High-shear mixer granulator for pharmaceutical production
Achieve optimal granulation with enhanced mixing efficiency, reducing wall caking and ensuring consistent high-quality results for pharmaceutical formulations.

Mixes and Granulates Pharmaceutical Powders
The high-shear mixer granulator from Syntegon, featuring the innovative Hüttlin Gentlewing impeller, is specifically designed for pharmaceutical and nutraceutical production lines. It excels in mixing and granulating powders into uniform granules, crucial for oral solid dosage forms like tablets and capsules. Its unique impeller design ensures superior mixing and reduced wall caking, enhancing yield and process reliability. You can achieve granulation of challenging products like high-potent APIs and effervescent tablets, with batch capacities ranging up to 1,800 liters. Automation is seamless with its PLC-controlled system, supporting remote operation and integration into existing lines.
Offering energy efficiency through optimized motor control, this equipment minimizes solvent use and pollution. Available in top or bottom drive configurations, it features a purged sealing system to prevent cross-contamination, and is constructed from corrosion-resistant materials suitable for GMP environments. Maintenance is straightforward with integrated CIP systems, ensuring rapid cleaning cycles. Customization options like variable impeller designs and containment upgrades are available to meet specific production needs.
Benefits
- Enhances yield and quality by minimizing wall caking and product residues.
- Ensures safety in handling high-potent APIs with purged sealing and containment options.
- Reduces cleaning time with efficient in-place CIP systems.
- Lowers energy consumption through optimized motor control.
- Offers flexible batch processing with a wide capacity range from R&D to large-scale production.
- Applications
- Sachets,Antiinfective drugs,Pharmaceutical tablets,Nutraceuticals,Pharmaceutical powder,Granules,Oral solid dosage forms,High-potent apis,Effervescent tablets,Capsules
- End products
- Vitamin d3 capsules,Glucagon powder for injection,Clarithromycin sachets,Chemotherapy tablets,Amoxicillin combination capsules,Probiotic supplements,Ibuprofen granules,Paracetamol tablets,Aspirin effervescent tablets
- Steps before
- Powder Mixing,API and Excipients Charging,Formulation Preparation
- Steps after
- Wet Milling,Fluid Bed Drying,Granule Sieving,Capsule Filling,Tablet Compression,Coating
- Input ingredients
- excipients,API,water-based liquids,organic solvents,binding agents
- Output ingredients
- granules,tablets,capsules,sachets
- Market info
- Syntegon is known for its expertise in processing and packaging technology, offering innovative solutions for the food and pharmaceutical industries. It has a strong reputation for advanced equipment, sustainability, and customer-oriented service.
- Impeller Type
- Gentlewing / 3-blade
- Drive Type
- Top (HTG) / Bottom (HBG)
- Batch Size
- 0.5 – 1,800 liters
- Usable Container Volume
- 20 – 80%
- Chopper Type
- Vertical
- Automation
- PROVICON control system
- Charging Options
- Pneumatic / Gravity
- End Point Detection
- Torque Measurement
- Sealing System
- Purge-sealed
- Cleaning Method
- Automated / UltraClean
- Batch Range
- 0.1 – 720 kg
- Dosing Type
- Inline spray system
- Cooling Option
- Heating/Cooling jacket
- Compliance
- CE / ATEX
- Power Supply
- Not specified
- Automation level
- Manual / PLC / SCADA
- Batch vs. continuous operation
- Batch
- Cleaning method
- CIP / Manual
- Density/particle size
- 0.5–2.5 g/cm³ / 50–1000 µm
- Batch size variability
- 20% to 80%
- Charging options
- Pneumatic or Gravity
- Heat sensitivity
- Managed with heated bowls
- Impeller Type
- Gentlewing / 3-blade
- Drive Type
- Top Drive / Bottom Drive
- Batch Size
- 0.1–1,800 kg
- Product Container Volume
- 0.5–1,800 L
- Footprint
- Compact
- Charging Option
- Pneumatic / Gravity
- Control System
- PROVICON Control System
- Impeller Type
- Gentlewing / 3-Blade Impeller
- Drive Type
- Top (HTG) / Bottom (HBG) Drive
- Charging Option
- Pneumatic / Gravity Filling
- Containment Upgrades
- Customized for High-Potent APIs
- Cleaning System
- Basic Automated / UltraClean Technology
- Batch Size
- 0.5 to 1,800 Liters
- Heated Components
- Heated Bowl,Lid,Filter Housing,Shaft
- Vacuum System
- Optional Solvent Recovery