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The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19th century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

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Mold the shells into shape with capsule manufacturing equipment

Capsule shells are composed of the body and the cap that closes the dosage. Capsule manufacturing equipment dips a series of steel pins into a drum filled with the base material. The wet molding pins move to the drying chamber to harden as they spin on their axis to ensure even distribution.

Once the shells are formed, they are stripped off the pins. But they are not yet finished for filling. The empty capsules must first be cut to the correct length and joined in a pre-lock position, ready for encapsulation.

Pair the API with the correct shell before the capsule filling process

Encapsulation technology lines up the capsule bodies on a bed of holders. A stainless steel dosage system pours the formula in the powder tray into the shells. The caps, aligned precisely in their holding section, are ready to be lowered onto the filled capsule bodies. The fins in the body enter the slits of the cap, locking them into position.

The encapsulated ingredients directly impact shell stability. Hygroscopic materials, for example, risk cracking the gelatin capsules. Capsule filling machines must account for the properties of the dosage formula and the materials, thickness, and shelf life of the shells.

Capsule production is either an automatic, semi-automatic or manual process. Manual capsule fillers are still used in smaller production facilities. However, for making large scale pharmaceutical capsules, automation is employed to maximize output and efficiency.

Control the water content in hard gelatin capsules to balance plasticity and containment

The first hard gelatin capsules were filled with pharmaceutical formulas in powder form. But one of the advantages of encapsulation is that it offers flexibility with a range of dosage solutions, from tablets to beads to micro-capsules.

This versatility means that the gelatin shells have to deliver stability. The gelatin mix must allow enough moisture content to create elasticity without altering the properties of the encapsulated APIs.

Insufficient drying temperature leads to undesirable air pockets in soft gelatin capsules

Soft gelatin capsules, also known as softgels, are suitable for non-aqueous solutions such as oil. The active pharmaceutical ingredients are dissolved or suspended into an oil-based form.

One of the challenges in producing softgel capsules is the formation of air bubbles in the gelatin base. This happens when the capsule manufacturing equipment fails to reach the right temperature during the drying stage, and air remains trapped in the mixture. These pockets of unreleased air weaken the structure of the capsule.

HPMC capsules are more suitable hygroscopic fillings

Hypromellose emerged as the plant-sourced alternative to gelatin. But HPMC capsules are less dependent on water content, making them a better solution for hygroscopic ingredients.

However, since Hypromellose has a higher oxygen permeability, the fill ingredients need anti-oxidant additives to compensate. HPMC capsules also require oxygen-resistant packaging, such as aluminum blister configurations.

Blister packs offer greater protection for pharmaceutical capsules

The packing solution depends on the type of capsule. Vitamin or food supplement capsules may be bottled in simple containers. However, a desiccant pouch helps to absorb moisture and maintain a controlled environment.

In the case of pharmaceutical capsules, the ingredients demand safer packaging. Blister packs are more secure and are more convenient for dosage control. Complete blister packaging solutions often include coding and die-cutting systems, but simple entry-level batch machines are also available.

Which capsules technology do you need?

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Integrated Uv-vis spectrophotometer for dissolution testing

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Automated dissolution testing system for 16 vessels

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Automatic blister packaging for pharmaceuticals

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Horizontal cartoning system for coffee pods

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Uv laser writer for high-speed tablet marking

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Inspection system for tablets chemical composition

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Particle analysation monitor

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Contained Visual Inspection System

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Continuous in-line softgel drying system

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Softgel drying tunnel

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Gelatin melters and tanks

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Rotating sample divider for large bulk materials

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Packaging system for stacked coffee pods

Efficiently package your pods with precise counting and sealing, ensuring optimal ...

Automatic case packaging for pods in single bags

Optimize your production line by streamlining the packaging of coffee and...

Filter paper pod production system

Streamline your production of single-serve beverages with precise weight control and sea...

Pod production system for filter paper pods

Streamline your pod production with a high-speed solution that ensures precise...

Label dispenser integration for packaging lines

Streamline labeling operations with precision and flexibility, ensuring yo...

Automated conveyor systems for food packaging lines

Seamlessly integrate high-speed product transport and handling into y...

Vacuum mixing system for emulsion and homogenization

Achieve seamless emulsion and homogenization with precision: this sy...

Integrity tester for filtration system validation

Ensure precise validation of your filtration systems with highly accura...

X-ray inspection system for large bulk products

Ensure consumer safety and product quality by efficiently detecting contam...

Water activity headspace analyzer for drug product samples

Ensure precise control of moisture levels across the entire p...

High-performance thermoforming tools for packaging

Optimize your packaging production with versatile thermoforming tools,...

