Let's make HPMC capsules
The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.
What hpmc capsules equipment do you need?
Easy to validate capsule filler
Staying competitive in today’s highly dynamic and highly regulated pharmaceutical prod...
Granulation line for pharmaceutical solid dosage forms
Granulation is a common technique in production of pharmaceutical ...
Industrial scale tablet coater
During the coating process, tablets pass many stages that can make them wet and sticky or cra...
Fluid bed dryer for pharmaceutical solid dosage form
Fluid bed drying is a pharmaceutical process carried out to reduce t...
Industrial high shear mixer granulator for drug formation
It is rather difficult to successfully produce a pharmaceutica...
Tablet coater for laboratory scale
Tablet coating can be applied for adding colours or glosses, or based around sugar in or...
Tablet counting machine
Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and c...
Pharmaceutical bottle unscrambler
Pharmaceutical packaging industry requires the ability to quickly manage the process yet ...
Dessicant inserting machine
Desiccant canisters play an important role in the pharmaceutical and nutraceutical industries. T...
Semi-automatic capsule filler
Hard gelatin capsules are a popular format for delivering a wide variety of pharmaceutical dos...
Automatic filling line for solid doses
For medium-scale production of solid doses such as tablets, capsules, and softgels t...
Automatic capsule loader
Capsules are a popular method of dosage delivery for a wide range of compounds. For anything other t...
Electronic capsule counter
For lab work or small batch production, hand counting of solid doses into dispensing containers i...
Capsule checkweigher
The production of pharmaceutical capsules requires that individual doses are checked for accuracy. In a ...
High-yield capsule filler
Pharmaceutical manufacturers require maximum yield from their encapsulation process for efficient ...
Conical mill for drug formulation
The efficient size reduction of granular powders is a key step in many pharmaceutical pro...
Granulation line of mixer and fluid bed dryer
A complete granulation line allows for the mixing and granulation of pharmac...
Microencapsulation system for your drug delivery system
Whether you want to improve the stability of nutrients, protect a...
High capacity capsule filler
In the highest volume pharmaceutical production environments, capsule filling needs to be extre...
Scale up capsule filler
For higher production volumes of pharmaceutical capsules, speed, accuracy and reliability of producti...
Entry level capsule filler
For the production of pharmaceutical doses in capsule form complete accuracy of fill is paramount...
Rotary tablet press
For pharmaceutical tablet producers looking to reduce waste, costs and increase production volume, a hig...
Fluid bed dryer for production scale
Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for dryi...
Fluid bed dryer for lab scale
Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compo...
Fluid bed dryer and mixer for lab scale
Designed for pharmaceutical R&D, a lab-scale fluid bed dryer and mixer/granulat...
High-shear mixer
For the efficient mixing of larger batches of pharmaceutical compounds and high-shear mixer provides the opti...
Entry-level high-shear mixer for drug formulation
For pilot and lab-scale pharmaceutical formulations, a high-shear granu...
R&D hard gelatin capsule sealing machine
When encapsulating products at temperatures up to + 80°C, these tend to solid...
High-speed blister machine
If you are looking for a compact machine that produces blisters with an output of up to 700 blist...
Horizontal intermittent motion cartoner
User-friendly cartooning solution with an intermittent motion for a wide range of p...
Horizontal continuous motion cartoner
An automatic cartoning machine designed for both high-speed operations and medium pac...
Entry-level blister machine
A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...
Compact blister machine
A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...
Case packer for cartons and bundles
Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...
Stretch bander
A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.
Vertical cartoner
A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...
Checkweigher for capsules
The new interactive indicator unit allows for even easier use. High-rigidity weighcells have been ...
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HPMC manufacturing equipment must operate at higher temperatures
HPMC is one of many types of pharmaceutical capsules. As a result, it will require slightly different production processing. HPMC capsules is produced using a dipping-pin method, similar to the technique used to produce gelatin capsules. But the Hypromellose solution needs to be kept at higher temperatures (around 70°C), and shells take longer to form on the manufacturing pins.
Moreover, the structure of HPMC capsules is significantly more fragile than that of gelatin. Processing with drying and filling equipment must therefore operate at a gentler pace.
Hygroscopic materials are compatible HPMC capsule ingredients
One limitation of traditional animal-based gelatin is that absorbent and adsorbent materials gradually weaken the shell walls.
On the other hand, HPMC capsules offer superior stability at a broader range of heat and moisture variances. This makes them better suited for hygroscopic formulations such as zinc chloride or sodium hydroxide.
HPMC opens opportunities for the production of vegan enteric-coated tablets
The generic capsule owes its success as a pharmacological product to the efficacious delivery of drugs. HPMC capsules are not only as easy to swallow as hard-gel alternatives, but they carry an identical dissolution rate in-vivo.
In addition, the matt properties of Hypromellose make it a viable option for delayed and extended-release medical formulations. HPMC, thus, shows promise for the manufacturing of plant-based enteric-coated tablets.
Processing steps involved in HPMC capsules making
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