challenges.

The system is also available in stainless steel and optional with an active flange execution. This range of versions is fully compatible and components fit seamlessly to each other no matter their material.

Single-use containment valves

The discharge of materials demands strict containment, particularly in the pharmaceutical industry. But big bags, even if sealed, can rip under sustained pressure while in dock position. The risk becomes significantly greater when handling toxic chemicals.
<h2>Big bag discharge docking station for sterile and toxic applications</h2>
Big Bag Discharge Docking System from Dec Group is a pressure-tight system designed for sterile and toxic processing. A wholly-sealed unit, the technology provides containment up to &lt;1 µg/m<sup>3</sup>.

The single dead zone free docking tube is enclosed by an automated cover and ensures a quick operation. An adjustable disposable ring seals the big bag spout, and any remaining liner is easily removed from the side port. The system can be built in various materials and coatings, including stainless steel and HC22.

High containment big bag discharge docking system

Loading powder from a container source to vessels, tanks, or mixers that are under pressure may be hazardous as it tends to explode due to electrostatic charging from collision of the powder particles. Controlling the batch loading of powder particles avoids the risk of explosion and integrating this system into other loading processes can increase safety, hygiene, and production output.


<h2>Loading powders in vessels safely by using both pressure and vacuum</h2>
The PTS powder transfer system from Dec, is a system that uses pressure and vacuum to transfer dry or wet powder and granules from a source to the loading access of vessels, tanks, or reactors. These include very fine powders (&lt;1 micron), wet and cohesive powders (above 50% wetness, as well as low MIE powders (&lt;1 mJ). The system drives the powder into the vessels with no product retention, no particle damage, no segregation, and very low electrostatic charging. It is equipped with a filtration concept using a flat membrane that enables dense phase conveying at a low velocity of 1-3m/s and powder concentrations of 50 to 150 kg powder per kg air. It is also available in an explosion-proof design that can handle 10 bars. The system is hygienic and easy to clean with no need for dismantling.

Powder transfer system

Safe transfer of liquids and hazardous powders into systems can be a challenge in pharma, biopharma and chemical industries. That’s because the slightest possibility of exposure or spillage could cause cross-contamination. Butterfly valves are expensive and clumsy to operate. Technicians require a better solution that is cheaper, faster and easy to operate.
<h2>Disposable Transfer System for Safe Powders and Liquids Transfer</h2>
Ezi-Dock EZI_FLOW™ CSV4 all-plastic valves are a simple, effective solution for transferring liquids and powders in the pharma and biopharma sphere. Their innovative design delivers the ultimate combination of high containment and low cost. They are suitable for reactor charging, extruder charging, powder filling lines and many other applications.

The operator offers up a charge bag containing liquid or powder to the EZI_FLOW™ all-plastic valve. They turn a toggle lever next, to securely attach these parts together. After they have achieved a contained seal they release the charge bag contents through the valve.

Single-use containment valve

Thermal and mechanical changes can lead to stresses in industrial piping systems. These stresses can be transferred to components causing misalignment and leakages. They may also cause inaccuracies in weighing and other sensitive measurements.


<h2><strong>Connect chutes and process equipment without pipe stress</strong></h2>
Andocksysteme offers a wide range of compensators and bellows to eliminate misalignment and stress-related issues. These components provide a reliable, stress-free connection between transfer chutes and process equipment with strict weighing requirements. They are ideal for transfer of powders in the pharmaceutical industry. A complete range of injection mold tooling allows Andocksysteme to produce compensators and bellows in the desired length and thickness.

The internal diameter of the compensator is matched to the diameter of the process-chute to eliminate difficult to clean crevices or ledges and allow effective WIP/CIP. Andocksysteme bellows and compensators offer a range of material hardness and connection standards. Material choices include FDA compliant white and black EPDM, Viton, silicone (on request) and FFKM / FFPM elastomers for particularly aggressive duties.

Bellows for pharmaceutical powders

Powder containment is the cornerstone of chemical and pharmaceutical manufacturing. Floating particles do not only represent efficiency loss but serious hazards too. Lack of tightness during the powder discharge process leads to cross-contamination and operational health risks.


<h3>Dock transfer systems squarely in place</h3>
The ASBV active/passive valve interface by Andocksysteme locks into position, minimizing exposure of material during powder discharge. The system has two split valves – one active, one passive – that can be easily and reliably centred on each other at a tolerance of ± 14 mm.

Once the units are docked, the valve discs open simultaneously, preventing exposure of the products during transfers. The dust-tight environment achieves contamination values lower than 1µg/m3.

The ASBV solution is fitted with EPDM seals and are optional with a wide range of materials, such as PTFE, offering top-range chemical resistance. All seals are made from FDA-approved materials and can handle a wide range of temperatures as well as explosion-proof executions.

Washing the ASBV interface is simple as the system can be connected to a WIP loop to flush out residual powders. These containment solutions serve applications with an exceptional performance and are easy to be integrated. Moreover, high quality parts and reduced complexity drives simple maintenance.

