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Capsule weighing

The two-piece capsule is a visual shorthand for all types of medical remedies. Advances in technology have made the production of hard-gelatin capsules a convenient delivery method for drugs and other ingested substances. But the simple solution requires micrometric precision to be manufactured to the proper pharmaceutical standards.

Hard gelatin capsules

The nonproprietary name for HPMC – hydroxypropyl methylcellulose – is such a mouthful that it has two abbreviations. Hypromellose is the other one. The non-ionized material offers a safe alternative to gelatin capsules, especially as most common API and excipients are suitable HPMC capsule ingredients.

HPMC capsules

Used in the pharmaceutical industry to produce tablets and capsules, among others, pharmaceutical granules are made to enhance the uniformity and flow of powder, increase the density of the blend and reduce dust and, therefore, toxic exposure. The choice of the granulation process, whether it is wet, dry, or direct compression, as well as the selection of appropriate pharmaceutical granulation equipment, depends on the specific drug being formulated.

Pharmaceutical granules

Softgel capsules fast-track the delivery of medication to the bloodstream. Unlike solid pills, they do not need to be broken down by the body before the drugs can be absorbed. Moreover, they are optimal vehicles for oils and fat-soluble formulations that cannot be compressed into tablets.

Softgel capsules

Multilayer tablets are a popular fixed-dose combination (FDC) offering a range of release profiles for effective drug delivery. Multilayer tablet technology solves challenges to API consistency, allowing manufacturers to develop formulations from incompatible ingredients while optimizing the release profile for immediate release and controlled release.

Multi-layer tablets

When taking a tablet, it is usually the job of our stomach to break down the medication to make it ready to be absorbed into the bloodstream. However, some drugs are not meant to be dissolved in the stomach because the acidic pH of the stomach can disintegrate the drug, making it no longer effective. Using tablet coating equipment that applies a polymer barrier to the tablet makes it possible to protect it from stomach acidity.

Enteric Coated Tablets

Microtablets range between 1 and 4 millimeters, making the dosage form an excellent delivery system in polypharmacy. The size of the products makes them easier pills to swallow, but microtablets production brings a unique set of complexities.

Microtablets

It has control panel exterior of stainless steel

Conveyor is both waterproof and non-water proof

High speed and high accuracy force balance

Possess metal detector

A checkweigher is a manual or an automatic machine used for checking the weight of packaged products. It is normally installed at the end of a production line and ensures that the weight of each unit is within the standard range. A high-speed production line requires a checkweigher that can match the speed of the process. Small or low-weight products, such as pharmaceutical capsules require high accuracy checkweighers for quality control purposes.

Industrial checkweighers

Food

Pharmaceutical

Weighing

Connect directly with world leading manufacturers of Weighing equipment and find technology to build or improve your production line.

Weighing &#8211; Making.com

The most important part of a capsule is its contents. But if the shell is not carefully made, the dosage ingredients inside lose effectiveness. From molding to sizing, capsule manufacturing equipment forms perfectly-matching husks ready for filling. The simplicity of encapsulation revolutionized pharmaceuticals since it was introduced in the 19<sup>th</sup> century. However, capsules are changing to increase delivery efficiency and reduce the dependency on gelatin.

Capsules

Our food chain starts in the soil, growing crops and livestock. But between the fields and the stores, there is a line of industrial food processing equipment. Processes may be as minimalistic as cleaning fruit and as complex as homogenizing milk alternatives made from pressed legumes. In each case, processing technology is an important link in the food production chain.

Pharmaceutical developments walk side by side with health advances to provide new medicines, treatments, and therapies that have increased life quality and extended life expectancy by years. Pharmaceutical manufacturing equipment helps deliver products to a great deal of the population, but there’s a significant share that doesn’t benefit from them yet. Over 2 billion people cannot get the medicines they need, according to the United Nations Industrial Development Organization, and local production might be a way to provide for these people.

