Capsule Making Equipment
Which capsules equipment do you need?
Restricted-access barrier systems
Aseptic barrier systems
Glove tester
Half-suit tester
Sterility test isolators
Negative pressure isolator
High-speed blister machine
Compact blister machine
Entry-level blister machine
Horizontal continuous motion cartoner
Horizontal intermittent motion cartoner
Vertical cartoner
Stretch bander
Case packer for cartons and bundles
R&D automatic capsule filler
R&D semi-automatic capsule filler
R&D capsule orientater
R&D hard gelatin capsule sealing machine
R&D electronic counter for capsules and tablets
Checkweigher
Checkweigher for capsules
Easy to validate capsule filler
High-yield capsule filler
Automatic capsule filler
Contained capsule filler
Automatic laboratory capsule filler
Automatic capsule filler for liquid solutions
Laboratory capsule filler for liquid solutions
Industrial capsule checkweigher
Economic dispersing machine for emulsions and suspensions
Ultra-fine dispersing machine for emulsions and suspensions
Laboratory dispersing machine for low-viscous masses
Versatile weight sorter for tablets & capsules
Benchtop weight sorter for tablets & capsules
Microencapsulation system for your drug delivery system
Entry-level high-shear mixer for drug formulation
High-shear mixer
Conical mill for drug formulation
Fluid bed dryer and mixer for lab scale
Fluid bed dryer for lab scale
Fluid bed dryer for production scale
Granulation line of mixer and fluid bed dryer
Entry level capsule filler
Scale up capsule filler
High capacity capsule filler
Capsule checkweigher
High capacity weight sorter for tablets & capsules
Waste minimization weight sorter for tablets & capsules
Automatic weigher and mixer of confectionery ingredients
Dissolver of confectionery syrups
Thin-film cooker for confectionery products
Starch-free depositor for hard candy
Portable IBC washer
IBC bin washer and dryer
CIP system for bulk tanks
GMP chamber washer
GMP washer
Loading basket for GMP washer
Entry-level chamber washer
Bulk chamber washer
Softgel capsules polisher
Gelatin melters and tanks
Softgel tumble dryer
Continuous in-line softgel drying system
Softgel drying tunnel
Automatic soft gelatin capsule machines
Laboratory scale soft gelatin capsule machine
Automatic capsule loader
Semi-automatic capsule filler
Automatic filling line for solid doses
Semi-automatic powder dosing machine
Electronic capsule counter
Suppository filling machine
Metal detector for tablets and capsules
Tablet counting machine
Pharmaceutical bottle unscrambler
Dessicant inserting machine
Fluid bed dryer for pharmaceutical solid dosage form
Industrial high shear mixer granulator for drug formation
Granulation line for pharmaceutical solid dosage forms
Particle analysation monitor
Lifter and De-duster for Tablets
High Speed Visual Inspection System for Tablets
High speed bottle filler with inspection
Effective Visual Inspection System for Capsules
Contained Visual Inspection System
Cold forming aluminum blister machine for capsules
Clinical trial lab sealer for a laminar airflow bench
Automatic medical forming and sealing blister machine for packing capsules and tablets
Semi-automatic forming and sealing blister machine
Blister inspection system
Flat carton serialization station
Inspection system for tablets chemical composition
Serialization and aggregation system
Serialization tracking system
Serialized labels inspection and printing station
Vision inspection system for tablets and capsules
Software to differentiate between the original pharmaceutical barcode and a reprint
Flat carton coding machine
Individual item serialization equipment
Serialization equipment for cases
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Select your capsules process
Tell us about your production challenge
What are you making?
Mold the shells into shape with capsule manufacturing equipment
Capsule shells are composed of the body and the cap that closes the dosage. Capsule manufacturing equipment dips a series of steel pins into a drum filled with the base material. The wet molding pins move to the drying chamber to harden as they spin on their axis to ensure even distribution.
Once the shells are formed, they are stripped off the pins. But they are not yet finished for filling. The empty capsules must first be cut to the correct length and joined in a pre-lock position, ready for encapsulation.
Pair the API with the correct shell before the capsule filling process
Encapsulation technology lines up the capsule bodies on a bed of holders. A stainless steel dosage system pours the formula in the powder tray into the shells. The caps, aligned precisely in their holding section, are ready to be lowered onto the filled capsule bodies. The fins in the body enter the slits of the cap, locking them into position.
The encapsulated ingredients directly impact shell stability. Hygroscopic materials, for example, risk cracking the gelatin capsules. Capsule filling machines must account for the properties of the dosage formula and the materials, thickness, and shelf life of the shells.
Capsule production is either an automatic, semi-automatic or manual process. Manual capsule fillers are still used in smaller production facilities. However, for making large scale pharmaceutical capsules, automation is employed to maximize output and efficiency.
Control the water content in hard gelatin capsules to balance plasticity and containment
The first hard gelatin capsules were filled with pharmaceutical formulas in powder form. But one of the advantages of encapsulation is that it offers flexibility with a range of dosage solutions, from tablets to beads to micro-capsules.
This versatility means that the gelatin shells have to deliver stability. The gelatin mix must allow enough moisture content to create elasticity without altering the properties of the encapsulated APIs.
Insufficient drying temperature leads to undesirable air pockets in soft gelatin capsules
Soft gelatin capsules, also known as softgels, are suitable for non-aqueous solutions such as oil. The active pharmaceutical ingredients are dissolved or suspended into an oil-based form.
One of the challenges in producing softgel capsules is the formation of air bubbles in the gelatin base. This happens when the capsule manufacturing equipment fails to reach the right temperature during the drying stage, and air remains trapped in the mixture. These pockets of unreleased air weaken the structure of the capsule.
HPMC capsules are more suitable hygroscopic fillings
Hypromellose emerged as the plant-sourced alternative to gelatin. But HPMC capsules are less dependent on water content, making them a better solution for hygroscopic ingredients.
However, since Hypromellose has a higher oxygen permeability, the fill ingredients need anti-oxidant additives to compensate. HPMC capsules also require oxygen-resistant packaging, such as aluminum blister configurations.
Blister packs offer greater protection for pharmaceutical capsules
The packing solution depends on the type of capsule. Vitamin or food supplement capsules may be bottled in simple containers. However, a desiccant pouch helps to absorb moisture and maintain a controlled environment.
In the case of pharmaceutical capsules, the ingredients demand safer packaging. Blister packs are more secure and are more convenient for dosage control. Complete blister packaging solutions often include coding and die-cutting systems, but simple entry-level batch machines are also available.