Semi-automatic filling system for cell and gene therapy
Optimize your cell and gene therapy processes with a modular filling solution that ensures aseptic conditions while minimizing product loss. Ideal for precise dispensing of viral vectors, intermediates, and final products, this system enhances line efficiency with scalable batch sizes and automated innovations.

Performs Aseptic Filling and Air Removal
The ValueCell FILL from Comecer is a semi-automatic aseptic filling system designed for the precise dispensing of cell and gene therapy products. It stands out with its integrated refrigerated storage and modular design, ensuring homogenous mixing with gentle paddle mixers, while maintaining sterility through controlled air removal. Suitable for pharmaceuticals, viral vectors, and cell therapeutics production, it efficiently scales to meet fluctuating demands with a capacity to fill up to 150 bags per hour. Utilizing a peristaltic pump system, it minimizes cell stress and product loss through reverse pumping, supporting continuous operation with customizable bag sizes and integration into existing pharma processes. Built for cGMP production, it features an intuitive touchscreen HMI for programmable filling, ensuring compliance with stringent pharmaceutical standards. The ValueCell FILL offers robust solutions for automated scaling and precision in high-stakes biopharmaceutical environments.
Benefits
- Ensures product integrity with aseptic filling in controlled environments.
- Minimizes product loss through reverse pumping, maximizing yield.
- Scales with production growth to meet varying batch sizes.
- Enhances operator efficiency with automated bag sealing solutions.
- Maintains compliance with cGMP production standards.
- Applications
- Viral vectors,Cell,Gene therapy,Intermediates,Final cell products,Media
- End products
- Mesenchymal stem cell products,Car-t cell therapies,Genetically modified stem cells,Adenoviral vectors,Induced pluripotent stem cells (ipscs),T-cell therapeutics,Monoclonal antibodies in media,Lentiviral vectors,Plasmid dna intermediates
- Steps before
- Cell culturing,Media preparation,Solution formulation,Dilution
- Steps after
- Cryopreservation,Quality control,Product storage,Distribution
- Input ingredients
- source material,viral vectors,intermediates,media,dilution components,cryopreserving components
- Output ingredients
- final cell product,filled bags,intermediate bags
- Market info
- Comecer is known for manufacturing advanced containment and isolation systems, particularly in the pharmaceutical and nuclear medicine sectors, with expertise in custom-engineered equipment, ensuring high safety and compliance standards.
- Automation
- Semi-automatic
- Fill rate
- Up to 150 bags in 1 hour (20 mL fill)
- Filling volume
- Customizable bag size range (50-250ml standard)
- Product loss
- Near zero product loss with reversible pump
- Operating Environment
- Suitable for Grade C environments
- Storage Temperature
- Refrigerated
- Control Interface
- Programmable touchscreen HMI
- Pump Speed
- Selectable for reduced cell stress
- Air Removal Method
- Initial bag collecting air during priming
- Reversable Pump
- Yes
- Mixing system
- Paddle mixers
- Paddle Mixer
- Gentle for homogenous mixture
- Bubble Sensors
- In-line bubble sensors
- Weigh Scales
- Ensure proper dispensing
- Quality Control Bag
- Built-in QC bag
- Bag Filling Paths
- Dual paths
- Automation level
- Manual / PLC
- Batch vs. continuous operation
- Batch
- Cleaning method
- Closed system
- Changeover time
- Minimal due to modular design
- Scalable batch sizes
- Customizable
- Air removal process
- Initial bag collecting air
- Product saving mechanism
- Reverse pumping
- Dual bag filling paths
- Efficient throughput
- Integrated mixing system
- Optional paddle mixers
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Machine footprint
- Compact
- Bag size range
- 50-250 ml
- Storage capacity
- Integrated large capacity refrigerator
- Reservoir feature
- Used for priming and air collection
- Control panel type
- Touchscreen HMI
- Discharge method
- Reverse pumping for product saving
- Modular structure
- Yes
- Refrigeration module
- Yes,with paddle mixers
- Control panel type
- Programmable touchscreen HMI
- Automation level
- PLC-controlled
- Bag size
- Customizable 50-250ml range
- Mixing system
- Gentle paddle mixers,optional automated mixing
- Bag manifold flexibility
- Adaptable number of bags on manifold
- Pump speed selection
- Adjustable for reduced cell stress
- Refrigeration module
- Integrated large capacity refrigerator
- Automated bag sealing
- Under development for future availability
- Batch size scalability
- Adaptable to production growth