Pharmaceuticals

Packaging

Continuous

Industrial measurement equipment is used as a crucial step before products leave the production line. These measuring instruments check for correct dosage and standards. Equipment for measurement and control employs a wide range of technologies to detect inconsistencies in volumes, sizes, weights, and fill levels as well as to inspect goods for quality against a set of criteria. Specialized measuring tools allow you to minimize the probability for error to its lowest possible, ensuring that both products and packaging meet your benchmarks.

Measurement &amp; Control

liquid

solid

The SSV-h checkweigher series of Anritsu are ideally suited for checking the weight of pharmaceutical and industrial products

A check weigher that is equipped with high speed/high accuracy force balance load cell. It meets stringent accuracy and reliability standards in

Checkweigher &#8211; Making.com

We open production technology to everyone

Making.com

anritsu-pharmaceutical-inspection-brochure-pdf

Anritsu-pharmaceutical-inspection-brochure.pdf

Feature high speed and accuracy

Advanced rejecting confirmation

Total screening data storage

  Meets GPM standards and validation requirements

The KW9001AP can measure up to 2,000 capsules; with each capsule individually checkweighed into three classifications every minute.

The new interactive indicator unit allows for even easier use. High-rigidity weighcells have been placed alternately on both sides of the weighing

Checkweigher for capsules &#8211; Making.com

ci-precision-weight-checking-brochure-pdf

CI-Precision-weight-checking-brochure.pdf

Sort a variety of doses without downtime for parts change

Suitable for continuous operation at up to 500,000 units per 24 hours

Reclaims weight-rejected product, reduces wastage

Highly accurate CI Precision balance

GMP design, all contact components stainless steel or PEEK

Among all dosage forms in use today, tablets constitute the most common one. They are pharmaceutical solid dosage forms containing active ingredients and excipients such as diluents, binders, glidants, and lubricants. Using tablet making equipment, these solid dosage forms are made by compression of granules or powder blends and then shaped by molding.

Tablets

Process

R&amp;D

Batch

In the pharmaceutical world, encapsulation refers to various techniques to enclose and protect the drug ingredients by forming the capsule shell. Encapsulation equipment changes depending on whether the manufacturer needs to produce a soft or hard gel capsule. For instance, encapsulation systems and machines for softgels control the entire process from start to finish because their shells are filled at the same time they are produced. On the other hand, the filling of hard gel capsules comes by separating the body from the cap, and after the filling operations, the two parts are sealed together again, forming the shell.

Encapsulation

Formulation technologies are an integral process in many industries such as pharma and food. Chemical mixtures require strict handling to combine the separate ingredients into the homogenized recipe that makes your final product. Formulation technology stores, mixes and subjects the elements to a range processing parameters according to your specifications to develop the base material. The resulting formulas are then weighed, formed, packaged, or sent for further formulation.

Formulation

By employing a weight sorter that is fully flexible and able to handle a wide variety of dose shapes and sizes you can benefit from reduced equipment cost

High capacity weight sorter for tablets &amp; capsules &#8211; Making.com

Sorts a variety of doses without downtime for parts change

Suitable for continuous operation at up to 210,000 units per 24 hours

Sorting is the process of arranging items systematically, using a specified criterion, to categorize and group similar items and identify non-conforming items for removal. The choice of a sorting machine depends on the type of item to sort, the sorting criteria, the number of categories that the items need to be sorted into, sorting speed, and accuracy. Sorting machines can be used in the food processing industry for sorting and categorizing fruits, vegetables, empty bottles, crates, and other items; other examples include sorting of tablets and capsules by weight for quality control in the pharmaceutical industry. As well as sorting waste in the recycling industry. Manual sorting is a laborious task however, with the use of specialized equipment, manufacturers are able to automate their sorting at high speeds.

