High-shear mixer granulator for pharmaceutical production

Achieve optimal granulation with enhanced mixing efficiency, reducing wall caking and ensuring consistent high-quality results for pharmaceutical formulations.

Mixes and Granulates Pharmaceutical Powders

The high-shear mixer granulator from Syntegon, featuring the innovative Hüttlin Gentlewing impeller, is specifically designed for pharmaceutical and nutraceutical production lines. It excels in mixing and granulating powders into uniform granules, crucial for oral solid dosage forms like tablets and capsules. Its unique impeller design ensures superior mixing and reduced wall caking, enhancing yield and process reliability. You can achieve granulation of challenging products like high-potent APIs and effervescent tablets, with batch capacities ranging up to 1,800 liters. Automation is seamless with its PLC-controlled system, supporting remote operation and integration into existing lines.

Offering energy efficiency through optimized motor control, this equipment minimizes solvent use and pollution. Available in top or bottom drive configurations, it features a purged sealing system to prevent cross-contamination, and is constructed from corrosion-resistant materials suitable for GMP environments. Maintenance is straightforward with integrated CIP systems, ensuring rapid cleaning cycles. Customization options like variable impeller designs and containment upgrades are available to meet specific production needs.

Benefits

  • Enhances yield and quality by minimizing wall caking and product residues.
  • Ensures safety in handling high-potent APIs with purged sealing and containment options.
  • Reduces cleaning time with efficient in-place CIP systems.
  • Lowers energy consumption through optimized motor control.
  • Offers flexible batch processing with a wide capacity range from R&D to large-scale production.

General


Applications
Sachets,Antiinfective drugs,Pharmaceutical tablets,Nutraceuticals,Pharmaceutical powder,Granules,Oral solid dosage forms,High-potent apis,Effervescent tablets,Capsules
End products
Vitamin d3 capsules,Glucagon powder for injection,Clarithromycin sachets,Chemotherapy tablets,Amoxicillin combination capsules,Probiotic supplements,Ibuprofen granules,Paracetamol tablets,Aspirin effervescent tablets
Steps before
Powder Mixing,API and Excipients Charging,Formulation Preparation
Steps after
Wet Milling,Fluid Bed Drying,Granule Sieving,Capsule Filling,Tablet Compression,Coating
Input ingredients
excipients,API,water-based liquids,organic solvents,binding agents
Output ingredients
granules,tablets,capsules,sachets
Market info
Syntegon is known for its expertise in processing and packaging technology, offering innovative solutions for the food and pharmaceutical industries. It has a strong reputation for advanced equipment, sustainability, and customer-oriented service.

Technical Specifications


Impeller Type
Gentlewing / 3-blade
Drive Type
Top (HTG) / Bottom (HBG)
Batch Size
0.5 – 1,800 liters
Usable Container Volume
20 – 80%
Chopper Type
Vertical
Automation
PROVICON control system
Charging Options
Pneumatic / Gravity
End Point Detection
Torque Measurement
Sealing System
Purge-sealed
Cleaning Method
Automated / UltraClean
Batch Range
0.1 – 720 kg
Dosing Type
Inline spray system
Cooling Option
Heating/Cooling jacket
Compliance
CE / ATEX
Power Supply
Not specified

Operating Characteristics


Automation level
Manual / PLC / SCADA
Batch vs. continuous operation
Batch
Cleaning method
CIP / Manual

Material Compatibility


Density/particle size
0.5–2.5 g/cm³ / 50–1000 µm

Product type Characteristics


Batch size variability
20% to 80%
Charging options
Pneumatic or Gravity
Heat sensitivity
Managed with heated bowls

Physical Characteristics


Impeller Type
Gentlewing / 3-blade
Drive Type
Top Drive / Bottom Drive
Batch Size
0.1–1,800 kg
Product Container Volume
0.5–1,800 L
Footprint
Compact
Charging Option
Pneumatic / Gravity

Custom Options


Control System
PROVICON Control System
Impeller Type
Gentlewing / 3-Blade Impeller
Drive Type
Top (HTG) / Bottom (HBG) Drive
Charging Option
Pneumatic / Gravity Filling
Containment Upgrades
Customized for High-Potent APIs
Cleaning System
Basic Automated / UltraClean Technology
Batch Size
0.5 to 1,800 Liters
Heated Components
Heated Bowl,Lid,Filter Housing,Shaft
Vacuum System
Optional Solvent Recovery