Containment capsule filling system for highly potent drugs

Ensure operator safety while filling capsules with high-potency drugs, including oncological and hormonal formulations, with this robust and precision-engineered containment system.

Ensures Safe Containment and Precise Capsule Filling

The SECUREFILL 6T from ACG is a high-containment capsule filling machine designed specifically for the precise and safe handling of highly potent active pharmaceutical ingredients (HPAPIs). Utilizing a monoblock structure of SS316L, this equipment incorporates HEPA filters, rapid transfer ports, and glove ports, maintaining a negative pressure environment to ensure operator safety. Ideal for biopharmaceuticals and oncological drug production, it efficiently handles the filling of capsules, soft gels, tablets, micro-tablets, and pellets. With a capacity of up to 6,000 capsules per hour, it supports both small batch and continuous production environments. The machine’s wet-in-place system and comprehensive containment features protect against formulation residues, facilitating easy cleaning and reducing contamination risks. Fully integrated for upstream and downstream processes, it complies with OEB level 4 standards and can seamlessly connect with check-weighers, metal detectors, and de-dusters, ensuring quality and safety across the production line.

Benefits

  • Ensures operator safety by maintaining containment within the OEL range of 1-10 µg/m³.
  • Supports efficient handling of highly potent drugs, reducing risk and compliance concerns.
  • Facilitates easy cleaning and minimizes contamination with its wet-in-place system.
  • Integrates with existing production lines, enhancing operational efficiency with upstream and downstream compatibility.
  • Certified for OEB level 4, ensuring adherence to strict safety and environmental standards.

General


Applications
Pharmaceutical capsules,Soft gels,Pellets,Hormonal drugs,Micro-tablets,Biopharmaceuticals,Highly potent active pharmaceutical ingredients (hpapis),Tablets,Oncological drugs,Antiviral formulations
End products
Oseltamivir phosphate capsules,Anastrozole,Acyclovir tablets,Omega-3 soft gels,Erythropoietin,Tamoxifen,Vitamin d pellets,Dexamethasone,Progesterone,Nirmatrelvir,Levothyroxine,Paroxetine micro-tablets,Multi-vitamin capsules,Azithromycin capsules,Ritonavir,Lamivudine,Trastuzumab,Interferon
Steps before
Granulation,Active pharmaceutical ingredient preparation,Material dosing,Mixing
Steps after
Capsule check-weighing,Metal detection,De-dusting,Packing
Input ingredients
pellets,tablets,micro-tablets,capsules,soft gels,highly potent active pharmaceutical ingredients (HPAPIs),oncological formulations,hormonal formulations,biopharmaceutical formulations,antiviral formulations
Output ingredients
filled capsules
Market info
ACG World is known for manufacturing capsules and capsule filling machines, providing integrated pharmaceutical solutions with a strong reputation for innovation, quality, and comprehensive service offerings in the pharmaceutical manufacturing industry.

Technical Specifications


Capsule sizes
00 - 5
Maximum speed
6,000 capsules/hr
OEL
1-10 µg/m³
Compliance
OEB up to level 4
Material of Construction
SS316L
Containment level
High containment
HEPA filter
Included
Wet-in-place system
Yes
Integrated systems
Check-weighers,metal detectors,de-dusters

Operating Characteristics


Batch vs. continuous operation
Batch
Cleaning method
Wet-in-place system
CIP/SIP
Wet-in-place
Automation level
PLC-controlled
Containment capability
OEB Level 4

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm


Occupational Exposure Band (OEB)
Level 4

Physical Characteristics


Control Panel Type
Touchscreen
Compact Footprint
Yes

Custom Options


Control panel type
PLC
Monoblock structure
SS316L
HEPA filters
Included
Glove ports
Included
Rapid transfer port (RTP)
Included