Sorting

For medium scale production, you can improve line efficiency and reduce setup costs by opting for a fully flexible weight sorter that can handle a wide

Waste minimization weight sorter for tablets & capsules &#8211; Making.com

bakerperkins_weighing_mixing_system-pdf

BakerPErkins_weighing_mixing_system.pdf

bakerperkins_confectionery-pdf

BakerPerkins Confectionery

It’s important to get timing and temperature right when making caramel, and this implies being vigilant. For small scale production of caramel, ensure that your heat source distributes heat evenly and monitor the caramelization process closely. This prevents recrystallization and burning the sugar. For medium to large scale caramel production, consider investing in automated caramel making equipment.

&nbsp;

Caramel

Chewable tablets are suitable for patients who have difficulty swallowing. Chewable tablet formulation masks the natural flavors of pharma drugs and alters their aftertaste. But besides the taste, chewable tablets favor the bioavailability of pharmaceutical ingredients.

Chewable tablets

Chewing gum is usually a polymer that you mix with flavorings – which is something most consumers have no clue about. In a survey in Iceland, 85% of people said they didn't know the product contained plastic. While there are non-plastic options more recently available, the gum base is usually natural latex or a synthetic substitute. To decrease the impacts on the environment, some producers are shifting towards more environmental-friendly options.

Chewing gum

Long was the time when you could only make dragée chocolate – or, to simplify it, to cover chocolate with a layer of chocolate or sugar and then polish it or not. Now, you can use a chocolate panning machine to offer different types of dragée items. Mind that the process of panning may slightly differ according to the product you are making.

Dragee products

Gummy candy are a very popular confectionery, because they are versatile and appeal to a wide variety of tastes. Another reason for the popularity of this delicious candy is the fact that it’s easy to produce, particularly in small quantities. For medium to large scale production of gummies, there is a multitude of gummy manufacturing equipment to help ensure that you end up with a good product.

Gummies

The kitchen toaster may be the first appliance that a jam jar brings to mind. But turning fruit into the classic spreadable involves an entire line of jam processing equipment. The meticulous preparation for high-capacity jam manufacturing puts paid to the old idiom 'money for jam'.

Sweets, candies, ice lolly, confection, lollypop, and even popsicles - lollipops, the hard candies attached to a short stick, go by different names. While choosing your lollipop equipment now is very different from the time of its creation, back in 1908, the opportunities to differentiate the product in the market are wider.

Lollipops

Gummies make everything more colorful. The squishy droplets make a tasty and practical carrier of special ingredients such as CBD oil. Chewing the gum increases the bioavailability of the substance as opposed to vaping. But before the cannabidiol can take effect, it must first be processed through a line of CBD gummy equipment.

CBD gummies

Chewy, sweet, and nutritious. Vitamin gummies were a couple’s attempt to get their child to take their essential micronutrients. The idea quickly caught on, and manufacturing vitamin gummies soon grew into a whole new industry.

Vitamin gummies

High accuracy of 0.1% per batch by using ingredients weight rather than volume

Reservoir tank provides for continuous cooker feeding between batches

20 recipe memory with up to 8 ingredients for each slurry gives maximum flexibility

  Easy to clean, with angled profiles used throughout to minimise accumulations

Up to 6,000kg per hour output for high capacity production

Industrial food processors are a vital component of the food processing industry. Large-scale food processing is made possible with the help of food processing equipment and automated food processing systems. Food production lines that utilize these technologies can increase efficiency, reduce costs, and maintain consistent quality control. But what exactly does an industrial food processor do? Simply put, it's a machine that processes raw materials into finished products. There are three types of food processors: batch processors, continuous processors, and combination processors. Batch processors are used for small-scale production runs, while continuous processors are ideal for high-volume production.

Food Processors

To make candy, all you need to do is create a syrup by dissolving sugar and boiling it to your desired consistency. For medium to large scale candy production, candy making equipment fully automates the whole process and takes care of other production regulations and standards (such as hygiene and proper homogenization). Planning on getting one? There’s a wide range of choices to pick from.