Fiber thermoforming system for sustainable packaging

Achieve fast, efficient production of biodegradable fiber packaging ...

Vertical intermittent motion stick packaging

Experience seamless packing for diverse products, from powders to dense paste...

Horizontal intermittent motion sachet packaging solution

Optimize your packaging operations with a versatile sachet solut...

Lifting column for drums and containers

Streamline your production with lifting columns designed for precise handling, blen...

High-speed blister packaging with integrated cartoner

Optimize your blister packaging process with a solution that seamle...

Pharma parts washer for efficient cleaning

Enhance your washing process efficiency with a compact solution designed to sav...

Bin tumbler for efficient mixing

Achieve precise blending and homogenizing of powders and granules with dual-inclination des...

Vacuum dryer for powders and granules

Achieve precise moisture control for sensitive materials with a versatile vacuum dryi...

X-ray inspection system for contaminant detection

Detect and eliminate foreign contaminants in a wide range of food produ...

Side entry mixer for industrial fluid mixing

Optimize your fluid mixing processes with high-speed side entry mixers, desig...

Vacuum conveyor for hygienic material transfer

For operations demanding swift, dust-free material handling, this solution ...

Laboratory and pilot scale blending module

Efficiently integrate multiple blending functions on a single drive for streaml...

Industrial bin blenders for uniform batch production

Optimize your blending process by achieving uniform mixtures with in...

Stainless steel intermediate bulk containers for pharmaceutical use

Ensure safe, efficient transport and handling of po...

Conical mills for size reduction in pharmaceutical production

Achieve precise particle size control with an innovative m...

Drum tippers for precise and safe drum handling

Streamline your operations by eliminating manual lifting and aligning proc...

High-capacity cgmp washer/dryer for cleanrooms

Optimize your cleanroom operations with this compact washer/dryer, designed...

Cost-effective rigid-wall isolator for aseptic applications

Ensure sterility and safety with a versatile isolation and d...

Laser particle sizer for accurate particle size distribution

Achieve precise control over particle size distribution wit...

Laboratory film coating system for development and clinical batches

Achieve precision in tablet coating with a versatil...

Pilot High shear granulator for wet granulation

Achieve consistent particle sizing and superior homogeneity in your powder...

Vacuum transfer system for powders and granules

Effortlessly transfer and manage powders and granules with seamless integr...

Double cone mixer for free flowing powders and granules

Achieve uniform blending of powders and granules with precision, ...

Intermittent stick pack system for pharmaceuticals

Effortlessly streamline your packaging process with a high-speed, mult...

Consumables for elemental analyzers

Optimize your laboratory’s elemental analysis with high-quality consumables desig...

Pharmaceutical granulation line

Streamline your production with an integrated system that combines mixing, granulation, and ...

Laboratory twin screw extruder for small batch processing

Efficiently develop formulations and conduct precise research ...

Weigh filler for bulk quantities 2-20kg

Optimizing your filling process with precision, this equipment handles bulk quantit...

Static checkweigher for accurate measurement

For those needing unparalleled precision, this static checkweigher ensures ex...

Precision weigh filler for food and pharma industries

Optimize precision in multi-component dosing with seamless integrat...

Microdosing system for granules and powder

Achieve precise dosing with minimal variance across all fills, ensuring consist...

High containment powder transfer valve

Ensure high containment for potent powders in your production line, reducing contami...

High containment powder transfer valve for bulk material

Ensure operator safety and prevent cross-contamination with robu...

Single use valves for powder transfer

Efficiently transfer powder ingredients with a single-use containment solution, ensur...

Bottle cleaning station for controlled environments

Ensure high-level decontamination of passive units and containers wit...

Single use powder handling bags for pharmaceutical ingredients

Achieve contamination-free powder transfers with ease, ma...

Bulk powder transfer safety device

Ensure stable and secure docking by minimizing equipment damage during powder transfer p...

Self-adhesive labeling system for bottles

Streamline your bottling operations with high-precision labeling that enhances p...

Coffee processing system for integrated coffee production

Enhance your coffee production with a versatile system that in...

Coffee roasting system

Optimize your coffee production from green beans to finely ground espresso with this versatile system,...

Material handling system for confectionery production

Optimize your production line with a system designed for efficient ...

Leak detection unit for coffee pods

Ensure the integrity of your coffee pods with precise leak detection, vital for maintai...

Cost-effective dosing container for minor ingredients automation

Optimize your production by streamlining ingredient han...

Closure system for aseptic containment

Achieve secure and verifiable seals for sterile pharmaceuticals with advanced closur...

Automatic visual inspection for sterile preparations

Ensure the integrity of sterile products with precise visual inspect...

