Containment capsule filling system for highly potent drugs
Ensure operator safety while filling capsules with high-potency drugs, including oncological and hormonal formulations, with this robust and precision-engineered containment system.

Ensures Safe Containment and Precise Capsule Filling
The SECUREFILL 6T from ACG is a high-containment capsule filling machine designed specifically for the precise and safe handling of highly potent active pharmaceutical ingredients (HPAPIs). Utilizing a monoblock structure of SS316L, this equipment incorporates HEPA filters, rapid transfer ports, and glove ports, maintaining a negative pressure environment to ensure operator safety. Ideal for biopharmaceuticals and oncological drug production, it efficiently handles the filling of capsules, soft gels, tablets, micro-tablets, and pellets. With a capacity of up to 6,000 capsules per hour, it supports both small batch and continuous production environments. The machine’s wet-in-place system and comprehensive containment features protect against formulation residues, facilitating easy cleaning and reducing contamination risks. Fully integrated for upstream and downstream processes, it complies with OEB level 4 standards and can seamlessly connect with check-weighers, metal detectors, and de-dusters, ensuring quality and safety across the production line.
Benefits
- Ensures operator safety by maintaining containment within the OEL range of 1-10 µg/m³.
- Supports efficient handling of highly potent drugs, reducing risk and compliance concerns.
- Facilitates easy cleaning and minimizes contamination with its wet-in-place system.
- Integrates with existing production lines, enhancing operational efficiency with upstream and downstream compatibility.
- Certified for OEB level 4, ensuring adherence to strict safety and environmental standards.
- Applications
- Pharmaceutical capsules,Soft gels,Pellets,Hormonal drugs,Micro-tablets,Biopharmaceuticals,Highly potent active pharmaceutical ingredients (hpapis),Tablets,Oncological drugs,Antiviral formulations
- End products
- Oseltamivir phosphate capsules,Anastrozole,Acyclovir tablets,Omega-3 soft gels,Erythropoietin,Tamoxifen,Vitamin d pellets,Dexamethasone,Progesterone,Nirmatrelvir,Levothyroxine,Paroxetine micro-tablets,Multi-vitamin capsules,Azithromycin capsules,Ritonavir,Lamivudine,Trastuzumab,Interferon
- Steps before
- Granulation,Active pharmaceutical ingredient preparation,Material dosing,Mixing
- Steps after
- Capsule check-weighing,Metal detection,De-dusting,Packing
- Input ingredients
- pellets,tablets,micro-tablets,capsules,soft gels,highly potent active pharmaceutical ingredients (HPAPIs),oncological formulations,hormonal formulations,biopharmaceutical formulations,antiviral formulations
- Output ingredients
- filled capsules
- Market info
- ACG World is known for manufacturing capsules and capsule filling machines, providing integrated pharmaceutical solutions with a strong reputation for innovation, quality, and comprehensive service offerings in the pharmaceutical manufacturing industry.
- Capsule sizes
- 00 - 5
- Maximum speed
- 6,000 capsules/hr
- OEL
- 1-10 µg/m³
- Compliance
- OEB up to level 4
- Material of Construction
- SS316L
- Containment level
- High containment
- HEPA filter
- Included
- Wet-in-place system
- Yes
- Integrated systems
- Check-weighers,metal detectors,de-dusters
- Batch vs. continuous operation
- Batch
- Cleaning method
- Wet-in-place system
- CIP/SIP
- Wet-in-place
- Automation level
- PLC-controlled
- Containment capability
- OEB Level 4
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Occupational Exposure Band (OEB)
- Level 4
- Control Panel Type
- Touchscreen
- Compact Footprint
- Yes
- Control panel type
- PLC
- Monoblock structure
- SS316L
- HEPA filters
- Included
- Glove ports
- Included
- Rapid transfer port (RTP)
- Included