Candy

Liquid

Eating is more than just nutrition, but we have found ways to increase the nourishing power of our foods. Nutraceuticals manufacturing, from vitamin C powder and probiotics to omega 3 oil, is a concentration of natural ingredients and health supplements that complement our diets. While dietary supplements are not quite haute cuisine, the process of extraction and purification is no less a blend of science and art.

Nutraceuticals

Spreads

During the Middle Ages, sugar sweets were a delicacy only for the rich due to the high cost of sugar. Thankfully, the discovery that sugar could be extracted from sugar beets made sweets affordable for everyone. The sweet category is broad, covering chocolates, chewing gums, sugar candies, and candied/glazed products with sugar. To make these confections, sugar manufacturing equipment needs to cover different steps within the production line such as sugar dissolution, syrup cooking and cooling.

Sweets

Industrial mixing equipment is used to combine two or more solid, liquid or gaseous segregated ingredients into a homogenous single product. The choice of mixing technology depends largely on the physical state of the ingredients and the desired final product. But the sensitivity of the ingredients, the process temperature, and pressure requirements are also critical factors. All these parameters result in a wide range of industrial mixers.

Mixing

The production of accurately proportioned and homogenous slurries is a vital first step before cooking in many confectionary processes. Traditional

Automatic weigher and mixer of confectionery ingredients &#8211; Making.com

acg-pam-accura-brochure-pdf

ACG-Pam-Accura-brochure.pdf

Suppositories consist of active pharmaceutical ingredients encased in a non-active base material. The sustained release of medication makes suppositories a preferred option for the long-term treatment of chronic conditions like diabetes, anemia, and AIDS.

Suppositories

The fizz of effervescent tablets is commonly associated with a vitamin C boost. But the soluble pill is an excellent drug delivery method for pediatric and geriatric patients. Sometimes referred to as carbon tablets, manufacturing effervescent tablets binds biocarbonate and citric acid that produce the smooth hiss as they dissolve in liquid.

Effervescent tablets

A dishwasher tablet is an essential detergent. It consists of a pressed mixture of sodium and potassium salts, surfactant, fragrance, and other filler agents, mixed with the help of tablet making machines. The products’ use in America and Europe is high, unlike in the Asian continent, where the price limits its usage. Its global market size will reach $990 million in 2026 from $475.6million in 2019, according to Grand View Research forecasts.

Dishwasher tablets

The wave of liquid soaps and detergents in the 1950s revolutionized home and personal care. Cheap and convenient, these off-the-shelf products fit perfectly into the lifestyle of the time. A few decades later, though, plastic waste put the sustainability of hygiene products into question. Refill tablet production technology answers that by eliminating single-use plastic. Instead of picking up a new bottle every time, end-users complete the formulation process in a multi-use container and with a simple instruction: just add water.

Refill tablets

It is strange how two tablets can belong to the same but at the same time to a different category depending on how the tablet itself is classified. For example, chewable tablets and effervescent tablets have two different routes of administration but both belong to the category of uncoated tablets. Uncoated tablets are prepared by compression of granules in which no coating is added after compression. They may be single-layer or multi-layer tablets.

Uncoated tablets

There are slight differences between human and animal pharmaceuticals, but that dissimilarity is enough to create new production challenges. Veterinary tablets formulation reflects the diversity of enzymes that different species use to break down substances. Although the methods involved are comparable to human drug manufacturing, equipment and processes need to adapt to a wider dosage variability in veterinary tablets.

Veterinary tablets

Handles 00el-4 and 00-4 capsule sizes

Changeover in less than 15 minutes for smaller models and less than 5 minutes for larger models

Capacity up to 200,000 capsules per hour

Provides detailed statistical analysis of weighed and rejected capsules

Complex processes call for continuous tracking and monitoring systems that help you to keep the manufacturing operation under control. The technology analyzes the components in the production phase for divergence in behavior or changes in conditions. Based on advanced software applications, monitoring platforms make sure that your products satisfy the quality criteria while they are being developed.