Particle size control equipment for pharmaceutical applications

Achieve precise particle size control for diverse materi...

Vibration batch dryer for difficult solids

Ensure efficient drying of complex solids prone to sticking and shape irregular...

Dry granulation technology

Achieve precise control over particle size and density with our compacting and granulation soluti...

Pharmaceutical roller compaction solution

Optimize your pharmaceutical tablet production with precision granulation and co...

Vacuum conveyor for powder and granule transfer

Ensure efficient and contamination-free transfer of powders and granules w...

Tube feeder for pharmaceutical and personal care industries

Optimize your production line with this high-speed tube feed...

Moisture analyzer for laboratory samples

Accurate moisture analysis is crucial for ensuring product quality in pharmaceutic...

Intermittent motion cartoning machine for blister packs

Optimize your packaging line with a space-efficient cartoning mac...

Desiccant inserter for pharmaceutical containers

Prevent product degradation by efficiently inserting desiccants into cont...

Vacuum powder filler for dairy and pharmaceutical products

Achieve precision and maintain product integrity with a versa...

Rotary roller vibrators for material flow assistance

Enhance material flow efficiency in your production line with high-f...

External electric motovibrator for increased safety in hazardous environments

Designed for environments with explosive...

Cushioned pneumatic linear vibrators for bulk solids

Combat material bridging and rat-holing with silent vibratory techno...

Ibc docking and discharge stations

Ensure seamless material transfer with dust-free docking and effective discharge, mainta...

Industrial container mixing system for high viscosity media

Effortlessly blend high-viscosity liquids and slurries with ...

Rotary pouch packaging system for food and powder products

Streamline your packaging process with a rotary system that e...

Endload automatic cartoning solution

Streamline your packaging line with this versatile cartoning solution, perfect for eff...

Top load cartoner for various carton shapes

Optimize your production line with a versatile cartoning solution, perfect for...

Topload cartoner for packaging cartons

Efficient flap closing for diverse carton sizes, ensuring gentle handling of sensiti...

Rotary premade pouch filler and sealer

Maximize production efficiency by seamlessly filling and sealing diverse pouch sizes...

Automatic rotary filler and sealer for premade pouches

Enhance your production line efficiency with a dual-lane system th...

Automatic rotary premade pouch filler and sealer

Optimize your production line with high-speed pouch filling and sealing, ...

Automatic rotary premade pouch filler for various industries

Streamline your pouch packaging process with precision fill...

Premade pouch fill and seal solution

Effortlessly fill and seal various pouch sizes for streamlined packaging in diverse fo...

Automatic rotary premade pouch filler for food products

Enhance your packaging line with a high-speed solution designed t...

Product inspection systems for contamination control

Ensure product safety and compliance with precision inspection techn...

Automated infeed and outfeed systems for packaging lines

Streamline your production line by integrating reliable infeed a...

Support structures for packaging lines

Enhance safety and efficiency in your production line with robust support structures...

Modified atmosphere packaging solutions for perishables

Extend the freshness and shelf life of perishable goods with prec...

Robotic palletizing and depalletizing systems

Enhance your production efficiency by automating the repetitive and labor-in...

Industrial printers and labelers for packaging

Ensure precise package identification and traceability with robust printing...

Robotic packaging integration for automated systems

Enhance your production line efficiency with seamless robotics integr...

Supply air filter systems for industrial cleanrooms

Ensure critical air purity and operational safety in sensitive enviro...

Containment single-use filter module

Ensure safe handling of high-potency substances and streamline filtration processes wi...

Industrial chiller systems for processing cooling

Optimize your production line with advanced chiller systems designed to...

Industrial food portioning system

Optimize your production flow with precision portioning equipment designed to handle a di...

Pneumatic diverting valve for powder and granule transfer

Efficiently redirect bulk materials from one point to another ...

Handheld particle counters for cleanroom environment monitoring

Ensure precision in contamination monitoring and quality...

Washing machine for pharmaceutical stoppers and caps

Streamline your aseptic processing with precise washing, sterilizati...

Sterility testing isolator for aseptic environment

Ensure precise sterility testing and prevent contamination with an iso...

Production-level ultrafiltration system for industrial applications

Achieve precise concentration and separation of val...

High-purity nitrogen generator for pharmaceutical and food industries

Achieve ultra-high purity levels in your producti...

Industrial freeze dryer for pharmaceutical applications

Enhance your production line with precision cleaning solutions fo...

Compact high-torque extruder for customizable extrusion tasks

Ensure precise control over your extrusion processes with ...

Atex approved hammer mills for high-capacity particle size reduction

Ensure precise and reliable particle size reductio...

