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The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19th century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Which capsules equipment do you need?

Restricted-access barrier systems

Create a physical barrier between the operator and the product. More flexible than an iso...

Aseptic barrier systems

Designed for sterile product and Potent API’s either with low or high OEL requirements.

Glove tester

Testing device of the containment capability of gloves, which is as important as the other parts of the integrate...

Half-suit tester

Designed to allow operators to perform sterility testing in an aseptic environment providing assurance of mat...

Sterility test isolators

Designed to avoid this risk and protect the product from both the process and externally generated f...

Negative pressure isolator

Used for products biologically hazardous, that also require minimized cross contamination.

High-speed blister machine

If you are looking for a compact machine that produces blisters with an output of up to 700 blist...

Compact blister machine

A compact blister machine ideal for packing tablets, capsules, ampoules and syringes and other applic...

Entry-level blister machine

A start-up solution for contract packing and generics manufacturing with an easy-to-get upgrade ...

Horizontal continuous motion cartoner

An automatic cartoning machine designed for both high-speed operations and medium pac...

Horizontal intermittent motion cartoner

User-friendly cartooning solution with an intermittent motion for a wide range of p...

Vertical cartoner

A cartoning solution that can be operated in either continuous or intermittent mode depending on the carton...

Stretch bander

A compact wrapping machine to seal your boxes with a max speed of 50 packs per minute.

Case packer for cartons and bundles

Pack cartons and bundles into RSC (Regular Slotted Case) cases and perform functions li...

R&D automatic capsule filler

Automatic capsule filling machine for powders, pellets, tablets, mini-tablets, capsule in capsu...

R&D semi-automatic capsule filler

Semi-automatic filling machine suitable to open, fill and close empty hard gelatin capsul...

R&D capsule orientater

A semi-automatic orienter for capsules with an output speed up to 6000 capsules.

R&D hard gelatin capsule sealing machine

When encapsulating products at temperatures up to + 80°C, these tend to solidify a...

R&D electronic counter for capsules and tablets

This machine has been designed to offer an ever-precise and reliable count...

Checkweigher

A check weigher that is equipped with high speed/high accuracy force balance load cell. It meets stringent accura...

Checkweigher for capsules

The new interactive indicator unit allows for even easier use. High-rigidity weighcells have been ...

Easy to validate capsule filler

Staying competitive in today's highly dynamic and highly regulated pharmaceutical production...

High-yield capsule filler

Pharmaceutical manufacturers require maximum yield from their encapsulation process for efficient ...

Automatic capsule filler

Capsule filling should be a worry-step in pharmaceutical and nutraceutical manufacturing.  The right...

Contained capsule filler

For pharmaceutical formulations that are highly active specialized capsule filling equipment is ofte...

Automatic laboratory capsule filler

Innovators in the highly regulated and highly dynamic pharmaceutical market place need ...

Automatic capsule filler for liquid solutions

Use of liquid filled hard capsules is increasingly popular with today's phar...

Laboratory capsule filler for liquid solutions

A recent important change in the industry is the trend toward providing liq...

Industrial capsule checkweigher

Pharmaceutical manufacturing demands the highest quality standards and completely consistent...

Economic dispersing machine for emulsions and suspensions

For products of medium viscosity and relatively consistent par...

Ultra-fine dispersing machine for emulsions and suspensions

Producing the finest micro-emulsions and suspensions require...

Laboratory dispersing machine for low-viscous masses

Laboratory mixers have not always been easy to work with.  Getting a...

Versatile weight sorter for tablets & capsules

Saving costs and improved production e...

Benchtop weight sorter for tablets & capsules

For laboratory pharmaceutical R&D w...

Microencapsulation system for your drug delivery system

Whether you want to improve the stability of nutrients, protect a...

Entry-level high-shear mixer for drug formulation

For pilot and lab-scale pharmaceutical ...

High-shear mixer

For the efficient mixing of larger batches of pharmaceutical compounds and hi...

Conical mill for drug formulation

The efficient size reduction of granular powders is a key...

Fluid bed dryer and mixer for lab scale

Designed for pharmaceutical R&D, a lab-scale fl...

Fluid bed dryer for lab scale

Fluidised bed drying (FBD) is a common process in the pharmace...

Fluid bed dryer for production scale

Fluidized bed drying (FBD) is a common process in the ...

Granulation line of mixer and fluid bed dryer

A complete granulation line allows for the m...