Monitoring

<span style="font-weight: 400">At last, you reached the final stage of processing your product - welcome to the packing world! Packing preserves and protects a product from damage, spoilage, and contamination while it makes its way from the production line to the consumer or further production. Depending on which industry your products belong to, the type of primary packaging equipment can change drastically. You need to pay careful attention to products with </span><span style="font-weight: 400">chemicals or hazardous substances since they can be potentially dangerous to human health. </span>

Packing

The Accura checkweigher for capsules from ACG-Pam checks empty, filled, or partially filled capsules at a rate from 40,000 to 200,000 capsules per hour.

Pharmaceutical manufacturing demands the highest quality standards and completely consistent production.  Weight variation; however, is a reality of any

Industrial capsule checkweigher &#8211; Making.com

Suitable for continuous operation at up to 105,000 units per 24 hours

Minimal downtime thanks to quick and easy maintenance

The SADE SP sorters from CI Precision for accurate weight sorting of tablets or capsules can handle a wide range of product shapes and sizes.

Saving costs and improved production efficiencies are possible by opting for a pharmaceutical weight sorter that is fully flexible and able to handle a

Versatile weight sorter for tablets &amp; capsules &#8211; Making.com

The billions of microbes living in our gut have a significant impact on gastrointestinal health, mood, and behavior. Every individual develops their microbiome community. Probiotic processing technology makes sure that harmful bacteria never outnumber good citizens.

Probiotics

Easily and automatically sort by weight or number within a compact benchtop footprint

Save time with sorting rate of up to 75 units per minute

GMP design with quick and easy cleaning, all contact components stainless steel or PEEK

Extreme accuracy up to +/- 0.5mg for even more precision

Option of a hopper for larger batches

The CI Precision SADE SP-B40 is a benchtop checkweigher for tablets and capsules that's easy to use and improves the accuracy and speed of your process.

For laboratory pharmaceutical R&amp;D work or use in clinical trials, a high-accuracy small-scale benchtop weight sorter is the perfect solution. However,

Benchtop weight sorter for tablets &amp; capsules &#8211; Making.com

High speed combined with high accuracy improves production efficiency

Available in a range of capacities to suit your exact requirements

Simple to operate with full touchscreen control and status monitoring

Measurable weight range from 0 to 1,800mg for complete flexibility

The production of pharmaceutical capsules requires that individual doses are checked for accuracy. In a production environment this also needs to be done

Capsule checkweigher &#8211; Making.com

<h3>Mold the shells into shape with capsule manufacturing equipment</h3>
Capsule shells are composed of the body and the cap that closes the dosage. Capsule manufacturing equipment dips a series of steel pins into a drum filled with the base material. The wet molding pins move to the drying chamber to harden as they spin on their axis to ensure even distribution.

Once the shells are formed, they are stripped off the pins. But they are not yet finished for filling. The empty capsules must first be cut to the correct length and joined in a pre-lock position, ready for encapsulation.

Encapsulation technology lines up the capsule bodies on a bed of holders. A stainless steel dosage system pours the formula in the powder tray into the shells. The caps, aligned precisely in their holding section, are ready to be lowered onto the filled capsule bodies. The fins in the body enter the slits of the cap, locking them into position.

The encapsulated ingredients directly impact shell stability. Hygroscopic materials, for example, risk cracking the gelatin capsules. Capsule filling machines must account for the properties of the dosage formula and the materials, thickness, and shelf life of the shells.

Capsule production is either an automatic, semi-automatic or manual process. Manual capsule fillers are still used in smaller production facilities. However, for making large scale pharmaceutical capsules, automation is employed to maximize output and efficiency.

Pair the API with the correct shell before the capsule filling process

<h3>Control the water content in hard gelatin capsules to balance plasticity and containment</h3>
The first hard gelatin capsules were filled with pharmaceutical formulas in powder form. But one of the advantages of encapsulation is that it offers flexibility with a range of dosage solutions, from tablets to beads to micro-capsules.