Semi-automatic capping machines for versatile applications

Enhance your packaging efficiency with versatile semi-automat...

Saturated steam sterilizer for pharmaceutical production

Ensure sterility for a diverse range of pharmaceutical products ...

Automated visual inspection for pharmaceutical products

Ensure the integrity and safety of your parenteral products with ...

Texture analyser for food and cosmetics testing

Ensuring consistent product quality across diverse food and cosmetic appli...

Material lifting system for dust-free transfer in pharma plants

Achieve seamless material transfer with reduced manual h...

Automated sample preparation workstation for content uniformity testing

Streamline your laboratory workflows with autom...

Automated sample preparation software for pharmaceutical testing

Streamline your laboratory’s sample preparation w...

Flow-through cell dissolution testing with Uv analysis

Effortlessly monitor real-time dissolution with flow-through cell ...

Powder flow tester for pharmaceutical powder flowability

Quickly assess powder flow characteristics to ensure consistent ...

Multi-parameter tablet hardness tester for laboratories

Optimize your tablet production line with a versatile tester that...

Automated dissolution testing with direct Hplc injection

Streamline your lab operations with precise and efficient direct...

Real-time Uv-vis analysis for dissolution testing

Efficiently perform dual dissolution tests simultaneously, seamlessly i...

Benchtop dissolution tester for multiple test runs

Streamline your laboratory’s workflow with a fully automated ben...

Self-cleaning dissolution tester for automated series testing

Achieve unparalleled precision in dissolution testing with...

Serialization equipment for cases

Serialization is a multi-stage process that includes printing, inspection, and labeling. ...

Individual item serialization equipment

Traceability is critical to quality assurance in the pharmaceutical sector. But ser...

Flat carton coding machine

The coding process is an essential step in the production line as it can provide trusted supply c...

Software to differentiate between the original pharmaceutical barcode and a reprint

Counterfeit products pose a serio...

Serialized labels inspection and printing station

Labels are a key component in pharmaceutical packaging lines as they in...

Serialization tracking system

To accommodate different products of varied sizes, the pharmaceutical industry requires handli...

Serialization and aggregation system

Manufacturers from the pharmaceutical industry require a variety of cartons, cases and...

Flat carton serialization station

The packaging lines in the pharmaceutical industry handle several flat cartons. Manual pa...

Clinical trial lab sealer for a laminar airflow bench

When running small production for clinical trials, stability studie...

Granulation line for pharmaceutical solid dosage forms

Granulation is a common technique in production of pharmaceutical ...

Fluid bed dryer for pharmaceutical solid dosage form

Fluid bed drying is a pharmaceutical process carried out to reduce t...

Industrial high shear mixer granulator for drug formation

It is rather difficult to successfully produce a pharmaceutica...

Pharmaceutical bottle unscrambler

Pharmaceutical packaging industry requires the ability to quickly manage the process yet ...

Dessicant inserting machine

Desiccant canisters play an important role in the pharmaceutical and nutraceutical industries. T...

Semi-automatic powder dosing machine

Powders or granules are common dose types used in many pharmaceutical and nutraceutica...

Suppository filling machine

Small-to-medium scale production of suppositories using pre-formed shells can be slow where manu...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a wa...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning an...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the productio...

Conical mill for drug formulation

The efficient size reduction of granular powders is a key step in many pharmaceutical pro...

Granulation line of mixer and fluid bed dryer

A complete granulation line allows for the mixing and granulation of pharmac...

Fluid bed dryer for production scale

Fluidized bed drying (FBD) is a common process in the pharmaceutical industry for dryi...

Fluid bed dryer for lab scale

Fluidised bed drying (FBD) is a common process in the pharmaceutical industry for drying compo...

Fluid bed dryer and mixer for lab scale

Designed for pharmaceutical R&D, a lab-scale fluid bed dryer and mixer/granulat...

High-shear mixer

For the efficient mixing of larger batches of pharmaceutical compounds and high-shear mixer provides the opti...

Entry-level high-shear mixer for drug formulation

For pilot and lab-scale pharmaceutical formulations, a high-shear granu...

Starch-free depositor for hard candy

Forming hard candies requires careful handling of syrups in order to avoid quality iss...

Thin-film cooker for confectionery products

Producing excellent confectionery products requires high quality cooking. Trad...

Dissolver of confectionery syrups

Many high quality confectionery products require a dissolved syrup as their starting poin...

Automatic weigher and mixer of confectionery ingredients

The production of accurately proportioned and homogenous slurrie...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Entry-level blister machine

A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

Checkweigher

A check weigher that is equipped with high speed/high accuracy force balance load cell. It meets stringent accura...

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