Entry level capsule filler

For the production of pharmaceutical doses in capsule form comple...

Scale up capsule filler

For higher production volumes of pharmaceutical capsules, speed, accu...

High capacity capsule filler

In the highest volume pharmaceutical production environments, c...

Capsule checkweigher

The production of pharmaceutical capsules requires that individual doses...

High capacity weight sorter for tablets & capsules

By employing a weight sorter that ...

Waste minimization weight sorter for tablets & capsules

For medium scale production, you ...

Automatic weigher and mixer of confectionery ingredients

The production of accurately pro...

Dissolver of confectionery syrups

Many high quality confectionery products require a dissol...

Thin-film cooker for confectionery products

Producing excellent confectionery products req...

Starch-free depositor for hard candy

Forming hard candies requires careful handling of syru...

Portable IBC washer

The thorough cleaning of bulk containers and other storage and processing...

IBC bin washer and dryer

Many pharmaceutical processes use IBCs of multiple sizes throughout ...

CIP system for bulk tanks

Clean in Place (CIP) technology offers many advantages, but tradit...

GMP chamber washer

The thorough cleaning of small product contact parts has always been chall...

GMP washer

In order to guarantee zero cross-contamination between production batches, the prop...

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be place...

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing ...

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceutical...

Softgel capsules polisher

The final stage in high quality softgel (or soft gelatin) capsule ...

Gelatin melters and tanks

When producing high quality softgels its important that the gelati...

Softgel tumble dryer

Softgel (or soft gelatin) capsules are a very popular means of deliverin...

Continuous in-line softgel drying system

High output softgel (or soft gelatin) capsule enca...

Softgel drying tunnel

Softgel capsules require a controlled secondary drying to reduce water ...

Automatic soft gelatin capsule machines

Soft gelatin (or softgel) capsules have become a po...

Laboratory scale soft gelatin capsule machine

Softgel (or soft gelatin) capsules are a ver...

Automatic capsule loader

Capsules are a popular method of dosage delivery for a wide range of compounds. For anything other t...

Semi-automatic capsule filler

Hard gelatin capsules are a popular format for delivering a wide variety of pharmaceutical dos...

Automatic filling line for solid doses

For medium-scale production of solid doses such as tablets, capsules, and softgels t...

Semi-automatic powder dosing machine

Powders or granules are common dose types used in many pharmaceutical and nutraceutica...

Electronic capsule counter

For lab work or small batch production, hand counting of solid doses into dispensing containers i...

Suppository filling machine

Small-to-medium scale production of suppositories using pre-formed shells can be slow where manu...

Metal detector for tablets and capsules

Identification of metallic contaminants is a vital part of pharmaceutical quality c...

Tablet counting machine

Production of pharmaceutical solid dosage forms usually require complete accuracy, flexibility, and c...

Pharmaceutical bottle unscrambler

Pharmaceutical packaging industry requires the ability to quickly manage the process yet ...

Dessicant inserting machine

Desiccant canisters play an important role in the pharmaceutical and nutraceutical industries. T...

Fluid bed dryer for pharmaceutical solid dosage form

Fluid bed drying is a pharmaceutical process carried out to reduce t...

Industrial high shear mixer granulator for drug formation

It is rather difficult to successfully produce a pharmaceutica...

Granulation line for pharmaceutical solid dosage forms

Granulation is a common technique in production of pharmaceutical ...

Particle analysation monitor

Products like granules, tablets and capsules require inspection at numerous steps in the produc...

Lifter and De-duster for Tablets

The use of several different tools for lifting, de-dusting, and polishing in the pharmaceut...

High Speed Visual Inspection System for Tablets

In order to ensure quality and standard specifications of tablets, capsule...

High speed bottle filler with inspection

Medicines in tablet, capsule, or soft gel forms undergo various processes before r...

Effective Visual Inspection System for Capsules

The attribute of capsule packing is a critical parameter that controls the...

Contained Visual Inspection System

In the medicine industry, it is important to ensure there are no defects in tablets or c...

Cold forming aluminum blister machine for capsules

Aluminum blisters are mainly used for packaging products that are sens...

Clinical trial lab sealer for a laminar airflow bench

When running small production for clinical trials, stability studie...

Automatic medical forming and sealing blister machine for packing capsules and tablets

Product safety is very importa...