This versatility means that the gelatin shells have to deliver stability. The gelatin mix must allow <a href="https://making.com/hard-gelatin-capsules" target="_blank" rel="noopener">enough moisture content</a> to create elasticity without altering the properties of the <a href="https://making.com/active-pharmaceutical-ingredients-api" target="_blank" rel="noopener">encapsulated APIs</a>.

Soft gelatin capsules, also known as softgels, are suitable for non-aqueous solutions such as oil. The active pharmaceutical ingredients are dissolved or suspended into an oil-based form.

One of the challenges in <a href="https://making.com/softgel-capsules" target="_blank" rel="noopener">producing softgel capsules</a> is the formation of air bubbles in the gelatin base. This happens when the capsule manufacturing equipment fails to reach the right temperature during the drying stage, and air remains trapped in the mixture. These pockets of unreleased air weaken the structure of the capsule.

Insufficient drying temperature leads to undesirable air pockets in soft gelatin capsules

Hypromellose emerged as the plant-sourced <a href="https://making.com/gelatin-powder" target="_blank" rel="noopener">alternative to gelatin</a>. But <a href="https://making.com/hpmc-capsules" target="_blank" rel="noopener">HPMC capsules</a> are <a href="https://making.com/hpmc-capsules" target="_blank" rel="noopener">less dependent on water content</a>, making them a better solution for hygroscopic ingredients.

However, since Hypromellose has a higher oxygen permeability, the fill ingredients need anti-oxidant additives to compensate. HPMC capsules also require oxygen-resistant packaging, such as aluminum blister configurations.

HPMC capsules are more suitable hygroscopic fillings

<h3>Blister packs offer greater protection for pharmaceutical capsules</h3>
The packing solution depends on the type of capsule. Vitamin or food supplement capsules may be bottled in simple containers. However, a desiccant pouch helps to absorb moisture and maintain a controlled environment.

In the case of pharmaceutical capsules, the ingredients demand safer packaging. Blister packs are more secure and are more convenient for dosage control. Complete <a href="https://making.com/technologies/blister-packing-equipment">blister packaging solutions</a> often include coding and die-cutting systems, but simple entry-level batch machines are also available.

Capsule Making Equipment

Find production technology for filling, forming, and packing capsules and connect directly with leading machine and equipment manufacturers worldwide.

Capsules &#8211; Making.com

Capsule Making Equipment - Making.com

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Parenteral preparations refer to drugs using non-oral means of administration. Injectables, such as needles and syringes, are used to deliver a drug into the systemic circulation directly in the veins, muscles, under the skin, or in the tissue.

These parenteral formulations are pharmaceutical dosage forms that have strict regulations on being sterile, pyrogen-free, and free from visible particulate matter including reconstituted sterile powders. Solutions, suspensions, emulsions, and gels with APIs intended for administration by injection are usually supplied in vials, ampoules, pre-filled syringes, or pens to facilitate ease of use.

Injectables

<p class="filterable-grid__description">Liquid dosage forms are designed for easy absorption. The body quickly carries the active ingredients through the system and triggers the required response. But the greatest advantage of this medicinal type is its flexibility in formulation and dispensation. From lotions and syrups to drops and sprays, liquid solutions can be adapted to different administration routes including parenteral, topical, and oral. The fundamental liquid dosage manufacturing process involves dissolving or suspending solutes in a fluid. But that is not enough. A precise blend of excipients is needed to make the medicine go down.</p>

Liquid dosage forms

What's new in pharmaceutical packaging? During Pharmapack, we met Chantal Younes, Key Account Manager at Aptar CSP Technology, who introduced us to the

Capsule weighing

Which capsule weighing equipment do you need?

Checkweigher

Checkweigher for capsules

High capacity weight sorter for tablets & capsules

Waste minimization weight sorter for tablets & capsules

Automatic weigher and mixer of confectionery ingredients

Industrial capsule checkweigher

Versatile weight sorter for tablets & capsules

Benchtop weight sorter for tablets & capsules

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