Semi-automatic filling system for cell and gene therapy

Optimize your cell and gene therapy processes with a modular filling solution that ensures aseptic conditions while minimizing product loss. Ideal for precise dispensing of viral vectors, intermediates, and final products, this system enhances line efficiency with scalable batch sizes and automated innovations.

Performs Aseptic Filling and Air Removal

The ValueCell FILL from Comecer is a semi-automatic aseptic filling system designed for the precise dispensing of cell and gene therapy products. It stands out with its integrated refrigerated storage and modular design, ensuring homogenous mixing with gentle paddle mixers, while maintaining sterility through controlled air removal. Suitable for pharmaceuticals, viral vectors, and cell therapeutics production, it efficiently scales to meet fluctuating demands with a capacity to fill up to 150 bags per hour. Utilizing a peristaltic pump system, it minimizes cell stress and product loss through reverse pumping, supporting continuous operation with customizable bag sizes and integration into existing pharma processes. Built for cGMP production, it features an intuitive touchscreen HMI for programmable filling, ensuring compliance with stringent pharmaceutical standards. The ValueCell FILL offers robust solutions for automated scaling and precision in high-stakes biopharmaceutical environments.

Benefits

  • Ensures product integrity with aseptic filling in controlled environments.
  • Minimizes product loss through reverse pumping, maximizing yield.
  • Scales with production growth to meet varying batch sizes.
  • Enhances operator efficiency with automated bag sealing solutions.
  • Maintains compliance with cGMP production standards.

General


Applications
Viral vectors,Cell,Gene therapy,Intermediates,Final cell products,Media
End products
Mesenchymal stem cell products,Car-t cell therapies,Genetically modified stem cells,Adenoviral vectors,Induced pluripotent stem cells (ipscs),T-cell therapeutics,Monoclonal antibodies in media,Lentiviral vectors,Plasmid dna intermediates
Steps before
Cell culturing,Media preparation,Solution formulation,Dilution
Steps after
Cryopreservation,Quality control,Product storage,Distribution
Input ingredients
source material,viral vectors,intermediates,media,dilution components,cryopreserving components
Output ingredients
final cell product,filled bags,intermediate bags
Market info
Comecer is known for manufacturing advanced containment and isolation systems, particularly in the pharmaceutical and nuclear medicine sectors, with expertise in custom-engineered equipment, ensuring high safety and compliance standards.

Technical Specifications


Automation
Semi-automatic
Fill rate
Up to 150 bags in 1 hour (20 mL fill)
Filling volume
Customizable bag size range (50-250ml standard)
Product loss
Near zero product loss with reversible pump
Operating Environment
Suitable for Grade C environments
Storage Temperature
Refrigerated
Control Interface
Programmable touchscreen HMI
Pump Speed
Selectable for reduced cell stress
Air Removal Method
Initial bag collecting air during priming
Reversable Pump
Yes
Mixing system
Paddle mixers
Paddle Mixer
Gentle for homogenous mixture
Bubble Sensors
In-line bubble sensors
Weigh Scales
Ensure proper dispensing
Quality Control Bag
Built-in QC bag
Bag Filling Paths
Dual paths

Operating Characteristics


Automation level
Manual / PLC
Batch vs. continuous operation
Batch
Cleaning method
Closed system
Changeover time
Minimal due to modular design
Scalable batch sizes
Customizable
Air removal process
Initial bag collecting air
Product saving mechanism
Reverse pumping
Dual bag filling paths
Efficient throughput
Integrated mixing system
Optional paddle mixers

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Physical Characteristics


Machine footprint
Compact
Bag size range
50-250 ml
Storage capacity
Integrated large capacity refrigerator
Reservoir feature
Used for priming and air collection
Control panel type
Touchscreen HMI
Discharge method
Reverse pumping for product saving
Modular structure
Yes
Refrigeration module
Yes,with paddle mixers

Custom Options


Control panel type
Programmable touchscreen HMI
Automation level
PLC-controlled
Bag size
Customizable 50-250ml range
Mixing system
Gentle paddle mixers,optional automated mixing
Bag manifold flexibility
Adaptable number of bags on manifold
Pump speed selection
Adjustable for reduced cell stress
Refrigeration module
Integrated large capacity refrigerator
Automated bag sealing
Under development for future availability
Batch size scalability
Adaptable to production growth