Semi-automatic forming and sealing blister machine

As a manufacturer of medical device, the packaging is a critical facto...

Blister inspection system

The pharma and healthcare industries widely use blister thermoforming machines to package a variet...

Flat carton serialization station

The packaging lines in the pharmaceutical industry handle several flat cartons. Manual pa...

Inspection system for tablets chemical composition

The packaging of pharmaceuticals and oral solid products such as table...

Serialization and aggregation system

Manufacturers from the pharmaceutical industry require a variety of cartons, cases and...

Serialization tracking system

To accommodate different products of varied sizes, the pharmaceutical industry requires handli...

Serialized labels inspection and printing station

Labels are a key component in pharmaceutical packaging lines as they in...

Vision inspection system for tablets and capsules

Pharmaceuticals and healthcare product manufacturers dealing with oral ...

Software to differentiate between the original pharmaceutical barcode and a reprint

Counterfeit products pose a serio...

Flat carton coding machine

The coding process is an essential step in the production line as it can provide trusted supply c...

Individual item serialization equipment

Traceability is critical to quality assurance in the pharmaceutical sector. But ser...

Serialization equipment for cases

Serialization is a multi-stage process that includes printing, inspection, and labeling. ...
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Tell us about your production challenge

When selecting production equipment for a production plant, it is important to talk to someone with experience in your field. Our industry experts have experience with various industrial applications. We’d love to help you!
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Mold the shells into shape with capsule manufacturing equipment

Capsule shells are composed of the body and the cap that closes the dosage. Capsule manufacturing equipment dips a series of steel pins into a drum filled with the base material. The wet molding pins move to the drying chamber to harden as they spin on their axis to ensure even distribution.

Once the shells are formed, they are stripped off the pins. But they are not yet finished for filling. The empty capsules must first be cut to the correct length and joined in a pre-lock position, ready for encapsulation.

Pair the API with the correct shell before the capsule filling process

Encapsulation technology lines up the capsule bodies on a bed of holders. A stainless steel dosage system pours the formula in the powder tray into the shells. The caps, aligned precisely in their holding section, are ready to be lowered onto the filled capsule bodies. The fins in the body enter the slits of the cap, locking them into position.

The encapsulated ingredients directly impact shell stability. Hygroscopic materials, for example, risk cracking the gelatin capsules. Capsule filling machines must account for the properties of the dosage formula and the materials, thickness, and shelf life of the shells.

Capsule production is either an automatic, semi-automatic or manual process. Manual capsule fillers are still used in smaller production facilities. However, for making large scale pharmaceutical capsules, automation is employed to maximize output and efficiency.

Control the water content in hard gelatin capsules to balance plasticity and containment

The first hard gelatin capsules were filled with pharmaceutical formulas in powder form. But one of the advantages of encapsulation is that it offers flexibility with a range of dosage solutions, from tablets to beads to micro-capsules.

This versatility means that the gelatin shells have to deliver stability. The gelatin mix must allow enough moisture content to create elasticity without altering the properties of the encapsulated APIs.

Insufficient drying temperature leads to undesirable air pockets in soft gelatin capsules

Soft gelatin capsules, also known as softgels, are suitable for non-aqueous solutions such as oil. The active pharmaceutical ingredients are dissolved or suspended into an oil-based form.

One of the challenges in producing softgel capsules is the formation of air bubbles in the gelatin base. This happens when the capsule manufacturing equipment fails to reach the right temperature during the drying stage, and air remains trapped in the mixture. These pockets of unreleased air weaken the structure of the capsule.

HPMC capsules are more suitable hygroscopic fillings

Hypromellose emerged as the plant-sourced alternative to gelatin. But HPMC capsules are less dependent on water content, making them a better solution for hygroscopic ingredients.

However, since Hypromellose has a higher oxygen permeability, the fill ingredients need anti-oxidant additives to compensate. HPMC capsules also require oxygen-resistant packaging, such as aluminum blister configurations.

Blister packs offer greater protection for pharmaceutical capsules

The packing solution depends on the type of capsule. Vitamin or food supplement capsules may be bottled in simple containers. However, a desiccant pouch helps to absorb moisture and maintain a controlled environment.

In the case of pharmaceutical capsules, the ingredients demand safer packaging. Blister packs are more secure and are more convenient for dosage control. Complete blister packaging solutions often include coding and die-cutting systems, but simple entry-level batch machines are also available.

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