High containment split butterfly valve

Valves fitted in blenders and dryers can have dead spaces that prevent complete processing of the product and negatively affect quality. Ordinary valves can also be difficult to clean and often need dis-assembly for complete cleaning.


<h2><strong>Control product flow with completely opening valves</strong></h2>
Ball valves from Andocksysteme are used in piping, blenders, mixers, dryers, reactors, agitator vessels and sluices to fully allow or completely shut the flow of a product. A segment ball valve consists of a housing and a ball segment supported on both sides by maintenance-free bearings and sealed with an inflatable seal. Andocksysteme ball valves allow even difficult flowing products to pass the valve's unobstructed full bore in a short amount of time. They can be used as both inlet and outlet valve.

Andocksysteme ball valves are also available with CIP nozzles or retractable CIP lances for cleaning without disassembly. They are ideal for dryers and blenders as they have a minimum of dead space which increases product quality. All Andocksysteme ball valves are certified according to air quality control TA-Luft VDI 2440.

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High containment segment ball valve

Drawing a sample for evaluation from a running process is not a simple task, especially when dealing with sensitive products. Sampling can break product containment and lead to issues with product quality as well as pose health hazards in the work environment.


<h2><strong>Take samples from a running process without compromising containment</strong></h2>
The ASAM Andocksysteme sampler is the first valve in the pharmaceutical and chemical industry capable of taking a sample from a running process under high containment requirements. The sampler consists of two parts each with one-half of a sphere. The active part of the sampler is firmly attached, with a pad-flange, to the process container from which sample is to be taken. The passive part of the sampler is equipped with a split valve with integrated bore hole and a container for the product sample. The sampler can also be connected to a glove box for evaluation. The containment values achievable are less than 0.01µg/m3.

The contamination-free sampler ASAM can be directly integrated to dryers, agitators, centrifuges, silos, product tubes and other process containers. The halves of the split valves with their specific PTFE seals make SIP and CIP applications possible by means of a special tool.

High containment sampler

Tubing frameworks can have rough welding joints, corners and sharp angles that are difficult to clean and maintain. Welded frameworks require time and effort to erect and cannot be easily collapsed for shipping or storage.


<h2>Build tubing frameworks quickly</h2>
ACON from Andocksysteme is a GMP compliant, removable connection for tubing. It can be used to build a tubing framework in all imaginable forms. ACON-connections are water tight and find applications in chemical, pharmaceutical and food industry. The clean, aseptic design is ideal for processing units in clean rooms. ACON connections have no angles, corners, welding joints or visual screws and are therefore easy to clean. Tubing frameworks are easy to assemble with ACON connections and minimize shipping and assembly costs.

Removable GMP compliant connections for tubing

Transferring powders from drums to process equipment such as reactors or mills can create dusty and hazardous conditions in a manufacturing environment and can be a source of worker exposure to hazardous substances in the pharmaceutical and bioprocess industries. Experienced biopharmaceutical manufacturers know that equipment designed for general industry use often falls short and rigid containment and transfer solutions for the biotech industry are often awkward and inefficient. Producers that embrace flexible solutions designed specifically for the challenges of our industry will find an advantage over competitors.


<h2>Safely and easily empty powder drums without sacrificing containment</h2>
ILC Dover is an industry leader in contained material handling solutions for high-tech manufacturers and end users including NASA. The company's flexible contained drum transfer system allows operators to empty the powdered contents of drums used in the pharmaceutical and bioprocess industries without exposure to the contents. The contents are also protected from potential contamination during the transfer process using this equipment. A flexible containment chamber made from ILC Dover’s rugged Armorflex material is anchored to a raised stainless steel frame using ergonomic bungee cords. The containment chamber includes a discharge sleeve, a drum sleeve, and 2 glove sleeves for operator manipulation of the drum lid and internal liner under contained conditions. A closed drum is placed on the integrated pneumatic drum lift and the drum sleeve is attached. The discharge sleeve is attached to a ring in the frame designed to interface with downstream process equipment. The containment chamber is at a height off the floor which allows the powder to be gravity fed into downstream process equipment or containment solutions placed under it. The operator then raises the drum to the containment chamber with the simple actuation of a lever and opens the lid using the integrated glove sleeves. This manual interaction allows the operator to ensure that all powder flows out of the drum liner to the next process stage without being directly exposed to it. When the drum is empty, its spent liner is placed inside of it and its lid replaced. It is then lowered back to the floor and discarded. The sleeves in the flexible containment system are twisted closed and crimped off ensuring no powder contamination of the surrounding environment. The containment chamber is then discarded and the process repeated for each new drum to be transferred.

Flexible contained drum transfer system

<span style="font-weight: 400">At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with </span><span style="font-weight: 400">chemicals or hazardous substances since they can be potentially dangerous to human health. </span>

Packing

Filling of transportation bags and discharging them into mix tanks or reactor vessels is often a source of contamination and there potential exposure of personnel to harmful substances.  Inadequate measures to avoid these issues often slow production and reduce profitability.  Experienced biopharmaceutical manufacturers know that equipment designed for general industry use often falls short and rigid containment and transfer solutions for the biotech industry are often awkward and inefficient. Producers that embrace flexible solutions designed specifically for the challenges of our industry will find an advantage over competitors.


<h2>A fast and clean flexible powder transfer system</h2>
ILC Dover is an industry leader in contained material handling solutions for high-tech manufacturers and end users including NASA. The company's EZ BioPac is a single use solution to contamination free powder transfer for the bioprocessing and pharmaceutical industries.  The system consists of a rigid polypropylene stand with an integrated plastic bag.  The stand holds the bag in an open funnel shape for filling and doubles as a lifting point when the bag is ready to be emptied from the bottom.  The bag is oversized and includes enough material to fold back over the stand during filling to protect the stand from any spillage during filling.  The funnel shape of the supported bag in the filling configuration allows for easy manual addition and subtraction of material to ensure accurate fill weights.  A charge neck at the bottom is clamped to your reactor vessel or fill the tank for discharging and a system of clamps is used to manually control material flow and seal the bag for disposal after it is empty.  Isolation of the contained material is thus maximized, greatly reducing cross-contamination of the powder by substances from the work area, and of the work area by the handled powder.

Flexible contained handling of powder transfer bags

Bagging is the process of packaging measured portions of a product into bags that protect it from spoilage, enable easy and safe transportation, and secure the product against tampering and pilferage. The choice of bagging equipment depends on the desired mass or volume per bag, the flow characteristics of the product, and bag construction and design. Bags vary in size from small sachets to bulk flexible containers. Bagging systems are often the last processing step that is generally integrated into a production line.

Bagging

Biotech equipment is used for cellular and biomolecular processing to develop products that improve our lives and the planet. With the help of specialized lab equipment, the active substance is manufactured or extracted from biological origin materials and typically produced in bioreactors by plant cells, microbial cells, yeast cultures, or mammalian cells. Cell isolation, cultivation, cell banking, and culture expansion are called upstream processes. After harvest, the production process moves into a downstream process to meet purity and quality requirements which is divided into cell disruption, purification, and polishing. Biotechnology equipment makes use of various laboratory machinery such as bioreactors, centrifuges and incubators.

Biotech

Testing device of the containment capability of gloves, which is as important as the other parts of the integrated system; and a simple, accessible means of checking interface integrity is critical.


<h2>Testing system to enable fast, easy measurement of glove containment efficiency</h2>
Glove Tester from Telstar Life-Sciences is a low cost manually operated single port testing device designed to allow both in situ and offline testing.

Constructed of acetyl or 316L stainless steel, the device uses air pressure to check glove integrity. It can be designed to suit all types of Telstar ACE glove ports as well as other port brands. The tester inflates the glove at +500Pa pressure for a period of at least five minutes. A leak is indicated by a drop in the pressure reading of the display gauge. An optional colour indicator gives an instant pass/fail assessment.

Glove tester

Contained transfer systems

API making equipment must observe rigorous quality control standards across the entire manufacturing process. The pharmacodynamic properties of active pharmaceutical ingredients API make them highly sensitive to their environment, making API manufacturing and production a tightly regulated field.

Active pharmaceutical ingredients (API)

The click and puff of inhalers is a universal signal for respiratory conditions. Inhalers quickly grew into preferred drug delivery systems for asthma and COPD. Dry inhaler powder formulation produces a more stable drug than liquid dosage forms. Moreover, inhaler ingredients are more resistant to bacterial growth.

Dry inhaler powder

The word parenteral comes from Greek and means outside the intestine (para=outside and enteron=intestine). In fact, when it comes to parenterals, we are referring to those dosage forms that are administered directly into the bloodstream using a hypodermic needle, avoiding going through the gastrointestinal tract. Using parenteral filling equipment, parenteral solutions are placed in containers such as vials, syringes, or ampoules.

Parenterals

Pharmaceutical cartridges are glass containers of cylindrical shape, suitable for liquid or solid pharmaceutical dosage forms. Generally, these are designed for a specific apparatus such as pre-filled syringes and autoinjectors. Drugs that can be placed in cartridges using a pharmaceutical cartridge filling equipment include insulin, dental anesthesia, and other emergency drugs for allergies.

Pharmaceutical cartridges

Some of the vaccines in use today were originally developed decades ago. But advances in research, expertise and vaccine development equipment provide immunizations from bacterial and viral diseases (antibodies and cell therapy) to more people every year. The Covid 19 pandemic highlights the urgent need to scale up the production of vaccines and ensure an automated as well as reproducible manufacturing environment.

Vaccines

Connect directly with world leading manufacturers of Contained transfer systems and find technology to build or improve your production line.